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| 1 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 2 | Phytoremediation of soil metals 显示文摘 | Channy R L Malikm | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 3 | Phytoremedi-ation of soil metals显示文摘 | Channy R L Malik M Li Y M | 1997 | Current Opinons in Biotech-nology1997，8，： | 1 |
| 4 | Phytoremediationof soil metals 显示文摘 | CHANNY R L MALIK M LI Y M | 1997 | Current Opinons in Biotechnology1997，8，3： | 1 |
| 5 | Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin显示文摘 | Hak-Ryul Kim Sejin Kim Eun-Jung Kim Jung-Hyun Park Sei-Hoon Yang Eun-Taik Jeong Channy Park Myung-Ja Youn Hong-Seob So Raekil Park | 2007 | Lung Cancer2007，，1： | 1 |
| 6 | Heme oxygenase-1 attenuates the cisplatin-induced apoptosis of auditory cells via down-regulation of reactive oxygen species generation显示文摘 | Hyung-Jin Kim Hong-Seob So Jeong-Han Lee Jae-Hyung Lee Channy Park Sung-Yeol Park Yun-Ha Kim Myung-Ja Youn Se-Jin Kim Sang-Young Chung Kang-Min Lee Raekil Park | 2006 | Free Radical Biology and Medicine2006，，10： | 1 |
| 7 | Plytoremediation of soil mentals显示文摘 | Channy R L Malikm | 1997 | Current Opinions in Biotechnology1997，8，： | 1 |
| 8 | Phytoremediation of soil metals显示文摘 | CHANNY R L MALIK M Li YM | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 9 | Phytoremediation of soilmetals显示文摘 | Channy R L Malik M Li Y M | 1997 | Current Opinons in Biotechnology1997，，8： | 1 |
| 10 | Phytoremediation of soil metals 显示文摘 | Channy R L Malik M Li Y M | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 11 | Phytoremediation of soil metals 显示文摘 | Channy R L Malik M Li Y M etal | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 12 | Phytoremdiation of soil metals显示文摘 | CHANNY R L MALIK M LI Y M | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 13 | Phytoremediation of soil metals 显示文摘 | Channy R L Malik M Li YM | 1997 | Cm''rent Opinons in Bioteehnology1997，8，3： | 1 |
| 14 | Phytoremediation of soil metals显示文摘 | Channy R L | 1997 | Current Opinions in Biotechnology1997，8，： | 1 |
| 15 | Phytoremediation of soil metals 显示文摘 | Channy R L Malik M Li Y M | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 16 | Phytoremediation of soil metals 显示文摘 | Channy R L Malikm | 1997 | Current Opinions in Biotechnology1997，，8： | 1 |
| 17 | Phytoremediation of soil metals显示文摘 | Channy R L Malik M Li Y M | 1997 | Current Opinons in Biotechnology1997，8，： | 1 |
| 18 | A Comparative Analysis of the Role of International Organizations in Financing Higher Education System: A Case Study of Nigeria and Cambodia显示文摘Among the key international organizations (IOs) operating in Nigeria and Cambodia in terms of activities impact are the World Bank, the International Monetary Fund (IMF), European Union (EU), the United Nations Children’s Fund (UNICEF), the United Nations Educational, Scientific, and Cultural Organization (UNESCO), and many Non-Governmental Organizations (NGOs) operating from both within and outside the two nations. Generally, the article accessed the impact of these IOs in higher education (HE) system of Nigerian and Cambodia. The major key goals of IO in both nations is to develop education policy, enhance quality of HE, prepare equity of accessing for HE, provide ideas of conducting researches, and provide plenty scholarship opportunities, but for several years, this goals are yet to be accomplished in both nations. In Nigeria context, the major reason for the frequent academic and non-academic strike as result of inadequate funding. While in Cambodia context, the major course of HE slow growth, poor infrastructure, and inadequate manpower, unemployment is as a result of weak intervention of IO in HE. Using secondary data, the paper reviews literatures in accessing the role of IO in financing HE system of both countries. The paper ended with recommendations that all IO should collaborate with the World Bank to impact HE in both countries. We also suggested that more attention should be withdrawn from basic education to HE into other to enhance rapid development of human capital. | DY Channy Ogunniran Moses Oladele | 2019 | US-China Education Review(A)2019，9，1： | 0 |
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