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| 1 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 2 | Cultivation of human liver cell lines with microcarriers acting as biological materials of bioartificial liver显示文摘AIM To improve the Cultivation efficiency and yield of human liver cell line CL--l.METHODS High--density cultivation of CL--l onmicrocarriers was carried out with periodicobservation of their growth and proliferation.The specific functions of human liver cell werealso determined.RESULTS Cells of CL-1 cell line grew well onmicrocarrier Cytodex--3 and on the 7th day thepeak was reached. The amount of CLI cells was2.13 x 10’ and the total amount of albuminsynthesis reached 71 .23 ig, urea synthesis23 .32 mg and diazepam transformation 619 .7 ugrespectively. The yield of CL-l on microcarrierswas 49.3 times that of conventional cultivation.The amounts of albumin synthesis, ureasynthesis and diazepam transformation were39.8 times, 41 .6 times and 33.3 times those ofconventional Cultivation, respectively.CONCLUSION The human liver cell line CL--1 canbe Cultivated to a high density with Cytodex--3and has better biological functions. High-densityCultivation of CLI on microcarriers can act asthe biological material of bioartificial liver. | Gao Y Xu XP Hu HZ Yang JZ | 1999 | World Journal of Gastroenterology1999，5，3： | 13 |
| 3 | Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration显示文摘INTRODUCTIONThe liver is one of the organs,which have potentialregenerative capability in mammalian animal.The study of the canine model indicated that theliver could regenerate to original size after 70%hepatectomy in only two weeks.So it is a hotresearch topic for the cellular and molecularmechanism of liver regeneration. | Cheng J Zhong YW Liu Y Dong J Yang JZ Chen JM | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 4 | Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture.显示文摘 | Li X Lu F Tian Q Yang Y Wang Q Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 9 |
| 5 | Primary porcine hepatocytes with portal vein serum cultured on microcarriers or in spheroidal aggregates显示文摘AIM To develop a culture mode providingdurable biomaterials with high yields andactivities used in bioartificial liver.METHODS Hepatocytes were isolated from awhole pig liver by Seglen’s method of orthotopicperfusion with collagenase.In culture onmicrocarriers,primary porcine hepatocyteswere inoculated at a concentration of 5×10~7/mLinto the static culture systems containing 2 g/LCytodex-3,then supplemented with 100 mL/Lfetal calf serum(FCS)or 100 mL/L porcineportal vein serum(PPVS)respectively.Inspheroidal aggregate culture hepatocytes wereinoculated into 100 mL siliconized flasks at aconcentration of 5.0×10~6/mL.RESULTS In culture on microcarriershepatocytes tended to aggregate on Cytodex-3obviously after being inoculated.Typical multi-cellular aggregated spheroids could be found inthe two systems 24 h-48 h after hepatocyteswere cultured.The morphological charact-eristics and synthetic functions were maintainedfor 5 wk in FCS culture system and 8 wk in PPVSculture system.In spheroidal aggregate cultureabout 80%-90% isolated hepatocytes becameaggregated spheroids 24h after cultured insuspension and mean diameter of the spheroidswas 100μm.The relationship among thehepatocytes resembled that in the liver in vivo.Synthetic functions of albumin and urea of the spheroids were twice those of hepatocytescultured on monolayers.CONCLUSION As high-yields and high-activitymodes of culture on microcarriers or inspheroidal aggregate culture with portal veinserum are promising to provide biomaterials forbioartificial liver(BAL)efficiently. | Gao Y Hu HZ Chen K Yang JZ | 2000 | World Journal of Gastroenterology2000，6，3： | 6 |
| 6 | Endogenous overproduction of beta-amyloid induces tau hyperphosphorylation and decreases the solubility of tau in N2a cells.显示文摘 | Wang YP Wang XC Tian Q Yang Y Zhang Q Zhang JY Zhallg YC Wang ZF Wang Q Li H Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 5 |
| 7 | Cloning and expression of a novel tinoblastoma binding protein cDNA,RBBP10显示文摘 | Chen JZ Yang QS Wang S | 2002 | Biochem Genet2002，40，78： | 1 |
| 8 | Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome显示文摘 | Zhao JZ Lin JJ Yang HY | 2010 | J Women′s Health2010，19，2： | 1 |
| 9 | Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery显示文摘 | Yang XZ Du JZ Dou S | | 0，，01： | 1 |
| 10 | A novel porous cells scaffold made of polylactide-dext-ran blend by combining phase-separation and particle-leaching techniques显示文摘 | Cai Q Yang J Bei JZ | 2002 | Biomaterials2002，23，： | 1 |
| 11 | In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH( DADLE), and its cyclic prodrugs显示文摘 | YANG JZ CHEN W BORCHARDT T | 2002 | J Pharmacol Exp Ther2002，303，2： | 1 |
| 12 | Standard for diagnosing vascular dementia,differentiating syndromes and evaluating curative effect显示文摘 | Tian JZ Han MX Tu JW Yang CZ Yang HM Zou YH Liu H | | 0，，： | 1 |
| 13 | Triterpenoid glycosides from the stems of Gordonia kwangsiensis 显示文摘 | Fu HZ Li C J Yang JZ | 2013 | Phytochemistry2013，85，： | 1 |
| 14 | Decreased soluble TGF-beta1,Tie-2,and angiopoietins serum levels in bone marrow after treating healthy donors with granulocyte colony-stimulating factor显示文摘 | Yang JZ Sun LX | 2012 | Transfus Apher Sci2012，47，1： | 1 |
| 15 | High mobility groupprotein box-1 and its relevance to cerebral ischemia显示文摘 | YANG QW WANG JZ* LI JC | 2010 | J CerebBlood Flow Metab2010，30，2： | 1 |
| 16 | Subchronic exposure to 2,3,7,8-tetrachorodibenzo-p-dioxin modulates the pathophysiology of endometriosis in the cynomolgus monkey显示文摘 | Agarwal SK Foster WG | 2000 | Toxicol Sci2000，56，2： | 1 |
| 17 | High-mobility group protein box-1 and its relevance to cerebral ischemia显示文摘 | YANG QW WANG JZ LI JC | 2010 | J Cereb Blood Flow Metab2010，30，2： | 1 |
| 18 | Molecular ecological network analyses 显示文摘 | Deng Y Jiang YH Yang YF He ZL Luo F Zhou JZ | 2012 | BMC Bioinform2012，13，1： | 1 |
| 19 | Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome显示文摘 | Zhao JZ Lin JJ Yang HY | 2010 | J Womens Health (Larchmt)2010，19，2： | 1 |
| 20 | Relative antioxidant activity of soybean isoflavones and their glycosides显示文摘 | Lee CH Yang L Xu JZ | 2005 | Food Chem2005，90，： | 1 |
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