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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions显示文摘Acute myeloid leukemia(AML) is an aggressive hematological malignancy, and the mechanism underlying immune system involvement in leukemia development is unclear. In the present study, we utilized a myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3(MLLT3/MLL-AF9)-induced AML mouse model with or without exposure to irradiation. We found that the leukemia cells could survive and expand in hosts with intact immune systems, whereas leukemia progression was accelerated in mice with impaired immune systems. Moreover, the leukemia cells escaped from host immunosurveillance via editing their immunogenicity, including the up-regulation of an inhibitory antigen(i.e., CD47) and the down-regulation of active antigens(i.e., CD86, CD54, retinoic acid early transcript(RAE), histocompatibility 2, D region locus b(H2-Db) and H2-Dd). Natural killer(NK) cells were activated in the early phase of AML progression, whereas T cells were stimulated in the late phase. Furthermore, NK cell depletion showed that NK cells were necessary for the elimination of leukemia cells in our AML mouse model. Notably, CD155/CD226 primarily mediated the interaction between NK cells and leukemia cells and contributed to the antitumor effects of NK cells during the early phase of AML. Clinical data from patients with diverse hematological malignancies showed that CD155 expression was decreased in hematological malignancies. Taken together, our results demonstrate that NK cells play a pivotal role in immunosurveillance against leukemia cells during the early stage of AML primarily through the CD226/CD155 interaction; however, NK cells are not sufficient to eliminate leukemia cells. | WANG YaJie CHEN Chen DONG Fang MA ShiHui XU Jing GONG YueMin CHENG Hui ZHOU Yuan CHENG Tao HAO Sha | 2015 | Science China(Life Sciences)2015，58，12： | 3 |
| 3 | Integrated radiative and evaporative cooling beyond daytime passive cooling power limit显示文摘Radiative cooling technologies can passively gain lower temperature than that of ambient surroundings without consuming electricity,which has emerged as potential alternatives to traditional cooling methods.However,the limitations in daytime radiation intensity with a net cooling power of less than 150 W·m^(−2) have hindered progress toward commercial practicality.Here,we report an integrated radiative and evaporative chiller(IREC)based on polyacrylamide hydrogels combined with an upper layer of breathable poly(vinylidene fluoride-co-trifluoroethylene)fibers,which achieves a record high practical average daytime cooling power of 710 W·m^(−2).The breathable fiber layer has an average emissivity of over 76%in the atmospheric window,while reflecting 90%of visible light.This IREC possesses effective daytime radiative cooling while simultaneously ensuring evaporative cooling capability,enhancing daytime passive cooling effectively.As a result,IREC presents the practicability for both personal cooling managements and industrial auxiliary cooling applications.An IREC-based patch can assist in cooling human body by 13℃ low for a long term and biocompatible use,and IREC can maintain the temperature of industrial storage facilities such as oil tanks at room temperature even under strong sunlight irradiation.This work delivers the highest performance daytime passive cooling by simultaneous infrared radiation and water evaporation,and provides a new perspective for developing highly efficient,scalable,and affordable passive cooling strategy. | Houze Yao Huhu Cheng Qihua Liao Xuanzhang Hao Kaixuan Zhu Yajie Hu Liangti Qu | 2023 | Nano Research Energy2023，2，2： | 2 |
| 4 | Near-Term Projections of Global and Regional Land Mean Temperature Changes Considering Both the Secular Trend and Multidecadal Variability显示文摘Near-term climate projections are needed by policymakers; however, these projections are difficult because internally generated climate variations need to be considered. In this study, temperature change scenarios in the near-term period 2017-35 are projected at global and regional scales based on a refined multi-model ensemble approach that considers both the secular trend(ST) and multidecadal variability(MDV) in the Coupled Model Intercomparison Project Phase 5(CMIP5) simulations. The ST and MDV components are adaptively extracted from each model simulation by using the ensemble empirical mode decomposition(EEMD) filter, reconstructed via the Bayesian model averaging(BMA) method for the historical period 1901-2005, and validated for 2006-16. In the simulations of the 'medium' representative concentration pathways scenario during 2017-35, the MDV-modulated temperature change projected via the refined approach displays an increase of 0.44℃(90% uncertainty range from 0.30 to 0.58℃) for global land, 0.48℃(90% uncertainty range from 0.29 to 0.67℃) for the Northern Hemispheric land(NL), and 0.29℃(90% uncertainty range from 0.23 to 0.35℃) for the Southern Hemispheric land(SL). These increases are smaller than those projected by the conventional arithmetic mean approach. The MDV enhances the ST in 13 of 21 regions across the world. The largest MDV-modulated warming effect(46%) exists in central America. In contrast,the MDV counteracts the ST in NL, SL, and eight other regions, with the largest cooling effect(220%) in Alaska. | Yajie QI Zhongwei YAN Cheng QIAN Ying SUN | 2018 | Journal of Meteorological Research2018，32，3： | 2 |
| 5 | Droplet Manipulation and Crystallization Regulation in Inkjet-Printed Perovskite Film Formation显示文摘Emerging organic–inorganic metal halide perovskite materials have become the focus of the optoelectronics research community owing to their excellent photoelectric properties.Nevertheless,challenges still exist for transferring the lab-made devices to largearea industrial modules.Inkjet printing(IJP)technology provides a promising way to fill the gap because of its precise droplet control and uniform large-scale deposition functions.Hence,an in-depth understanding of inkjet-printed perovskite films in terms of droplet manipulation and crystallization regulation is critical for upscaling the perovskite devices to commercial usage.In this review,we give an overview of inkjet-printed high-quality perovskite films and provide guidelines on inkjet-printing large-scale highperformance perovskite devices.First,we analyze theories of droplet formation and perovskite nucleation/crystallization dynamics and then focus on summarizing the perovskite film-formation strategies via IJP,in the aspects of ink engineering,the printing process,and posttreatment.Furthermore,we review the recent advances of inkjet-printed perovskite films on optoelectronic devices,such as perovskite solar cells,perovskite light-emitting diodes,and perovskite photodetectors.Finally,we highlight the“Trilogy Strategies,”including ink engineering,printing process,and posttreatment for printing high-quality perovskite films. | Yajie Cheng Hangjuan Wu Junjie Ma Pengwei Li Zhenkun Gu Shuangquan Zang Liyuan Han Yiqiang Zhang Yanlin Song | 2022 | CCS Chemistry2022，4，5： | 1 |
| 6 | 显示文摘 | Harris V G Chen Zhaohui Cheng Yajie | 2006 | J Appl Phys2006，99，08： | 1 |
| 7 | Preparation of cuprous oxide particles of different crystallinity 显示文摘 | YAJIE D YADONG L CHENG W | 2001 | J Colloid Interface Sci2001，243，： | 1 |
| 8 | Preparation of cuprous oxide particles of different crystallinity显示文摘 | Dong Yajie Li Yadong Wsmg Cheng | 2001 | Journal of Colloid and Interface Science2001，243，1： | 1 |
| 9 | Inhibitory effect of coriander(Coriandrum sativum L.)extract marinades on the formation of polycyclic aromatic hydrocarbons in roasted duck wings显示文摘Coriander(Coriandrum sativum L.)is recognized for its antioxidant property,as a kind of natural phenolic-rich ingredient.Polycyclic aromatic hydrocarbons(PAHs)present a class of heat-driven hazards in foods,especially the processed meat.In this study,the effect of coriander root and leaf extract on the formation and inhibition of PAH8 in roasted duck wings was firstly investigated.Coriander root extract(CRE)and coriander leaf extract(CLE)with five concentration groups(200,400,600,800,1000 mg/L)were prepared respectively to marinate the duck wings.CRE marinade exhibited greater inhibitory effect on PAH8 formation in roasted duck wings that ranged from 65.0%-87.4%.The electron spin resonance study indicated a significantly positive correlation between PAH8 and free radical level,suggesting the participation of radicals in PAHs formation.Also,it was speculated that the inhibitory effect on PAH8 was related to the phenolic compounds identified in coriander marinades.CRE made greater inhibitory effect on the formation of PAH8 and could be considered as a kind of natural source to mitigate PAHs in heat-processed meat products. | Yajie Yu Yiqun Cheng Chong Wang Suhong Huang Yang Lei Ming Huang Xibin Zhang | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 10 | Preparation of Cuprous Oxide Particles of Different Crystallinity显示文摘 | Dong Yajie Li Yadong Wang Cheng | 2001 | Journal of Colloid and Interface Science2001，243，1： | 1 |
| 11 | 显示文摘 | Dong Yajie Li Yadong Wang Cheng | 2003 | J Colloid Interface Sci2003，243，： | 1 |
| 12 | Tumor microenvironment-responsive MnSiO_(3)-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy显示文摘Compared with traditional photodynamic therapy(PDT),ultrasound(US)triggered sonodynamic therapy(SDT)has a wide application prospect in tumor therapy because of its deeper penetration depth.Herein,a novel MnSiO_(3)-Pt(MP)nanocomposite composed of Mn Si O_(3)nanosphere and noble metallic Pt was successfully constructed.After modification with bovine serum albumin(BSA)and chlorine e6(Ce6),the multifunctional nanoplatform Mn SiO_(3)-Pt@BSA-Ce6(MPBC)realized the magnetic resonance imaging(MRI)-guided synergetic SDT/chemodynamic therapy(CDT).In this nanoplatform,sonosensitizer Ce6 can generate singlet oxygen(^(1)O_(2))to kill cancer cells under US irradiation.Meanwhile,the loaded Pt has the ability to catalyze the decomposition of overexpressed hydrogen peroxide(H_(2)O_(2))in tumor microenvironment(TME)to produce oxygen(O_(2)),which can conquer tumor hypoxia and promote the SDT-induced^(1)O_(2)production.In addition,MP can degrade in mildly acidic and reductive TME,causing the release of Mn^(2+).The released Mn^(2+) not only can be used for MRI,but also can generate hydroxyl radical(^·OH)for CDT by Fenton-like reaction.The multifunctional nanoplatform MPBC has high biological safety and good anticancer effect,which displays the great latent capacity in biological application. | Fan Jiang Chunzheng Yang Binbin Ding Shuang Liang Yajie Zhao Ziyong Cheng Min Liu Bengang Xing Ping’an Ma Jun Lin | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 13 | Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles显示文摘Indolylarylsulfones(IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs) with a unique scaffold and possess potent antiviral activity.To address the high cytotoxicity and improve safety profiles of IASs,we introduced various sulfonamide groups linked by alkyl diamine chain to explore the entrance channel of non-nucleoside inhibitors binding pocket.48 compounds were designed and synthesized to evaluate their anti-HIV-1 activities and reverse transcriptase inhibition activities.Especially,compound R_(10)L_(4) was endowed with significant inhibitory activity towards wild-type HIV-1(EC_(50(WT))=0.007μmol/L,SI=30,930) as well as a panel of single-mutant strains exemplified by L100I(EC_(50)=0.017μmol/L,SI=13,055),E138K(EC_(50)=0.017μmol/L,SI=13,123) and Y181C(EC_(50)=0.045μmol/L,SI=4753) which were superior to Nevirapine and Etravirine.Notably,R_(10)L_(4) was characterized with significantly reduced cytotoxicity(CC_(50)=216.51μmol/L) and showed no remarkable in vivo toxic effects(acute and subacute toxicity).Moreover,the computer-based docking study was also employed to characterize the binding mode between R_(10)L_(4) and HIV-1 RT.Additionally,R_(10)L_(4) presented an acceptable pharmacokinetic profile.Collectively,these results deliver precious insights for next optimization and indicate that the sulfonamide IAS derivatives are promising NNRTIs for further development. | Shenghua Gao Letian Song Yusen Cheng Fabao Zhao Dongwei Kang Shu Song Mianling Yang Bing Ye Wei Zhao Yajie Tang Erik De Clercq Christophe Pannecouque Peng Zhan Xinyong Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 14 | Pepper variome reveals the history and key loci associated with fruit domestication and diversification显示文摘Pepper(Capsicum spp.)is an important vegetable crop that provides a unique pungent sensation when eaten.Through construction of a pepper variome map,we examined the main groups that emerged during domestication and breeding of C.annuum,their relationships and temporal succession,and the molecular events underlying the main transitions.The results showed that the initial differentiation in fruit shape and pungency,increase in fruit weight,and transition from erect to pendent fruits,as well as the recent appearance of large,blocky,sweet fruits(bell peppers),were accompanied by strong selection/fixation of key alleles and introgressions in two large genomic regions.Furthermore,we identified Up,which encodes a BIG GRAIN protein involved in auxin transport,as a key domestication gene that controls erect vs pendent fruit orientation.The up mutation gained increased expression especially in the fruit pedicel through a 579-bp sequence deletion in its 5′upstream region,resulting in the phenotype of pendent fruit.The function of Up was confirmed by virus-induced gene silencing.Taken together,these findings constitute a cornerstone for understanding the domestication and differentiation of a key horticultural crop. | Yacong Cao Kang Zhang Hailong Yu Shumin Chen Donghui Xu Hong Zhao Zhenghai Zhang Yinqing Yang Xiaozhen Gu Xinyan Liu Haiping Wang Yaxin Jing Yajie Mei Xiang Wang Véronique Lefebvre Weili Zhang Yuan Jin Dongliang An Risheng Wang Paul Bosland Xixiang Li IIan Paran Baoxi Zhang Giovanni Giuliano Lihao Wang Feng Cheng | 2022 | Molecular Plant2022，15，11： | 0 |
| 15 | DNA crosslinking and recombination-activating genes 1/2(RAG1/2)are required for oncogenic splicing in acute lymphoblastic leukemia显示文摘Background:Abnormal alternative splicing is frequently associated with carcinogenesis.In B-cell acute lymphoblastic leukemia(B-ALL),double homeobox 4 fused with immunoglobulin heavy chain(DUX4/IGH)can lead to the aberrant production of E-26 transformation-specific family related gene abnormal transcript(ERGalt)and other splicing variants.However,the molecular mechanism underpinning this process remains elusive.Here,we aimed to know how DUX4/IGH triggers abnormal splicing in leukemia.Methods:The differential intron retention analysis was conducted to identify novel DUX4/IGH-driven splicing in B-ALL patients.X-ray crystallography,small angle X-ray scattering(SAXS),and analytical ultracentrifugation were used to investigate how DUX4/IGH recognize double DUX4 responsive element(DRE)-DRE sites.The ERGalt biogenesis and B-cell differentiation assays were performed to characterize the DUX4/IGH crosslinking activity.To check whether recombination-activating gene 1/2(RAG1/2)was required for DUX4/IGH-driven splicing,the proximity ligation assay,co-immunoprecipitation,mammalian two hybrid characterizations,in vitro RAG1/2 cleavage,and shRNA knock-down assays were performed.Results:We reported previously unrecognized intron retention events in Ctype lectin domain family 12,member A abnormal transcript(CLEC12Aalt)and chromosome 6 open reading frame 89 abnormal transcript(C6orf89alt),where also harbored repetitive DRE-DRE sites.Supportively,X-ray crystallography and SAXS characterization revealed that DUX4 homeobox domain(HD)1-HD2 might dimerize into a dumbbell-shape trans configuration to crosslink two adjacent DRE sites.Impaired DUX4/IGH-mediated crosslinking abolishes ERGalt,CLEC12Aalt,and C6orf89alt biogenesis,resulting in marked alleviation of its inhibitory effect on B-cell differentiation.Furthermore,we also observed a rare RAG1/2-mediated recombination signal sequence-like DNA edition in DUX4/IGH target genes.Supportively,shRNA knock-down of RAG1/2 in leukemic Reh cells consistently impaired the biogenesis of ERGalt,CLEC12Aalt,and C6orf89alt.Conclusions:All these results suggest that DUX4/IGH-driven DNA crosslinking is required for RAG1/2 recruitment onto the double tandem DRE-DRE sites,catalyzing V(D)J-like recombination and oncogenic splicing in acute lymphoblastic leukemia. | Hao Zhang Nuo Cheng Zhihui Li Ling Bai Chengli Fang Yuwen Li Weina Zhang Xue Dong Minghao Jiang Yang Liang Sujiang Zhang Jianqing Mi Jiang Zhu Yu Zhang Sai-Juan Chen Yajie Zhao Xiang-Qin Weng Weiguo Hu Zhu Chen Jinyan Huang Guoyu Meng | 2021 | Cancer Communications2021，41，11： | 0 |
| 16 | Illuminating the cells:transient transformation of citrus to study gene functions and organelle activities related to fruit quality显示文摘Although multiple microscopic techniques have been applied to horticultural research,few studies of individual organelles in living fruit cells have been reported to date.In this paper,we established an efficient system for the transient transformation of citrus fruits using an Agrobacterium-mediated method.Kumquat(Fortunella crassifolia Swingle)was used;it exhibits higher transformation efficiency than all citrus fruits that have been tested and a prolonged-expression window.Fruits were transformed with fluorescent reporters,and confocal microscopy and live-cell imaging were used to study their localization and dynamics.Moreover,various pH sensors targeting different subcellular compartments were expressed,and the local pH environments in cells from different plant tissues were compared.The results indicated that vacuoles are most likely the main organelles that contribute to the low pH of citrus fruits.In summary,our method is effective for studying various membrane trafficking events,protein localization,and cell physiology in fruit and can provide new insight into fruit biology research. | Jinli Gong Zhen Tian Xiaolu Qu Qiunan Meng Yajie Guan Ping Liu Chuanwu Chen Xiuxin Deng Wenwu Guo Yunjiang Cheng Pengwei Wang | 2021 | Horticulture Research2021，8，1： | 0 |
| 17 | Observations of the solar corona during the total solar eclipse on 21 August 2017显示文摘The Sun’s tenuous outer atmosphere,the corona,emits only about one-millionth as much light as the solar surface.In ancient times the corona was observed by human beings only during total solar eclipses,when the strong emission of visible light from the photosphere was completely blocked by the Moon.In 1931, | Hui Tian ZhongQuan Qu YaJie Chen LinHua Deng ZhengHua Huang Hao Li Yue Zhong Yu Liang JingWen Zhang YiGong Zhang BaoLi Lun XiangMing Cheng XiaoLi Yan ZhiKe Xue YuXin Xin ZhiMing Song YingJie Zhu Tanmoy Samanta | 2017 | Earth and Planetary Physics2017，1，1： | 0 |
| 18 | Immigration,transformation,and emission control of sulfur and nitrogen during gasification of MSW:Fundamental and engineering review显示文摘This paper proposes a comprehensive summary and analysis of an important issue during municipal solid waste(MSW)gasification-sulfur and nitrogen pollution.It provides an overview of the fundamentals of MSW and the basic aspects of nitrogen and sulfur elements.Their characteristics of immigration,transformation and distribution during gasification with control solutions in realized or potential engineering are also concluded.The analysis indicates that the complete scenario of the occurrence form of sulfur and nitrogen elements in MSW is difficult to obtain,owing to the diverse sources and complicated compositions.However,with the assistance of advanced characterization and quantification methods(XPS,XRD,TG-FTIR,et al.),the common sulfur-and nitrogen-containing compounds in both organic and inorganic states can be detected.Adjustment of gasification conditions can regulate the transformation of these elements for emission control.The multiple pollutants including H_(2)S,SO_(x),COS,NH_(3),HCN and NO_(x)cannot be eliminated by one-step treatment but a combination of adsorption and catalytic treatments may realize the control goal.This research aims to benefit meeting emission standards during MSW gasification and to provide a reference for other processes such as incineration,pyrolysis and other feedstocks like biomass and refuse derived fuel(RDF). | Shuchao Cheng Xueyu Ding Xinxin Dong Mengjie Zhang Xinqi Tian Yang Liu Yaji Huang Baosheng Jin | 2023 | Carbon Resources Conversion2023，6，3： | 0 |
| 19 | Recent progress in self-repairing coatings for corrosion protection on magnesium alloys and perspective of porous solids as novel carrier and barrier显示文摘Featuring low density and high specific strength, magnesium(Mg) alloys have attracted wide interests in the fields of portable devices and automotive industry. However, the active chemical and electrochemical properties make them susceptible to corrosion in humid, seawater, soil,and chemical medium. Various strategies have revealed certain merits of protecting Mg alloys. Therein, engineering self-repairing coatings is considered as an effective strategy, because they can enable the timely repair for damaged areas, which brings about long-term protection for Mg alloys. In this review, self-repairing coatings on Mg alloys are summarized from two aspects, namely shape restoring coatings and function restoring coatings. Shape restoring coatings benefit for swelling, shrinking, or reassociating reversible chemical bonds to return to the original state and morphology when coatings broken;function self-repairing coatings depend on the release of inhibitors to generate new passive layers on the damaged areas. With the advancement of coating research and to fulfill the demanding requirements of applications, it is an inevitable trend to develop coatings that can integrate multiple functions(such as stimulus response, self-repairing, corrosion warning,and so on). As a novel carrier and barrier, porous solids, especially covalent organic frameworks(COFs), have been respected as the future development of self-repairing coatings on Mg alloys, due to their unique, diverse structures and adjustable functions. | Yajie Yang Yufei Wang Mei-Xuan Li Tianshuai Wang Dawei Wang Cheng Wang Min Zha Hui-Yuan Wang | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
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