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| 1 | Capecitabine maintenance therapy for XT chemotherapy-sensitive patients with metastatic triple-negative breast cancer显示文摘Objective: To investigate the efficacy and safety of capecitabine maintenance therapy(MT) after initial capecitabine plus docetaxel(XT) chemotherapy in patients with metastatic triple-negative breast cancer(m TNBC).Methods: Fifty-five m TNBC patients treated with XT chemotherapy between May 2007 and June 2013 were retrospectively analyzed. When initial disease control was achieved by the combination chemotherapy, capecitabine was continued for 32 patients(MT), while 23 patients remained without any treatment(nonMT). We compared progression-free survival(PFS) and safety of both groups.Results: The median PFS of 55 patients was 8.1 months, overall median PFS time of 32 patients in the capecitabine MT group and 23 in the non-MT group was 10.1 vs. 6.7 months(P=0.032), respectively. When compared PFS time of maintenance treatment, single-agent capecitabine prolonged PFS by 7.1 months, for non-MT patients, the PFS without any treatment was 3.1 months, and this between-group difference was statistically significant(P=0.003). Adverse events, including of hematologic toxicity, gastrointestinal toxicities, hand-foot syndrome and abnormal liver function were not significantly different between two groups.Conclusions: After initial disease control was achieved with the XT combination chemotherapy, capecitabine MT can significantly prolong PFS time with a favorable safety profile in m TNBC patients. | Xu Liang Lijun Di Guohong Song Ying Yan Chaoying Wang Hanfang Jiang Huiping Li | 2014 | Chinese Journal of Cancer Research2014，26，5： | 8 |
| 2 | Research on an Mg–Zn alloy as a degradable biomaterial显示文摘 | Shaoxiang Zhang Xiaonong Zhang Changli Zhao Jianan Li Yang Song Chaoying Xie Hairong Tao Yan Zhang Yaohua He Yao Jiang Yujun Bian | 2009 | Acta Biomaterialia2009，，2： | 5 |
| 3 | Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling显示文摘Transforming growth factor-beta(TGF-β)type II receptor(TβRII)levels are extremely low in the brain tissue of patients with Alzheimer’s disease.This receptor inhibits TGF-β1/SMAD signaling and thereby aggravates amyolid-beta deposition and neuronal injury.Dab2,a specific adapter protein,protects TβRII from degradation and ensures the effective conduction of TGF-β1/SMAD signaling.In this study,we used an adenoviral vector to overexpress the Dab2 gene in the mouse hippocampus and investigated the regulatory effect of Dab2 protein on TGF-β1/SMAD signaling in a mouse model of Alzheimer’s disease,and the potential neuroprotective effect.The results showed that the TβRII level was lower in APP/PS1 mouse hippocampus than in normal mouse hippocampus.After Dab2 expression,hippocampal TβRII and p-SMAD2/3 levels were significantly increased,while amyloid-beta deposition,microglia activation,tumor necrosis factor-βand interleulin-6 levels and neuronal loss were significantly attenuated in APP/PS1 mouse brain tissue.These results suggest that Dab2 can exhibit neuroprotective effects in Alzheimer’s disease by regulating TGF-β1/SMAD signaling. | Lei Song Yue Gu Jing Jie Xiaoxue Bai Ying Yang Chaoying Liu Qun Liu | 2014 | Neural Regeneration Research2014，9，1： | 4 |
| 4 | In vitro degradation, hemolysis and MC3T3-E1 cell adhesion of biodegradable Mg–Zn alloy显示文摘 | Shaoxiang Zhang Jianan Li Yang Song Changli Zhao Xiaonong Zhang Chaoying Xie Yan Zhang Hairong Tao Yaohua He Yao Jiang Yujun Bian | 2009 | Materials Science & Engineering C2009，，6： | 2 |
| 5 | Effects of equal channel angular extrusion and aging treatment on R phase transformation behaviors and Ti 3 Ni 4 precipitates of Ni-rich TiNi alloys显示文摘 | Xiaoning Zhang Baoyu Xia Jie Song Bin Chen Xiaolin Tian Yingmin Hao Chaoying Xie | 2011 | Journal of Alloys and Compounds2011，，21： | 1 |
| 6 | Teaching Reform of“Automatic Control Theory Course for the Independent College Students”2010 international Conference on E-health Networking显示文摘 | xueling song zheying song chaoying liu | 2010 | Digital Ecosystems and Technologies2010，，： | 1 |
| 7 | Parallel computation of the regional ocean modeling system显示文摘 | WangP Song Y T ChaoY | 2005 | International Journal of High Performance Computing Applications2005，19，4： | 1 |
| 8 | Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine显示文摘 | Ningning Dong Jing Yu Chaoying Wang Xiaohui Zheng Zheng Wang Lijun Di Guohong Song Budong Zhu Li Che Jun Jia Hanfang Jiang Xinna Zhou Xiaoli Wang Jun Ren | 2012 | Journal of Cancer Research and Clinical Oncology2012，，7： | 1 |
| 9 | Effect of Aging on Superelastic Behaviors of a Metastable β Ti-Mo-based alloy显示文摘 | Jie Song Xiaoning Zhang Xiaogang Sun Hong Jiang Zhiguo Fan Chaoying Xie M. H. Wu | 2012 | Journal of Materials Engineering and Performance2012，，3： | 1 |
| 10 | Research on Real-time Simulation and Control of Linear 1-stage Inverted Pendulum显示文摘 | Song Zheying Song Xueling Liu Chaoying | 2013 | Journal of Computers2013，8，4： | 1 |
| 11 | Microstructures and mechanical deformation behaviors of ultrafine-grained commercial pure (grade 3) Ti processed by two-step severe plastic deformation显示文摘 | Zhiguo Fan Hong Jiang Xiaogang Sun Jie Song Xiaoning Zhang Chaoying Xie | 2009 | Materials Science & Engineering A2009，，1： | 1 |
| 12 | Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors显示文摘With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses. | Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 13 | Revisiting chemoresistance in ovarian cancer:Mechanism,biomarkers,and precision medicine显示文摘Among the gynecological cancers,ovarian cancer is the most lethal.Its therapeutic options include a combination of chemotherapy with platinum-based compounds and cytoreductive surgery.Most ovarian cancer patients exhibit an initial response to platinum-based therapy,however,platinum resistance has led to up to 80%of this responsive cohort becoming refractory.Ovarian cancer recurrence and drug resistance to current chemotherapeutic options is a global challenge.Chemo-resistance is a complex phenomenon that involves multiple genes and signal transduction pathways.Therefore,it is important to elucidate on the underlying molecular mechanisms involved in chemo-resistance.This inform decisions regarding therapeutic management and help in the identification of novel and effective drug targets.Studies have documented the individual bidmarkers of platinum-resistance in ovarian cancer that are potential therapeutic targets.This review summarizes the molecular mechanisms of platinum resistance in ovarian cancer,novel drug targets,and clinical outcomes. | Chong Guo Chaoying Song Jiali Zhang Yisong Gao Yuying Qi Zongyao Zhao Chengfu Yuan | 2022 | Genes & Diseases2022，9，3： | 0 |
| 14 | Multi-Time Scale Operation and Simulation Strategy of the Park Based on Model Predictive Control显示文摘Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve the expected economy.This paper constructs an operating simulation model of the park power grid operation considering demand response and proposes a multi-time scale operating simulation method that combines day-ahead optimization and model predictive control(MPC).In the day-ahead stage,an operating simulation plan that comprehensively considers the user’s side comfort and operating costs is proposed with a long-term time scale of 15 min.In order to cope with power fluctuations of photovoltaic,wind turbine and conventional load,MPC is used to track and roll correct the day-ahead operating simulation plan in the intra-day stage to meet the actual operating operation status of the park.Finally,the validity and economy of the operating simulation strategy are verified through the analysis of arithmetic examples. | Jun Zhao Chaoying Yang Ran Li Jinge Song | 2024 | Energy Engineering2024，121，3： | 0 |
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