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| 1 | Characterization of a Putative New Semi-Dominant Reduced Height Gene, Rht_NM9, in Wheat(Triticum aestivum L.)显示文摘Plant height is an important agronomic trait in cereal crops, and can affect both plant architecture and grain yield. New dwarfing genes are required for improving the genetic diversity of wheat. In this study, a novel dwarf mutant, NM9, was created by treating seeds of the wheat variety NAU9918 with ethyl methanesulfonate(EMS). NM9 showed obvious phenotypic changes, which were distinct from those caused by other dwarfing genes, especially the reduced plant height, increased effective tiller number, and elongated spike and grain length. The reduced plant height in NM9 was attributable to a semi-dominant dwarfing gene Rht_NM9, which was flanked by two closely linked SNP markers, SNP34 and SNP41, covering an 8.86-Mb region on the chromosome arm 2AS. The results of gibberellic acid(GA) sensitivity evaluation, comparative genomics analysis and allelism test indicated that Rht_NM9 was neither allelic to Rht7 and Rht21 nor homoeoallelic to Rht8, so Rht_NM9 was proposed to be a new dwarfing locus on the homoeologous group 2 chromosomes of wheat. Rht_NM9has a negative effect on plant height and positive effects on effective tiller number and grain size, thus, Rht_NM9 could be used for elucidating the mechanisms underlying plant architecture and grain development. | Yuan Lu Liping Xing Shujuan Xing Ping Hu Chaofan Cui Mingyi Zhang Jin Xiao Haiyan Wang Ruiqi Zhang Xiue Wang Peidu Chen Aizhong Cao | 2015 | Journal of Genetics and Genomics2015，42，12： | 6 |
| 2 | Development and validation of reverse transcription loop - mediated iso-thermal amplification for detection of PRRSV 显示文摘 | Chen Changmu Cui Shangjin Zhang Chaofan | 2010 | Virus Genes2010，40，1： | 1 |
| 3 | A multiplex PCR for rapid and simtxLtaneous detection of porcine circovirus type 2, porcine parvovirus, porcine pseudorabies virus, and porcine reproductive and respiratory syndrome virusin clinical specimens 显示文摘 | Fengxiong Yue Shangjin Cui Chaofan Zhang | 2009 | Virus Genes2009，38，： | 1 |
| 4 | Development and validation of reverse transcription loopmediated isothermal amplification for detection of PRRSV显示文摘 | Chen Changmu Cui Shangjin Zhang Chaofan | 2010 | Virus Genes2010，40，： | 1 |
| 5 | A multiplex PCR for rapid and simultaneous detection of porcine circovirus type 2, porcine parvovirus, porcine pseudorabies virus, and porcine reproductive and respiratory syndrome virus in clinical specimens显示文摘 | Fengxiong Yue Shangjin Cui Chaofan Zhang Kyoung-Jin Yoon | 2009 | Virus Genes2009，，3： | 1 |
| 6 | Development and validation of reverse transcription loop-mediated isothermal amplification for detection of PRRSV 显示文摘 | Chen Changmu Cui Shangjin Zhang Chaofan | 2010 | Virus Genes2010，40，： | 1 |
| 7 | Correlation between the gut microbiome and neurodegenerative diseases:a review of metagenomics evidence显示文摘A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis.As a contributing factor,microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis.High-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms,and for both neuroimmune and neuroendocrine systems.Here,we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases,with an emphasis on multi-omics studies and the gut virome.The pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also elucidated.Finally,we discuss the role of diet,prebiotics,probiotics,postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases. | Xiaoyan Liu Yi Liu Junlin Liu Hantao Zhang Chaofan Shan Yinglu Guo Xun Gong Mengmeng Cui Xiubin Li Min Tang | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 8 | Clinical outcomes of asymptomatic low-grade esophagitis:results from a multicenter Chinese cohort显示文摘Background:Asymptomatic low-grade(Los Angeles Classification Grades A and B)esophagitis is common in clinical practice with unclear clinical outcomes.This study aimed to explore the clinical outcomes of asymptomatic low-grade esophagitis.Methods:This was a multicenter cohort study conducted by three academic hospitals in China.Asymptomatic low-grade esophagitis patients between January 2015 and December 2019 were included.Mucosal healing condition 1year after initial diagnosis,symptomoutcomes,and proton-pump inhibitor(PPI)use within 1year after initial diagnosis were studied and compared.Results:A total of 248 asymptomatic low-grade esophagitis patients were included.Esophagitis disappeared in 76.2%of patients 1 year after initial diagnosis.In terms of symptom outcomes,89.9%of patients did not present gastroesophageal reflux disease(GERD)symptoms within 1 year after initial diagnosis.No significant difference was found in the proportion of patients who presented GERD symptoms and in the proportion of patients with persistent esophagitis between the PPI group and the non-PPI group(all P>0.05).Patients with initial Grade B esophagitis were more likely to present follow-up GERD symptoms(16.0%vs 7.5%,P=0.041)and had more severe follow-up esophagitis than those with Grade A(P<0.001).Patients with follow-up GERD symptoms were more likely to have persistent esophagitis than those without.Conclusions:This study demonstrated that asymptomatic low-grade esophagitis had relatively benign clinical outcomes.Patients with initial Grade B esophagitis and patients with follow-up GERD symptoms were more likely to be those who are in genuine need of further follow-up and treatments. | Songfeng Chen Xuelian Xiang Xiaohao Zhang Qianjun Zhuang Niandi Tan Xun Hou Mengyu Zhang Junnan Hu Chaofan Duan Yi Cui Jinhui Wang Xiangbin Xing Nina Zhang Yinglian Xiao | 2022 | Gastroenterology Report2022，10，1： | 0 |
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