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| 1 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 2 | Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening显示文摘Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research. | Qiangqiang Tang Xiaoyu Li Chen Lai Lei Li Hongkai Wu Yingjun Wang Xuetao Shi | 2021 | Bioactive Materials2021，6，1： | 5 |
| 3 | Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019显示文摘During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection. | Wenkuan Liu Shuyan Qiu Li Zhang Hongkai Wu Xingui Tian Xiao Li Duo Xu Jing Dai Shujun Gu Qian Liu Dehui Chen Rong Zhou | 2022 | Virologica Sinica2022，37，3： | 5 |
| 4 | Gearbox fault diagnosis using adaptive redundant Lifting Scheme显示文摘 | Jiang Hongkai He Zhengjia Duan Chendong Chen Peng | 2005 | Mechanical Systems and Signal Processing2005，，8： | 1 |
| 5 | Research on duration for perilous rock to form 显示文摘 | CHEN Hongkai TANG Hongmei ZHU Hui | 2006 | Wseas Transactions on Aaalied and Theoretical Mechanics2006，，2： | 1 |
| 6 | Essential principle of debris flow dynamics显示文摘 | Chen Hongkai Tang Hongmei | 2006 | Wseas Transactions on Fluid Mechanics2006，10，1： | 1 |
| 7 | Optimum design on the per- formance parameters of a two-stage combined semiconductor thermoe- lectric heat pump显示文摘 | Lai Hongkai Pan Yuzhuo Chen Jincan | 2004 | Semiconductor Science and Technology2004，19，1： | 1 |
| 8 | Photolumineseence of phosphors for PDP with VUV excitation 显示文摘 | Lu Hsiaochi Chen Hongkai Tseng Tzuyi | 2005 | Electron Spectroscopy and Related Phenomena2005，，： | 1 |
| 9 | Bacterial-fungal interactions under agricultural settings:from physical to chemical interactions显示文摘Bacteria and fungi are dominant members of environmental microbiomes.Various bacterial-fungal interactions(BFIs)and their mutual regulation are important factors for ecosystem functioning and health.Such interactions can be highly dynamic,and often require spatiotemporally resolved assessments to understand the interplay which ranges from antagonism to mutualism.Many of these interactions are still poorly understood,especially in terms of the underlying chemical and molecular interplay,which is crucial for inter-kingdom communication and interference.BFIs are highly relevant under agricultural settings;they can be determinative for crop health.Advancing our knowledge related to mechanisms underpinning the interactions between bacteria and fungi will provide an extended basis for biological control of pests and pathogens in agriculture.Moreover,it will facilitate a better understanding of complex microbial community networks that commonly occur in nature.This will allow us to determine factors that are crucial for community assembly under different environmental conditions and pave the way for constructing synthetic communities for various biotechnological applications.Here,we summarize the current advances in the field of BFIs with an emphasis on agriculture. | Yaqi Zhou Hongkai Wang Sunde Xu Kai Liu Hao Qi Mengcen Wang Xiaoyulong Chen Gabriele Berg Zhonghua Ma Tomislav Cernava Yun Chen | 2022 | Stress Biology2022，2，1： | 1 |
| 10 | Band alignment and polarization engineering inκ-Ga_(2)O_(3)/GaN ferroelectric heterojunction显示文摘Ferroelectric-semiconductor heterostructures offer an alternative strategy to manipulate polarization towards advanced devices with engineered functionality and improved performance.In this work,we report on the heteroepitaxial construction,band structure alignment and polarization engineering of the single-phasedκ-Ga_(2)O_(3)/GaN ferroelectric/polar heterojunction.A type-II band alignment is determined at theκ-Ga_(2)O_(3)/GaN polar hetero-interface,with a valence band offset of(1.74±0.1)eV and a conduction band offset of(0.29■0.1)eV.Besides the band edge discontinuity,charge dipoles induced by spontaneous polarization lead to the observed band bending with built-in potentials of 0.9 and 0.33 eV,respectively,at theκ-Ga_(2)O_(3)surface andκ-Ga_(2)O_(3)/GaN interface.The polarization switching properties of ferroelectricκ-Ga_(2)O_(3)are identified with a remanent polarization of approximately 2.7μC/cm^(2)via the direct hysteresis remanent polarization/voltage(P-V)loop measurement.These findings allow the rational design ofκ-Ga_(2)O_(3)ferroelectric/polar heterojunction for the application of power electronic devices,advanced memories and even ultra-low loss negative capacitance transistors. | Yanting Chen Hongkai Ning Yue Kuang Xing-Xing Yu He-He Gong Xuanhu Chen Fang-Fang Ren Shulin Gu Rong Zhang Youdou Zheng Xinran Wang Jiandong Ye | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，7： | 1 |
| 11 | Rodingite in the Purang Ophiolite and Its Geological Implication, Southwest Tibet显示文摘The Yarlung Zangbo Suture Zone(YZSZ)separates the Lhasa block of the Eurasian plate to the north from the Indian plate to the south,along a^2000km discontinuous E–W trending suture zone,several heterogeneous remnants of the Neo-Tethyan oceanic floor have been preserved from the subduction recycling.The Purang ophiolite massif is one of the most spectacular | LI Xuping KONG Fanmei CHEN Hongkai ZHANG Xin | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 1 |
| 12 | of phosphors for PDP with VUV excitation 显示文摘 | Lu HsiaoChi Chen HongKai Tseng Tzu-Yi | 2005 | Journal of Electron Spectroscopy and Related Phenomena2005，，： | 1 |
| 13 | Effects of p , p ′-dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells显示文摘 | XianZhi Xiong AiGuo Wang GuoHong Liu HongKai Liu Chong Wang Tao Xia XueMin Chen KeDi Yang | 2005 | Environmental Research2005，，3： | 1 |
| 14 | Defornmble Shape Preserving Video Retargeting With Salient Curve Matching显示文摘 | Botao Wang Hongkai Xiong Zhiquan Ren Chang Wen Chen | 2014 | IEEE Journal on Emer- ging and Selected Topics in Circuits and Systems2014，4，1： | 1 |
| 15 | Gearbox fault diagnosis using adaptive redundant lifting scheme显示文摘 | Jiang Hongkai He Zhengjia Duan Chendong Chen Peng | 2006 | Mechaniced systems and signal processing2006，20，： | 1 |
| 16 | The impacts of climate change on hydrology in a typical glacier region A case study in Hailuo Creek watershed of Mt.Gongga in China显示文摘The glaciers of the Hengduan Mountains play an important role in the hydrology processes of this region. In this study, the HBV Light model, which relies on a degree-day model to simulate glacier melting, was employed to simulate both glacier runoff and total runoff. The daily temperature and precipitation at the Hailuo Creek No. 1 Glacier from 1952 to 2009 were obtained from daily meteorological observed data at the glacier and from six national meteorological stations near the Hailuo Creek Basin. The daily air temperature, precipitation, runoff depth, and monthly potential evaporation in 1995, 1996, and 2002 were used to obtain a set of optimal parameters, and the annual total runoff and glacier runoff of the Hailuo Creek Glacier(1952–2009) were calculated using the HBV Light model. Results showed the average annual runoff in the Hailuo Creek Basin was 2,114 mm from 1952 to 2009, of which glacial melting accounted for about 1,078 mm. The river runoff in the Hailuo Creek catchment increased as a result of increased glacier runoff. Glacier runoff accounted for 51.1% of the Hailuo Creek stream flow in 1994 and increased to 72.6% in 2006. About 95% of the increased stream flow derived from the increased glacier runoff. | GuoFeng Zhu YuanQing He DaHe Qin HongKai Gao Tao Pu DongDong Chen Kai Wang | 2016 | Research in Cold and Arid Regions2016，8，3： | 0 |
| 17 | Shipborne oceanic high-spectral-resolution lidar for accurate estimation of seawater depth-resolved optical properties显示文摘Lidar techniques present a distinctive ability to resolve vertical structure of optical properties within the upper water column at both day-and night-time.However,accuracy challenges remain for existing lidar instruments due to the ill-posed nature of elastic backscatter lidar retrievals and multiple scattering.Here we demonstrate the high performance of,to the best of our knowledge,the first shipborne oceanic high-spectral-resolution lidar(HSRL)and illustrate a multiple scattering correction algorithm to rigorously address the above challenges in estimating the depth-resolved diffuse attenuation coefficient Kd and the particulate backscattering coefficient bbp at 532 nm.HSRL data were collected during day-and night-time within the coastal areas of East China Sea and South China Sea,which are connected by the Taiwan Strait.Results include vertical profiles from open ocean waters to moderate turbid waters and first lidar continuous observation of diel vertical distribution of thin layers at a fixed station.The root-mean-square relative differences between the HSRL and coincident in situ measurements are 5.6%and 9.1%for Kd and bbp,respectively,corresponding to an improvement of 2.7-13.5 and 4.9-44.1 times,respectively,with respect to elastic backscatter lidar methods.Shipborne oceanic HSRLs with high performance are expected to be of paramount importance for the construction of 3D map of ocean ecosystem. | Yudi Zhou Yang Chen Hongkai Zhao Cedric Jamet Davide Dionisi Malik Chami Paolo Di Grolamo James H.Churnside Aleksey Malinka Huade Zhao Dajun Qiu Tingwei Cui Qun Liu Yatong Chen Sornsiri Phongphattarawat Nanchao Wang Sijie Chen Peng Chen Ziwei Yao Chengfeng Le Yuting Tao Peituo Xu Xiaobin Wang Binyu Wang Feitong Chen Chuang Ye Kai Zhang Chong Liu Dong Liu | 2022 | Light(Science & Applications)2022，11，10： | 0 |
| 18 | Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome:A comparative cohort study in China显示文摘Background Venovenous extracorporeal membrane oxygenation(VV-ECMO)has been demonstrated to be effective in treating patients with virus-induced acute respiratory distress syndrome(ARDS).However,whether the management of ECMO is different in treating H1N1 influenza and coronavirus disease 2019(COVID-19)-associated ARDS patients remains unknown.Methods This is a retrospective cohort study.We included 12 VV-ECMO-supported COVID-19 patients admitted to The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Eighth People's Hospital,and Wuhan Union Hospital West Campus between January 23 and March 31,2020.We retrospectively included VV-ECMO-supported patients with COVID-19 and H1N1 influenza-associated ARDS.Clinical characteristics,respiratory mechanics including plateau pressure,driving pressure,mechanical power,ventilatory ratio(VR)and lung compliance,and outcomes were compared.Results Data from 25 patients with COVID-19(n=12)and H1N1(n=13)associated ARDS who had received ECMO support were analyzed.COVID-19 patients were older than H1N1 influenza patients(P=0.004).The partial pressure of arterial carbon dioxide(PaCO_(2))and VR before ECMO initiation were significantly higher in COVID-19 patients than in H1N1 influenza patients(P<0.001 and P=0.004,respectively).COVID-19 patients showed increased plateau and driving pressure compared with H1N1 subjects(P=0.013 and P=0.018,respectively).Patients with COVID-19 remained longer on ECMO support than did H1N1 influenza patients(P=0.015).COVID-19 patients who required ECMO support also had fewer intensive care unit and ventilator-free days than H1N1.Conclusions Compared with H1N1 influenza patients,COVID-19 patients were older and presented with increased PaCO_(2) and VR values before ECMO initiation.The differences between ARDS patients with COVID-19 and influenza on VV-ECMO detailed herein could be helpful for obtaining a better understanding of COVID-19 and for better clinical management. | Yonghao Xu Yin Xi Shuijiang Cai Yuheng Yu Sibei Chen Weijie Guan Weibo Liang Hongkai Wu Weiqun He Xilong Deng Yuanda Xu Rong Zhang Manshu Li Jieyi Pan Zhenting Liang Ya Wang Shaofeng Kong Xiaoqing Liu Zheng Lv Yimin Li | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
| 19 | Purang Utramafic Complex and Their Geological Origin, Southwest Tibet显示文摘Purang ultramafic complex of western Tibet consists of spinel peridotites,olivine websterite,rodingite and later intruded gabbro-diabase veins.The spinel peridotites consist of lherzolite,harzburgite and dunite.All Purang peridotites are rich in MgO,but depleted in Al2O3,CaO and TiO2 relative to primary mantle values,indicating | LI Xuping KONG Fanmei CHEN Hongkai | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 0 |
| 20 | Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes显示文摘Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health,especially among immunocompromised populations.Given the intricate problem of dramatic increase in resistance to common biocides,the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding.In this study,Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine(ε-PL)decorated aldehyde functionalized mesoporous silica SBA-15(CHO-SBA-15)for the selective coordination of silver ions,which was affirmed by various physicochemical methods.Besides the identified broad-spectrum antibacterial activities,the as-prepared Schiff-base silver nanocomplex(CHO-SBA-15/ε-PL/Ag,CLA-1)exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates,SBA-15/ε-PL/Ag and CHO-SBA-15/Ag,respectively.In addition,CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver species.Significantly,CLA-1 kills Candida albicans cells,inhibits biofilm formation,and eliminates preformed biofilms,with no development of resistance during continuous serial passaging.The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species.In mouse models of multidrug-resistant C.albicans infection,CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs,amphotericin B and fluconazole.Moreover,CLA-1 treatment induces negligible toxicity against normal tissues with safety.Therefore,this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes. | Ling Cai Yanqiang Huang Yuanyuan Duan Qiao Liu Qilan Xu Jia Jia Jianming Wang Qian Tong Peipei Luo Yujie Wen Luming Peng Qian Wu Xudong Hang Huijun Jiang Ping Zhu Yanmei Yang Boshen Zhou Liping Zeng Hongkai Bi Jin Chen | 2021 | Nano Research2021，14，8： | 0 |
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