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| 1 | p53 gene therapy in combination with transcatheter arterial chemoembolization for HCC:One-year follow-up显示文摘AIM:To evaluate the efficacy and safety of combination therapy with recombinant adenovirus p53 injection (rAdp53) and transcatheter hepatic arterial chemoembolization (TACE) for advanced hepatocellular carcinoma (HCC).METHODS:A total of 82 patients with advanced HCC treated only with TACE served as control group.Another 68 patients with HCC treated with TACE in combination with recombinant adenovirus-p53 injection served as p53 treatment group.Patients were followed up for 12 mo.Safety and therapeutic effects were evaluated according to the improvement in clinical symptoms,leukocyte count,Karnofsky and RECIST criteria.Survival rate was calculated with Kaplan-Meier method.RESULTS:The total effective rate was 58.3% for p53 treatment group,and 26.5% for control group (P < 0.05).The incidence of gastrointestinal symptoms was lower in p53 treatment group than in control group (P < 0.05).The 3-,6-and 12-mo survival rates were significantly higher for p53 treatment group than for control group (P < 0.01).The combination treatment was well tolerated with such adverse events as fever (51.5%,P=0.006) and pain of muscles and joints (13.2%,P=0.003),which were significantly higher than the chemotherapy.Except for these minor adverse effects,no severe vector-related complications were identified.With respect to the efficacy,patients in p53 treatment group had less gastrointerestinal symptoms (P=0.062),better improvement in tumor-related pain (P=0.003),less downgrade of leukocyte counts (P=0.003) and more upgrade of Karnofsky performance score (P=0.029) than those in control group.The total effective rate (CR + PR) for p53 treatment group and control group was 58.3% and 26.5%,respectively,with distributions of different effect in two groups (P=0.042).The survival rates were 89.71%,76.13%,and 43.30% for p53 treatment group,and 68.15%,36.98%,and 24.02% for control group,respectively,3,6 and 12 mo after treatment,suggesting that the survival rates are significantly higher for p53 treatment group than for control group (P=0.0002).CONCLUSION:The rAd-p53 gene therapy in combination with TACE is a safe and effective treatment modality for advanced HCC. | Yong-Song Guan Yuan Liu Qing He Xiao Li Lin Yang Ying Hu Zi La | 2011 | World Journal of Gastroenterology2011，17，16： | 21 |
| 2 | Radiometric cross-calibration of the CBERS-02 CCD camera with the TERRA MODIS显示文摘For the application of the CCD camera, the most important payload on CBERS-02, the key is to provide long-term stable radiometric calibration coefficients. Although the vicarious calibration had been proved successful, it had its limitations such as test site requirement and unsuitable for historical data. Cross-calibration is one of the alternative methods, but it needs synchro surface spectrum to achieve spectral band matching factors. Our effort is to probe the influences on these factors. Simulations with a lot of surface spectrum showed that the factors changed with the viewing geometry, atmospheric condition and surface targets. However, simulating with the same viewing geometry and atmospheric condition, the spectral band matching factors of the same or similar surface targets’ spectrum acquired from different dates and different places would like to be consistent to each other within 1%―5%. Thus, the synchro measurement data can be substituted by the same or similar target from other source. Based on this method, using the MODIS as the reference, the cross-calibration was performed for CCD camera. The research demonstrated that the traditional method with single calibration site was inappropriate for CCD camera, since the offsets for its four spectral bands were not zeros. With four calibration sites, these offsets were obtained. And the camera was detected to degrade with dates based on four times of cross-calibrations. | LI Xiaoying1,2,3, GU Xingfa1,3,4, MIN Xiangjun5, YU Tao1,3, FU Qiaoyan5, ZHANG Yong1,2,3 & LI Xiaowen1,3 1. State Key Laboratory of Remote Sensing Science, Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101, China 2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China 3. The Center for National Spaceborne Demonstration, Beijing 100101, China 4. Institut National de la Recherche Agronomique, Climat Sol Environnement, 84914 Avignon, France 5. China Center for Resource Satellite Data and Application, Beijing 100830, China | 2005 | Science China(Technological Sciences)2005，48，S2： | 15 |
| 3 | p53 gene in treatment of hepatic carcinoma:Status quo显示文摘Hepatocellular carcinoma (HCC) is one of the 10 most common cancers worldwide. There is no ideal treatment for HCC yet and many researchers are trying to improve the effects of treatment by changing therapeutic strategies. As the majority of human cancers seem to exhibit either abnormal p53 gene or disrupted p53 gene activation pathways, intervention to restore wild-type p53 (wt-p53) activities is an attractive anti-cancer therapy including HCC. Abnormalities of p53 are also considered a predisposition factor for hepatocarcinogenesis. p53 is frequently mutated in HCC. Most HCCs have defects in the p53-mediated apoptotic pathway although they carry wt-p53. High expression of p53 in vivo may exert therapeutic effects on HCC in two aspects: (1) High expression of exogenous p53 protein induces apoptosis of tumor cells by inhibiting proliferation of cells through several biologic pathways and (2) Exogenous p53 renders HCC more sensitive to some chemotherapeutic agents. Several approaches have been designed for the treatment of HCC via the p53 pathway by restoring the tumor suppression function from inactivation, rescuing the mutated p53 gene from instability, or delivering therapeutic exogenous p53. Products with p53 status as the target have been studied extensively in vitro and in vivo . This review elaborates some therapeutic mechanisms and advances in using recombinant human adenovirus p53 and oncolytic virus products for the treatment of HCC. | Yong-Song Guan Zi La Lin Yang Qing He Ping Li | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 4 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 5 | Effect of CO_2 enrichment on the glucosinolate contents under different nitrogen levels in bolting stem of Chinese kale (Brassica alboglabra L.)显示文摘The effects of CO2 enrichment on the growth and glucosinolate (GS) concentrations in the bolting stem of Chinese kale (Brassica alboglabra L.) treated with three nitrogen (N) concentrations (5, 10, and 20 mmol/L) were investigated. Height, stem thickness, and dry weights of the total aerial parts, bolting stems, and roots, as well as the root to shoot ratio, significantly increased as CO2 concentration was elevated from 350 to 800 μl/L at each N concentration. In the edible part of the bolting stem, 11 individual GSs were identified, including 7 aliphatic and 4 indolyl GSs. GS concentration was affected by the elevated CO2 concentration, N concentration, and CO2×N interaction. At 5 and 10 mmol N/L, the concentrations of aliphatic GSs and total GSs significantly increased, whereas those of indolyl GSs were not affected, by elevated atmospheric CO2. However, at 20 mmol N/L, elevated CO2 had no significant effects on the concentrations of total GSs and total indolyl GSs, but the concentrations of total aliphatic GSs significantly increased. Moreover, the bolting stem carbon (C) content increased, whereas the N and sulfur (S) contents decreased under elevated CO2 concentration in the three N treatments, resulting in changes in the C/N and N/S ratios. Also the C/N ratio is not a reliable predictor of change of GS concentration, while the changes in N and S contents and the N/S ratio at the elevated CO2 concentration may influence the GS concentration in Chinese kale bolting stems. The results demonstrate that high nitrogen supply is beneficial for the growth of Chinese kale, but not for the GS concentration in bolting stems, under elevated CO2 condition. | Gui-xiao LA Ping FAN Yi-bo TENG Ya-juan LI Xian-yong LIN | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，6： | 7 |
| 6 | The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People显示文摘Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people. | LI Kui LIANG Yu SUN Yin ZHANG Ling Xia YI Xin CHEN Yong GU SANG LA MU WANG Jian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 7 | Absolute radiometric calibration of CBERS-02 IRMSS thermal band显示文摘Based on the laboratory calibration before launch of CBERS-02 IRMSS thermal infrared channel, the onboard blackbody calibration, the radiometric cross- calibration against TERRA MODIS corresponding channel and the in-flight field calibration at Lake Qinghai: water surface radiometric calibration test site of China on Aug. 17, 2004 are carried out in this research. When making onboard blackbody calibration of CBERS-02 IRMSS, it is necessary to understand inside structures and light path in IRMSS camera and receive and process calibration blackbody signals at normal and high temperatures. Onboard blackbody calibration results of each detector are very important to relative radiometric calibration of images processing and absolute radiometric calibration of each detector. In-flight field calibration mainly contains field experiments, obtaining synchronous images, spectrum marching and MODTRAN radiative transmi- ssion computation. Radiometric cross-calibration of CBERS-02 IRMSS thermal band against TERRA MODIS selected 6 times synchronous images of two sensors passing through Lake Qinghai and Lake Taihu from August to December, 2004 to compute the cross calibration data. Combining the in-flight field calibration and radiometric cross calibration data, the absolute radiometric calibration coefficients are calculated by the linear regression method. This new calibration model can obviously control the radiometric calibration uncertainties aroused by the single point method used in the in-flight calibration of CBERS-02 IRMSS, this kind of sensors cannot receive the cosmic background radiation. In this research, the radiometric calibration coefficients obtained through the linear regression model are 8.53 (gain, unit: DN/W m?2sr?1μm?1) and 44.92 (offset, unit: DN). | ZHANG Yong1,2,3, GU Xingfa1,3,4, YU Tao1,3, ZHANG Yuxiang5, CHEN Liangfu1,3, LI Xiaoying1,2,3, LI Xiaowen1,3 & HE Liming6 1. State Key Laboratory of Remote Sensing Science, Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101, China 2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China 3. The Center for National Spaceborne Demonstration, Beijing 100101, China 4. Institut National de la Recherche Agronomique, Climat Sol Environnement, 84914 Avignon, France 5. National Satellite Meteorological Center, Beijing 100081, China 6. State Environmental Protection Administration, Beijing 100029, China | 2005 | Science China(Technological Sciences)2005，48，S2： | 6 |
| 8 | Anthocyanin profi les and color properties of red wines made from Vitis davidii and Vitis vinifera grapes显示文摘Spine grape(Vitis davidii Foex.)is an important wild grape species native to China.Fifteen red spine grape clones and three red Vitis vinifera grape varieties were used to evaluate the differences in the anthocyanin profiles and color properties of wines made from V.davidii and V.vinifera grapes.Among spine wines,‘Junzi#2’wine had the highest total phenolic and total anthocyanin,‘Xiangzhenzhu’wine had the highest total flavonoids,and‘Junzi#1’wine had the highest total tannin.The anthocyanin compositions of all of the spine wines were dominated by Mv-3,5-diglucoside.The total individual anthocyanin contents in spine wines,except‘Gaoshan#5’,‘Junzi#5055’,‘Junzi#5061’,and‘Junzi#5044’,were signifi cantly higher than in V.vinifera wines.Most of the spine wines had a stronger red intensity and a brighter chroma with a bluer hue than V.vinifera wines.Correlation analysis revealed that the color properties were closely related to the anthocyanin composition.These results suggest that wines made from spine grapes may be useful for the wine industry for their color properties and high individual anthocyanin contents. | Yanlun Ju La Yang Xiaofeng Yue Yunkui Li Rui He Shenglin Deng Xin Yang Yulin Fang | 2021 | Food Science and Human Wellness2021，10，3： | 5 |
| 9 | In flight MTF monitoring and compensation for CCD camera on CBERS-02显示文摘In this article, the approach of simulating ideal tarp scene was proposed to determine the MTF for CCD camera on CBERS-02. The MTF acquired from this technique was compared to those from some common methods. MTFs achieved from different approaches were employed to compensate the CCD images based on three restoration algorithms: the iterative method, the Wiener filter and the modified inverse filter (MIF). The two-dimensional MTF was established with the value at frequency 0.5 for 45° directional MTF as the value at its four corners. This article addressed the variations of the restored CCD images with different techniques of constructing two-dimensional MTF, restoring algorithms and determining the in-flight MTFs. Results showed images restored with the MTF determined from the technique of simulating ideal tarp scene represent the real scene best. And the restoration technique based on the MIF would produce better restored images than the other two techniques. This research also demonstrated that the two-dimensional MTF used for restoration should be interpolated under the control of the MTF for 45° axis, rather than by multiplying the cross-orbit MTF with along-orbit MTF. | GU Xingfa1,2,3, LI Xiaoying1,2,4, MIN Xiangjun5, YU Tao1,2, SUN Jijuan5, ZENG Yong1,2,4, XU Hua1,2 & GUO Ding2,6 1. State Key Laboratory of Remote Sensing Science, Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101, China 2. The Center for National Spaceborne Demonstration, Beijing 100101, China 3. Institut National de la Recherche Agronomique, Climat Sol Environnement, 84914 Avignon, France 4. Graduate University of Chinese Academy of Sciences, Beijing 100039, China 5. China Center for Resource Satellite Data and Application, Beijing 100830, China 6. University of Electronic Science and Technology of China, Chengdu 610054, China | 2005 | Science China(Technological Sciences)2005，48，S2： | 4 |
| 10 | The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment显示文摘The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian 'atmospheric water tower' and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation of sensible heat flux can be reduced via modifying the heat transfer parameterization over the TP, and considering climatic signals in some key areas of the TP can improve the skill for rainfall forecast in the central and eastern parts of China. Furthermore, the TIPEX-Ⅲ has been promoting the technology in processing surface observations, soundings, and radar observations, improving the quality of satellite retrieved soil moisture and atmospheric water vapor content products as well as high-resolution gauge–radar–satellite merged rainfall products, and facilitating the meteorological monitoring, forecasting, and data sharing operations. | Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun CHEN Yanju LIU Jian LI Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 11 | Transient elastography: A non-invasive tool for assessing liver fibrosis in HIV/HCV patients显示文摘AIM: To assess the prevalence of advanced liver fibrosis (ALF) in human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HIV/HCV patients using transient elastography, and to identify factors associated with ALF. METHODS: Between September 2008 and October 2009, 71 HIV mono-infected, 57 HIV/HCV co-infected and 53 HCV mono-infected patients on regular follow-up at our Center were enrolled in this study. Alcohol intake, the main parameters of liver function, presence of HCV-RNA, HIV-RNA, duration of highly active anti-retroviraltherapy (HAART) and CD4 cell count were recorded. ALF was defined as liver stiffness (LS) ≥ 9.5 kPa. To estimate liver fibrosis (LF) a further 2 reliable biochemical scores, aspartate aminotransferase platelet ratio index (APRI) and FIB-4, were also used. RESULTS: LS values of co-infected patients were higher than in either HIV or HCV mono-infected patients (χ 2M H = 4, P < 0.04). In fact, LS ≥ 9.5 was significantly higher in co-infected than in HIV and HCV mono-infected pa-tients (χ 2 = 5, P < 0.03). Also APRI and the FIB-4 index showed more LF in co-infected than in HIV mono-infect-ed patients (P < 0.0001), but not in HCV mono-infected patients. In HIV?HCV co-infected patients, the extent of LS was significantly associated with alcohol intake (P < 0.04) and lower CD4+ cell count (P < 0.02). In HCV pa-tients, LS was correlated with alcohol intake (P < 0.001) and cholesterol levels (P < 0.03). Body mass index, dia-betes, HCV-and HIV-viremia were not significantly cor-related with LS. In addition, 20% of co-infected patients had virologically unsuccessful HAART; in 50% compliance was low, CD4+ levels were < 400 cells/mm 3 and LS was > 9.5 kPa. There was no significant correlation between extent of LF and HAART exposure or duration of HAART exposure, in particular with specific dideoxynucleoside analogues. CONCLUSION: ALF was more frequent in co-infected than mono-infected patients. This result correlated with lower CD4 levels. Protective immunological effects of HAART on LF progression outweigh its hepatotoxic effects. | Valentina Li Vecchi Maurizio Soresi Claudia Colomba Giovanni Mazzola Pietro Colletti Maurizio Mineo Paola Di Carlo Emanuele La Spada Giovanni Vizzini Giuseppe Montalto | 2010 | World Journal of Gastroenterology2010，16，41： | 4 |
| 12 | Edge enhancement through scattering media enabled by optical wavefront shaping显示文摘Edge enhancement is a fundamental and important topic in imaging and image processing,as perception of edge is one of the keys to identify and comprehend the contents of an image.Edge enhancement can be performed in many ways,through hardware or computation.Existing methods,however,have been limited in free space or clear media for optical applications;in scattering media such as biological tissue,light is multiple scattered,and information is scrambled to a form of seemingly random speckles.Although desired,it is challenging to accom-plish edge enhancement in the presence of multiple scattering.In this work,we introduce an implementation of optical wavefront shaping to achieve efficient edge enhancement through scattering media by a two-step operation.The first step is to acquire a hologram after the scattering medium,where information of the edge region is accurately encoded,while that of the nonedge region is intentionally encoded with inadequate accuracy.The second step is to decode the edge information by time reversing the scattered light.The capability is demonstrated experimentally,and,further,the performance,as measured by the edge enhancement index(EI)and enhancement-to-noise ratio(ENR),can be controlled easily through tuning the beam ratio.EI and ENR can be reinforced by^8.5 and^263 folds,respectively.To the best of our knowledge,this is the first demonstration that edge information of a spatial pattern can be extracted through strong turbidity,which can potentially enrich the comprehension of actual images obtained from a complex environment. | ZIHAO LI ZHIPENG Yu HUI HUI HUANHAO LI TIANTING ZHONG HONGLIN LU PUXIANG LA | 2020 | Photonics Research2020，8，6： | 4 |
| 13 | Investigation and management of Toxoplasma gondii infection in pregnancy and infancy: a prospective study显示文摘目的: Toxoplasma gondii 感染在怀孕期间提出严肃的风险到胎儿,因此及时、精确的诊断是必要的。这研究的目的是经由评估母亲的免疫学的地位和可能性到改进诊断、治疗学的途径估计先天的感染的频率。 | Paola DI CARLO Amelia ROMANO Alessandra CASUCCIO Salvatore CILLINO Maria Gabriella SCHIMMENTI Giorgio MANCUSO Stella LA CHIUSA Vincenzo NOVARA Daniela INGRASSIA Valentina LI VECCHI Marcello TRIZZINO Lucina TITONE | 2011 | Acta Pharmacologica Sinica2011，32，8： | 3 |
| 14 | Barley:a potential cereal for producing healthy and functional foods显示文摘Barley is the fourth largest cereal crop in the world.It is mainly used for feeding,beer production and food.Barley is receiving more attention from both agricultural and food scientists because of its special chemical composition and health benefits.In comparison with other cereal crops,including wheat,rice and maize,barley grains are rich in dietary fiber(such asβ-glucan)and tocols,which are beneficial to human health.It is well proved that diets rich in those chemicals can provide protection against hypertension,cardiovascular disease,and diabetes.Barley has been widely recognized to have great potential as a healthy or functional food.In this review,we present information about studies on the phys-ical structure of the barley grain and the distribution of its main chemical components,nutrient and functional composition of barley grain and their health benefits,and the approaches of improving and utilizing the nutrient and functional chemicals in barley grain.With the development of processing technologies,functional components in barley grains,especiallyβ-glucan,can be efficiently extracted and concentrated.Moreover,nutrient and functional components in barley grains can be efficiently improved by precise breeding and agronomic approaches.The review high-lights the great potential of barley used as healthy and functional foods,and may be instructive for better utilization of barley in food processing. | La Geng Mengdi Li Guoping Zhan Lingzhen Ye | 2022 | Food Quality and Safety2022，6，2： | 3 |
| 15 | Fiber gas sensor-integrated smart face mask for roomtemperature distinguishing of target gases显示文摘小、便携式、便宜的便携煤气的传感器在人的健康并且环境监视的即时察觉有大潜在的申请。在这个工作,我们与围单人赛的碳制作了灵活纤维气体传感器 nanotube (SWCNT ) ,多围的碳 nanotube (MWCNT ) ,和 ZnO 量察觉到元素的装饰点的 SWCNT (SWCNTs@ZnO ) 。这些灵活纤维气体传感器能在房间温度被操作与好敏感和恢复时间检测目标气体。他们也展出了优异长期的稳定性,以及好设备机械弯曲能力和坚韧性。把这些灵活煤气的传感器集成到脸面具,制作的便携的聪明的脸面具能被用来有选择地检测 C 2 H 5 哦,由与不同颜色读相应 LEDs 的 HCHO,和 NH 3 。如此的脸面具在新窗户中在事情和便携 electronics.Open | Zhiyi Gao Zhoe n g Lou Shuai Chen La Li Kai Jiang Zuoling Fu Wei Han Guozhen Shen | 2018 | Nano Research2018，11，1： | 3 |
| 16 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 17 | Synthesis and biological evaluation of glyco-GA compounds as anticancer agents显示文摘A series of novel glyco-gambogic acid(GA) compounds were synthesized and evaluated for their in vitro anti-proliferative activity against human hepatocellular carcinoma(HCC) cells.All compounds showed much better aqueous solubility(0.92- 1.89 mg/mL) than GA(0.013 mg/mL),and displayed potent inhibition on HCC cells(IC_(50):0.21-12.23μmol/L) and little affects on non-tumor liver cells(IC_(50):42.56-86.43μmol/L),suggesting that glyco-GA compounds selectively inhibit HCC proliferation,and may be promising candidates for further intensive study. | Li Qin He Zhong Hu La Mei Yuan Xiao Shan Wang Yi Hua Zhang | 2012 | Chinese Chemical Letters2012，23，4： | 2 |
| 18 | Moro orange juice prevents fatty liver in mice显示文摘AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced obesity.METHODS:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 wk.Liver morphology,gene expression of lipid transcription factors,and metabolic enzymes were assessed.RESULTS:Mice fed HFD displayed increased body weight,insulin resistance and dyslipidemia.Moro juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total cholesterol.Mice fed HFD showed liver steatosis associated with ballooning.Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid oxidation.Consistently,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 activity.CONCLUSION:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver. | Federico Salamone Giovanni Li Volti Lucilla Titta Lidia Puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano | 2012 | World Journal of Gastroenterology2012，18，29： | 2 |
| 19 | Extraction and Antioxidant Functions of Polysaccharides from Seaweed显示文摘Dried seaweed powder was used as the raw material to extract polysaccharides by ethanol precipitation after water bath. Extraction temperature,extraction duration,solution pH and solid to liquid ratio were selected as technical parameters which required to be optimized. With the extraction rate of seaweed polysaccharides as an index,single-factor experiment and orthogonal experiment were carried out to determine the optimal extraction technique. Seaweed polysaccharides were extracted with the optimal technical parameters to analyze the biological activities. Savage method was used to process seaweed polysaccharide extract. In vitro biological activities of preliminarily purified seaweed polysaccharides were investigated successively,including reducing ability,antioxidant ability and antibacterial activity. The results showed that there was a positive correlation between polysaccharide concentration and its reducing ability,antioxidant ability and antibacterial activity. Furthermore,there was also a correlation among the reducing ability,antioxidant ability and antibacterial activity of seaweed polysaccharides; the relationship between each two of these three indicators was similar to positive linear correlation. | Hongrui LI Jie YAN Senze QIN Yanqing CHEN Haixiong LA | 2015 | Agricultural Biotechnology2015，4，6： | 2 |
| 20 | Potential energy curves for the X^1Σ_g^+, B^1△_g and B′~1Σ_g^+ states of C_2 using MRCI and approximate CI methods显示文摘The potential energy curves for the X1Σ g+, B1△g and B′1Σ g+ states of C2 have been studied by using MRC and approximate CI methods, and are benchmarked against the calculations of full configuration in teraction (FCI). The results obtained by MRCI method agree with the FCI very well, and even are accu rate enough to compare other approximate methods as benchmark, when the calculations of FCI ar not feasible. The approximate CI methods mentioned in this paper are reliable for treating chemica problems. | LI AnYang1, WANG YuBin2, DOU YuSheng1,3 & WEN ZhenYi1,2 1 Institute of Bio-information, Chongqing University of Post and Telecommunication, Chongqing 400065, China 2 Institute of Modern Physics, Northwest University, Xi’an 710069, China 3 Department of Physical Sciences, Nicholls State University, PO Box 2022, Thibodaux, LA 70310, U. S. A | 2007 | Science China Chemistry2007，50，5： | 2 |
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