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| 1 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 2 | The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People显示文摘Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people. | LI Kui LIANG Yu SUN Yin ZHANG Ling Xia YI Xin CHEN Yong GU SANG LA MU WANG Jian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 3 | Absolute radiometric calibration of CBERS-02 IRMSS thermal band显示文摘Based on the laboratory calibration before launch of CBERS-02 IRMSS thermal infrared channel, the onboard blackbody calibration, the radiometric cross- calibration against TERRA MODIS corresponding channel and the in-flight field calibration at Lake Qinghai: water surface radiometric calibration test site of China on Aug. 17, 2004 are carried out in this research. When making onboard blackbody calibration of CBERS-02 IRMSS, it is necessary to understand inside structures and light path in IRMSS camera and receive and process calibration blackbody signals at normal and high temperatures. Onboard blackbody calibration results of each detector are very important to relative radiometric calibration of images processing and absolute radiometric calibration of each detector. In-flight field calibration mainly contains field experiments, obtaining synchronous images, spectrum marching and MODTRAN radiative transmi- ssion computation. Radiometric cross-calibration of CBERS-02 IRMSS thermal band against TERRA MODIS selected 6 times synchronous images of two sensors passing through Lake Qinghai and Lake Taihu from August to December, 2004 to compute the cross calibration data. Combining the in-flight field calibration and radiometric cross calibration data, the absolute radiometric calibration coefficients are calculated by the linear regression method. This new calibration model can obviously control the radiometric calibration uncertainties aroused by the single point method used in the in-flight calibration of CBERS-02 IRMSS, this kind of sensors cannot receive the cosmic background radiation. In this research, the radiometric calibration coefficients obtained through the linear regression model are 8.53 (gain, unit: DN/W m?2sr?1μm?1) and 44.92 (offset, unit: DN). | ZHANG Yong1,2,3, GU Xingfa1,3,4, YU Tao1,3, ZHANG Yuxiang5, CHEN Liangfu1,3, LI Xiaoying1,2,3, LI Xiaowen1,3 & HE Liming6 1. State Key Laboratory of Remote Sensing Science, Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101, China 2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China 3. The Center for National Spaceborne Demonstration, Beijing 100101, China 4. Institut National de la Recherche Agronomique, Climat Sol Environnement, 84914 Avignon, France 5. National Satellite Meteorological Center, Beijing 100081, China 6. State Environmental Protection Administration, Beijing 100029, China | 2005 | Science China(Technological Sciences)2005，48，S2： | 6 |
| 4 | The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment显示文摘The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian 'atmospheric water tower' and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation of sensible heat flux can be reduced via modifying the heat transfer parameterization over the TP, and considering climatic signals in some key areas of the TP can improve the skill for rainfall forecast in the central and eastern parts of China. Furthermore, the TIPEX-Ⅲ has been promoting the technology in processing surface observations, soundings, and radar observations, improving the quality of satellite retrieved soil moisture and atmospheric water vapor content products as well as high-resolution gauge–radar–satellite merged rainfall products, and facilitating the meteorological monitoring, forecasting, and data sharing operations. | Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun CHEN Yanju LIU Jian LI Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 5 | Fiber gas sensor-integrated smart face mask for roomtemperature distinguishing of target gases显示文摘小、便携式、便宜的便携煤气的传感器在人的健康并且环境监视的即时察觉有大潜在的申请。在这个工作,我们与围单人赛的碳制作了灵活纤维气体传感器 nanotube (SWCNT ) ,多围的碳 nanotube (MWCNT ) ,和 ZnO 量察觉到元素的装饰点的 SWCNT (SWCNTs@ZnO ) 。这些灵活纤维气体传感器能在房间温度被操作与好敏感和恢复时间检测目标气体。他们也展出了优异长期的稳定性,以及好设备机械弯曲能力和坚韧性。把这些灵活煤气的传感器集成到脸面具,制作的便携的聪明的脸面具能被用来有选择地检测 C 2 H 5 哦,由与不同颜色读相应 LEDs 的 HCHO,和 NH 3 。如此的脸面具在新窗户中在事情和便携 electronics.Open | Zhiyi Gao Zhoe n g Lou Shuai Chen La Li Kai Jiang Zuoling Fu Wei Han Guozhen Shen | 2018 | Nano Research2018，11，1： | 3 |
| 6 | Synergistic effect and different toxicities of adjuvant components of Realgar–Indigo Naturalis formula显示文摘Objective:Realgar–Indigo Naturalis formula(RIF)is a well-known arsenic-containing preparation that is used to treat acute promyelocytic leukemia(APL)in China.In recent multicenter clinical trials,complete remission rates in APL patients have ranged from 96.08%to 100%.RIF has a satisfactory therapeutic effect,but its safety is a widespread concern,since the preparation contains arsenic,a wide-ranging and naturally occurring toxicant.In this study,in order to determine the toxic potential of RIF,acute toxicity and sub chronic toxicity assays were performed to evaluate the toxic potential of Realgar and the adjuvant components of RIF in addition to Realgar’s synergy with these adjuvant components.Methods:KM mice and Wistar rats were selected for these experiments.To evaluate acute toxicity,the toxic effects of a single dose of a gradient of concentrations of Realgar were firstly determined.Then,the toxic effects of combinations of gradient doses of Realgar and fixed doses of Indigo naturalis and Salvia miltiorrhiza were evaluated.Results:The results showed that when Realgar was used alone,the2756.73 mg/kg(equivalent to 23.6 mg/kg).However,theto 936.90 mg/kg when Realgar was used with I.naturalis.By contrast,theto 7538.86 mg/kg when Realgar was used with S.miltiorrhiza.Hence,I.naturalis strengthened the toxicity of Realgar,whereas S.miltiorrhiza displayed the opposite effect.The sub chronic toxicity assessment results revealed a trend that was consistent with acute toxicity.Changes in the levels of different valence states of arsenic were also taken into account.The test results of the effects of in vitro combinations of Realgar and adjuvant components on soluble arsenic dissolution showed that I.naturalis increased the level of soluble arsenic in Realgar extracts and I.naturalis suspensions when the Realgar/I.naturalis ratio was 2,1.5,and 1.0.However,S.miltiorrhiza did not affect it.Conclusion:Based on the collective experimental results presented here,it can be concluded that the toxicity of RIF is the result of the soluble arsenic in Realgar and that the I.naturalis and S.miltiorrhiza in the RIF exert completely opposite effects on the toxicity of Realgar.This maybe an intelligent explanation for the compatibility of this formula,and this RIF study may therefore be viewed as a classic case of traditional Chinese medicine research on compatibility. | Huan-Hua Xu Zeng-Chun Ma Qiao-Li Shi Shi-Han Yang La Jiang Xiang-Mei Chen Yue Gao | 2018 | Chinese Herbal Medicines2018，10，2： | 3 |
| 7 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 8 | Video capsule endoscopy in left ventricular assist device recipients with obscure gastrointestinal bleeding显示文摘AIM: To assess whether video capsule endoscopy(VCE) affects the outcomes of left ventricular assist devices(LVADs) recipients with gastrointestinal bleeding.METHODS: This is a retrospective study of LVAD recipients with obscure gastrointestinal bleeding(OGIB) who underwent VCE at a tertiary medical center between 2005 and 2013. All patients were admitted and monitored with telemetry and all VCE and subsequent endoscopic procedures were performed as inpatients. A VCE study was considered positive only when P2 lesions were found and was regarded as negative if P1 or P0 were identified. All patients were followed until heart transplant, death, or the end of the study.RESULTS: Between 2005 and 2013, 30 patients with LVAD underwent VCE. Completion rate of VCE was 93.3% and there was no capsule retention. No interference of VCE recording or the function of LVAD was found. VCE was positive in 40% of patients(n = 12). The most common finding was active small intestinal bleeding(50%) and small intestinal angiodysplasia(33.3%). There was no difference in the rate of recurrent bleeding between patients with positive and negative VCE study(50.0% vs 55.6%,P = 1.00) during an average of 11.6 ± 9.6 mo follow up. Among patients with positive VCE, the recurrent bleeding rate did not differ whether subsequent endoscopy was performed(50% vs 50%, P = 1.00).CONCLUSION: VCE can be safely performed in LVAD recipients with a diagnostic yield of 40%. VCE does not affect recurrent bleeding in LVAD patients regardless of findings. | Surachai Amornsawadwattana Michael Nassif David Raymer Shane La Rue Chien-Huan Chen | 2016 | World Journal of Gastroenterology2016，22，18： | 2 |
| 9 | Extraction and Antioxidant Functions of Polysaccharides from Seaweed显示文摘Dried seaweed powder was used as the raw material to extract polysaccharides by ethanol precipitation after water bath. Extraction temperature,extraction duration,solution pH and solid to liquid ratio were selected as technical parameters which required to be optimized. With the extraction rate of seaweed polysaccharides as an index,single-factor experiment and orthogonal experiment were carried out to determine the optimal extraction technique. Seaweed polysaccharides were extracted with the optimal technical parameters to analyze the biological activities. Savage method was used to process seaweed polysaccharide extract. In vitro biological activities of preliminarily purified seaweed polysaccharides were investigated successively,including reducing ability,antioxidant ability and antibacterial activity. The results showed that there was a positive correlation between polysaccharide concentration and its reducing ability,antioxidant ability and antibacterial activity. Furthermore,there was also a correlation among the reducing ability,antioxidant ability and antibacterial activity of seaweed polysaccharides; the relationship between each two of these three indicators was similar to positive linear correlation. | Hongrui LI Jie YAN Senze QIN Yanqing CHEN Haixiong LA | 2015 | Agricultural Biotechnology2015，4，6： | 2 |
| 10 | Protein-only' or 'virino' in prion diseases?显示文摘60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are briefly but critically reviewed. Instead of providing a comprehensive coverage of the research history, attentions in this view are drawn toward both the major breakthrough in the advancement of protein-only hypothesis, and the puzzle why this hypothesis has not been fully accepted. In order to resolve the prion enigma in neuroscience, it is suggested that both technical and concept barriers remain to be crossed. Since prion research is a multi-interdisciplinary subject, this view is intended to both facilitate a bette r understanding of prion phenomenon by more scientists in natural science, and invite scientists outside the fields of molecular genetics and protein science for collaboration. | YANG Chiming (Chi Ming Yang) & CHEN Yi1. Institute for Life Science and Health at UCSD, P.O.Box 12035, La Jolla, CA 92039, USA 2. Institute of Chemistry, Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Yang Chiming | 2000 | Chinese Science Bulletin2000，45，3： | 2 |
| 11 | Continuous Fabrication of Ti_(3)C_(2)T_x MXene-Based Braided Coaxial Zinc-Ion Hybrid Supercapacitors with Improved Performance显示文摘Zinc-ion hybrid fiber supercapacitors(FSCs)are promising energy storages for wearable electronics owing to their high energy density,good flexibility,and weavability.However,it is still a critical challenge to optimize the structure of the designed FSC to improve energy density and realize the continuous fabrication of super-long FSCs.Herein,we propose a braided coaxial zinc-ion hybrid FSC with several meters of Ti_(3)C_(2)T_x MXene cathode as core electrodes,and shell zinc fiber anode was braided on the surface of the Ti_(3)C_(2)T_x MXene fibers across the solid electrolytes.According to the simulated results using ANSYS Maxwell software,the braided structures revealed a higher capacitance compared to the spring-like structures.The resulting FSCs exhibited a high areal capacitance of 214 mF cm^(-2),the energy density of 42.8μWh cm^(-2)at 5 mV s^(-1),and excellent cycling stability with 83.58%capacity retention after 5000 cycles.The coaxial FSC was tied several kinds of knots,proving a shape-controllable fiber energy storage.Furthermore,the knitted FSC showed superior stability and weavability,which can be woven into watch belts or embedded into textiles to power smart watches and LED arrays for a few days. | Bao Shi La Li Aibing Chen Tien-Chien Jen Xinying Liu Guozhen Shen | 2022 | Nano-Micro Letters2022，14，2： | 2 |
| 12 | Risk indicators for early childhood caries in Taiwan 显示文摘 | Tsai A1 Chen CY Li LA | 2006 | Community Dent Oral Epidemiol2006，34，6： | 1 |
| 13 | Effect of La2O3 doping on the tunable and dielectric properties of BST/MgO composite for microwave tunable application 显示文摘 | LAING R H DONG X L CHEN Y | 2006 | Maoromol Chem Phys2006，，95： | 1 |
| 14 | Effect of La2O3 doping on the tunable and dielectric properties of BST/MgO composite for microwave tunable application显示文摘 | LAING R H DONG X L CHEN Y | 2006 | Mater Chem Phys2006，95，2： | 1 |
| 15 | Detection of immunoglobulin light-chain mRNA in lymp-hoid tissues using a practical in situ hybridization method显示文摘 | Weiss LM Movahed LA Chen YY | 1999 | Am J Pathol1999，137，4： | 1 |
| 16 | A modified osmotic shock for periplasmic release of a recombinant creatinase from Eseherichia coli 显示文摘 | Chen YC Chen LA Chen SJ | 2004 | Biochem Eng J2004，19，3： | 1 |
| 17 | Expression of G1 cyclins, cycle-dependent kinase,and cyclin dependent kinase inhibitors in androgen-induced prostate proliferation in castrated tars显示文摘 | Chen Y Robles AI Martinez LA | 1996 | Cell Groth Differ1996，7，11： | 1 |
| 18 | Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced supervaide generation and tyrosyl phosphorylation of proteins in human neutrophila 显示文摘 | Chen G La H Wang C | 2002 | Clin China Acta2002，326，12： | 1 |
| 19 | 显示文摘 | JIN Z CHEN R COLON LA | 1997 | Anal Chem1997，69，： | 1 |
| 20 | Characteristics,correlates,and outcomes of child-hood and adolescent depressive disorders显示文摘 | RAO U CHEN LA | 2009 | Dialogues Clin Neuros-ci2009，11，1： | 1 |
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