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| 1 | Three-dimensional modeling and simulation of asphalt concrete mixtures based on X-ray CT microstructure images显示文摘X-ray CT(computed tomography) was used to scan asphalt mixture specimen to obtain high resolution continuous cross-section images and the meso-structure.According to the theory of three-dimensional(3D) reconstruction,the 3D reconstruction algorithm was investigated in this paper.The key to the reconstruction technique is the acquisition of the voxel positions and the relationship between the pixel element and node.Three-dimensional numerical model of asphalt mixture specimen was created by a self-developed program.A splitting test was conducted to predict the stress distributions of the asphalt mixture and verify the rationality of the 3D model. | Hainian Wang Zhihan Huang Lei Li Zhanping You Yu Chen | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，1： | 30 |
| 2 | Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging An animal and clinical study显示文摘In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes (T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]) following cerebral infarction. The pathological changes were divided into three phases: early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase (less than 2 hours post-infarction), there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase (2-4 hours post-infarction), a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase (4-6 hours post-infarction), significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients (10/51) had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients (8/35) had an onset time less than 6 hours. These data suggest that defining the 'therapeutic time window' as the time 6 hours after infarction may not be suitable for all patients. Integrated application of MRI sequences including T2WI, T2FLAIR, DW-MRI, and apparent diffusion coefficient mapping should be used to examine the ischemic penumbra, which may provide valuable information for identifying the 'therapeutic time window'. | Hong Lu Hui Hu Zhanping He Xiangjun Han Jing Chen Rong Tu | 2012 | Neural Regeneration Research2012，7，31： | 16 |
| 3 | Gene interference regulates aquaporin-4 expression in swollen tissue of rats with cerebral ischemic edema Correlation with variation in apparent diffusion coefficient显示文摘To investigate the effects of mRNA interference on aquaporin-4 expression in swollen tissue of rats with ischemic cerebral edema, and diagnose the significance of diffusion-weighted MRI, we injected 5 μL shRNA- aquaporin-4 (control group) or siRNA- aquaporin-4 solution (1:800) (RNA interference group) into the rat right basal ganglia immediately before occlusion of the middle cerebral artery. At 0.25 hours after occlusion of the middle cerebral artery, diffusion-weighted MRI displayed a high signal; within 2 hours, the relative apparent diffusion coefficient decreased markedly, aquaporin-4 expression increased rapidly, and intracellular edema was obviously aggravated; at 4 and 6 hours, the relative apparent diffusion coefficient slowly returned to control levels, aquaporin-4 expression slightly increased, and angioedema was observed. In the RNA interference group, during 0.25- 6 hours after injection of siRNA- aquaporin-4 solution, the relative apparent diffusion coefficient slightly fluctuated and aquaporin-4 expression was upregulated; during 0.5-4 hours, the relative apparent diffusion coefficient was significantly higher, while aquaporin-4 expression was significantly lower when compared with the control group, and intracellular edema was markedly reduced; at 0.25 and 6 hours, the relative apparent diffusion coefficient and aquaporin-4 expression were similar when compared with the control group; obvious angioedema remained at 6 hours. Pearson's correlation test results showed that aquaporin-4 expression was negatively correlated with the apparent diffusion coefficient (r = -0.806, P < 0.01). These findings suggest that upregulated aquaporin-4 expression is likely to be the main molecular mechanism of intracellular edema and may be the molecular basis for decreased relative apparent diffusion coefficient. Aquaporin-4 gene interference can effectively inhibit the upregulation of aquaporin-4 expression during the stage of intracellular edema with time-effectiveness. Moreover, diffusion-weighted MRI can accurately detect intracellular edema. | Hui Hu Hong Lu Zhanping He Xiangjun Han Jing Chen Rong Tu | 2012 | Neural Regeneration Research2012，7，21： | 14 |
| 4 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 5 | Controlling morphology evolution of AIN nanostructures:influence of growth conditions in physical vapor transport显示文摘A series of AIN nanostructures were synthesized by an ultrahigh-temperature, catalyst-free, physical vapor transport(PVT) process. Energy dispersive X-ray spectroscopy(EDX), X-ray diffraction(XRD), X-Ray photoelectron spectroscopy(XPS),high resolution transmission electron microscopy(HRTEM) detection show that high quality AIN nanowires were prepared. Nanostructures including nanorings, nanosprings, nanohelices, chainlike nanowires, six-fold symmetric nanostructure and rod-like structure were successfully obtained by controlling the growth duration and temperature. The morphology evolution was attributed to electrostatic polar charge model and the crystalline lattice structure of AIN. | Lei Jin Hongjuan Cheng Jianli Chen Song Zhang Yongkuan Xu, and Zhanping Lai | 2018 | Journal of Semiconductors2018，39，7： | 4 |
| 6 | Sensitivity analysis of longitudinal cracking on asphalt pavement using MEPDG in permafrost region显示文摘Longitudinal cracking is one of the most important distresses of asphalt pavement in permafrost regions. The sensitivity analysis of design parameters for asphalt pavement can be used to study the influence of every parameter on longitudinal cracking, which can help optimizing the design of the pavement structure. In this study, 20 test sections of Qinghai e Tibet Highway were selected to conduct the sensitivity analysis of longitudinal cracking on material parameter based on Mechanistic-Empirical Pavement Design Guide(MEPDG) and single factorial sensitivity analysis method. Some computer aided engineering(CAE) simulation techniques, such as the Latin hypercube sampling(LHS) technique and the multiple regression analysis are used as auxiliary means.Finally, the sensitivity spectrum of material parameter on longitudinal cracking was established. The result shows the multiple regression analysis can be used to determine the remarkable influence factor more efficiently and to process the qualitative analysis when applying the MEPDG software in sensitivity analysis of longitudinal cracking in permafrost regions. The effect weights of the three parameters on longitudinal cracking in descending order are air void, effective binder content and PG grade. The influence of air void on top layer is bigger than that on middle layer and bottom layer. The influence of effective asphalt content on top layer is bigger than that on middle layer and bottom layer, and the influence of bottom layer is slightly bigger than middle layer.The accumulated value of longitudinal cracking on middle layer and bottom layer in the design life would begin to increase when the design temperature of PG grade increased. | Chen Zhang Hainian Wang Zhanping You Biao Ma | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，1： | 4 |
| 7 | A review on the best practices in concrete pavement design and materials in wet-freeze climates similar to Michigan显示文摘The research presented in this paper aims to identify best practices of design and materials for concrete pavements in wet-freeze climates similar to the Michigan State. For the purposes of this paper, a best practice is a procedure that has been shown by field-validated research or experience to produce improved results and that is established or proposed as a standard suitable for widespread implementation. The local wet-freeze climate makes the requirements for Michigan's pavement system different from many other regions. Wetfreeze climates can result in various concrete pavement distress mechanisms such as thermally-induced cracking, freeze-thaw deterioration, accelerated cracking due to loss of support, frost heave, and material degradation. Therefore, appropriate procedures for design and material selection need to be selected to withstand high precipitation and freezing winter temperatures. Failure to take into account the climatic conditions may lead to inadequate or reduced pavement performance. However, utilizing appropriate techniques and materials could potentially improve the quality and increase the service life of the concrete pavement. Three design methods and five materials have been identified, and examples of their successful performance in wet-freeze climates are provided. In addition, the reasons that give them the superior performance in wet-freeze climates are discussed in detail. | Naser P. Sharifi Siyu Chen Zhanping You Thomas Van Dam Christopher Gilbertson | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，3： | 3 |
| 8 | ADAMTS4 level in Patients with stable coronary artery disease and acute coronary syndromes显示文摘 | ZhaNP Chen Y Xu FY | 2010 | Biomed Pharmacotherapy2010，64，3： | 1 |
| 9 | General drain model for double-gate SOI MOSFETs 显示文摘 | Chen Zhanping Wei Liqiong Xu Mingzhen | 1996 | Chinese Journal of Semiconductors1996，17，10： | 1 |
| 10 | Sleep architecture, periodic breathing and mood disturbance of expeditioners at Kunlun Station(4087 m) in Antarctica显示文摘Several studies have reported the detrimental impacts of hypoxia exposure on sleep.Chinese Kunlun Station(altitude 4087 m)is located at Dome A,the highest point on the Antarctic ice sheet and one of the most extreme environments on Earth.This study investigated alteration of sleep,breathing and mood status in healthy expeditioners at Kunlun Station at Dome A.The study examined 10 male volunteers of the inland transverse party to Kunlun Station during the 31st Chinese National Antarctic Research Expedition,and valid data from eight volunteers were analyzed.Sleep structure,breathing pattern and mood were monitored using portable polysomnography(PSG)and profile of mood state(POMS)at two time points:(1)at Zhongshan Station(10 m)before departure to Kunlun Station;(2)on nights 12–13 of residence at Kunlun Station.Slow-wave sleep(Stage 3 non-rapid eye movement)was markedly reduced at Kunlun Station(P<0.01).Total sleep time,sleep efficiency and sleep latency showed no significant changes.Total respiratory events(P<0.05),apnea/hypopnea index(AHI)(P<0.05)and hypopnea index(P<0.01)substantially increased at Kunlun Station.The most common respiratory disorder was periodic breathing,occurring almost exclusively during non-rapid eye movement sleep.The oxygen desaturation index increased markedly(P<0.05),while nocturnal oxygen saturation dramatically fell at Kunlun Station(P<0.05).Vigor scores decreased at Kunlun Station(P<0.05).Expeditioners exhibited reduced slow wave sleep,induced periodic breathing,decreased oxygen saturation and decreased vigor at Kunlun Station. | XU Chengli LIU Shiying KONG Zhanping CHEN Nan | 2020 | Advances in Polar Science2020，31，3： | 0 |
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