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| 1 | Cyber-physical-social System in Intelligent Transportation显示文摘A cyber-physical system(CPS) is composed of a physical system and its corresponding cyber systems that are tightly fused at all scales and levels.CPS is helpful to improve the controllability,efficiency and reliability of a physical system,such as vehicle collision avoidance and zero-net energy buildings systems.It has become a hot R&D and practical area from US to EU and other countries.In fact,most of physical systems and their cyber systems are designed,built and used by human beings in the social and natural environments.So,social systems must be of the same importance as their CPSs.The indivisible cyber,physical and social parts constitute the cyber-physical-social system(CPSS),a typical complex system and it’s a challengeable problem to control and manage it under traditional theories and methods.An artificial systems,computational experiments and parallel execution(ACP) methodology is introduced based on which data-driven models are applied to social system.Artificial systems,i.e.,cyber systems,are applied for the equivalent description of physical-social system(PSS).Computational experiments are applied for control plan validation.And parallel execution finally realizes the stepwise control and management of CPSS.Finally,a CPSS-based intelligent transportation system(ITS) is discussed as a case study,and its architecture,three parts,and application are described in detail. | Gang Xiong Fenghua Zhu Xiwei Liu Xisong Dong Wuling Huang Songhang Chen Kai Zhao | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，3： | 8 |
| 2 | Isolation and identification of a potential biocontrol agent Bacillus subtilis QM3 from Qinghai yak dung in China显示文摘 | Hu Qingping Xu Jianguo Song Peng Song Jinning Chen Wuling | 2008 | World Journal of Microbiology and Biotechnology2008，24，11： | 1 |
| 3 | Types and microstructures of pores in shales of the Ordovician Wulalike Formation at the western margin of the Ordos Basin, China显示文摘Shale samples from the Ordovician Wulalike Formation at the western margin of the Ordos Basin are studied to define the types, microstructures and connectivity of pores as well as the relationships between the pore structures and gas content of the samples by using experimental techniques such as high-resolution field emission scanning electron microscopy (FESEM), mercury injection capillary pressure (MICP), low-temperature nitrogen adsorption (LTNA), CO_(2) adsorption, and focused ion beam scanning electron microscopy (FIB-SEM). The results show that the shale has 10 different lithofacies, typical mixed sedimentary characteristics, and poorly developed pores. The reservoir space mainly consists of intercrystalline pores, dissolution pores, intergranular pores, and micro-fissures, with organic pores occasionally visible. The pore size is mostly within 0.4–250 nm range but dominated by micropores and mesopores less than 20 nm, with pore numbers peaking at pore sizes of 0.5 nm, 0.6 nm, 0.82 nm, 3 nm, and 10 nm, respectively. The pores are poorly connected and macropores are rarely seen, which may explain the low porosity and low permeability of the samples. Samples with high content of organic matter and felsic minerals are potential reservoirs for oil and gas with their favorable physical properties and high connectivity. The pores less than 5 nm contribute significantly to the specific surface area and serve as important storage space for adsorbed gas. | Wuling Mo Min Wang Fangwen Chen Zhengliang Huang Ying Li Yu Yan Ren Jiang Tong Lin Junfeng Cui | 2023 | Energy Geoscience2023，4，3： | 0 |
| 4 | In Vitro Nanobody Library Construction by Using Gene Designated-Region Pan-Editing Technology显示文摘Camelid single-domain antibody fragments(nanobodies)are an emerging force in therapeutic biopharmaceuticals and clinical diagnostic reagents in recent years.Nearly all nanobodies available to date have been obtained by animal immunization,a bottleneck restricting the large-scale application of nanobodies.In this study,we developed three kinds of gene designatedregion pan-editing(GDP)technologies to introduce multiple mutations in complementarity-determining regions(CDRs)of nanobodies in vitro.Including the integration of G-quadruplex fragments in CDRs,which induces the spontaneous multiple mutations in CDRs;however,these mutant sequences are highly similar,resulting in a lack of sequences diversity in the CDRs.We also used CDR-targeting traditional gRNA-guided base-editors,which effectively diversify the CDRs.And most importantly,we developed the self-assembling gRNAs,which are generated by reprogrammed tracrRNA hijacking of endogenous mRNAs as crRNAs.Using base-editors guided by self-assembling gRNAs,we can realize the iteratively diversify the CDRs.And we believe the last GDP technology is highly promising in immunization-free nanobody library construction,and the full development of this novel nanobody discovery platform can realize the synthetic evolution of nanobodies in vitro. | Zhiyuan Niu Zhixia Luo Pengyang Sun Linwei Ning Xinru Jin Guanxu Chen Changjiang Guo Lingtong Zhi Wei Chang Wuling Zhu | 2022 | BioDesign Research2022，，1： | 0 |
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