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| 1 | Experimental study on the laminar flame speed of hydrogen/natural gas/air mixtures显示文摘Laminar flame speeds of hydrogen/natural gas/air mixtures have been measured over a full range of fuel compositions(0-100%volumetric fraction of H_(2))and a wide range of equivalence ratio using Bunsen burner.High sensitivity scientific CCD camera is use to capture the image of laminar flame.The reaction zone area is employed to calculate the laminar flame speed.The initial temperature and pressure of fuel air mixtures are 293 K and 1 atm.The laminar flame speeds of hydrogen/air mixture and natural gas/air mixture reach their maximum values 2.933 and 0.374 m/s when equivalence ratios equal to 1.7 and 1.1,respectively.The laminar flame speeds of hydrogen/natural gas/air mixtures rise with the increase of volumetric fraction of hydrogen.Moreover,the increase in laminar flame speed as the volumetric fraction of hydrogen increases presents an exponential increasing trend versus volumetric fraction of hydrogen.Empirical formulas to calculate the laminar flame speeds of hydrogen,natural gas,and hydrogen/natural gas mixtures are also given.Using these formulas,the laminar flame speed at different hydrogen fractions and equivalence ratios can be calculated. | Chen DONG Qulan ZHOU Xiaoguang ZHANG Qinxin ZHAO Tongmo XU Shi’en HUI | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 4 |
| 2 | The establishment of polypeptide PSMA-targeted chimericantigen receptor-engineered natural killer cells forcastration-resistant prostate cancer and the induction of ferroptosis-related cell death显示文摘Background:The mortality of castration-resistant prostate cancer(CRPC)is high due to lack of an effective treatment.Chimeric antigen receptor(CAR)-based therapy is a promising immunotherapeutic strategy.Here,we aimed to design a novel CAR-natural killer(NK)cells with a clinically significant tumoricidal effect on CRPC.Methods:We constructed novel CAR-NK92MI cells with a CD244-based recombinant lentiviral vector.Different intracellular segments(CD244,NKG2D,or CD3ζ)were screened to identify the best candidate according to cell lysis assay and CD107a expression levels.To enhance the affinity of the CAR to the tumor antigen,we compared an antibody specific for prostate-specific membrane antigen(anti-PSMA)with PSMA-targeted polypeptide(p-PSMA),which was screened by phage display combinatorial library.Then,CAR-NK92MI cells with both a high affinity for PSMA and a strong tumoricidal capacity were generated.In addition,we verified their tumor-killing effect in vitro and in vivo.The release of cytokine by NK92MI cells was compared with that by CAR-NK92MI cells through flow cytometry and enzyme-linked immunosorbent assay.Moreover,ferroptosis-related cell death was explored as a possible underlying mechanism.Results:Three different CAR intracellular regions CAR1(CD244),CAR2(CD244,NKG2D)and CAR3(CD244,NKG2D,and CD3ζ)were constructed.CAR2 was chosen to confer a stronger tumoricidal ability on CAR-NK92MI cells.Compared with anti-PSMA,p-PSMA exhibited enhanced affinity for the tumor antigen.Thus,p-PSMA-CAR-NK92MI cells,which expressed CAR with a polypeptide-based antigen-binding region,an intracellular CD244 and a NKG2D costimulatory domain,were generated.They could selectively and successfully kill PSMA+target cells and exhibited specific lysis rate of 73.19%for PSMA-positive C4-2 cells and 33.04%for PSMA-negative PC3 cells.Additionally,p-PSMA-CAR-NK92MI cells had significantly higher concentrations of IFN-γ,TNF-αand granzyme B than NK92MI cells.In a CRPC cancer xenograft model,p-PSMA-CAR-NK92MI cells significantly inhibited tumor growth and exerted a more consistent killing effect than NK92MI cells.Moreover,ferroptosis is a potential mechanism through which CAR-NK92MI cells attack cancer cells,and is triggered by IFN-γ.Conclusions:p-PSMA-CAR-NK92MI cells can effectively kill CRPCPSMA+cells in vitro and in vivo.This strategy may provide additional treatment options for patients with CRPC. | Liyuan Wu Fei Liu Le Yin Fangming Wang Hui Shi Qinxin Zhao Feiya Yang Dong Chen Xiying Dong Yuchun Gu Nianzeng Xing | 2022 | Cancer Communications2022，42，8： | 2 |
| 3 | Experimental investigation of heat transfer and pressure drop characteristics of H-type finned tube banks 显示文摘 | Chen Heng Wang Yungang Zhao Qinxin Ma Haidong Li Yuxin Chen Zhongya | 2014 | Energies2014，7，11： | 1 |
| 4 | Numerical study on laminar flame speed of natural gas-carbon monoxide-air mixtures显示文摘Laminar flame speeds of natural gas-carbon monoxide-air mixtures are calculated by CHEMKIN II with GRI Mech-3.0 over a large range of fuel compositions,equivalence ratios,and initial temperatures.The calculated results of natural gas are compared with previous experimental results that show a good agreement.The calculated laminar flame speeds of natural gas-carbon monoxide-air mixtures show a nonmonotonic increasing trend with volumetric fraction of carbon monoxide and an increasing trend with the increase of initial temperature of mixtures.The maximum laminar flame speed of certain fuel blend reaches its biggest value when there is 92%volumetric fraction of carbon monoxide in fuel at different initial temperatures.Five stoichiometric natural gas-carbon monoxide-air mixtures are selected to study the detailed chemical structure of natural gas-carbon monoxide-air mixtures.The results show that at stoichiometric condition,the fuel blend with 80%volumetric fraction of carbon monoxide has the biggest laminar flame speed,and the C normalized total production rate of methane with 80%volumetric fraction of carbon monoxide is the largest of the five stoichiometric mixtures. | Chen DONG Qulan ZHOU Qinxin ZHAO Tongmo XU Shi’en HUI | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 1 |
| 5 | Power generation expansion planning model towards low-carbon economy and its application in China显示文摘 | Chen Qinxin Kang Chongqing Xia Qing | 2010 | IEEE Trans on Power Systems2010，25，2： | 1 |
| 6 | Modeling flexible operation mechanism of CO2 capture power plant and its effects on power-system operation显示文摘 | Chen Qinxin Kang Chongqing Xia Qing | 2010 | IEEE Trans on Energy Conversion2010，25，3： | 1 |
| 7 | Performance Assessment of a Novel Polygeneration System Based on the Integration of Waste Plasma Gasification,Tire Pyrolysis,Gas Turbine,Supercritical CO_(2)Cycle and Organic Rankine Cycle显示文摘In this paper,a novel polygeneration system involving plasma gasifier,pyrolysis reactor,gas turbine(GT),supercritical CO_(2)(S-CO_(2))cycle,and organic Rankine cycle(ORC)has been developed.In the proposed scheme,the syngas is obtained by the gasification and the pyrolysis is first burned and drives the gas turbine for power generation,and then the resulting hot exhaust gas is applied to heat the working fluid for the supercritical CO_(2)cycle and the working fluid for the bottom organic Rankine cycle.In addition to the electrical output,the pyrolysis subsystem also produces pyrolysis oil and char.Accordingly,energy recovery is achieved while treating waste in a non-hazardous manner.The performance of the new scheme was examined by numerous methods,containing energy analysis,exergy analysis,and economic analysis.It is found that the net total energy output of the polygeneration system could attain 19.89 MW with a net total energy efficiency of 52.77%,and the total exergy efficiency of 50.14%.Besides,the dynamic payback period for the restoration of the proposed project is only 3.31 years,and the relative net present value of 77552640 USD can be achieved during its 20-year lifetime. | FENG Fuyuan LI Tongyu AN Jizhen CHEN Heng WANG Yi’nan XU Gang ZHAO Qinxin LIU Tong | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 8 | Synthesis of amorphous Pd-based nanocatalysts for efficient alcoholysis of styrene oxide and electrochemical hydrogen evolution显示文摘Amorphous nanomaterials with long-range disordered structures could possess distinct properties and promising applications,especially in catalysis,as compared with their conventional crystalline counterparts.It is imperative to achieve the controlled preparation of amorphous noble metal-based nanomaterials for the exploration of their phase-dependent applications.Here,we report a facile wet-chemical reduction strategy to synthesize various amorphous multimetallic Pd-based nanomaterials,including PdRu,PdRh,and PdRuRh.The phase-dependent catalytic performances of distinct Pd-based nanomaterials towards diverse catalytic applications have been demonstrated.Specifically,the usage of PdRu nanocatalysts with amorphous and crystalline face-centered cubic(fcc)phases can efficiently switch the ring-opening route of styrene oxide to obtain different products with high selectivity through alcoholysis reaction and hydrogenation reaction,respectively.Moreover,when used as an electrocatalyst for hydrogen evolution reaction(HER),the synthesized amorphous PdRh nanocatalyst exhibits low overpotential and high turnover frequency values,outperforming its crystalline fcc counterpart and most of the reported Pd-based HER electrocatalysts. | Yiyao Ge Jingjie Ge Biao Huang Xixi Wang Guigao Liu Xiang-Huan Shan Lu Ma Bo Chen Guanghua Liu Songmo Du An Zhang Hongfei Cheng Qingbo Wa Shiyao Lu Lujiang Li Qinbai Yun Kuo Yuan Qinxin Luo Zhichuan J.Xu Yonghua Du Hua Zhang | 2023 | Nano Research2023，16，4： | 0 |
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