|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nab-paclitaxel(abraxane)-based chemotherapy to treat elderly patients with advanced non-small-cell lung cancer:a single center,randomized and open-label clinical trial显示文摘Background:The purpose of this study is to evaluate the clinical efficacy and safety of abraxane-based chemotherapy with/without nedaplatin in elderly patients with non-small-cell lung cancer(NSCLC).Materials and methods:From October 2009 to January 2013,48 elderly patients(>65 years) with NSCLC were investigated in this clinical trial.The patients were randomized and equally allocated into arms A and AP:(A) abraxane(130 mg/m^2,days 1,8);(B) abraxane + nedaplatin(20 mg/m^2 days 1-3,q3w).The parameters of objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),overall survival(OS) and side effects were evaluated between two arms.Results:Over 80%of the patients completed four cycles of chemotherapy.The total ORR was 21.3%,DCR was 55.3%,PFS 4.5 months and OS 12.6 months.No significant difference was found between arms A and AP in terms of ORR(16.7%vs.26.1%,P=0.665) or DCR(55.3%vs.56.5%,P=0.871).The median PFS in arm A was 3.3 months[25-75%confidence interval(CI):3.1-7.2]and 5.5 months(25-75%CI:3.2-7.0) in arm AP with no statistical significance(P=0.640).The median OS in arm A was 12.6 months(25-75%CI:5.7-26.2) and 15.1 months(25-75%CI:6.4-35.3) in arm AP with no statistical significance(P=0.770).The side effects were mainly grade 1-2.The incidence of grade 3-4 toxicities was 29.1%in arm A and 62.5%in arm AP with a statistical significance(P=0.020).Conclusions:Compared with combined therapy,abraxane alone chemotherapy was beneficial for elderly NSCLC patients with better tolerability and less adverse events,whereas did not significantly differ in terms of ORR,DCR,PFS or OS. | Hanrui Chen Xuewu Huang Shutang Wang Xinting Zheng Jietao Lin Peng Li Lizhu Lin | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 2 | Efficient and Secure Multi-Signature Scheme Based on Trusted Computing显示文摘一个新多签名计划与协议由信任计算(TC ) 支持了的直接匿名的证实(DAA ) 的延期被建议技术。签名人是隐私的分析和模拟结果表演很好与动态匿名,公钥和签名被保护有签名成员,的数字的长度独立人士没有修改公钥,新签名人被允许加入签名,并且秘密关键倾倒或漏引起的攻击能被避免。 | HAO Liming YANG Shutang LU Songnian CHEN Gongliang | 2008 | Wuhan University Journal of Natural Sciences2008，13，2： | 1 |
| 3 | Synthesis and characterization of CdS nanoparticles in the presence of oleic acid as solvent and stabilizer 显示文摘 | Li Na Zhang Xiaoling Chen Shutang | 2011 | Journal of Physics and Chemistry of Solids2011，72，： | 1 |
| 4 | On spatial periodic orbits and spatial chaos显示文摘 | Chen Guanrong Liu Shutang | 2003 | International Journal of Bifurcation and Chaos in Applied Sciences and Engineering2003，13，4： | 1 |
| 5 | On spatial Lyapunov exponents and spatial chaos显示文摘 | Liu Shutang Chen Guanrong | 2003 | International Journal of Bifurcation and Chaos in Applied Sciences and Engineering2003，13，5： | 1 |
| 6 | On generalized synchronization of spatial chaos显示文摘 | Chen Guanrong Liu Shutang | 2003 | Chaos Solitons & Fractals2003，15，2： | 1 |
| 7 | Size-Controlled Synthesis of Au Nanoparticles and Nanowires and Their Application as SERS Substrates显示文摘 | Hou Xiaomiao Zhang Xiaoling Chen Shutang | 2011 | Colloid Surf A2011，384，123： | 1 |
| 8 | Two-dimensional model of elastically coupled molecular motors 显示文摘 | Zhang Hongwei Wen Shutang Chen Gairong | 2012 | Chin Phys B2012，21，3： | 1 |
| 9 | CdSe quantum dots decorated by mercaptosuccinic acid as fluorescence probe for Cu 2+显示文摘 | Shutang Chen Xiaoling Zhang Qiuhua Zhang Xiaomiao Hou Qi Zhou Jilin Yan Weihong Tan | 2011 | Journal of Luminescence2011，，5： | 1 |
| 10 | Adding power of artificial intelligence to situational awareness of large interconnections dominated by inverter‐based resources显示文摘Large‐scale power systems exhibit more complex dynamics due to the increasing inte-gration of inverter‐based resources(IBRs).Therefore,there is an urgent need to enhance the situational awareness capability for better monitoring and control of power grids dominated by IBRs.As a pioneering Wide‐Area Measurement System,FNET/GridEye has developed and implemented various advanced applications based on the collected synchrophasor measurements to enhance the situational awareness capability of large‐scale power grids.This study provides an overview of the latest progress of FNET/GridEye.The sensors,communication,and data servers are upgraded to handle ultra‐high density synchrophasor and point‐on‐wave data to monitor system dynamics with more details.More importantly,several artificial intelligence(AI)‐based advanced appli-cations are introduced,including AI‐based inertia estimation,AI‐based disturbance size and location estimation,AI‐based system stability assessment,and AI‐based data authentication. | Lin Zhu Yinfeng Zhao Yi Cui Shutang You Wenpeng Yu Shengyuan Liu He Yin Chang Chen Yuru Wu Wei Qiu Mirka Mandich Hongyu Li Adedasola Ademola Chengwen Zhang Chujie Zeng Xinlan Jia Weikang Wang Haoyu Yuan Huaiguang Jiang Jin Tan Yilu Liu | 2021 | High Voltage2021，6，6： | 0 |
| 11 | Trade-offs between the accumulation of cuticular wax and jasmonic acid-mediated herbivory resistance in maize显示文摘Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory infestation.Composed of a complex mixture of very-long-chain fatty acids(VLCFAs)and their derivatives,cuticular wax constitutes the first physical line of defense against herbivores.Here,we report the function of Glossy 8(ZmGL8),which encodes a 3-ketoacyl reductase belonging to the fatty acid elongase complex,in orchestrating wax production and jasmonic acid(JA)-mediated defenses against herbivores in maize(Zea mays).The mutation of GL8 enhanced chemical defenses by activating the JA-dependent pathway.We observed a trade-off between wax accumulation and JA levels across maize glossy mutants and 24 globally collected maize inbred lines.In addition,we demonstrated that mutants defective in cuticular wax biosynthesis in Arabidopsis thaliana and maize exhibit enhanced chemical defenses.Comprehensive transcriptomic and lipidomic analyses indicated that the gl8 mutant confers chemical resistance to herbivores by remodeling VLCFA-related lipid metabolism and subsequent JA biosynthesis and signaling.These results suggest that VLCFA-related lipid metabolism has a critical role in regulating the trade-offs between cuticular wax and JA-mediated chemical defenses. | Jiong Liu Lu Li Zhilong Xiong Christelle AMRobert Baozhu Li Shan He Wenjie Chen Jiasheng Bi Guanqing Zhai Siyi Guo Hui Zhang Jieping Li Shutang Zhou Xi Zhang Chun‐Peng Song | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 12 | Tunable photocycle kinetics of a hybrid bacteriorhodopsin/quantum dot system显示文摘The inclusion of inorganic nanoparticles in biological environments has led to the creation of hybrid nanosystems that are employed in a variety of applications. One such system includes quantum dots (QDs) coupled with the photoactive protein, bacteriorhodopsin (BR), which has been explored in developing enhanced photovoltaic devices. In this work, we have discovered that the kinetics of the BR photocycle can be manipulated using CdSe/CdS (core/shell) QDs. The photocycle lifetime of protein samples with varying QD amounts were monitored using time-resolved absorption spectroscopy. Concentration-dependent elongations of the bR and M state lifetimes were observed in the kinetic traces, thus suggesting that excitonic coupling occurs between BR and QDs. We propose that the pairing of BR with QDs has the potential to be utilized in protein-based computing applications, specifically for real-time holographic processors, which depend on the temporal dynamics of the bR and M photointermediates. | Terianna J. Wax Jordan A. Greco Shutang Chen Nicole L. Wagner Jing Zhao Robert R. Birge | 2019 | Nano Research2019，12，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员