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| 1 | Science Mapping:A Systematic Review of the Literature显示文摘Purpose: We present a systematic review of the literature concerning major aspects of science mapping to serve two primary purposes: First, to demonstrate the use of a science mapping approach to perform the review so that researchers may apply the procedure to the review of a scientific domain of their own interest, and second, to identify major areas of research activities concerning science mapping, intellectual milestones in the development of key specialties, evolutionary stages of major specialties involved, and the dynamics of transitions from one specialty to another.Design/methodology/approach: We first introduce a theoretical framework of the evolution of a scientific specialty. Then we demonstrate a generic search strategy that can be used to construct a representative dataset of bibliographic records of a domain of research. Next, progressively synthesized co-citation networks are constructed and visualized to aid visual analytic studies of the domain's structural and dynamic patterns and trends. Finally, trajectories of citations made by particular types of authors and articles are presented to illustrate the predictive potential of the analytic approach.Findings: The evolution of the science mapping research involves the development of a number of interrelated specialties. Four major specialties are discussed in detail in terms of four evolutionary stages: conceptualization, tool construction, application, and codification. Underlying connections between major specialties are also explored. The predictive analysis demonstrates citations trajectories of potentially transformative contributions.Research limitations: The systematic review is primarily guided by citation patterns in the dataset retrieved from the literature. The scope of the data is limited by the source of the retrieval, i.e. the Web of Science, and the composite query used. An iterative query refinement is possible if one would like to improve the data quality, although the current approach serves our purpose adequately. More in-depth analyses of each specialty would be more revealing by incorporating additional methods such as citation context analysis and studies of other aspects of scholarly publications.Practical implications: The underlying analytic process of science mapping serves many practical needs, notably bibliometric mapping, knowledge domain visualization, and visualization of scientific literature. In order to master such a complex process of science mapping, researchers often need to develop a diverse set of skills and knowledge that may span multiple disciplines. The approach demonstrated in this article provides a generic method for conducting a systematic review.Originality/value: Incorporating the evolutionary stages of a specialty into the visual analytic study of a research domain is innovative. It provides a systematic methodology for researchers to achieve a good understanding of how scientific fields evolve, to recognize potentially insightful patterns from visually encoded signs, and to synthesize various information so as to capture the state of the art of the domain. | Chaomei Chen | 2017 | Journal of Data and Information Science2017，2，2： | 596 |
| 2 | 坚守与拓展:中美图书馆学情报学教育科学定位的思考显示文摘数字时代中美图书馆学情报学教育的科学定位应当是'坚守与拓展'。坚守,就是对已有优势的图书馆学的教育不能削弱,而应加强。拓展,就是要将教育内容从传统优势扩大到相关领域,特别是一些新兴的、跨学科、交叉学科领域。参考文献10。 | 叶继元 Chaomei Chen | 2007 | 中国图书馆学报2007，33，2： | 37 |
| 3 | A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle显示文摘Traditional Chinese herbs(TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test(TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized. The relationship between the concentration of quinine and animal preference index(PI) was obtained. Then the PI of TCH was measured through TBP, and bitterness results were converted into a unified numerical system using the relationship of concentration and PI. To verify the authenticity and sensitivity of quantified results,human sensory testing and electronic tongue testing were applied. The quantified results showed a good discrimination ability. For example, the bitterness of Coptidis Rhizoma was equal to 0.0579 mg/mL quinine, and Nelumbinis Folium was equal to 0.0001 mg/mL. The validation results proved that the newassessment method for TCH was objective and reliable. In conclusion, this study provides an option for the quantification of bitterness and the evaluation of taste masking effects. | Xue Han Hong Jiang Li Han Xi Xiong Yanan He Chaomei Fu Runchun Xu Dingkun Zhang Junzhi Lin Ming Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 17 |
| 4 | Interaction between en- dogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension显示文摘The aim of the study was to investigate the in-teraction between nitric oxygenase (NOS)/ nitric oxide (NO) and heme oxygenase (HO)/ carbon monoxide (CO) system in the pathogenesis of hypoxic pulmonary hypertension. On a rat model of hypoxic pulmonary hypertension, the pulmo-nary artery pressure was measured, and NO formation and expression of NOS in pulmonary tissues were examined after treatment with ZnPP-IX, an HO-1 inhibitor. The pulmonary artery pressure, CO formation and expression of HO-1 in pulmonary tissues were examined after treatment with L-NAME, a NOS inhibitor. We found that pulmonary hy-pertension developed after 2-week hypoxia, while the con-centration of NO in the pulmonary tissue homogenates and the expression of NOS in intrapulmonary artery endothelial cells decreased markedly. ZnPP-IX worsened pulmonary hypertension of hypoxic rats. However, it increased endoge-nous production of NO and the expression of NOS obviously. The concentration of CO in the pulmonary tissue homoge-nates and the expression of HO-1 in intrapulmonary artery smooth muscle cells increased markedly with hypoxic pul-monary hypertension. L-NAME worsened pulmonary hy-pertension of hypoxic rats, but inhibited CO formation and HO-1 expression (P < 0.01). The results of this study sug-gested that endogenous NOS/NO and HO/CO systems might interact with each other and therefore play an important regulating role in hypoxic pulmonary hypertension. | SHI Yun, DU Junbao, GUO Zhiliang, ZENG Chaomei & TANG Chaoshu Department of Pediatrics, the First Hospital, Peking University, Beijing 100034, China Correspondence should be addressed to Du Junbao (e-mail: junbaodu@ ht.rol.cn) | 2003 | Chinese Science Bulletin2003，48，1： | 8 |
| 5 | PREDICTION OF YIELD FUNCTIONS ON BCC POLYCRYSTALS显示文摘由非线性的优化理论,我们在希尔的标准形式预言单个电子消息传输方式晶体的收益功能。然后,我们在 Sach 的模型下面在电子消息传输方式多晶体Ω的宏观的收益功能上给一个公式,在在Ω的所有 BCCcrystallites 的收益功能的体积一般水准作为 BCC 多晶体的宏观的收益功能被拿的地方。Inconstructing 公式,我们试着在宏观的收益功能,取向分发功能(ODF ) ,和单个电子消息传输方式之中发现关系水晶的粘性。为一个单轴的张力的问题的收益压力的一个表达式在泰勒的模型下面被导出以便把表达式与宏观的收益函数的作比较。 | Huang Mojia Fu Mingfu Zheng Chaomei | 2006 | Acta Mechanica Solida Sinica2006，19，1： | 5 |
| 6 | Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis显示文摘Curcumin,the medically active component from Curcuma longa(Turmeric),is widely used to treat inflammatory diseases.Protein interaction network(PIN) analysis was used to predict its mechanisms of molecular action.Targets of curcumin were obtained based on ChE MBL and STITCH databases.Protein–protein interactions(PPIs) were extracted from the String database.The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology(GO) enrichment analysis based on molecular complex detection(MCODE).A PIN of curcumin with 482 nodes and 1688 interactions was constructed,which has scale-free,small world and modular properties.Based on analysis of these function modules,the mechanism of curcumin is proposed.Two modules were found to be intimately associated with inflammation.With function modules analysis,the anti-inflammatory effects of curcumin were related to SMAD,ERG and mediation by the TLR family.TLR9 may be a potential target of curcumin to treat inflammation. | Yanxiong Gan Shichao Zheng Jan P.A.Baak Silei Zhao Yongfeng Zheng Nini Luo Wan Liao Chaomei Fu | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 5 |
| 7 | Mapping the research on scientific collaboration显示文摘The aim of this paper was to identify the trends and hot topics in the study of scientific collaboration via scientometric analysis.Information visualization and knowledge domain visualization techniques were adopted to determine how the study of scientific collaboration has evolved.A total of 1,455 articles on scientific cooperation published between 1993 and 2007 were retrieved from the SCI,SSCI and A&HCI databases with a topic search of scientific collaboration or scientific cooperation for the analysis.By using CiteSpace,the knowledge bases,research foci,and research fronts in the field of scientific collaboration were studied.The results indicated that research fronts and research foci are highly consistent in terms of the concept,origin,measurement,and theory of scientific collaboration.It also revealed that research fronts included scientific collaboration networks,international scientific collaboration,social network analysis and techniques,and applications of bibliometrical indicators,webmetrics,and health care related areas. | HOU Jianhua CHEN Chaomei YAN Jianxin | 2010 | Chinese Journal of Library and Information Science2010，，1： | 4 |
| 8 | Denitrification in Qi'ao Island coastal zone,the Zhujiang Estuary in China显示文摘Samples of sediments and the overlying water were collected in the Qi'ao Island coastal zone,the Zhujiang(Pearl River) Estuary(ZE).Denitrification rates,sediment oxygen demand(SOD),and fluxes of inorganic nitrogen compounds were investigated with N2 flux method,using a self-designed continuous flow through and auto-sampling system.The results indicate that the denitrification rates varied between 222 and 908 μmol/(m2·h) with an average of 499 μmol /(m2·h).During incubation,the sediments absorbed dissolved oxygen in the overlying water with SOD ranging from 300 to 2 363 μmol/(m2·h).The denitrification rates were highly correlated with the SOD(r2=0.77) regardless of the NO-3+NO-2 concentrations in the overlying water,organic carbon contents in sediments and water temperature,suggesting that the SOD was probably the main environmental factor controlling the denitrification in the Qi'ao Island coastal zone.There was a net flux of NO-3+NO-2 into the sediments from the overlying water.The NH+4 flux from sediments into water as the result of mineralization was between 12.3 and 210.3 μmol/(m2·h),which seems limited by both organic carbon content in sediment and dissolved oxygen concentration in the overlying water. | WANG Hu ZHOU Huaiyang PENG Xiaotong YANG Qunhui QIN Chaomei YIN Xijie CHEN Guangqian | 2009 | Acta Oceanologica Sinica2009，28，1： | 4 |
| 9 | A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy显示文摘The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment. | Yihan Wu Jingjing Li Xuemei Zhong Jinfeng Shi Yanfen Cheng Chenglin He Jiaxin Li Liang Zou Chaomei Fu Meiwan Chen Jinming Zhang Huile Gao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 4 |
| 10 | Toeplitz and Hankel Products on Bergman Spaces of the Unit Ball显示文摘作者在加权的 Bergman 空间为 Toeplitz 产品的围住的海角给一些新必要条件联合起来的球的 α2 ,在 f 和 g 在单位上是分析的的地方,成球形。Hankel 产品 H f H 在联合起来的球的加权的 Bergman 空间的 g * 被学习,并且类似于那些 Stroethoff 和郑的结果在统一磁盘的设置获得了被证明。 | Yufeng LU Chaomei LIU | 2009 | Chinese Annals of Mathematics,Series B2009，30，3： | 3 |
| 11 | Tracing knowledge diffusion显示文摘 | Chaomei Chen Diana Hicks | 2004 | Scientometrics2004，，2： | 2 |
| 12 | Balancing selection and wild gene pool contribute to resistance in global rice germplasm against planthopper显示文摘Interactions and co-evolution between plants and herbivorous insects are critically important in agriculture.Brown planthopper(BPH)is the most severe insect of rice,and the biotypes adapt to feed on different rice genotypes.Here,we present genomics analyses on 1,520 global rice germplasms for resistance to three BPH biotypes.Genome-wide association studies identified 3,502 single nucleotide polymorphisms(SNPs)and 59 loci associated with BPH resistance in rice.We cloned a previously unidentified gene Bph37 that confers resistance to BPH.The associated loci showed high nucleotide diversity.Genome-wide scans for trans-species polymorphisms revealed ancient balancing selection at the loci.The secondarily evolved insect biotypes II and III exhibited significantly higher virulence and overcame more rice varieties than the primary biotype I.In response,more SNPs and loci evolved in rice for resistance to biotypes II and III.Notably,three exceptional large regions with high SNP density and resistance-associated loci on chromosomes 4 and 6 appear distinct between the resistant and susceptible rice varieties.Surprisingly,these regions in resistant rice might have been retained from wild species Oryza nivara.Our findings expand the understanding of long-term interactions between rice and BPH and provide resistance genes and germplasm resources for breeding durable BPH-resistant rice varieties. | Cong Zhou Qian Zhang Yu Chen Jin Huang Qin Guo Yi Li Wensheng Wang Yongfu Qiu Wei Guan Jing Zhang Jianping Guo Shaojie Shi Di Wu Xiaohong Zheng Lingyun Nie Jiaoyan Tan Chaomei Huang Yinhua Ma Fang Yang Xiqin Fu Bo Du Lili Zhu Rongzhi Chen Zhikang Li Longping Yuan Guangcun He | 2021 | Journal of Integrative Plant Biology2021，63，10： | 2 |
| 13 | Towards an explanatory and computational theory of scientific discovery显示文摘 | Chaomei Chen Yue Chen Mark Horowitz Haiyan Hou Zeyuan Liu Donald Pellegrino | 2009 | Journal of Informetrics2009，，3： | 2 |
| 14 | Searching for intellectual turning points: Progressive Knowledge Domain Visualization显示文摘 | Chen Chaomei | 2004 | Proceed- ings of the National Academy of Sciences of the United States of America (PNAS)2004，，1： | 1 |
| 15 | Visualizing knowledge domains 显示文摘 | Katy B Chaomei C Kevin W B | 2003 | Annual Review of Information Science & Technology2003，37，1： | 1 |
| 16 | CiteSpace II:Detecting and visualizing emerg- ing trends and transient patterns in scientific literature 显示文摘 | Chaomei Chen | 2006 | Journal of the American Society for Information Science and Technology2006，57，3： | 1 |
| 17 | CiteSpace II : Detecting and Visualizing Emerging Trends and Transient Patterns in Scientific Literature 显示文摘 | Chaomei Chen | 2006 | JOURNAL OF THE AMERICAN SOCIETY FOR IN FORMATION SCIENCE AND TECHNOLOGY2006，57，3： | 1 |
| 18 | CiteSpace II : Detecting and Visualizing Emerging Trends and Transient Patterns in Scientific Literature显示文摘 | Chen Chaomei | | Journal of the American Society for Information Science and Technology0，57，3： | 1 |
| 19 | CiteSpace Ⅱ : detecting and visualizing emer- ging trends and transient patterns in scientific literature 显示文摘 | CHEN Chaomei | 2006 | Journal of the American Society for Information Science and Technology2006，57，3： | 1 |
| 20 | CiteSpace Ⅱ : Detecting and visualizing emerging trends and transient patterns in scientific literature 显示文摘 | Chen Chaomei | 2006 | Journal of the American Society for Information Science and Technology2006，57，3： | 1 |
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