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| 1 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 2 | 三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤显示文摘【据Hepatology 2021年2月报道】题:三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤(作者Chen SY等)肝缺血再灌注(IR)损伤是肝移植术后器官功能障碍的主要原因,其主要涉及炎症反应和细胞凋亡等过程。作为调控多种细胞炎症和凋亡的关键介质,三结构域蛋白27(TRIM27)在肝IR损伤中的作用值得研究。 | CHEN SY ZHANG HP LI J 陈三洋 | 2021 | 临床肝胆病杂志2021，37，6： | 11 |
| 3 | Comparison of clinical outcomes of oral erythroleukoplakia treated with photodynamic therapy using either light-emitting diode or laser light显示文摘 | Yu CH Lin HP Chen HM Yang H | 2009 | Lasers Surg Med2009，41，： | 1 |
| 4 | Serial cytokine levels in pa- tients with severe sepsis显示文摘 | Wu HP Chen CK Chung K | 2009 | Inflamm Res2009，5，： | 1 |
| 5 | Icariin, a flavonoid fr- om the herb Epimedium enhances the osteogenic differen- tiation of rat primary bone marrow stromal cells显示文摘 | Chen KM Ge BF Ma HP | 2005 | Pharmazie2005，60，12： | 1 |
| 6 | Heat shock protein 70/MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in v ivo 显示文摘 | Ye J Chen GS Song HP | 2004 | Cancer Immunol Immunother2004，53，9： | 1 |
| 7 | Cu-curbitacin B inhibits growth,arrests the cell cycle,and potentiatesantiproliferative efficacy of cisplatin in cutaneous squamous cell car-cinoma cell lines显示文摘 | Chen W Leiter A Yin D Meiring M Louw VJ Koeffler HP | 2010 | Int J Oncol2010，37，3： | 1 |
| 8 | Binding affinity to and dependence on some opioids in Sf 9 insect cells expressing human mu-opioid receptor显示文摘 | Liu ZH He Y Jin WQ Chen XJ Zhang HP Shen QX | 2003 | Acta Pharmacol Sin(中国药理学报)2003，24，9： | 1 |
| 9 | Egr-1 regulates auto- phagy in cigarette smoke-induced chronic obstructive pul- monary disease 显示文摘 | Chen ZH Kim HP Sciurba FC | 2008 | PLoS ONE2008，3，10： | 1 |
| 10 | Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro显示文摘 | Ming LG Zhou J Cheng GZ Ma HP Chen KM | 2011 | Pharmacology2011，88，12： | 1 |
| 11 | Cryogun cryotherapy for oral leukoplakia显示文摘 | Lin HP Chen HM Cheng SJ | 2012 | Head Neck2012，34，9： | 1 |
| 12 | Assessments of nasal bone fracture effects on nasal airflow:A computational fluid dynamics study显示文摘 | Chen XB Lee HP Chong VF | | 0，，1： | 1 |
| 13 | Clinical characteristics and prognosis of diffuse proliferative lupus nephritis with thrombotic microangiopathy 显示文摘 | Hu WX Liu ZZ Chen HP | 2010 | Lupus2010，19，14： | 1 |
| 14 | Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease显示文摘 | Chen ZH Kin HP Lee SJ | 2008 | PLoS One2008，3，10： | 1 |
| 15 | Inhibitory effects of ploymyxin B(PMB) on the nuclear factor-kappa B (NF-KB) acti- vation and the expression of precollagen I , III of human umbilical artery smooth muscle cell induced by umbilical serums of preeclampsia 显示文摘 | Jiang RZ Chen HP Xu XY | 2006 | Chin Med J2006，119，： | 1 |
| 16 | Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical genera- tion : implications for neuroprotection 显示文摘 | Chen W Jia Z Zhu H Li Y Misra HP | 2010 | Neurochem Res2010，35，2： | 1 |
| 17 | Study on the expression of an- giotensin II (ANG II) receptor subtype 1 (AT1R) in the placenta of pregnancy-induced hypertension 显示文摘 | Thapa L He CM Chen HP | 2004 | Placenta2004，25，7： | 1 |
| 18 | VKORCI haplotypes in five East-Asian populations and Indians显示文摘 | LeeMT Chen CH Chuang HP | 2009 | Pharmacogenomics2009，10，10： | 1 |
| 19 | IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway显示文摘 | Lee DF Kuo HP Chen CT | 2007 | Cell2007，130，： | 1 |
| 20 | Sasanquasaponin protects rat cardiomyoeytes against oxidative stress induced by anoxiareoxygenation injury 显示文摘 | Chen HP He M Huang QR | 2007 | Eur J Pharmacol2007，575，13： | 1 |
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