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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Response of Pinus koraiensis seedling growth to different light conditions based on the assessment of photosynthesis in current and one-year-old needles显示文摘As one of the three major five-leaved pines in the northern hemisphere,Pinus koraiensis is the most important dominant tree species in the natural mixed-broadleaved Korean pine forests.However,the regeneration of P.koraiensis under the canopy of secondary forest stands is poor because of the light limitation.This study was conducted to understand how P.koraiensis seedlings adapt to different light intensities and what would be the optimum light level for their establishment and growth.Three repetition plots with four light intensities(15%,30%,60%and 100%of the natural incident irradiances,achieved by suspending layers of black nylon net above and surrounding the plots)were set up under natural climate conditions in a montane region in eastern Liaoning Province,Northeast China.A total of 80 P.koraiensis seedlings with similar height and root collar diameter were transplanted into four plots.After one year of acclimation to the specific light conditions,the seasonal variations of the photosynthetic variables and needle traits of the current and one-year-old needles,and the growth parameters were observed under four light intensities.The results indicated that:(1)The seedling at60%treatment exhibited the greatest growth,which agreed with the response of the light-saturated photosynthetic rates(Amax)and the dark respiration rate(Rd)in the current and one-year-old needles,i.e.,Rd at60%treatment was significantly lower than that at 100%treatment,but Amax did not differ between the seedlings at 100%and 60%treatments.(2)The P.koraiensis seedlings have a certain photosynthetic plasticity to adapt the light conditions by adjusting their needle traits and regulating the physiological processes,because Amax,Rd,light saturation point and compensation point,the needle mass area,needle nitrogen and chlorophyll contents were significantly(p<0.05)correlated with the light intensities.Especially,Amax at 100%and 60%treatments was significantly higher(p<0.05)than that at 30%and 15%treatments for both current and one-year-old needles.(3)The needles of different ages played a commutative role during the growing season,i.e.,the one-year-old needles played a major role for the photosynthesis in the early growing season;the current year needles did in the later growing season.This ensured the effective photosynthesis throughout the growing season.These findings suggest that P.koraiensis is the in-between heliophilous and shade-tolerant tree species at least for the seedlings up to 8 years. | Jiaojun Zhu Kai Wang Yirong Sun Qiaoling Yan | 2014 | Journal of Forestry Research2014，25，1： | 13 |
| 3 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 4 | An efficient data compression technique based on BPDN for scattered fields from complex targets显示文摘Dear editor,For complex targets,the scattered fields vary rapidly with frequency or aspect angle owing to diverse scattering mechanisms[1].To comprehensively learn the characteristics of a target’s signature,a large number of radar cross section(RCS) | Xiangyin QUAN Bingchen ZHANG Zhengdao WANG Chao GAO Yirong WU | 2017 | Science China(Information Sciences)2017，60，10： | 5 |
| 5 | Research on Mobile Internet Mobile Agent System Dynamic Trust Model for Cloud Computing显示文摘This paper analyzes the reasons for the formation of security problems in mobile agent systems, and analyzes and compares the security mechanisms and security technologies of existing mobile agent systems from the perspective of blocking attacks. On this basis, the host protection mobile agent protection technology is selected, and a method to enhance the security protection of mobile agents (referred to as IEOP method) is proposed. The method first encrypts the mobile agent code using the encryption function, and then encapsulates the encrypted mobile agent with the improved EOP protocol IEOP, and then traces the suspicious execution result. Experiments show that using this method can block most malicious attacks on mobile agents, and can protect the integrity and confidentiality of mobile agents, but the increment of mobile agent tour time is not large. | Weijin Jiang Yang Wang Yirong Jiang Jiahui Chen Yuhui Xu Lina Tan | 2019 | China Communications2019，16，7： | 5 |
| 6 | The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)caused by the SARS-CoV-2 coronavirus has become a global pandemic.The SARS-CoV-2 genome has a similarity of 96.2%to that of RaTG13,a bat SARS-CoV-2-related coronavirus detected in Rhinolophus affinis(Paraskevis et al.,2020;Zhou et al.,2020).The SARS-CoV-2 genome also has 85.5%−92.4%sequence similarity to SARS-CoV-2-related coronaviruses from Malayan pangolins that have been seized in anti-smuggling operations in southern China(Guangdong-Pangolin(GD-Pangolin-CoV)and Guangxi-Pangolin(GX-Pangolin-CoV)genomes)(Liu et al.,2019;Lam et al.,2020). | Tao Li Xiaolu Tang Changcheng Wu Xinmin Yao Yirong Wang Xuemei Lu Jian Lu | 2020 | Science China(Life Sciences)2020，63，10： | 3 |
| 7 | A New Time-Aware Collaborative Filtering Intelligent Recommendation System显示文摘Aiming at the problem that the traditional collaborative filtering recommendation algorithm does not fully consider the influence of correlation between projects on recommendation accuracy,this paper introduces project attribute fuzzy matrix,measures the project relevance through fuzzy clustering method,and classifies all project attributes.Then,the weight of the project relevance is introduced in the user similarity calculation,so that the nearest neighbor search is more accurate.In the prediction scoring section,considering the change of user interest with time,it is proposed to use the time weighting function to improve the influence of the time effect of the evaluation,so that the newer evaluation information in the system has a relatively large weight.The experimental results show that the improved algorithm improves the recommendation accuracy and improves the recommendation quality. | Weijin Jiang Jiahui Chen Yirong Jiang Yuhui Xu Yang Wang Lina Tan Guo Liang | 2019 | Computers, Materials & Continua2019，，8： | 3 |
| 8 | Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis显示文摘The ginsenoside Rgfound in Panax species has extensive pharmacological properties,in particular anti-cancer effects.However,its natural yield in Panax plants is limited.Here,we report a multimodular strategy to improve yields of Rgin a Panax ginseng chassis,combining engineering of triterpene metabolism and overexpression of a lignin biosynthesis gene,phenylalanine ammonia lyase(PAL).We first performed semi-rational design and site mutagenesis to improve the enzymatic efficiency of Pq3-O-UGT2,a glycosyltransferase that directly catalyzes the biosynthesis of Rgfrom Rh.Next,we used clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing to knock down the branch pathway of protopanaxatriol-type ginsenoside biosynthesis to enhance the metabolic flux of the protopanaxadiol-type ginsenoside Rg.Overexpression of PAL accelerated the formation of the xylem structure,significantly improving ginsenoside Rgaccumulation(to 6.19-fold higher than in thecontrol).Wecombinedoverexpression of the ginsenoside aglycon synthetic genes squalene epoxidase,Pq3-O-UGT2,and PAL with CRISPR/Cas9-based knockdown of CYP716A53v2 to improve ginsenoside Rgaccumulation.Finally,we produced ginsenoside Rgat a yield of 83.6 mg/L in a shake flask(7.0 mg/g dry weight,21.12-fold higher than with wild-type cultures).The highproduction system established in this study could be a potential platform to produce the ginsenoside Rgcommercially for pharmaceutical use. | Lu Yao Huanyu Zhang Yirong Liu Qiushuang Ji Jing Xie Ru Zhang Luqi Huang Kunrong Mei Juan Wang Wenyuan Gao | 2022 | Journal of Integrative Plant Biology2022，64，9： | 3 |
| 9 | Studies on MB-SAR 3D imaging algorithm using Yule-Walker method显示文摘Multibaseline synthetic aperture radar(MB-SAR) can form a synthetic aperture in the height direction with multiple parallel observations,so it has the resolving capability in the height direction and can realize three-dimensional(3D) imaging for the target.The analytic model of MB-SAR based on spectrum estimation is analyzed in this paper.Based on the more general geometric model,we derive the signal model for MB-SAR 3D imaging.And then Yule-Walker algorithm is proposed to realize MB-SAR 3D imaging meanwhile the principle is analyzed and the steps of Yule-Walker algorithm are given.This algorithm can get the 3D image of the target with high resolution using fewer observations.Finally,the experimental results of MB-SAR 3D imaging using Yule-Walker algorithm are presented,which are generated with the simulated data and the data collected in anechoic chamber. | WANG Bin WANG YanPing HONG Wen TAN WeiXian WU YiRong | 2010 | Science China(Information Sciences)2010，53，9： | 3 |
| 10 | NOVEL SYNTHETIC METHOD OF LINGNINAMINETYPE ASPHALT EMULSIFIER显示文摘The slurry sealing with cationic emulsified asphalt,which is a new technique inhighway construction,is rapidly extended at home and abroad.The technique should apply an ex-cellent slow set cationic cmulsifier.Now,slow set emulsifiers are ligninamines which are synthesizedby trimethylamine-epichlorohydrin route.Owing to high price and unstable quality,the extendingof slurry sealing technique is affected seriously.We prepare the ligninamine by a novel syntheticmethod.By the novel method,the cost of production is reduced by more than 30%,and the prod-ucts have stable quality,high emulsifying function and broad daptability for various asphalts.Thenovel synthetic method uses soda lignin,secondary amines and inexpensive aminating assistants asraw materials.The technological process of the method may use either one or two-step process,andthe technological condition are uncomplicated and easy to master.master. | Wu Baoguo (1) Yang Yirong (1) Pan Xuefeng (1) Wang Xiaoshui (1) Liu Guangping (1) | 1992 | Journal of Northeast Forestry University1992，3，1： | 2 |
| 11 | Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat显示文摘Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly known. In Chlamydomonas, Dynein-f controls flagellar waveforms but is dispensable for beating. The flagellar assembly of its heavy chains (HCs) requires its intermediate chain (IC) IC140 but not IC138. Here we show that, unlike its Chlamydomonas counte『part, vertebrate Dynein-f is essential for ciliary beat. We confirmed that Wdr78 is the vertebrate orthologue of IC3 Wdr78 associated with Dynein-f subunits such as Dnah2 (a HC) and Wdr63 (IC140 orthologue). It was expressed as a motile cilium-specific protein in mammalian cells. Depletion of Wdr78 or Dnah2 by RNAi paralyzed mouse ependymal cilia. Zebrafish Wdr78 morphants displayed ciliopathy-related phenotypes, such as curved bodies, hydrocephalus, abnormal otolith, randomized left-right asymmetry, and pronephric cysts, accompanied with paralyzed pronephric cilia. Furthermore, all the HCs and ICs of Dynein-f failed to localize in the Wdr78-depleted mouse ependymal cilia. Therefore, both the functions and subunit dependency of Dynein-fare altered in evolution, probably to comply with ciliary roles in higher organisms. | Yirong Zhang Yawen Chen Jianqun Zheng Juan Wang Shichao Duan Wei Zhang Xiumin Yan Xueliang Zhu | 2019 | Journal of Molecular Cell Biology2019，11，5： | 2 |
| 12 | Preparation of a multi-hapten antigen and broad specificity polyclonal antibodies for a multiple pesticide immunoassay 显示文摘 | Wang Shuting Gui Wenjun Guo Yirong | 2007 | Analytica Chimica Acta2007，587，： | 1 |
| 13 | Pyrolysis of Polystyrene Waste in a Fluidized-reactor to Obtain Styrene Monomer and Gasoline Fraction显示文摘 | Yirong Liu Jialin Qian Jianqiu Wang | 2000 | Fuel Processing Technology2000，63，3： | 1 |
| 14 | Interactions of vegetation succession, soil bio-chemical properties and microbial communities in a Karst ecosystem显示文摘 | Hanhua Zhu Xunyang He Kelin Wang Yirong Su Jinshui Wu | 2012 | European Journal of Soil Biology2012，，： | 1 |
| 15 | Linearizability of the polynomial differential systems with a resonant singular point 显示文摘 | Wang Qinlong Liu Yirong | 2008 | Bull Sci math2008，132，： | 1 |
| 16 | Molecular Simulation of Transesterification of Ethylene Carbonate and Methanol Catalyzed by Ionic Liquids显示文摘Four ionic liquids [BMIM]OH, [BMIM]IM, [BMIM]Br, and [BMIM]PF6 were synthesized and characterized by infrared spectroscopy. Then the effects of ionic liquids(ILs), cocatalysts, and reaction temperature on the catalytic performance for transesterification of ethylene carbonate and methanol were investigated with orthogonal experiments. The influence of cations and anions of ILs on catalytic activity was revealed by the density functional theory(DFT). The reaction mechanism was proposed based on the experimental results and DFT. The results demonstrated that the optimal catalyst was [Bmim]PF6/CaO, which exhibited the advantages of high activity, excellent stability, and easy recycling. Under the optimized conditions covering a catalytic temperature of 130 °C, an ionic liquid/cocatalyst mass ratio of 5:1, and a catalyst dosage of 4.0%, the conversion rate could reach 65.23% with a dimethyl carbonate selectivity of 98.95%. No significant loss of catalyst activity was detected after 7 recycle times. | Guo Liying Wu Hao Wang Yirong Cui Zhongyi Chen Yanming | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 1 |
| 17 | Mobile Internet Mobile Agent System Dynamic Trust Model for Cloud Computing显示文摘In mobile cloud computing,trust is a very important parameter in mobile cloud computing security because data storage and data processing are performed remotely in the cloud.Aiming at the security and trust management of mobile agent system in mobile cloud computing environment,the Human Trust Mechanism(HTM)is used to study the subjective trust formation,trust propagation and trust evolution law,and the subjective trust dynamic management algorithm(MASTM)is proposed.Based on the interaction experience between the mobile agent and the execution host and the third-party recommendation information to collect the basic trust data,the public trust host selection algorithm is given.The isolated malicious host algorithm and the integrated trust degree calculation algorithm realize the function of selecting the trusted cluster and isolating the malicious host,so as to enhance the security interaction between the mobile agent and the host.Given algorithm simulation and verification were carried out to prove its feasibility and effectiveness. | Weijin Jiang Yang Wang Yirong Jiang Yuhui Xu Jiahui Chen Lina Tan Guo Liang | 2020 | Computers, Materials & Continua2020，，1： | 1 |
| 18 | Source identification and prediction of nitrogen and phosphorus pollution of Lake Taihu by an ensemble machine learning technique显示文摘Effective control of lake eutrophication necessitates a full understanding of the complicated nitrogen and phosphorus pollution sources,for which mathematical modeling is commonly adopted.In contrast to the conventional knowledge-based models that usually perform poorly due to insufficient knowledge of pollutant geochemical cycling,we employed an ensemble machine learning(ML)model to identify the key nitrogen and phosphorus sources of lakes.Six ML models were developed based on 13 years of historical data of Lake Taihu’s water quality,environmental input,and meteorological conditions,among which the XGBoost model stood out as the best model for total nitrogen(TN)and total phosphorus(TP)prediction.The results suggest that the lake TN is mainly affected by the endogenous load and inflow river water quality,while the lake TP is predominantly from endogenous sources.The prediction of the lake TN and TP concentration changes in response to these key feature variations suggests that endogenous source control is a highly desirable option for lake eutrophication control.Finally,one-month-ahead prediction of lake TN and TP concentrations(R2 of 0.85 and 0.95,respectively)was achieved based on this model with sliding time window lengths of 9 and 6 months,respectively.Our work demonstrates the great potential of using ensemble ML models for lake pollution source tracking and prediction,which may provide valuable references for early warning and rational control of lake eutrophication. | Yirong Hu Wenjie Du Cheng Yang Yang Wang Tianyin Huang Xiaoyi Xu Wenwei Li | 2023 | Frontiers of Environmental Science & Engineering2023，17，5： | 1 |
| 19 | Visual sensing method based on texture analysis for automatic seam tracking sys- tems显示文摘 | Zou Yirong Du Dong Wang Li | 2011 | Lecture Notes in Electrical Engineering2011，133，2： | 1 |
| 20 | Development of a McAb- based immunoassay for parathion and influence of the competitor structure显示文摘 | Chunmei Wang Yihua Liu Yirong Guo | 2009 | Food chemistry2009，115，2： | 1 |
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