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174篇 您的检索式:作者名="Chen RB"
    题名 作者 年代 出处 被引量
1酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB 2021中华高血压杂志2021,29,2:9
2小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 2015神经损伤与功能重建2015,10,1:9
3The combined administration of partially HLA-matched irradiated allogeneic lymphocytes and thalidomide in advanced renal cell carcinoma -a case report 显示文摘Chen Q Lin RB Ye YB 2010Med Oncol2010,27,2:1
4Improvement in respiratory function after vertebroplasty and kyphoplasty显示文摘RB Dong L Chen Y Gu 2009International Orthopaedics2009,33,6:1
5Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways显示文摘Chen CC Stairs DB Boxer RB 2012Genes Dev2012,26,19:1
6A kindred of Miao nationality affected with Grebe-Quelce-Salgado achondrogenesis显示文摘Feng B Chen RB Luo JG 1985Acta Genet Sinica1985,12,:1
7Radiologic findings in acute urinary tract obstruction显示文摘Chen MY Zagoria RJ Dyer RB 1997Emerg Med1997,15,3:1
8Treatment and stabilization of complex wounds involving the pelvic bone,groin,and femur with the inferiorly based rectus abdominis musculocutaneous flap and the use of power color Doppler imaging in preoperative evaluation显示文摘Chen JJ Giese S Jeffrey RB 1999Ann Plast Surg1999,43,5:1
9The novel marker, D0G1,is expressed ubiquitously in gastrointestinal stromal tumors ir-respective of KIT or PDGFRA mutation status 显示文摘West RB Corless CL Chen X 2004Am J Pathol2004,165,1:1
10A comparison of infections in different ICU's within the same hospital 显示文摘Brown RB Hosmer D Chen HC 1985Crit Care Med1985,13,6:1
11Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4.显示文摘Smeltz RB Chen J Hu L I J 0,,:1
12Intravenous urography:technique and interpretation显示文摘Dyer RB Chen MY Zagoria RJ 2001Radio Graphics2001,21,4:1
13Clusterin as a biomarker in murine and human intestinal neoplasia 显示文摘Chen X Halberg RB Ehrhardt WM 2003Proc Natl Acad Sci USA2003,100,:1
14Genetic variation of Japanese encephalitis virus in nature显示文摘Chen WR Tesh RB Rico-Hesse R 1990J Gen Virol1990,71,12:1
15Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza显示文摘bd Elazem IS Chen HS Bates RB et aZ 2002Antiviral Res2002,55,1:1
16Expression and purification of untagged full length HCV NSSB显示文摘Wang QM Johnson RB Chen DY 2004Protein Expression Purification2004,35,:1
17A new genotype of Japanese encephalitis virus from Indonesia 显示文摘Chen WR Rico-Hesse R Tesh RB 1992Am J Trop Med Hyg1992,47,1:1
18Genetic variation of Japanese encephalitis virus in nature显示文摘Chen WR Tesh RB Rico-Hesse R 1990J Gen Virol1990,71,12:1
19Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1(HIV-1)integrse from Salvia miltiorrhiza显示文摘Abd-Elazem IS Chen HS Bates RB 2002Antiviral Res2002,55,1:1
20Genetic variation of Japanese encephalitis virus in nature显示文摘Chen WR Tesh RB Rico-Hesse R 1990J Gen Virol1990,71,12:1
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