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| 1 | Characterizing spatial distribution and sources of heavy metals in the soils from mining-smelting activities in Shuikoushan,Hunan Province,China显示文摘The spatial variation of heavy metals in the soils in Shuikoushan mining-smelting area,Hunan Province,China,was investigated using multivariate and geo-statistic analysis.A total of 106 composite soil samples were collected in an area of about 100 km2. Concentrations of total As,Cd,Pb,Zn,Cu and Cr were measured using inductively coupled plasma mass spectrometry(ICP-MS) . Arsenic and Pb were found to have a common source,indicating the same sources and spreading processes,such as aerosols and airborne particulates from smelting chimneys.Airborne sources from smelting chimneys contributed greatly to Cd in the area,which demonstrated the same dispersion pattern as As and Pb.However,two hot spots of Cd around smelters were possibly enlarged by wastewaters,demonstrating another important source of Cd in Shuikouhsan.Geo-statistic interpolated mapping demonstrated that hotspots of Zn were only found proximal to the large smelters,suggesting that Zn primarily came from the chimneys of larger smelters. The major Cu hot-spots appeared closely to the tailing dam,indicating that weathering and leaching of tailings were the major sources of Cu contamination in Shuikoushan.Our findings indicated that airborne volatile particles and aerosols contributed the most to As,Cd,Pb,Zn and Cu contamination,while Cd and Cu may also derive from the discharge of wastewater from smelters and the leaching of tailings,respectively. | WEI Chaoyang WANG Cheng YANG Linsheng | 2009 | Journal of Environmental Sciences2009，21，9： | 48 |
| 2 | Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome显示文摘Accumulating evidence suggests that ketogenic diets(KDs)mediate the rise of circulating ketone bodies and exert a potential antiinflammatory effect;however,the consequences of this unique diet on colitis remain unknown.We performed a series of systematic studies using a dextran sulfate sodium(DSS)animal model of inflammatory colitis.Animals were fed with a KD,low-carbohydrate diet(LCD),or normal diet(ND).Germ-free mice were utilized in validation experiments.Colon tissues were analyzed by transcriptome sequencing,RT2 profiler PCR array,histopathology,and immunofluorescence.Serum samples were analyzed by metabolic assay kit.Fecal samples were analyzed by 16S rRNA gene sequencing,liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry.We observed that KD alleviated colitis by altering the gut microbiota and metabolites in a manner distinct from LCD.Quantitative diet experiments confirmed the unique impact of KD relative to LCD with a reproducible increase in Akkermansia,whereas the opposite was observed for Escherichia/Shigella.After colitis induction,the KD protected intestinal barrier function,and reduced the production of R0Ryt+CD3_group 3 innate lymphoid cells(ILC3s)and related inflammatory cytokines(IL-17a,IL-18,IL-22,Ccl4).Finally,fecal microbiota transplantation into germ-free mice revealed that the KD-mediated colitis inhibition and ILC3 regulation were dependent on the modification of gut microbiota.Taken together,our study presents a global view of microbiome-metabolomics changes that occur during KD colitis treatment,and identifies the regulation of gut microbiome and ILC3s as novel targets involving in IBD dietary therapy. | Cheng Kong Xuebing Yan Yongqiang Liu Linsheng Huang Yefei Zhu Jide He Renyuan Gao Matthew F.Kalady Ajay Goel Huanlong Qin Yanlei Ma | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 8 |
| 3 | Alterations in intestinal microbiota of colorectal cancer patients receiving radical surgery combined with adjuvant CapeOx therapy显示文摘An intricate relationship exists and interactions occur between gut microbiota and colorectal cancer(CRC).Radical surgery combined with adjuvant chemotherapy(AC) serves as the mainstream therapeutic scheme for most CRC patients.The current research was conducted to assess the effect of surgery or chemotherapy on gut microbiota.Forty-three CRC patients who received radical surgery and AC were enrolled.Fecal samples were collected preoperatively,postoperatively,and after the first to fifth cycles of postoperative chemotherapy.The microbial community of each sample was analyzed using high throughput 16S rRNA amplicon sequencing.Compared with preoperative samples,fecal samples collected postoperatively exhibited a significant decrease of obligate anaerobes,tumor-related bacteria,and butyric acid-producing bacteria.However,a significant increase of some conditional pathogens was observed.In addition,the AC regimen(CapeOx) was found to alter intestinal microbiota dramatically.In particular,several changes were observed after chemotherapy including an increase of pathogenic bacteria,the 'rebound effect' of chemotherapy-adapted bacteria,the shift of lactate-utilizing microbiota from Veillonella to Butyricimonas and Butyricicoccus,as well as the decrease of probiotics.Both radical surgery and CapeOx chemotherapy exert a non-negligible effect on the gut microbiota of CRC patients.Microbiota-based intervention may be beneficial for patients during postoperative clinical management. | Cheng Kong Renyuan Gao Xuebing Yan Linsheng Huang Jide He Hao Li Jie You Huanlong Qin | 2019 | Science China(Life Sciences)2019，62，9： | 7 |
| 4 | Access to residential care in Beijing, China: making the decision to relocate to a residential care facility显示文摘 | YANG CHENG MARK W. ROSENBERG WUYI WANG LINSHENG YANG HAIRONG LI | 2011 | Ageing and Society2011，，8： | 3 |
| 5 | Aging, health and place in residential care facilities in Beijing, China显示文摘 | Yang Cheng Mark W. Rosenberg Wuyi Wang Linsheng Yang Hairong Li | 2010 | Social Science & Medicine2010，，3： | 2 |
| 6 | Optimization of Hydrolysis Conditions for the Isolation of Angiotensin-I Converting Enzyme(ACE) Inhibitory Peptides from Rhopilema hispidum显示文摘To obtain the maximum angiotensin-I converting enzyme(ACE) inhibitory activity, the protein hydrolysis conditions of the jellyfish Rhopilema hispidum were optimized using response surface methodology(RSM). Trypsin was selected to produce R. hispidum protein hydrolysates(RPH) with ACE inhibitory activity. The optimal parameters for producing protein hydrolysates with the highest ACE inhibitory activity were as follows: hydrolysis time 5 h, hydrolysis temperature 50℃, and the enzyme-to-substrate ratio 6%. Under these conditions, the ACE inhibitory rate of RPH could reach 64.28% ± 5.72%. In addition, RPH contained high levels of Gly, Glu, Pro, Ala, Asp and Arg, with a molecular weight distribution range of 0.32–6.84 kDa. The following three novel ACE inhibitory peptides were isolated and identified: Ile-Gly-Glu-Thr-Gly-Pro, Gly-Ala-Thr-Gly-Pro-Ala-Gly-Tyr-Val and Gly-AlaPhe-Gly-Pro-Gly-Gly-Leu-Val-Gly-Arg-Pro. The IC_(50) values of the ACE inhibitory activity of these three purified peptides were 19.07, 27.42 and 31.26 μmol L^(-1), respectively. These results suggested that proteins and peptides isolated from R. hispidum could be utilized as antihypertensive functional food sources. | SUN Zhenliang QIN Huanlong CAO Duo YAN Xuebing LI Hao HUANG Linsheng QU Xiao KONG Cheng WANG Man | 2018 | Journal of Ocean University of China2018，17，6： | 2 |
| 7 | Mesoseale analyses of the Sichuan flood catastrophe, 11-15 July 1981 显示文摘 | Kuo Ying-Hwa Cheng Linsheng Anthes R A | 1986 | Mon Wea Rev1986，114，： | 1 |
| 8 | Numerical simulation of the 1981 Sichuan flood, Part I: Evolution of amesoscale southwest vortex显示文摘 | Yinghwa Kuo Linsheng Cheng Jianwen Bao | 1988 | Mon Wea Rev1988，116，12： | 1 |
| 9 | Synthesis, characterization and film morphology of dodecylpolysiloxane显示文摘 | AN Qiufeng CHENG Guangwen LI Linsheng | 2006 | J Appli Polym Sci2006，101，6： | 1 |
| 10 | Mesoscale analyisis of the Sichuan flood catastrophe, 11- 15 July 1981 显示文摘 | Kuo Ying-Hwa Cheng Linsheng A R Anthes | 1986 | Mon Wea Rev1986，114，： | 1 |
| 11 | Synthesis, characterization, and film morphology of dodecylpolysiloxane 显示文摘 | An Qiufeng Cheng Guangwen Li Linsheng | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
| 12 | Synthesis, characterization, and film morphology of dodecylpolysiloxane 显示文摘 | An Qiufeng Cheng Guangwen Li Linsheng | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
| 13 | Synthesis,characterization,and film morphology of dodecylpolysiloxane显示文摘 | AN Qiufeng CHENG Guangwen Li Linsheng | 2006 | J Appl Polym Sci2006，101，6： | 1 |
| 14 | Synthesis, Characterization and film morphology of dodecylpolysiloxane显示文摘 | Qiufeng An Guangwen Cheng Linsheng Li | 2006 | Journal of Applied Polymer Science2006，101，6： | 1 |
| 15 | Development of a Severe Sand-dust Storm Model and its Application to Northwest China显示文摘 | Xiao-Ling Zhang Linsheng Cheng Yong-Seung Chung | 2003 | Water Air and Soil Pollution: Focus2003，，2： | 1 |
| 16 | Association of cancer prevention awareness with liver cancer screening participation rates among a high-risk population:results from rural Anhui Province显示文摘To the Editor:Liver cancer(LC)is one of the most commonly diagnosed cancers and the leading cause of cancer mortality in the world,with approximately 905,677 new cases and 830,180 deaths in 2020.[1]Clearly,the huge burden exerted by LC highlights the need to effectively decrease the incidence and mortality of LC.Unfortunately,survival rates of LC have been maintained at a low level to date.A recent meta-analysis showed that the age-standardized 5-year LC survival rate in China was 10.1%in 2003 to 2005 and 12.1%in 2012 to 2015.[2]The poor prognosis of LC may be partly attributed to the advanced stages once diagnosed for most patients,suggesting that early detection,early diagnosed,and early treatment of LC are warranted.[3] | Zhenqiu Zha Yili Lyu Lingli Liu Tengfei Dong Beijing Cheng Linsheng Yang Zhirong Liu | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 17 | Access to residential care in Beijing, China: making the decision to relocate to a residential care facility显示文摘 | YANG CHENG MARK W. ROSENBERG WUYI WANG LINSHENG YANG HAIRONG LI | 2011 | Ageing and Society2011，，： | 1 |
| 18 | Aging, health and place in residential care facilities in Beijing, China显示文摘 | Yang Cheng Mark W. Rosenberg Wuyi Wang Linsheng Yang Hairong Li | 2010 | Social Science & Medicine2010，，3： | 1 |
| 19 | Metabolic features of the tumor microenvironment of gastric cancer and the link to the systemic macroenvironment显示文摘 | Jiye Aa Lianzhen Yu Min Sun Linsheng Liu Mengjie Li Bei Cao Jan Shi Jin Xu Liping Cheng Jun Zhou Tian Zheng Xinwen Wang Chunyan Zhao Rongrong Gu Fengyi Zhang Ruihua Shi Guangji Wang | 2012 | Metabolomics2012，，1： | 1 |
| 20 | Mesoscale analyses of Sichuan flood catastrophe 11--15 July 1981 显示文摘 | Kou Y H Cheng Linsheng Richard A A | 1986 | Mon Wea Rev1986，114，11： | 1 |
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