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您的检索式：作者名="Cheng Yinglei"
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| 1 | A NOVEL ALGORITHM OF MULTI-SENSOR IMAGE FUSION BASED ON WAVELET PACKET TRANSFORM显示文摘In order to enhance the image information from multi-sensor and to improve the abilities of the information analysis and the feature extraction, this letter proposed a new fusion approach in pixel level by means of the Wavelet Packet Transform (WPT). The WPT is able to decompose an image into low frequency band and high frequency band in higher scale. It offers a more precise method for image analysis than Wavelet Transform (WT). Firstly, the proposed approach employs HIS (Hue, Intensity, Saturation) transform to obtain the intensity component of CBERS (China-Brazil Earth Resource Satellite) multi-spectral image. Then WPT transform is employed to decompose the intensity component and SPOT (Systeme Pour I'Observation de la Therre ) image into low frequency band and high frequency band in three levels. Next, two high frequency coefficients and low frequency coefficients of the images are combined by linear weighting strategies. Finally, the fused image is obtained with inverse WPT and inverse HIS. The results show the new approach can fuse details of input image successfully, and thereby can obtain a more satisfactory result than that of HM (Histogram Matched)-based fusion algorithm and WT-based fusion approach. | Cheng Yinglei Zhao Rongchun Hu Fuyuan Li Ying | 2006 | Journal of Electronics(China)2006，23，2： | 3 |
| 2 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
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