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| 1 | Late Quaternary glacial chronology on the eastern slope of Gongga Mountain,eastern Tibetan Plateau,China显示文摘The Gongga Mountain is the largest area of modern glaciation in the Hengduan Mountains and,with a summit elevation of 7556 m,is the highest mountain on the eastern margin of the Tibetan Plateau.During the Quaternary glacial-interglacial cycles the Gongga Mountain was extensively and repeatedly glaciated,and glacial landforms and outwash deposits from multiple glaciations are well-preserved in valleys,in basins,and on piedmonts.To constrain the glacial chronology of the eastern slope of Gongga Mountain,sample sites were selected based on the distribution and weathering of glacial tills,relationships among glacial deposits,and soil development on moraines.Dating of the tills and glaciofluvial deposits was undertaken with electron spin resonance(ESR) and optically stimulated luminescence(OSL).The ages of the glacial deposits can be divided into four clusters:2.2±0.5,11.9±0.6,35.9±2.7-58.0±6.3 and 119.2±15.9-194.2±32.8 ka.Five glacial advances in this region have been identified,which are equivalent in age to the Little Ice Age(LIA),Neoglaciation,marine oxygen isotope stage(MIS) 2,mid-MIS3,and MIS6.The largest local last glacial maximum(LGML) occurred on Gongga Mountain during mid-MIS3,characterized by a cold-humid climate,rather than the global Last Glacial Maximum(LGMG) of MIS2.The Gongga,Nanmenguangou(NMGG) and Yajiageng Glaciations occurred during the late part of the last glacial cycle,the middle of the last glacial cycle and the penultimate glacial cycle,respectively.On the basis of geomorphological,sedimentological,and compositional characteristics,landforms of the Moxi Platform and terraces can be grouped by facies and geochronology.In combination with the dating results,this analysis indicates the basal part of the Moxi Platform between Xinxin and the Moxi Hotel is correlative with the till of the Nanguanmen Glaciation(mid-MIS3).This basal unit has occasional lenses of glaciofluvial sandy gravel and lacustrine sediments.The remainder of the Moxi Platform and the terraces beside the platform are glaciofluvial deposits occasionally mixed with debris flow deposits and range in age from MIS3 to Holocene. | WANG Jie PAN BaoTian ZHANG GuoLiang CUI Hang CAO Bo GENG HaoPeng | 2013 | Science China Earth Sciences2013，56，3： | 11 |
| 2 | Chondroitinase ABC plus bone marrow mesenchymal stem cells for repair of spinal cord injury显示文摘As chondroitinase ABC can improve the hostile microenvironment and cell transplantation is proven to be effective after spinal cord injury, we hypothesized that their combination would be a more effective treatment option. At 5 days after T8 spinal cord crush injury, rats were injected with bone marrow mesenchymal stem cell suspension or chondroitinase ABC 1 mm from the edge of spinal cord damage zone. Chondroitinase ABC was first injected, and bone marrow mesenchymal stem cell suspension was injected on the next day in the combination group. At 14 days, the mean Basso, Beattie and Bresnahan score of the rats in the combination group was higher than other groups. Hematoxylin-eosin staining showed that the necrotic area was significantly reduced in the combination group compared with other groups. Glial fibrillary acidic protein-chondroitin sulfate proteoglycan double staining showed that the damage zone of astrocytic scars was significantly reduced without the cavity in the combination group. Glial fibrillary acidic protein/growth associated protein-43 double immunostaining revealed that positive fibers traversed the damage zone in the combination group. These results suggest that the combination of chondroitinase ABC and bone marrow mesenchymal stem cell transplantation contributes to the repair of spinal cord injury. | Chun Zhang Xijing He Haopeng Li Guoyu Wang | 2013 | Neural Regeneration Research2013，8，11： | 10 |
| 3 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 4 | 有表面机械磨损处理辅助的合金钢强化渗硼动力学显示文摘用表面机械磨损处理(SMAT)在AISI H13钢上制备一层纳米结构的表面层。研究了这种SMAT试样的渗硼性能和粗晶粒对应物的比较。SMAT试样的硼扩散深度在600℃,2 h渗硼后的峰值是8μm,比粗晶粒试样深得多。在SMAT试样上用600℃接着更高温度的双重渗硼处理能合成厚得多的渗硼层。而且SMAT试样的活化能是1403 kJ/mol,比粗晶粒的209.4 kJ/mol低得多。结果表明,用双重渗硼处理的SMAT试样能明显增强渗硼动力学。而且热疲劳试验表明,具有优良抗氧化性和高温机械强度的渗硼层能有效延迟热疲劳裂纹的萌生,阻碍它们的传播。所以经双重渗硼处理的H13钢的热疲劳性能可以大大提升。 | Haopeng Yang Xiaochun Wu Zhe Yang Shengjun Pu Hongbin Wang | 2014 | 热处理技术与装备2014，35，2： | 7 |
| 5 | Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells显示文摘Monoallelic gene expression refers to the phenomenon that all transcripts of a gene in a cell are expressed from only one of the two alleles in a diploid organism. Although monoallelic gene expression has been occasionally reported with bulk transcriptome analysis in plants, how prevalent it is in individual plant cells remains unknown. Here, we developed a single-cell RNA-seq protocol in rice and investigated allelic expression patterns in mesophyll cells of indica(93-11) and japonica(Nipponbare) inbred lines, as well as their F1 reciprocal hybrids. We observed pervasive monoallelic gene expression in individual mesophyll cells, which could be largely explained by stochastic and independent transcription of two alleles. By contrast, two mechanisms that were proposed previously based on bulk transcriptome analyses, parent-oforigin effects and allelic repression, were not well supported by our data. Furthermore, monoallelically expressed genes exhibited a number of characteristics, such as lower expression levels, narrower H3K4me3/H3K9ac/H3K27me3 peaks, and larger expression divergences between 93-11 and Nipponbare. Taken together, the development of a single-cell RNA-seq protocol in this study offers us an excellent opportunity to investigate the origins and prevalence of monoallelic gene expression in plant cells. | Yingying Han Xiao Chu Haopeng Yu Ying-Ke Ma Xiu-Jie Wang Wenfeng Qian Yuling Jiao | 2017 | Science Bulletin2017，62，19： | 5 |
| 6 | Recent progress in interface modification for dye-sensitized solar cells显示文摘Interface modification on the TiO2/dye/electrolyte interface of dye-sensitized solar cells (DSCs) is one of the most effective approaches to suppress the charge recombination,improve electron injection and transportation,and thus ameliorate the conversion efficiency and stability of DSCs.Conventional research focusing on the photoanodes interface modification before sensitization in dye-sensitized solar cells has been carried out and reviewed.However,recent studies showed that post-modification after sensitization of the TiO2 electrode also plays a significant role on the TiO2/dye/electrolyte interface.This post-modification using the immersing method could deprotonate dye molecules,prohibit the dye aggregation and retard the recombination reaction.As a result,it has great influence on the devices' photovoltaic performance.This interface modification could also provide an approach to broaden the response of the solar spectrum by introducing an alternative assembling structure.An in-situ meaning of using a co-adsorbent is employed to modify the interface in the DSCs,which could retard the aggregation of the dye molecules and enhance the conversion efficiency.In addition,electrolyte additives can be used to modify the TiO2/dye/electrolyte interface through some unique mechanisms.Based on the background of interface modification of photoanodes before sensitization,this review introduces various interface modifications after sensitization of dye-sensitized solar cells and their mechanisms. | MA BeiBei,GAO Rui,WANG LiDuo,ZHU YiFeng,SHI YanTao,GENG Yi,DONG HaoPeng & QIU Yong Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education Department of Chemistry,Tsinghua University,Beijing 100084,China | 2010 | Science China Chemistry2010，53，8： | 4 |
| 7 | Particle swarm optimization-based algorithm of a symplectic method for robotic dynamics and control显示文摘Multibody system dynamics provides a strong tool for the estimation of dynamic performances and the optimization of multisystem robot design. It can be described with differential algebraic equations(DAEs). In this paper, a particle swarm optimization(PSO) method is introduced to solve and control a symplectic multibody system for the first time. It is first combined with the symplectic method to solve problems in uncontrolled and controlled robotic arm systems. It is shown that the results conserve the energy and keep the constraints of the chaotic motion, which demonstrates the efficiency, accuracy, and time-saving ability of the method. To make the system move along the pre-planned path, which is a functional extremum problem, a double-PSO-based instantaneous optimal control is introduced. Examples are performed to test the effectiveness of the double-PSO-based instantaneous optimal control. The results show that the method has high accuracy, a fast convergence speed, and a wide range of applications.All the above verify the immense potential applications of the PSO method in multibody system dynamics. | Zhaoyue XU Lin DU Haopeng WANG Zichen DENG | 2019 | Applied Mathematics and Mechanics(English Edition)2019，40，1： | 3 |
| 8 | Therapeutic strategies of glioblastoma (GBM):The current advances in the molecular targets and bioactive small molecule compounds显示文摘Glioblastoma(GBM)is the most common aggressive malignant tumor in brain neuroepithelial tumors and remains incurable.A variety of treatment options are currently being explored to improve patient survival,including small molecule inhibitors,viral therapies,cancer vaccines,and monoclonal antibodies.Among them,the unique advantages of small molecule inhibitors have made them a focus of attention in the drug discovery of glioblastoma.Currently,the most used chemotherapeutic agents are small molecule inhibitors that target key dysregulated signaling pathways in glioblastoma,including receptor tyrosine kinase,PI3K/AKT/mTOR pathway,DNA damage response,TP53 and cell cycle inhibitors.This review analyzes the therapeutic benefit and clinical development of novel small molecule inhibitors discovered as promising anti-glioblastoma agents by the related targets of these major pathways.Meanwhile,the recent advances in temozolomide resistance and drug combination are also reviewed.In the last part,due to the constant clinical failure of targeted therapies,this paper reviewed the research progress of other therapeutic methods for glioblastoma,to provide patients and readers with a more comprehensive understanding of the treatment landscape of glioblastoma. | Hui Liu Weimin Qiu Tianyu Sun Lei Wang Chenxi Du Yanyu Hu Wenyuan Liu Feng Feng Yao Chen Haopeng Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 9 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 10 | Olfactory ensheathing cell transplantation for spinal cord injury An 18-year bibliometric analysis based on the Web of Science显示文摘OBJECTIVE:Olfactory ensheathing cell (OEC) transplantation is a promising new approach for the treatment of spinal cord injury (SCI),and an increasing number of scientific publications are devoted to this treatment strategy.This bibliometric analysis was conducted to assess global research trends in OEC transplantation for SCI.DATA SOURCE:All of the data in this study originate from the Web of Science maintained by the Institute for Scientific Information,USA,and includes SCI-EXPANDED,SSCI,A&HCI,CPCI-S,CPCI-SSH,BKCI-S,BKCI-SSH,CCR-EXPANDED and IC.The Institute for Scientific Information's Web of Science was searched using the keywords 'olfactory ensheathing cells' or 'OECs' or 'olfactory ensheathing glia' or 'OEG' or 'olfactory ensheathing glial cells' or 'OEGs' and 'spinal cord injury' or 'SCI' or 'spinal injury' or 'spinal transection' for literature published from January 1898 to May 2012.DATA SELECTION:Original articles,reviews,proceedings papers and meeting abstracts,book chapters and editorial materials on OEC transplantation for SCI were included.Simultaneously,unpublished literature and literature for which manual information retrieval was required were excluded.MAIN OUTCOME MEASURES:All selected literatures addressing OEC transplantation for SCI were evaluated in the following aspects:publication year,document type,language,author,institution,times cited,Web of Science category,core source title,countries/territories and funding agency.RESULTS:In the Web of Science published by the Institute for Scientific Information,the earliest literature record was in April,1995.Four hundred and fourteen publications addressing OEC transplantation for SCI were added to the data library in the past 18 years,with an annually increasing trend.Of 415 records,405 publications were in English.Two hundred and fifty-nine articles ranked first in the distribution of document type,followed by 141 reviews.Thirty articles and 20 reviews,cited more than 55 times by the date the publication data were downloaded by us,can be regarded as the most classical references.The journal Experimental Neurology published the most literature (32 records),followed by Glia.The United States had the most literature,followed by China.In addition,Yale University was the most productive institution in the world,while The Second Military Medical University contributed the most in China.The journal Experimental Neurology published the most OEC transplantation literature in the United States,while Neural Regeneration Research published the most in China.CONCLUSION:This analysis provides insight into the current state and trends in OEC transplantation for SCI research.Furthermore,we anticipate that this analysis will help encourage international cooperation and teamwork on OEC transplantation for SCI to facilitate the development of more effective treatments for SCI. | Zikuan Leng Xijing He Haopeng Li Dong Wang Kai Cao | 2013 | Neural Regeneration Research2013，8，14： | 2 |
| 11 | Synthesis, self- assembly and photoindueed surface-relief gratings of a polyaerylate-based Azo polyeleetrolyte显示文摘 | Yaning He Haopeng Wang Xinlin Luo | 2004 | Optical Materials2004，26，： | 1 |
| 12 | Preparation Of Hydrophobic Association Polyacrylamide In A New Micellar Copoly- merization System And Its Hydrophobically Associative Property 显示文摘 | Baojiao Gao Haopeng Guo Jian Wang And Yan Zhang | 2008 | Macromolecules2008，41，： | 1 |
| 13 | Preparation of hydrophobic association polyacrylamide in a new micellar copolymerization system and its hydrophobically associative property显示文摘 | Gao Baojiao Guo Haopeng Wang Jian | 2008 | Macromolecules2008，41，8： | 1 |
| 14 | Sustainable production of acrolein: investigation of solid acid-base catalysts for gas-phase dehydration of glycerol 显示文摘 | CHAI Songhai WANG Haopeng LIANG Yu | 2007 | Green Chemistry2007，9，： | 1 |
| 15 | Synthesis,self-assembly and photoinduced surface-relief gratings of a polyacrylate-based Azo polyelectrolyte显示文摘 | HE Yaning WANG Haopeng LUO Xinlin | 2004 | Optical Materials2004，26，： | 1 |
| 16 | Key elements for designing and performing a CRISPR/Cas9-based genetic screen显示文摘Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limitations in reverse genetic screens, with successes in various biological contexts. Here, we outline these CRISPR/Cas9-based screens, provide guidance on the design of effective screens and discuss the potential future directions of development of this field. | Wanjing Shang Fei Wang Gaofeng Fan Haopeng Wang | 2017 | Journal of Genetics and Genomics2017，44，9： | 1 |
| 17 | Preparation of hydrophobic association polyacrylamide in a new micellar copolymerization system and its hydrophobically associative property显示文摘 | Gao Baojiao Guo Haopeng Wang Jian | 2008 | Macromolecules2008，41，8： | 1 |
| 18 | Sustainable production of acrolein:investigation of solid acid-base catalysts for gas-phase dehydration of glycerol显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2007 | Green Chemistry2007，9，： | 1 |
| 19 | A protective AAV vaccine for SARS-CoV-2显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the COVID-19 pandemic,with more than 528 million infections and 6.2 million deaths.To fight against this rapidly spreading pandemic,prophylactic vaccines have been developed using different techniques,such as inactivated virus,messenger RNAs,recombinant proteins,and viral-vectored vaccines.However,rapidly spreading variants of SARS-CoV-2,such as alpha,beta,delta,and omicron variants,have been emerging. | Simeng Zhao Junzi Ke Boyu Yang Fangzhi Tan Jie Yang Chao-Po Lin Haopeng Wang Guisheng Zhong | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 20 | Proliferation and differentiation of reactive nestin^+/GFAP^+ cells in an adult rat model of compression-induced spinal cord injury显示文摘BACKGROUND:Studies have demonstrated that astrocytes may possess similar properties to neural stem cells/neural precursor cells and have the potential to differentiate into neurons. OBJECTIVE:To observe neuroepithelial stem cell protein(nestin) and glial fibrillary acidic protein (GFAP) expression following spinal cord injury,and to explore whether nestin^+/GFAP^+ cells,which are detected at peak levels in gray and white matter around the ependymal region of the central canal in injured spinal cord,possess similar properties of neural stem cells. DESIGN,TIME AND SETTING:A randomized,controlled experiment.The study was performed at the Key Laboratory of Environment and Genes Related to Diseases(Xi'an Jiaotong University), Ministry of Education between January 2004 and December 2006. MATERIALS:Rabbit anti-rat nestin,β-tubulinⅢ,mouse anti-rat GFAP,galactocerebroside(GaLC) antibodies were utilized,as well as flow cytometry. METHODS:A total of 60 male,Sprague Dawley rats,aged 8 weeks,were randomly assigned to control(n = 12) and model(n = 48) groups.The spinal cord injury model was established in the model group by aneurysm clip compression,while the control animals were not treated.The gray and white matter around the ependymal region of the central canal exhibited peak expression of nestin^+/GFAP^+ cells.These cells were harvested and prepared into single cell suspension,followed by primary and passage cultures.The cells were incubated with serum-containing neural stem cell complete medium. MAIN OUTCOME MEASURES:Nestin and GFAP expression in injured spinal cord was determined using immunohistochemistry and double-labeled immunofluorescence at 1,3,5,7,14,28,and 56 days post-injury.In addition,cell proliferation and differentiation were detected using immunofluorescence cytochemistry and flow cytometry. RESULTS:Compared with the control group,the model group exhibited significantly increased nestin and GFAP expression(P<0.05),which reached peak levels between 3 and 7 days.The majority of cells in the ependymal region around the central canal were nestin^+/GFAP^- cells,while the gray and white matter around the ependymal region were full of nestin^+/GFAP^+ cells,with an astrocytic-like appearance.A large number of nestin^+/GFAP^+ cells were observed in the model group cell culture,and the cells formed clonal spheres and displayed strong nestin-positive immunofluorescence staining.Following induced differentiation,a large number of GaLC-nestin,β-tubulinⅢ-nestin,and GFAP-nestin positive cells were observed.However,no obvious changes were seen in the control group.Cells in S stage,as well as the percentage of proliferating cells,in the model group were significantly greater than in the control group(P<0.01). CONCLUSION:Spinal cord injury in the adult rat induced high expression of nestin^+/GFAP^+ in the gray and white matter around the ependymal region of the central canal.These nestin^+/GFAP^+ cells displayed the potential to self-renew and differentiate into various cells.The cells could be neural stem cells of the central nervous system. | Pinglin Yang Xijing He Haopeng Li Binshang Lan Guoyu Wang Yiheng Liu | 2009 | Neural Regeneration Research2009，4，10： | 1 |
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