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| 1 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 2 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 3 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 4 | Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration显示文摘INTRODUCTIONThe liver is one of the organs,which have potentialregenerative capability in mammalian animal.The study of the canine model indicated that theliver could regenerate to original size after 70%hepatectomy in only two weeks.So it is a hotresearch topic for the cellular and molecularmechanism of liver regeneration. | Cheng J Zhong YW Liu Y Dong J Yang JZ Chen JM | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 5 | A New Anthraquinone from Clinopodium polycephalum Glyceroyl-1,6,8-trihydroxy-3-methyl-9,10-dioxo-2-anthracene Carboxylate显示文摘A new anthraquinone, Glyceroyl-l, 6, 8 -trihydroxy-3 -methyl-9, 10-dioxo-2 -anthracenecarboxylate 1, was isolated from Clinopodium polycephalum. The chemical structure was determined by spectroscopic methods. | Chen, JY Chen, JM Wan, CL Yang, JS Xiao, PG | 1998 | Chinese Chemical Letters1998，9，2： | 5 |
| 6 | 帕金森病患者睡眠障碍——病例对照调查显示文摘目的 观察帕金森病 (Parkinson sdisease ,PD)患者出现睡眠障碍的频率及比较睡眠障碍与抗PD药物、情绪、PD运动障碍程度之间的关系。方法 随机病例 对照 ,量表方式调查了澳大利亚新南威尔士大学脑捐献中心非痴呆PD患者 5 2例、同龄非PD对照组 5 0例 ,为增加信息的可靠程度 9%被调查者采用直接会见方式、2 7%附加电话问询进一步确认症状的可靠性与准确性。结果 完成调查表者 38例PD患者和 32例年龄匹配的对照组均在社区居住。PD组与对照组比较有较多的白天过量嗜睡 ( 4 5 %比 6 % )、不安腿 ( 5 0 %比 19% )和睡眠异常运动 ( 34%比 0 % ) ,此类症状多在PD诊断后的 3~ 5年内发现。上述异常表现与患者情绪障碍及药物无关。结论 多数PD患者存在睡眠障碍 ,且发现这些症状多出现在PD诊断后平均 3~ 5年 ,L | 鲁佑瑜 王少石 JM Henderson Chen Lincoln | 2004 | 中国神经精神疾病杂志2004，30，3： | 3 |
| 7 | TWO NORDITERPENOID ALKALOIDS FROM ACONITUM LEUCOSTOMUM显示文摘TWO NORDITERPENOID ALKALOIDS FROM ACONITUM LEUCOSTOMUMTWONORDITERPENOIDALKALOIDSFROMACONITUMLEUCOSTOMUM￥JianMinYUE;JunXUandHa... | Yue, JM Xu, J Sun, HD Chen, SN Chen, YZ | 1996 | Chinese Chemical Letters1996，7，8： | 2 |
| 8 | Texture description and segmentation through fractal geometry显示文摘 | Keller JM Chen S Crownover RM | 1989 | Computer Graphics Image Prooess1989，，45： | 2 |
| 9 | Human lens epithelial cell line显示文摘 | Ibaraki N Chen SC Lin LR Okamoto H Pipas JM Reddy VN | 1998 | Exp Eye Res1998，67，5： | 1 |
| 10 | Regulation of signal transudation pathway and gene expression by mood stabilizers and antidepressants显示文摘 | Chen G Hasanat KA BebehuK JM | 1999 | Psychosom Med1999，61，5： | 1 |
| 11 | Cloning and expression of mouse legumain, a lysosmal endopeptidase 显示文摘 | Chen JM Dando PM Stevens RA | 1988 | Biochem J1988，335，1： | 1 |
| 12 | Pain generation in lumbar and cervical facet joints显示文摘 | Cavanaugh JM Lu Y Chen C | 2006 | J Bone Joint Surg Am2006，88，2： | 1 |
| 13 | The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation显示文摘 | Chen JF Mandel EM Thomson JM | 2006 | Nat Genet2006，38，2： | 1 |
| 14 | Increased aquaporin-4 expression in ammonia-treated cultured astrocytes显示文摘 | Rama-Rao KV Chen M Simard JM | 2003 | Neuroreport2003，14，18： | 1 |
| 15 | Role of matrix metalloproteinases in renal pathophysiologies 显示文摘 | Catania JM Chen G Parrish AR | 2007 | Am J Physiol Renal Physiol2007，292，3： | 1 |
| 16 | A role for the apoptosis inhibitory factor AIM/Spa/Api6 in atheroselerosis develop ment显示文摘 | Arai S Shelton JM Chen M | 2005 | Cell Metab2005，1，3： | 1 |
| 17 | Nematophin, a novel antimicrobial substance produced by Xenorhabdus nematophilus (Enterobactereaceae) 显示文摘 | Li JX Chen GH Webster JM | 1997 | Can J Microbiol1997，43，： | 1 |
| 18 | Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats 显示文摘 | Cai Y Chen JW Jiang JM | 2010 | Journal of Ethnopharmacology2010，131，1： | 1 |
| 19 | Synergistic effects of NGF, CNTF and GDNF on functional recovery following sciatic nerve inju- ry in rats显示文摘 | Chen J Chu YF Chen JM | 2010 | Adv Med Sci2010，55，： | 1 |
| 20 | Pain generation in lumbar and cervical facet joints显示文摘 | Cavanaugh JM Lu Y Chen C | | 0，，： | 1 |
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