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| 1 | 正相-反相两步高效液相色谱法制备毫克量级维生素D_3异构体显示文摘利用正相半制备柱和反相分析柱的两步高效液相色谱法,在实验室规模制备了毫克是级维生素D_3的三个重要异构体——维生素D_3前体、光甾醇_3和速甾醇_3·维生素D_3原体,7-去氢胆固醇的光照是在一个装有UVB荧光灯的光治疗室中进行。采用紫外分光光度法和高效液相色谱法对制得的三个异构体进行了定性定量分析。在这三个异构体检测极限下,除了维生素D_3前体中有不超过0.25%的维生素D_3杂质外,三个产品中均没有发现任何除它本身之外的其他异构体杂质。 | 陆志仁 TC Chen MF Holick | 1992 | 药学学报1992，27，5： | 5 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | A useful model to audit liver resolution from cirrhosis in rats using functional proteomics显示文摘 | LIU EH CHEN MF YEH TS | 2007 | J Surg Res2007，138，2： | 1 |
| 4 | Intra-abdominal pressure monitoring as a guideline in the nonoperative management of blunt hepatic trauma 显示文摘 | Fang JF Chen MF | 2001 | J Trauma2001，51，1： | 1 |
| 5 | A reappeaial of cholangiocarcinoma in patient wuth hepatolithiasais显示文摘 | Jan yy Wang cs | 1993 | Cancer1993，71，： | 1 |
| 6 | Asymmetric dimethylarginine induces TNF-α production via ROS/NF-Kb dependent pathway in human monocytic cells and the inhibitory effect of reinioside C显示文摘 | Zhang GG Bai YP Chen MF | 2008 | Vascular Pharmacol2008，48，： | 1 |
| 7 | The regeneration of cirrhotic after partial hepatectomy:a study using the rat carbon tetrachloride-induced cirrhotic model显示文摘 | Chen MF Hwang TL | 1994 | Proc Nat Sci Counc Repub China B1994，18，2： | 1 |
| 8 | Inhibitory effect of vitamin C in combination with vitamin K3 on tumor growth and metastasis of Lewis lung carcinoma xenografted in C57BL/6 mice显示文摘 | Chen MF Yang CM Su CM | 2011 | Nutr Cancer2011，63，： | 1 |
| 9 | Maternal glucose concentration influences fetal growth,gestation and pregnancy complications显示文摘 | Scholl TO Sowers MF Chen X | 2001 | Am J Epcdemiol2001，154，6： | 1 |
| 10 | Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level显示文摘 | Tang WJ Hu CP Chen MF | 2006 | Can J Physiol Phammcol2006，84，2： | 1 |
| 11 | Demonstration of the induction of apoptosis (programmed cell death) by tetrandrine, a novel anti-inflammatory agent显示文摘 | Teh BS Chen P Lavin MF | | 0，，： | 1 |
| 12 | Vitamin D deficiency:a worldwide problem with health consequences显示文摘 | Holick MF Chen TC | 2008 | Am J Clin Nutr2008，87，4： | 1 |
| 13 | reduced levels of both circu- lating cd4+ cd25+ cd127 (low/neg)and cd4+ cd8(neg)invariant natural killer regulatory tcells in stable heart transplant recipients 显示文摘 | Chen M Mohtize M Mattei MF | 2011 | Clin Exp hnmunol2011，163，1： | 1 |
| 14 | Chinical studies of mucinproducing choiangiocellular carcinoma: a study of 22 histopathology proven eases显示文摘 | Chen MF Jan YY Chen TC | 1998 | AnnSurg1998，227，： | 1 |
| 15 | Clinical investigation of acupuncture in the treatment of gastric dysmotility显示文摘 | Zhang AL Chen RX Kang MF | 1994 | Chin Acupunct1994，14，1： | 1 |
| 16 | Reciprocal regulatory interaction between human herpesvirus 8 and human immunodeficiency virus type 1显示文摘 | Huang LM Chao MF Chen MY | 2001 | J Biol Chem2001，276，13： | 1 |
| 17 | Biomechanieal comparison of in- strumented posterior lumbar interbody fusion with one or two cages by fi- nite element analy- sis显示文摘 | Chiang MF Zhong ZC Chen CS | 2006 | Spine2006，31，68： | 1 |
| 18 | A useful model to audit liver reso- lution from cirrhosis in rats using functional preteomics 显示文摘 | Liu EH Chen MF Yeh TS | 2007 | J Surg Res2007，138，2： | 1 |
| 19 | Contemporary man- agement of penile cancer including surgery and adjuvant radiotherapy: an experience inTaiwan 显示文摘 | Chen MF Chen WC Wu CT | 2004 | World J Urol2004，22，1： | 1 |
| 20 | Maternal glucose concen- tration influences fetal growth, gestation, and pregnancy compli- cations显示文摘 | Scholl To Sowers MF Chen X | 2001 | Am J Epcdemiol2001，154，6： | 1 |
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