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| 1 | Organochlorine compounds and polycyclic aromatic hydrocarbons in surface sediment from Baiyangdian Lake,North China:Concentrations,sources profiles and potential risk显示文摘Organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polycyclic aromatic hydrocarbons(PAHs) were determined in nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river(Fuhe River) in North China.Total concentrations of OCPs,PCBs and PAHs in sediments ranged from 5.4 to 707.6 ng/g,2.3 to 197.8 ng/g,and 101.3 to 6360.5 ng/g,respectively.The levels of contaminants in Fuhe River were significantly higher than those in Baiyandian Lake.For hexachlorocyclohexane(HCHs) and dichlorodiphenytrichloroethanes(DDTs),α-HCH and p,p-DDT were predominant isomers;while for PCBs,PCB 28/31,PCB 40/103,PCB 60,PCB 101,and PCB 118 were predominant congeners.Possible sources derived from historical usage for OCPs and incomplete combustion fuel,wood,and coal and exhaustion of boats or cars for PAHs.Risk assessment of sediment indicated that sediments in Fuhe River were likely to pose potential biological adverse impact. | Guocheng Hu Xiaojun Luo Fengchao Li Jiayin Dai Jianyang Guo Shejun Chen Cao Hong Bixian Mai Muqi Xu | 2010 | Journal of Environmental Sciences2010，22，2： | 42 |
| 2 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 3 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 4 | Molecular mechanism of adsorption/desorption hysteresis:dynamics of shale gas in nanopores显示文摘Understanding the adsorption and desorption behavior of methane has received considerable attention since it is one of the crucial aspects of the exploitation of shale gas.Unexpectedly,obvious hysteresis is observed from the ideally reversible physical sorption of methane in some experiments.However,the underlying mechanism still remains an open problem.In this study,Monte Carlo(MC) and molecular dynamics(MD) simulations are carried out to explore the molecular mechanisms of adsorption/desorption hysteresis.First,a detailed analysis about the capillary condensation of methane in micropores is presented.The influence of pore width,surface strength,and temperature on the hysteresis loop is further investigated.It is found that a disappearance of hysteresis occurs above a temperature threshold.Combined with the phase diagram of methane,we explicitly point out that capillary condensation is inapplicable for the hysteresis of shale gas under normal temperature conditions.Second,a new mechanism,variation of pore throat size,is proposed and studied.For methane to pass through the throat,a certain energy is required due to the repulsive interaction.The required energy increases with shrinkage of the throat,such that the originally adsorbed methane cannot escape through the narrowed throat.These trapped methane molecules account for the hysteresis.Furthermore,the hysteresis loop is found to increase with the increasing pressure and decreasing temperature.We suggest that the variation of pore throat size can explain the adsorption/desorption hysteresis of shale gas.Our conclusions and findings are of great significance for guiding the efficient exploitation of shale gas. | Jie Chen FengChao Wang He Liu HengAn Wu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，1： | 3 |
| 5 | Sink node placement strategies for wire- less sensor networks 显示文摘 | Chen Fengchao Li Ronglin | 2013 | Wireless Personal Communications2013，68，2： | 1 |
| 6 | Isolationand characterization of novel cellulase genes from uncultured microorganisms in different environmental niches显示文摘 | WANG Fengchao LI Fan CHEN Guanjun | 2009 | Microbiological Research2009，164，6： | 1 |
| 7 | Reduced syncytin-1 expression in choriocarcinoma BeWo cells activates the calpain1–AIF-mediated apoptosis, implication for preeclampsia显示文摘 | Qiang Huang Haibin Chen Fengchao Wang Brian C. Brost Jinping Li Yu Gao Zongfang Li Ya Gao Shi-Wen Jiang | 2014 | Cellular and Molecular Life Sciences2014，，16： | 1 |
| 8 | Capturing the hierarchically assorted modules of protein–protein interactions in the organized nucleome显示文摘Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear events.To decipher the global connectivity of nuclear proteins and the hierarchically organized modules of their interactions,we conducted two rounds of cross-linking mass spectrometry(XL-MS)analysis,one of which followed a quantitative double chemical cross-linking mass spectrometry(in vivo qXL-MS)workflow,and identified 24,140 unique crosslinks in total from the nuclei of soybean seedlings.This in vivo quantitative interactomics enabled the identification of 5340 crosslinks that can be converted into 1297 nuclear protein–protein interactions(PPIs),1220(94%)of which were non-confirmative(or novel)nuclear PPIs compared with those in repositories.There were 250 and 26 novel interactors of histones and the nucleolar box C/D small nucleolar ribonucleoprotein complex,respectively.Modulomic analysis of orthologous Arabidopsis PPIs produced 27 and 24 master nuclear PPI modules(NPIMs)that contain the condensate-forming protein(s)and the intrinsically disordered region–containing proteins,respectively.These NPIMs successfully captured previously reported nuclear protein complexes and nuclear bodies in the nucleus.Surprisingly,these NPIMs were hierarchically assorted into four higher-order communities in a nucleomic graph,including genome and nucleolus communities.This combinatorial pipeline of 4C quantitative interactomics and PPI network modularization revealed 17 ethylene-specific module variants that participate in a broad range of nuclear events.The pipeline was able to capture both nuclear protein complexes and nuclear bodies,construct the topological architectures of PPI modules and module variants in the nucleome,and probably map the protein compositions of biomolecular condensates. | Shuaijian Dai Shichang Liu Chen Zhou Fengchao Yu Guang Zhu Wenhao Zhang Haiteng Deng Al Burlingame Weichuan Yu Tingliang Wang Ning Li | 2023 | Molecular Plant2023，16，5： | 0 |
| 9 | Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment显示文摘Although DNA mutation drives stem cell aging,how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly understood.Here,using a mouse model of irradiation-induced premature aging and middle-aged mice,we show that DNA mutation accumulation in hematopoietic stem cells(HSCs)during aging upregulates their surface expression of major histocompatibility complex class II(MHCII).MHCII upregulation increases the chance for recognition by bone marrow(BM)-resident regulatory T cells(Tregs),resulting in their clonal expansion and accumulation in the HSC niche.On the basis of the establishment of connexin 43(Cx43)-mediated gap junctions,BM Tregs transfer cyclic adenosine monophosphate(cAMP)to aged HSCs to diminish apoptotic priming and promote their survival via activation of protein kinase A(PKA)signaling.Importantly,targeting the HSC–Treg interaction or depleting Tregs effectively prevents the premature/physiological aging of HSCs.These findings show that aged HSCs use an active self-protective mechanism by entrapping local Tregs to construct a prosurvival niche and obtain a clonal advantage. | Weinian Liao Chaonan Liu Ke Yang Jun Chen Yiding Wu Shuzhen Zhang Kuan Yu Lisha Wang Li Ran Mo Chen Fang Chen Yang Xu Song Wang Fengchao Wang Qian Zhang Jinghong Zhao Lilin Ye Changhong Du Junping Wang | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 10 | Mup-knockout mice generated through CRISPR/ Cas9-mediated deletion for use in urinary protein analysis显示文摘主要尿蛋白质(MUP ) 是在老鼠尿的最丰富的蛋白质种类,为超过 90% 全部的蛋白质内容的财务。21 Mup 基因和 21 pseudogenes 在染色体 4 上在约 2 megabase 对(Mbp ) 的一个区域被聚类。一个 Mup 大美人老鼠模型将极大地在老鼠尿的 proteomic 分析的领域里便于研究。这里,我们用 CRISPR/Cas9 系统报导 2.2 Mbp 的 Mup 基因簇的成功的大美人。同型结合的 Mup 大美人老鼠幸存到成人生活并且没展出明显的缺点。non-MUP 的 proteomes 的模式在同型结合的 Mup 大美人老鼠的尿蛋白质类似于钠 dodecyl 硫酸盐 polyacrylamide 胶化电气泳动判定的野类型的老鼠的那些。连接酶的 immunosorbent 试金的敏感显著地在 Mup 大美人提高了老鼠检测尿蛋白质是的 non-MUP。简言之,我们开发了一个 Mup 大美人老鼠模型。这个老鼠模型将是有用的因为测试那的尿 biomarker 的研究可以为人有关联。 | Haixia Yang Wei Zhang Shan Lu Guangqing Lu Hongjuan Zhang Yinghua Zhuang Yue Wang Mengqiu Dong Yu Zhang Xingang Zhou Peng Wang Lei Yu Fengchao Wang Liang Chen | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 0 |
| 11 | Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence显示文摘Background:The trade-off between the benefits of regular physical activity(PA)and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear.This study aimed to examine whether ambient fine particulate matter(PM_(2.5))exposure modified the impacts of PA volume and intensity on hypertension risk.Methods:We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.PA volume and intensitywere assessed by questionnaire,and high-resolution(1 km×1 km)PM_(2.5)estimates were generated using a satellite-based model.Results:During 413,516 person-years of follow-up,12,100 incident hypertension cases were identified.PM_(2.5)significantly modified the relationship between PA and hypertension incidence(p_(interaction)<0.001).Increased PA volume was negatively associated with incident hypertension in the low PM_(2.5)stratum(<59.8μg/m^(3),ptrend<0.001),with a hazard ratio of 0.81(95%confidence interval(95%CI):0.74-0.88)when comparing the fourth with the first quartile of PA volume.However,the health benefits were not observed in the high PM_(2.5)stratum(≥59.8μg/m^(3),p_(trend)=0.370).Moreover,compared with light PA intensity,vigorous intensity was related to a 20%(95%CI:9%-29%)decreased risk of hypertension for participants exposed to low PM_(2.5),but a 17%(95%CI:4%-33%)increased risk for those with high PM_(2.5)levels.Conclusion:PA was associated with a reduced risk of hypertension only among participants with low PM_(2.5)exposure.Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement. | Qiong Liu Keyong Huang Fengchao Liang Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Ying Deng Ying Li Dongsheng Hu Xiangfeng Lu Yang Liu Dongfeng Gu Fangchao Liu Jianfeng Huang | 2022 | Journal of Sport and Health Science2022，11，6： | 0 |
| 12 | Nonlinear harmonic wave manipulation in nonlinear scattering medium via scattering-matrix method显示文摘Scattering of waves, e.g., light, due to medium inhomogeneity is ubiquitous in physics and isconsidered detrimental for many applications. Wavefront shaping technology is a powerful tool to defeatscattering and focus light through inhomogeneous media, which is vital for optical imaging, communication,therapy, etc. Wavefront shaping based on the scattering matrix (SM) is extremely useful in handling dynamicprocesses in the linear regime. However, the implementation of such a method for controlling light in nonlinearmedia is still a challenge and has been unexplored until now. We report a method to determine the SM ofnonlinear scattering media with second-order nonlinearity. We experimentally demonstrate its feasibility inwavefront control and realize focusing of nonlinear signals through strongly scattering quadratic media.Moreover, we show that statistical properties of this SM still follow the random matrix theory. The scattering-matrix approach of nonlinear scattering medium opens a path toward nonlinear signal recovery, nonlinearimaging, microscopic object tracking, and complex environment quantum information processing. | Fengchao Ni Haigang Liu Yuanlin Zheng Xianfeng Chen | 2023 | Advanced Photonics2023，5，4： | 0 |
| 13 | A simple infrared nanosensor array based on carbon nanoparticles显示文摘一简单(2 | Junjie DAI LongyanYUAN Qize ZHONG Fengchao ZHANG Hongfei CHEN Chao YOU Xiaohong FAN Bin HU Jun ZHOU | 2012 | Frontiers of Optoelectronics2012，5，3： | 0 |
| 14 | Optogenetic gene editing in regional skin显示文摘Dear Editor,Significant breakthrough in science often relies on the development of original tools that can perform novel functions,thus help reveal previously unknown knowledge that is not feasible to obtain using conventional tools or methods.Genetic manipulation has become a standard practice in almost all biological research fields;consequently gene expression control systems such as Cre and rtTA are indispensable tools for biomedical studies.1,2 Inducible systems of the standard gene regulation tools are controlled by addition of freely diffusible small molecules such as an antibiotic or a steroid analogue.1-3. | Fei Li Zhiwei Lu Wenbo Wu Nannan Qian Fengchao Wang Ting Chen | 2019 | Cell Research2019，29，10： | 0 |
| 15 | A new hypotrich ciliate,Oxytricha xianica sp.nov.,with notes on the morphology and phylogeny of a Chinese population of Oxytricha auripunctata Blatterer&Foissner,1988(Ciliophora,Oxytrichidae)显示文摘The morphology and infraciliature of the new hypotrichous ciliate,Oxytricha xianica sp.nov.,and a Chinese population of Oxytricha auripunctata Blatterer&Foissner,1988,are investigated using live observation and protargol staining.Oxytricha xianica sp.nov.is defined by the body size 85-130µm×30-50µm in vivo,the typical oxytrichid 18 frontoventral-transverse cirri,cortical granules absent,undulating membranes reduced or absent,three caudal cirri,dorsal kineties in Oxytricha pattern,and two ellipsoidal macronuclear nodules.The Chinese population of O.auripunctata differs slightly from other populations in the arrangement and color of cortical granules and position of anterior end of dorsal kinety 4.Phylogenetic analyses based on SSU-rDNA sequences support the assertion that O.auripunctata belongs to Oxytricha and Oxytrichidae. | Jingyi Wang Tengteng Zhang Fengchao Li Alan Warren Yanbo Li Chen Shao | 2021 | Marine Life Science & Technology2021，3，3： | 0 |
| 16 | Mup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysis显示文摘The originally published version of this manuscript contained incomplete funding information. The funding information has since been updated to read as follows. | Haixia Yang Wei Zhang Shan Lu Guangqing Lu Hongjuan Zhang Yinghua Zhuang Yue Wang Mengqiu Dong Yu Zhang Xingang Zhou Peng Wang Lei Yu Fengchao Wang Liang Chen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 0 |
| 17 | RNF219 interacts with CCR4-NOT in regulating stem cell differentiation显示文摘Regulation of RNA stability plays a crucial role in gene expression control.Deadenylation is the initial rate-limiting step for the majority of RNA decay events.Here,we show that RING finger protein 219(RNF219)interacts with the CCR4-NOT deadenylase complex.RNF219-CCR4-NOT exhibits deadenylation activity in vitro.RNA-seq analyses identify some of the 2-cell-specific genes and the neuronal genes significantly downregulated upon RNF219 knockdown,while upregulated after depletion of the CCR4-NOT subunit CNOTIO in mouse embryonic stem(ES)cells.RNF219 depletion leads to impaired neuronal lineage commitment during ES cell differentiation.Our study suggests that RNF219 is a novel interacting partner of CCR4-NOT and required for maintenance of ES cell pluripotency. | Hao Du Chen Chen Yan Wang Yang Yang Zhuanzhuan Che Xiaoxu Liu Siyan Meng Chenghao Guo Manman Xu Haitong Fang Fengchao Wang Chengqi Lin Zhuojuan Luo | 2020 | Journal of Molecular Cell Biology2020，12，11： | 0 |
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