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| 1 | Nab-paclitaxel(abraxane)-based chemotherapy to treat elderly patients with advanced non-small-cell lung cancer:a single center,randomized and open-label clinical trial显示文摘Background:The purpose of this study is to evaluate the clinical efficacy and safety of abraxane-based chemotherapy with/without nedaplatin in elderly patients with non-small-cell lung cancer(NSCLC).Materials and methods:From October 2009 to January 2013,48 elderly patients(>65 years) with NSCLC were investigated in this clinical trial.The patients were randomized and equally allocated into arms A and AP:(A) abraxane(130 mg/m^2,days 1,8);(B) abraxane + nedaplatin(20 mg/m^2 days 1-3,q3w).The parameters of objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),overall survival(OS) and side effects were evaluated between two arms.Results:Over 80%of the patients completed four cycles of chemotherapy.The total ORR was 21.3%,DCR was 55.3%,PFS 4.5 months and OS 12.6 months.No significant difference was found between arms A and AP in terms of ORR(16.7%vs.26.1%,P=0.665) or DCR(55.3%vs.56.5%,P=0.871).The median PFS in arm A was 3.3 months[25-75%confidence interval(CI):3.1-7.2]and 5.5 months(25-75%CI:3.2-7.0) in arm AP with no statistical significance(P=0.640).The median OS in arm A was 12.6 months(25-75%CI:5.7-26.2) and 15.1 months(25-75%CI:6.4-35.3) in arm AP with no statistical significance(P=0.770).The side effects were mainly grade 1-2.The incidence of grade 3-4 toxicities was 29.1%in arm A and 62.5%in arm AP with a statistical significance(P=0.020).Conclusions:Compared with combined therapy,abraxane alone chemotherapy was beneficial for elderly NSCLC patients with better tolerability and less adverse events,whereas did not significantly differ in terms of ORR,DCR,PFS or OS. | Hanrui Chen Xuewu Huang Shutang Wang Xinting Zheng Jietao Lin Peng Li Lizhu Lin | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 2 | EFFECT OF TIDAL FLOW ON ESTUARINE SEDIMENTATION显示文摘Based on the equations of motion for a two-phase flow, the writers present a set of four equations for foe one-dimensional sediment-laden flow in a prismatic channel in alluvium. Two cases are then considered. In one case. a theoretical expression of sediment concentration is derived for flow in the neighborhood of a tidal bore moving in an otherwise gradually and slowly varied flow in a rectangular channel of negligible resistance. In the other case. numerical computations are carried out on the four of the four bole equations for a reach of natural river. Computed discharge and concentration hydrographs come close to field data. | Cai Shutang Huang Juqing Professor, Department of Modern Mechanics. University of Science and Technology of China. Hefei. Anhui Province. China: Shanghai institute of Applied Mathematics and Mechanics, Shanghai, China. Engineer. Zhejiang Provincial Institure of Estuarine and Coastal Engineering Research, Hangzhou. Zhejiang Province, China. | 1990 | International Journal of Sediment Research1990，5，1： | 5 |
| 3 | An Arabidopsis thaliana (Ler) inbred line AFDL exhibiting abnormal flower development mainly caused by reduced AP1 expression显示文摘The genetic network controlling flowering and flower development consists of a set of floral integrator genes that play a role in light sensing,hormone signaling and developmental pathways.These integrators activate the expression of meristem identity genes LEAFY (LFY) and APETALA1 (AP1) to initiate the flowering transition.However,how the expression of key genes,such as AP1,responds to diverse signals during flower development remains largely unknown.Here,we report that an Arabidopsis abnormal flower development inbred line (AFDL) exhibits a phenotype similar to the ap1 mutant,with delayed flowering time and a high frequency of transition of flower meristems into inflorescence meristems after flowering.The flower organs with an abnormal first whorl lack the second whorl and the increased number of inflorescences at the first-and second-whorl positions most closely resembled the phenotypes of ap1/cal double mutants.Interestingly,both normal and abnormal flowers coexisted in a single individual.Microarray and quantitative real-time PCR analysis revealed that the expression of AP1 was significantly reduced,while the expression of its interacting genes TERMINAL FLOWER 1 (TFL1),SHORT VEGETATIVE PHASE (SVP),AGAMOUS-like 24 (AGL24),SEPALLATA (SEP) and CAULIFLOWER (CAL) and upstream genes FLOWERING LOCUS C (FLC) and FLM were increased in AFDL,which could serve to explain its phenotype.The expression of genes responsive to different stimuli dramatically changed in AFDL relative to the wild type,as revealed by the differential display of transcripts,indicating that this expression variation is subject to a threshold,leading to an on/off expression pattern of the master regulatory gene (such as AP1) of flower development. | QI XiaoLi JIANG Yao TANG Fang WANG MinJie HU JianJun ZHAO ShuTang SHA Wei LU MengZhu | 2011 | Chinese Science Bulletin2011，56，1： | 4 |
| 4 | А Novel AP Placement Algorithm Based on User Distribution for Indoor WLAN System显示文摘AP deployment is significant for indoor WLAN system to achieve seamless coverage. The available algorithms do not take user distribution into consideration so that poor user coverage and imbalanced network load occur. Therefore, this paper proposed a novel AP placement algorithm to bridge the AP deployment with user distribution. The proposed algorithm employs statistics theory to model the user distribution as its location and probability. Then we obtain the AP location based on the fuzzy C-clustering algorithm. The proposed algorithm is practical for implementation, which means the actual signal transmission isn't required in our proposed method. The simulation results show that the proposed algorithm could automatically achieve a good AP deployment with different user distribution, and provide a good performance in the maximum users and AP load balance in WLAN. | ShuTang Lin Ma Yubin Xu | 2016 | China Communications2016，13，10： | 3 |
| 5 | PagGRF12a interacts with PagGIF1b to regulate secondary xylem development through modulating PagXND1a expression in Populus alba×P.glandulosa显示文摘Growth-regulating factors(GRFs)are important regulators of plant development and growth,but their possible roles in xylem development in woody plants remain unclear.Here,we report that Populus alba×Papulus glandulosa PagGRF12a negatively regulates xylem development in poplar.PagGRF12a is expressed in vascular tissues.Compared to non-transgenic control plants,transgenic poplar plants overexpressing PagGRF12a exhibited reduced xylem width and plants with repressed expression of PagGRF12a exhibited increased xylem width.Xylem NAC domain 1(XND1)encodes a NAC domain transcription factor that regulates xylem development and transcriptional analyses revealed that PagXND1a is highly upregulated in PagGRF12a-overexpressing plants and downregulated in PagGRF12a-suppressed plants,indicating that PagGRF12a may regulate xylem development through PagXND1a.Transient transcriptional assays and chromatin immunoprecipitation-polymerase chain reaction assays confirmed that PagGRF12a directly upregulates PagXND1a.In addition,PagGRF12a interacts with the GRF-Interacting Factor(GIF)PagGIF1b,and this interaction enhances the effects of PagGRF12a on PagXND1a.Our results indicate that PagGRF12a inhibits xylem development by upregulating the expression of PagXND1a. | Jinnan Wang Houjun Zhou Yanqiu Zhao Cheng Jiang Jihong Li Fang Tang Yingli Liu Shutang Zhao Jianjun Hu Xueqin Song MengZhu Lu | 2021 | Journal of Integrative Plant Biology2021，63，10： | 3 |
| 6 | A Method to Implement Full Anonymous Attestation for Trusted Computing Platform显示文摘Trusted computing (TC) technology is brought out by trusted computing group (TCG) to make computing as safe and reliable as people expect. Attestation is one main function speci- fied by TCG, which is the means by which a trusted computer assures a remote computer whose platform is not tampered with. There are two protocols that implement attestation without dis- closing the platform’s real identity, which are Privacy CA-based protocol and direct anonymous attestation (DAA) protocol. However, in the first protocol the privacy CA is the bottleneck and the platform’s identity will be disclosed if the privacy CA is com- promise, while DAA protocol can do profiling when dealing with rogue hardware device. In this paper, we propose a DAA-extended new approach to ensure full anonymous attestation that can not only detect a rogue TPM, but also reveal rogue TPM’s real iden- tity. | HAO Liming SUN Xun YANG Shutang LU Songnian | 2007 | Wuhan University Journal of Natural Sciences2007，12，1： | 3 |
| 7 | Global disturbance rejection of a class of nonlinear systems with unknown exosystems显示文摘An asymptotic rejection algorithm is proposed for a class of nonlinear systems that have not only additive nonlinear uncertainties but also unknown disturbances. The disturbances are generated from an unknown exosystem, and are assumed to be sinusoidal disturbances with unknown amplitude and frequency. By using the technique of backstepping and adaptive control, a nonlinear state feedback controller is designed. Under the proposed controller, the system’s state variables asymptotically converge to zero, and the disturbances are rejected completely. The approach used is an integration of the robust stabilization technique, adaptive technique, and backstepping technique. | Yuan JIANG Shutang LIU | 2009 | 控制理论与应用(英文版)2009，7，4： | 3 |
| 8 | Transcriptional and temporal response of Populus stems to gravi-stimulation显示文摘Plants modify development in response to external stimuli, to produce new growth that is appropriate for environmental conditions. For example, gravistimulation of leaning branches in angiosperm trees results in modifications of wood development, to produce tension wood that pulls leaning stems upright. Here, we use gravistimulation and tension wood response to dissect the temporal changes in gene expression underlying wood formation in Populus stems. Using time-series analysis of seven time points over a 14-d experiment, we identified8,919 genes that were differentially expressed between tension wood(upper) and opposite wood(lower) sides of leaning stems. Clustering of differentially expressed genes showed four major transcriptional responses, including gene clusters whose transcript levels were associated with Higtwo types of tissue-specific impulse responses that peaked at about 24–48 h, and gene clusters with sustained changes in transcript levels that persisted until the end of the 14-d experiment. Functional enrichment analysis of those clusters suggests they reflect temporal changes in pathways associated with hormone regulation, protein localization, cell wall biosynthesis and epigenetic processes. Time-series analysis of gene expression is an underutilized approach for dissecting complex developmental responses in plants, and can reveal gene clusters and mechanisms influencing development. | Matthew Zinkgraf Suzanne Gerttula Shutang Zhao Vladimir Filkov Andrew Groover | 2018 | Journal of Integrative Plant Biology2018，60，7： | 2 |
| 9 | Identification of G protein-coupled receptors required for vitellogenesis and egg development in an insect with panoistic ovary显示文摘G protein-coupled receptors(GPCRs),a superfamily of integral transmembrane proteins regulate a variety of physiological processes in insects.Juvenile hormone(JH)is known to stimulate Vitellogenin(Vg)synthesis in the fat body,secretion into the hemolymph and uptake by developing oocytes.However,the role of GPCRs in JH-dependent insect vitellogenesis and oocyte maturation remains elusive.In the present study,we performed transcriptomic analysis and RNA interference(RNAi)screening in vitellogenic females of the migratory locust Locusta migratoria.Of 22 GPCRs identified in ovarian transcriptome,LGR4,OR-A1,OR-A2,Mthl1,Mthl5 and Smo were most abundant in the ovary.By comparison,mAChR-C expressed at higher levels in the fat body,whereas Oct/TyrR,OARβ,AdoR and ADGRA3 were at higher expression levels in the brain.Our RNAi screening demonstrated that knockdown of six GPCRs resulted in defective phenotypes of Vg accumulation in developing oocytes,accompanied by blocked ovarian development and impaired oocyte maturation.While LGR4 and Oct/TyrR appeared to control Vg synthesis in the fat body,OR-A1,OR-A2,mAChR-C and CirlL regulated Vg transportation and uptake.The findings provide fundamental evidence for deciphering the regulatory mechanisms of GPCRs in JH-stimulated insect reproduction. | Hongyuan Zheng Baojuan Zeng Tiantian Shang Shutang Zhou | 2021 | Insect Science2021，28，4： | 2 |
| 10 | Recent Developments of FNET/GridEye—A Situational Awareness Tool for Smart Grid显示文摘Wide-area monitoring systems(WAMS)are becoming increasingly vital for enhancing power grid operators’situational awareness capabilities.As a pilot WAMS that was initially deployed in 2003,the frequency monitoring network FNET/GridEye uses GPS-time-synchronized monitors called frequency disturbance recorders(FDRs)to capture dynamic grid behaviors.Over the past ten years,a large number of publications related to FNET/GridEye have been reported.In this paper,the most recent developments of FNET/GridEye sensors,data centers,and data analytics applications are reviewed.These works demonstrate that FNET/GridEye will become a costeffective situational awareness tool for the future smart grid. | Yong Liu Wenxuan Yao Dao Zhou Ling Wu Shutang You Hesen Liu Lingwei Zhan Jiecheng Zhao Haoyang Lu Wei Gao Yilu Liu | 2016 | CSEE Journal of Power and Energy Systems2016，2，3： | 2 |
| 11 | Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development显示文摘最后形成能是的肌醇 1,3,4,5-tetrakisphosphate 和肌醇 1,3,4,6-tetrakisphosphate 的肌醇 1,3,4-trisphosphate 5/6 kinase (ITPK ) phosphorylates 肌醇 1,3,4-trisphosphate 转了到肌醇 hexaphosphate (IP6 ) 和玩重要角色在植物生长和开发期间。在 Arabidopsis 有 4 个通常认为的 ITPK 成员。表示模式分析证明 ITPK2 组成地在各种各样的纸巾被表示。ITPK2 的 T-DNA 猛烈异种被识别,扫描电子显微镜学(SEM ) 分析证明种子的外皮结构覆盖不规则地在 itpk2-1 异种的种子被形成,导致种子上衣的增加的渗透到 tetrazolium 腌。由煤气的层析的进一步的分析在房间墙中结合了类脂化合物聚酯单体的集体 spectrometry 在软木脂和角质的作文证实了戏剧的减少,它联系到种子上衣和哪个伴有种子上衣开发的形成的渗透。这些结果显示 ITPK2 在种子上衣开发和类脂化合物聚酯障碍形成起一个必要作用。 | Yong Tang Shutang Tan Hongwei Xue | 2013 | Acta Biochimica et Biophysica Sinica2013，45，7： | 2 |
| 12 | Impact of Simultaneous Activities on Frequency Fluctuations:Comprehensive Analyses Based on Real Measurement Data from the FNET/GridEye显示文摘Simultaneous human activities,such as the Super Bowl game,would cause certain impacts on frequency fluctuations in power systems.With the help of FNET/GridEye measurements,this paper aims to give comprehensive analyses on the frequency fluctuations during Super Bowl LIV held on Feb.2,2020,so as to better understand several phenomena caused by simultaneous activities which will help system operations and controls.First,recent developments of the FNET/GridEye are briefly introduced.Second,the frequency fluctuations of the Eastern Interconnection(El),western electricity coordinating council(WECC),and electric reliability council of Texas(ERCOT)power systems during Super Bowl LIV are analyzed.Third,frequency fluctuations of Super Bowl Sunday and ordinary Sundays in 2020 are compared.Finally,the differences of frequency fluctuations among different years during the Super Bowl and their change trends are also given.Furthermore,several possible explanations,including the simultaneity of electricity consumption at the beginning of commercial breaks and the halftime show,the increasing usage of the Internet,and the increasing size of TV screens,are illustrated in detail in this paper. | Shengyuan Liu Shutang You Chujie Zeng Yinfeng Zhao Wenxuan Yao Yilu Liu Zhenzhi Lin | 2021 | CSEE Journal of Power and Energy Systems2021，7，2： | 1 |
| 13 | Oscillation mode identification based on wide-area ambient measurements using multivariate empirical mode decomposition显示文摘 | Shutang You | 2016 | Electric Power System Research2016，，134： | 1 |
| 14 | 显示文摘 | Shutang Zhu A. Chwang | 2002 | Experiments in Fluids2002，，4： | 1 |
| 15 | Variance analysis and performance evaluation of different crumb rubber modified (CRM) asphalt显示文摘 | Shutang Liu Weidong Cao Jianguo Fang | 2009 | Construction and Building Materials2009，，23： | 1 |
| 16 | Effect of power density on the properties of μc-Si:H deposited by VHF-PECVD 显示文摘 | Guo Xuejun Lu Jingxiao Wen shutang | 2008 | Chinese journal of semiconductors2008，29，6： | 1 |
| 17 | Separation of regular waves by a transfer function method 显示文摘 | Zhu Shutang | 1999 | Ocean Engineering1999，26，： | 1 |
| 18 | Test Results for Polymer Flooding in Daqing Oilfield显示文摘TestResultsforPolymerFloodinginDaqingOilfield￥ZhangJingcun;GaoShutangandJiangXiangcheng(ResearchInstituteofPetroleumEsplorati... | Zhang Jingcun Gao Shutang and Jiang Xiangcheng(Research Institute of Petroleum Esploration andDevelopment, Daqing Petroleum Administration) | 1995 | China Oil & Gas1995，2，2： | 1 |
| 19 | The alkaline/surfactant/polymer pilot performance of saertu,west central,Daqing oilfield显示文摘 | Gao Shutang Li Huabin Yang Zhenyu | 1996 | Soc Petrol Engrs Reserv Engng1996，11，3： | 1 |
| 20 | Video Shot Boundary Detection in MPEG Compressed Sequences Using SVM Learning显示文摘A number of automated video shot boundary detection methods for indexing a videosequence to facilitate browsing and retrieval have been proposed in recent years.Among these methods,the dissolve shot boundary isn’t accurately detected because it involves the camera operation and objectmovement.In this paper,a method based on support vector machine (SVM) is proposed to detect thedissolve shot boundary in MPEG compressed sequence.The problem of detection between the dissolveshot boundary and other boundaries is considered as two-class classification in our method.Featuresfrom the compressed sequences are directly extracted without decoding them,and the optimal classboundary between two classes are learned from training data by using SVM.Experiments,whichcompare various classification methods,show that using proposed method encourages performance ofvideo shot boundary detection. | GUO Lihua YANG Shutang LIJianhua TONGZhipeng(School of Electronic and Information Technology,Shanghai JiaoTong University Shanghai 200030 China) | 2003 | Journal of Electronic Science and Technology of China2003，1，1： | 1 |
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