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| 1 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 2 | Effect of berber- ine on the differentiation of adipocyte 显示文摘 | ZHOU LB CHEN MD WANG X | 2003 | Zhonghua Yi Xue Za Zhi2003，83，4： | 1 |
| 3 | Accurate reconstruction of discontinuous mandible using a reverse engineering/computer- aided design/rapid prototyping technique: a preliminary clinical study显示文摘 | Zhou LB Shang HT He LS | 2010 | J Oral Maxillofac Surg2010，68，9： | 1 |
| 4 | Germ-line and acquired mutations of INI1 in atypical teratoid/rhabdoid tumors显示文摘 | Biegel JA Zhou JY Rorke LB | 1999 | Cancer1999，59，1： | 1 |
| 5 | WT1 regulates epicardial ep- ithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways显示文摘 | Von Gise A Zhou B Honor LB | 2011 | Dev Biol2011，，356： | 1 |
| 6 | Synthetic gelatinases inhibitor attenuates electromagnetic pulse induced blood brain barrier disruption by inhibiting gelatinases mediated ZO 1 degradation in rats显示文摘 | Qiu LB Zhou Y Wang Q | 2011 | Toxicology2011，285，12： | 1 |
| 7 | Risk f actors for human illness with avian influenza ( H5N1 ) virus infection in China 显示文摘 | Zhou L Liao QH Dong LB | 2009 | J Infect Dis2009，199，12： | 1 |
| 8 | Reconstruction of cu- rved mandibular angle defects using a new internal tra- nsport distraction device: An experiment in goats显示文摘 | Zhou LB Shang HT Hu M | 2008 | Br J Oral Maxillofae Surg2008，46，6： | 1 |
| 9 | WT1 regulates epieardial epithelial to mesenchymal transition through 13-catenin and retinoic acid signaling pathways 显示文摘 | von Gise A Zhou B Honor LB | | Dev Biol0，56，2： | 1 |
| 10 | Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer 显示文摘 | Etiz D Marks LB Zhou SM | 2002 | Int J Radiat Oncol Biol Phys2002，53，4： | 1 |
| 11 | Reconstruction of curved mandibular angle defects using a new interal reansport distraction device:an experiment in goats显示文摘 | Zhou LB Shang HT Hu M | 2008 | Br J Oral Maxillofac Surg2008，46，： | 1 |
| 12 | Adult mouse epicardium modulates myocardial injury by secreting paracrine factors 显示文摘 | Zhou B Honor LB He H | 2011 | J Clin Invest2011，121，5： | 1 |
| 13 | Adult mouse epicardium modulates myocardial injury by secreting paracrine factors 显示文摘 | Zhou B Honor LB He H | 2011 | J Clin Invest2011，121，5： | 1 |
| 14 | SYNTHESIS OF FULLERENE PYRROLIDINES CONTAINING SUBSTITUTED PHENYL GROUPS THROUGH AZOMETHINE YLIDE ADDITION显示文摘SYNTHESIS OF FULLERENE PYRROLIDINES CONTAINING SUBSTITUTED PHENYL GROUPS THROUGH AZOMETHINE YLIDE ADDITIONDeJianZHOU;LiangBin... | Zhou, DJ Gan, LB Tan, HS Luo, CP Huang, CH Pan, JQ Lu, MJ Wu, Y | 1995 | Chinese Chemical Letters1995，6，12： | 1 |
| 15 | Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish显示文摘 | Chen ZZ Cheng CHC Zhang JF Cao LX Chen L Zhou LH Jin YD Ye H Deng C Dai ZH Xu QH Hu P Sun SH Shen Y Chen LB | | 0，，： | 1 |
| 16 | Accurate reconstruction of discontinuous mandible using a reverse engineering/com purer-aided design/rapid prototyping technique: a prelimi- nary clinical study显示文摘 | Zhou LB Shang HT He LS | 2010 | J Oral Maxillofac Surg2010，68，9： | 1 |
| 17 | Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer 显示文摘 | Etiz D Marks LB Zhou SM | 2002 | Int J Radiat Oncol Biol Phys2002，53，4： | 1 |
| 18 | Accurate reconstruction of discontinuous mandible using a reverse engineering/computer-aided design/rapid prototyping technique:a preliminary clinical study显示文摘 | Zhou LB Shang HT He LS | 2010 | J Oral Maxillofac Surg2010，68，9： | 1 |
| 19 | Live-animal markets and influenza A(H7N9) virus infection显示文摘 | Bao CJ Cui LB Zhou MH | 2013 | N Engl J Med2013，368，24： | 1 |
| 20 | Copper(I) iodide catalyzed domino process to quinazolin - 4 ( 3 H ) - ones 显示文摘 | Zhou J Fu LB Lv M | 2008 | Synthesis2008，24，： | 1 |
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