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| 1 | Experimental study on the laminar flame speed of hydrogen/natural gas/air mixtures显示文摘Laminar flame speeds of hydrogen/natural gas/air mixtures have been measured over a full range of fuel compositions(0-100%volumetric fraction of H_(2))and a wide range of equivalence ratio using Bunsen burner.High sensitivity scientific CCD camera is use to capture the image of laminar flame.The reaction zone area is employed to calculate the laminar flame speed.The initial temperature and pressure of fuel air mixtures are 293 K and 1 atm.The laminar flame speeds of hydrogen/air mixture and natural gas/air mixture reach their maximum values 2.933 and 0.374 m/s when equivalence ratios equal to 1.7 and 1.1,respectively.The laminar flame speeds of hydrogen/natural gas/air mixtures rise with the increase of volumetric fraction of hydrogen.Moreover,the increase in laminar flame speed as the volumetric fraction of hydrogen increases presents an exponential increasing trend versus volumetric fraction of hydrogen.Empirical formulas to calculate the laminar flame speeds of hydrogen,natural gas,and hydrogen/natural gas mixtures are also given.Using these formulas,the laminar flame speed at different hydrogen fractions and equivalence ratios can be calculated. | Chen DONG Qulan ZHOU Xiaoguang ZHANG Qinxin ZHAO Tongmo XU Shi’en HUI | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 4 |
| 2 | Effects of Long-term Creep at Elevated Temperatures on Rupture Ductility in 9Cr-1Mo-V-Nb-N Steel显示文摘Besides the creep strength, creep ductility has also been recognized as an important material parameter, since low ductility is often associated with notch sensitivity and concomitant prema-ture failure, especially brittle fracture. Creep rupture data of 9Cr-1Mo-V-Nb-N show that the creep ductility decreases with decreasing stress at constant temperatures or with decreasing tem-perature at constant stresses. SEM and TEM were used to investigate the mechanism of creep brittleness. The results indicate that the decrease of rupture ductility after long-term creep is related to the decrease of mobile dislocation density, the coarsening and coalescence of carbides and the decrease of shear lip size. | Zhu, Lihui Zhao, Qinxin Gu, Haicheng Lu, Yansun
| 1998 | Journal of Materials Science & Technology1998，14，3： | 3 |
| 3 | The establishment of polypeptide PSMA-targeted chimericantigen receptor-engineered natural killer cells forcastration-resistant prostate cancer and the induction of ferroptosis-related cell death显示文摘Background:The mortality of castration-resistant prostate cancer(CRPC)is high due to lack of an effective treatment.Chimeric antigen receptor(CAR)-based therapy is a promising immunotherapeutic strategy.Here,we aimed to design a novel CAR-natural killer(NK)cells with a clinically significant tumoricidal effect on CRPC.Methods:We constructed novel CAR-NK92MI cells with a CD244-based recombinant lentiviral vector.Different intracellular segments(CD244,NKG2D,or CD3ζ)were screened to identify the best candidate according to cell lysis assay and CD107a expression levels.To enhance the affinity of the CAR to the tumor antigen,we compared an antibody specific for prostate-specific membrane antigen(anti-PSMA)with PSMA-targeted polypeptide(p-PSMA),which was screened by phage display combinatorial library.Then,CAR-NK92MI cells with both a high affinity for PSMA and a strong tumoricidal capacity were generated.In addition,we verified their tumor-killing effect in vitro and in vivo.The release of cytokine by NK92MI cells was compared with that by CAR-NK92MI cells through flow cytometry and enzyme-linked immunosorbent assay.Moreover,ferroptosis-related cell death was explored as a possible underlying mechanism.Results:Three different CAR intracellular regions CAR1(CD244),CAR2(CD244,NKG2D)and CAR3(CD244,NKG2D,and CD3ζ)were constructed.CAR2 was chosen to confer a stronger tumoricidal ability on CAR-NK92MI cells.Compared with anti-PSMA,p-PSMA exhibited enhanced affinity for the tumor antigen.Thus,p-PSMA-CAR-NK92MI cells,which expressed CAR with a polypeptide-based antigen-binding region,an intracellular CD244 and a NKG2D costimulatory domain,were generated.They could selectively and successfully kill PSMA+target cells and exhibited specific lysis rate of 73.19%for PSMA-positive C4-2 cells and 33.04%for PSMA-negative PC3 cells.Additionally,p-PSMA-CAR-NK92MI cells had significantly higher concentrations of IFN-γ,TNF-αand granzyme B than NK92MI cells.In a CRPC cancer xenograft model,p-PSMA-CAR-NK92MI cells significantly inhibited tumor growth and exerted a more consistent killing effect than NK92MI cells.Moreover,ferroptosis is a potential mechanism through which CAR-NK92MI cells attack cancer cells,and is triggered by IFN-γ.Conclusions:p-PSMA-CAR-NK92MI cells can effectively kill CRPCPSMA+cells in vitro and in vivo.This strategy may provide additional treatment options for patients with CRPC. | Liyuan Wu Fei Liu Le Yin Fangming Wang Hui Shi Qinxin Zhao Feiya Yang Dong Chen Xiying Dong Yuchun Gu Nianzeng Xing | 2022 | Cancer Communications2022，42，8： | 2 |
| 4 | Experimental investigation of heat transfer and pressure drop characteristics of H-type finned tube banks 显示文摘 | Chen Heng Wang Yungang Zhao Qinxin Ma Haidong Li Yuxin Chen Zhongya | 2014 | Energies2014，7，11： | 1 |
| 5 | Mechanism research on coupling effect between dew point corrosion and ash deposition显示文摘 | Wang Yungang Zhao Qinxin Zhang Zhixiang Zhang Zhichao Tao Wenquan | | 0，，01： | 1 |
| 6 | Numerical study on laminar flame speed of natural gas-carbon monoxide-air mixtures显示文摘Laminar flame speeds of natural gas-carbon monoxide-air mixtures are calculated by CHEMKIN II with GRI Mech-3.0 over a large range of fuel compositions,equivalence ratios,and initial temperatures.The calculated results of natural gas are compared with previous experimental results that show a good agreement.The calculated laminar flame speeds of natural gas-carbon monoxide-air mixtures show a nonmonotonic increasing trend with volumetric fraction of carbon monoxide and an increasing trend with the increase of initial temperature of mixtures.The maximum laminar flame speed of certain fuel blend reaches its biggest value when there is 92%volumetric fraction of carbon monoxide in fuel at different initial temperatures.Five stoichiometric natural gas-carbon monoxide-air mixtures are selected to study the detailed chemical structure of natural gas-carbon monoxide-air mixtures.The results show that at stoichiometric condition,the fuel blend with 80%volumetric fraction of carbon monoxide has the biggest laminar flame speed,and the C normalized total production rate of methane with 80%volumetric fraction of carbon monoxide is the largest of the five stoichiometric mixtures. | Chen DONG Qulan ZHOU Qinxin ZHAO Tongmo XU Shi’en HUI | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 1 |
| 7 | Performance Assessment of a Novel Polygeneration System Based on the Integration of Waste Plasma Gasification,Tire Pyrolysis,Gas Turbine,Supercritical CO_(2)Cycle and Organic Rankine Cycle显示文摘In this paper,a novel polygeneration system involving plasma gasifier,pyrolysis reactor,gas turbine(GT),supercritical CO_(2)(S-CO_(2))cycle,and organic Rankine cycle(ORC)has been developed.In the proposed scheme,the syngas is obtained by the gasification and the pyrolysis is first burned and drives the gas turbine for power generation,and then the resulting hot exhaust gas is applied to heat the working fluid for the supercritical CO_(2)cycle and the working fluid for the bottom organic Rankine cycle.In addition to the electrical output,the pyrolysis subsystem also produces pyrolysis oil and char.Accordingly,energy recovery is achieved while treating waste in a non-hazardous manner.The performance of the new scheme was examined by numerous methods,containing energy analysis,exergy analysis,and economic analysis.It is found that the net total energy output of the polygeneration system could attain 19.89 MW with a net total energy efficiency of 52.77%,and the total exergy efficiency of 50.14%.Besides,the dynamic payback period for the restoration of the proposed project is only 3.31 years,and the relative net present value of 77552640 USD can be achieved during its 20-year lifetime. | FENG Fuyuan LI Tongyu AN Jizhen CHEN Heng WANG Yi’nan XU Gang ZHAO Qinxin LIU Tong | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 8 | Zebrafish Foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression显示文摘Chamber maturation is a significant process in cardiac development. Disorders of this crucial process lead to a range of congenital heart defects. Foxc1a is a critical transcription factor reported to regulate the specification of cardiac progenitor cells. However, little is known about the role of Foxc1a in modulating chamber maturation. Previously, we reported that foxc1a-null zebrafish embryos exhibit disrupted heart structures and functions. In this study, we observe that ventricle structure and cardiomyocyte proliferation are abolished during chamber maturation in foxc1a-null zebrafish embryos. To observe the endogenous localization of Foxc1a in the hearts of living embryos, we insert eyfp at the foxc1a genomic locus using TALEN. Analysis of the knockin zebrafish show that foxc1a is widely expressed in ventricular cardiomyocytes during chamber development. Cardiac RNA sequencing analysis reveals the downregulated expression of the Hippo signaling effector wwtr1. Dual-luciferase and chromatin immunoprecipitation assays reveal that Foxc1a can bind directly to three sites in the wwtr1 promoter region. Furthermore, wwtr1m RNA overexpression is sufficient to reverse the ventricle defects during chamber maturation. Conditional overexpression of nkx2.5 also partially rescues the ventricular defects during chamber development. These findings demonstrate that wwtr1 and nkx2.5 are direct targets of Foxc1a during ventricular chamber maturation. | Luqingqing He Qinxin Zhang Dongya Jiang Yunfeng Zhang Yuxuan Wei Yuxi Yang Nan Li Shuang Wang Yunyun Yue Qingshun Zhao | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 9 | Membrane dual-targeting probes:A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection显示文摘Fluorescence-guided surgery(FGS)with tumor-targeted imaging agents,particularly those using the near-infrared wavelength,has emerged as a real-time technique to highlight the tumor location and margins during a surgical procedure.For accurate visualization of prostate cancer(PCa)boundary and lymphatic metastasis,we developed a new approach involving an efficient self-quenched near-infrared fluorescence probe,Cy-KUE-OA,with dual PCa-membrane affinity.Cy-KUE-OA specifically targeted the prostate-specific membrane antigen(PSMA),anchored into the phospholipids of the cell membrane of PCa cells and consequently showed a strong Cy7-de-quenching effect.This dual–membrane-targeting probe allowed us to detect PSMA-expressing PCa cells both in vitro and in vivo and enabled clear visualization of the tumor boundary during fluorescence-guided laparoscopic surgery in PCa mouse models.Furthermore,the high PCa preference of Cy-KUE-OA was confirmed on surgically resected patient specimens of healthy tissues,PCa,and lymph node metastases.Taken together,our results serve as a bridge between preclinical and clinical research in FGS of PCa and lay a solid foundation for further clinical research. | Ling-Ling Wu Qinxin Zhao Qinghua Wang Qingyang Zhang Feiya Yang Bo Zheng Hai-Yu Hu Nianzeng Xing | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 10 | Experimental investigations on combustion characteristics of syngas composed of CH_(4),CO,and H_(2)显示文摘The residual gas and remained raw gas in dual gas resources polygeneration system are quite complex in components(mainly CH_(4),CO,and H_(2)),and these results to the distinguished differences in combustion reaction.Experimental investigations on basic combustion characteristics of syngas referred above are conducted on a laboratory-scale combustor with flame temperature and flue gas composition measured and analyzed.Primary air coefficient(PA),total air coefficient(TA),and components of the syngas(CS)are selected as key factors,and it is found that PA dominates mostly the ignition of syngas and NOx formation,while TA affects the flue gas temperature after high temperature region and NOx formation trend to be positive as H_(2)/CO components increase.The results provide references for industrial utilization. | Qingwei FAN Shien HUI Qulan ZHOU Qinxin ZHAO Tongmo XU | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 0 |
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