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| 1 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 2 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 3 | Influence of electric field on the quenched-in vacancy and solute clustering during early stage ageing of Al-Cu alloy显示文摘The effects of electric field on the evolution of excess quenched-in vacancy as well as solute clustering in Al-4wt%Cu alloy, and on the vacancy migration and formation enthalpy of pure aluminum were investigated, using positron annihilation lifetime spectroscopy, high-angle annular dark-field scanning transmission electron microscopy, transmission electron microscopy, hardness measurement and four-probe electrical resistivity measurement. The results showed that the electric field improved age hardening response obviously and postponed the decay of excess vacancies for 30 min during the early stage ageing of Al-4wt%Cu alloy. A large number of 2–4 nm GP zones with dense distribution were observed after 1 min ageing with an electric field applied. The electric field-assisted-aged sample owned a lower coarsening rate of GP zone, which was about three fifths of that in the aged sample without an electric field, from 1 min to 120 min ageing. The electric field contributed 8% increase of the vacancy migration enthalpy(0.663 ± 0.021 e V) of pure Al, comparing with that(0.611 ± 0.023 e V) of pure Al without an electric field. The increase of vacancy migration enthalpy, induced by the electric field, was responsible for the difference on evolution of quenched-in vacancy, rapid solute clustering and age hardening improvement during the early stage ageing of Al-4wt%Cu alloy. | Shang Fu Ying Zhang Huiqun Liu Danqing Yi Bin Wang Yong Jiang Zhiquan Chen Ning Qi | 2018 | Journal of Materials Science & Technology2018，34，2： | 3 |
| 4 | Optimization of Extraction Process and Antioxidant Activity of Polysaccharide in Embelia parviflora Wall.by RSM显示文摘[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to provide a basis for the further development and utilization of E.parviflora.[Methods]The solid-to-liquid ratio,extraction temperature,extraction time and extraction times were used as single factors to investigate the effects.On this basis,the response surface methodology(RSM)was used to optimize the extraction process of polysaccharide in E.parviflora.DPPH and ABTS free radicals were used to investigate the antioxidant capacity of polysaccharide in E.parviflora.[Results]The optimal solid-to-liquid ratio for extraction of polysaccharide from E.parviflora was 32∶1(mL/g),extraction temperature was 77℃,and extraction time was 36 min.The IC50 values of DPPH and ABTS were 0.04 and 0.03 mg/mL,respectively.[Conclusions]The optimized extraction process of polysaccharide in E.parviflora is stable,the extraction rate is high,and has strong antioxidant activity.It is expected to provide a reference for the industrial extraction of polysaccharide from E.parviflora. | Wenli LI Xianxian LIU Xiaolian LIANG Yong CHEN Danqing PANG Zhouyan HUANG Qian HAN Wenjun LIU Liangni CHEN | 2020 | Medicinal Plant2020，11，3： | 2 |
| 5 | Trophic relationships in the Changjiang River estuarine salt marshes: preliminary investigation from δ^(13)C and δ^(15)N analysis显示文摘To obtain information on food web structure in salt marshes of the Changjiang (Yangtze) River Estuary, the δ13C and δ15N values of primary producers and consumers were determined. The mean δ13C values of 31 dominant consumers ranged from -23.13‰ to -14.37‰. Except for several species (Eriocheir sinensis, Sinonovacula constricta and Potamocorbula ustulata), consumers had intermediate δ13C values between those of benthic microalgae and Spartina alterniflora. The mean δ15N values of 31 dominant consumers varied between 6.87‰ and 13.33‰, which indicate three trophic levels in salt marshes of the Changjiang River Estuary. A total of 18 macroinvertebrates species and four fish species represented primary consumers with trophic levels ranging from 2.0 to 2.7. Secondary consumers included two macroinvertebrates and seven fishes with trophic levels varying between 3.0 and 3.9. The consumers were divided into three trophic guilds, i.e., detritivorous/algae feeders, omnivores and carnivores. The detrital food chain was the main energy flow pathway in the salt marsh food web of the Changjiang River Estuary, and the marsh vascular plants were at least as equally important as microphytobenthos for secondary production. The important trophic function of the salt marsh habitats in the estuary is revealed. | QUAN Weimin HUANG Danqing CHU Tianjiang SHENG Qiang FU Cuizhang CHEN Jiakuan WU Jihua | 2009 | Acta Oceanologica Sinica2009，28，3： | 2 |
| 6 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 2 |
| 7 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 1 |
| 8 | 显示文摘 | Zhang Liming Chen Danqing | 2002 | Colloids and Surfaces2002，205，3： | 1 |
| 9 | An investigation of adsorption of lead (Ⅱ) and copper(Ⅱ) ions by water-insoluble starch graft copolymers显示文摘 | Chen Danqing | 2002 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2002，205，3： | 1 |
| 10 | Intratumoral Heterogeneity Determines Discordant Results of Diagnostic Tests for Human Epidermal Growth Factor Receptor (HER) 2 in Gastric Cancer Specimens显示文摘 | Jiyuan Yang Hesheng Luo Yan Li Junchuan Li Zhiqiang Cai Xiaoyan Su Danqing Dai Wei Du Tingxuan Chen Ming Chen | 2012 | Cell Biochemistry and Biophysics2012，，1： | 1 |
| 11 | Intratumoral Heterogeneity Determines Discordant Results of Diagnostic Tests for Human Epidermal Growth Factor Receptor (HER) 2 in Gastric Cancer Specimens显示文摘 | Jiyuan Yang Hesheng Luo Yan Li Junchuan Li Zhiqiang Cai Xiaoyan Su Danqing Dai Wei Du Tingxuan Chen Ming Chen | 2012 | Cell Biochemistry and Biophysics2012，，1： | 1 |
| 12 | Intratumoral Heterogeneity Determines Discordant Results of Diagnostic Tests for Human Epidermal Growth Factor Receptor (HER) 2 in Gastric Cancer Specimens显示文摘 | Jiyuan Yang Hesheng Luo Yan Li Junchuan Li Zhiqiang Cai Xiaoyan Su Danqing Dai Wei Du Tingxuan Chen Ming Chen | 2012 | Cell Biochemistry and Biophysics2012，，1： | 1 |
| 13 | Intratumoral Heterogeneity Determines Discordant Results of Diagnostic Tests for Human Epidermal Growth Factor Receptor (HER) 2 in Gastric Cancer Specimens显示文摘 | Jiyuan Yang Hesheng Luo Yan Li Junchuan Li Zhiqiang Cai Xiaoyan Su Danqing Dai Wei Du Tingxuan Chen Ming Chen | 2012 | Cell Biochemistry and Biophysics2012，，1： | 1 |
| 14 | Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation显示文摘Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored. We report here that mutations in Acsl, the Drosophila ortholog of human ACSL3 and ACSL4, result in developmental defects of the mushroom body (MB), the center of olfactory learning and memory. Specifically, Acsl mutants show fewer MB neuroblasts (Nbs) due to reduced proliferation activity and premature differentiation. Consistently, these surviving Nbs show reduced expression of cyclin E, a key regulator of the G1-to S-phase cell cycle transition, and nuclear mislocalization of the transcriptional factor Prospero, which is known to repress self-renewal genes and activate differentiating genes. Furthermore, RNA-seq analysis reveals downregulated Nb-and cell-cyclerelated genes and upregulated neuronal differentiation genes in Acsl mutant Nbs. As Drosophila Acsl and human ACSL4 are functionally conserved, our findings provide novel insights into a critical and previously unappreciated role of Acsl in neurogenesis and the pathogenesis of ACSL4-related ID. | Mingyue Jia Danqing Meng Mo Chen Tingting Li Yong Q.Zhang Aiyu Yao | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 15 | The Mycoplasma gallisepticum α-enolase is cell surface-exposed and mediates adherence by binding to chicken plasminogen显示文摘 | Hongjun Chen Shengqing Yu Xinyue Shen Danqing Chen Xvsheng Qiu Cuiping Song Chan Ding | 2011 | Microbial Pathogenesis2011，，： | 1 |
| 16 | Construction of mini-Tn4001 transposon vector for Mycoplasma gallisepticum显示文摘The detailed genetic analysis of mycoplasmas has long been hampered by the lack of appropriate tools for genetic manipulation. In this study, the transposon vector, mini-Tn4001tetM, was constructed containing the tnp gene, encoding a transposase gene in Staphylococcus aureus, two copies of the IS256 inverted repeat sequence (inner and outer) and the tetM gene, from the Enterococcus faecalis Tn916 transposon, conferring resistance to tetracycline. This vector was electro-transformed into Mycoplasma gallisepticum (MG). The recombinant cells were screened by tetracycline selection. The results indicated that the transposon vector could replicate in MG strain R by successive passages, indicating that MG is a potential vector for expressing protective antigens of other pathogens. | CHEN HongJun, ZHAO ChunMei, SHEN XieYue, CHEN DanQing, YU ShengQing & DING Chan Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China | 2010 | Science China(Life Sciences)2010，53，11： | 1 |
| 17 | Ex- ternalities of Mandatory IFRS Adoption: Evidence from Cross-Border Spillover Effects of Financial In- formation on Investment Eflficiency显示文摘 | Chen Chen Danqing Young and Zili Zhuang | 2013 | The Account- ing Review2013，，： | 1 |
| 18 | Internal oxidation thermodynamics and microstructures of Ag-Y alloy显示文摘 | Wu Chunping Yi Danqing Chen Jingchao | 2007 | Trans Non-ferrous Met Soc Chain2007，17，2： | 1 |
| 19 | Externalities of mandatory IFRS a doption:evidence from cross-border spillover effects of financial information on investment efficiency显示文摘 | Chen C Danqing Y Zili Z | 2013 | Accounting Review2013，88，3： | 1 |
| 20 | BrΦnsted acid-promoted ‘on-water’ C(sp^3)-H functionalization fot the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction显示文摘The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules,which have showed broad and interesting biological activities.The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community.In this communication,we report an efficient BrΦnsted acid-promoted C(sp^3)-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine,2-formylbenzoic acid and various anilines.The title compounds were generated in high to excellent yields(up to 96%)regardless of the electronic nature and steric effects of the substituents.In this reaction,an isoindolinone scaffold,one C-C single bond,and two C-N bonds were formed simultaneously with high atom economy.In this work,we have envisioned that the methyl group linked to the electron-deficient Nheterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry.Besides,the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. | Shuo Yuan Sixi Wang Min Zhao Danqing Zhang Jinjie Chen Jian-Xin Li Jingya Zhang Yihui Song Jinyi Wang Bin Yu Hongmin Liu | 2020 | Chinese Chemical Letters2020，31，2： | 1 |
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