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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Effects of anaerobic composting on tetracycline degradation in swine manure显示文摘Oxytetracycline(OTC) and tetracycline(TC) are the most common TC antibiotics used in human and veterinary medicine.Residual amounts of these antibiotics in manure pose a potential threat to public and ecological health as a result of the potential for them to be released to the environment following land application of manure from animals treated with antibiotics.We investigated the degradation of OTC and TC during anaerobic composting.We tested the effects of temperature and antibiotic concentration on degradation rates in a control and in manure spiked with TCs.We examined changes in p H,biological degradation material(BDM),and moisture corresponding with antibiotic degradation of TCs in the swine manure.Results showed that the OTC and TC concentrations decreased by between 68.54% and 95.50% in all nine treatments following 14 days of anaerobic composting,and the highest removal ef ficiencies were observed at an incubation temperature of 55°C and initial concentrations of 10.36 μg·g^(-1),and 5.96 μg·g^(-1) of OTC and TC,respectively,which were degraded by 95.50%,and 90.06%.During composting at 55 °C and at added concentrations of 5 μg·g^(-1),OTC decreased rapidly,and the time required for50% and 90% degradation was 4.1 and 9.8 days,respectively;for TC,these values were 4.4 and 14.0 days,respectively.Removal ef ficiencies for all TCs correlated well with moisture content of the manure.These results show that composting may be a practical and useful means to reduce concentrations of OTC and TC in swine manure prior to its land application. | Yixuan Chu Chengran Fang Hua Wang Xinkai Wu Yijie Gu Ji Shu | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 6 |
| 3 | Future vehicles:interactive wheeled robots显示文摘Owing to the lack of variety of interactions in automatic driving,the interactive cognition and evolution growth of self-driving vehicles in uncertain and complex environments have been proposed,making future vehicles interactive wheeled robots. | Nan MA Deyi LI Wen HE Yue DENG Jiahong LI Yue GAO Hong BAO Huan ZHANG Xinkai XU Yuansheng LIU Zhixuan WU Li CHEN | 2021 | Science China(Information Sciences)2021，64，5： | 4 |
| 4 | Dacrycarpus pattern shedding new light on the early floristic exchange between Asia and Australia显示文摘The recent discovery of mummified Dacrycarpus remains from the Miocene Erzitang Formation of the Guiping Basin,Guangxi,southern China,essentially contests our concepts of floristic exchange between Australia and China.East Asia has several biodiversity hotpots and is a key region for understanding the origin and evolution of the biodiversity in the N orthern Hemisphere[1].Most Gondwanan elements in East Asia are those formerly distributed across much wide areas in the Southern Hemisphere,but their modern distributions are the results of complex geological and climatic changes.Understanding the biogeographical history of Gondwanan taxa,and the mechanism underpinning their current distributions,help in understanding and conserving extant biodiversity. | Xinkai Wu Xiaoyan Liu Tatiana Kodrul Cheng Quan Jianhua Jin | 2019 | National Science Review2019，6，6： | 3 |
| 5 | Modelling-based evaluation of the effect of quarantine control by the Chinese government in the coronavirus disease 2019 outbreak显示文摘Dear Editor,The recent outbreak of novel coronavirus disease 2019(COVID-19)has already become a global-scale epidemic.Since the case from China was reported on Dec 30th,2019(Huang et al.,2020;Li et al.,2020),the pathogen was soon identified as a new coronavirus on Jan 7th. | Xinkai Zhou Zhigui Wu Ranran Yu Shanni Cao Wen Fang Zhen Jiang Fang Yuan Chao Yan Dijun Chen | 2020 | Science China(Life Sciences)2020，63，8： | 3 |
| 6 | MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway显示文摘 | Jianqiang Bao Ding Li Li Wang Jingwen Wu Yanqin Hu Zhugang Wang Yan Chen Xinkai Cao Cizhong Jiang Wei Yan Chen Xu | 2012 | Journal of Biological Chemistry2012，，26： | 2 |
| 7 | Real-time queue length estimation for congested signalized intersections显示文摘 | Liu H X Wu Xinkai Ma Wenteng | 2009 | Transportation Research Part C:Emerging Technologies2009，17，4： | 1 |
| 8 | Simultaneous biosorption of cadmium (II) and lead (II) ions by pretreated biomass of Phanerochaete chrysosporium显示文摘 | Qingbiao Li Songtao Wu Gang Liu Xinkai Liao Xu Deng Daohua Sun Yuelin Hu Yili Huang | 2003 | Separation and Purification Technology2003，，1： | 1 |
| 9 | Real-time queue length estimation for congested sig nalized intersections显示文摘 | Henry X Liu Xinkai Wu Wenteng Ma etc | 2009 | Transportation Research Part C:Emerging Technologies2009，17，4： | 1 |
| 10 | Real-time queue length estimation for congested signalized intersections显示文摘 | Henry X. Liu Xinkai Wu Wenteng Ma Heng Hu | 2009 | Transportation Research Part C2009，，4： | 1 |
| 11 | Real-time queue length estimation for congested signalized intersections 显示文摘 | LIU X Henry WU Xinkai MA Wenteng | 2009 | Transportation Research Part C2009，17，： | 1 |
| 12 | Study on Steel Slag and Fly Ash Composite Portland Cement显示文摘 | Wu Xuequan Zhu Hong Hou Xinkai | 1999 | Cement and Concrete Research1999，29，17： | 1 |
| 13 | Real-time queue length estimation for congested signalized intersections显示文摘 | Henry X. Liu Xinkai Wu Wenteng Ma Heng Hu | 2009 | Transportation Research Part C2009，，4： | 1 |
| 14 | Real-time queue length estimation for congested signalized intersections显示文摘 | Liu Henry Wu Xinkai Ma Wenteng | 2009 | Transportation Research Part C2009，17，： | 1 |
| 15 | Realtime queue length estimation for congested signalized intersections显示文摘 | Henry X Liu Xinkai Wu Wenteng Ma | | 0，，： | 1 |
| 16 | Study on Steel Slag and Fly Ash Composite Portland Cement显示文摘 | Wu Xuequan Zhu Hong Hou Xinkai | 1999 | Cement andConerete Research1999，29，： | 1 |
| 17 | Real - time Queue Length Estimation for Congested Signalized Intersections 显示文摘 | LIU H X WU Xinkai MA Wenteng | 2009 | Transportation Research Part C: Technology2009，17，4： | 1 |
| 18 | Study on steel slag and fly ash composite Portland cement显示文摘 | Xuequan Wu Zhu Hong Hou Xinkai | 1999 | Cement and Concrete Research1999，，29： | 1 |
| 19 | Real- time queue length estimation for congested signalized intersections显示文摘 | Liu H X Wu Xinkai Ma Wenteng | 2009 | Transportation Research Part C2009，17，4： | 1 |
| 20 | Identification of Oversaturated Intersections Using High-resolution Traffic Signal Data 显示文摘 | WU Xinkai LIU H X GETTMAN D | 2010 | Transportation Research Part C: Technology2010，18，4： | 1 |
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