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您的检索式：作者名="Chengang Lyu"
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| 1 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 2 | High-sensitivity, high-spatial-resolution distributed strain sensing based on a poly(methyl methacrylate) chirped fiber Bragg grating显示文摘In this study,a high-sensitivity,high-spatial-resolution distributed strain-sensing approach based on a poly(methyl methacrylate)chirped fiber Bragg grating(CFBG)is proposed and experimentally demonstrated.Linearly chirped FBGs in a polymer optical fiber provide an alternative to the silica fiber owing to the lower Young’s modulus,which can yield a higher stress sensitivity under the same external force.According to the spatial wavelength-encoded characteristic of the CFBG,a fully distributed strain measurement can be achieved by optical frequency-domain reflectometry.Through time-/space-resolved short-time Fourier transform,the applied force can be located by the beat frequency originated from the space-induced time delay and measured by the differential frequency offset originated from the strain-induced dispersion time delay.In a proof-of-concept experiment,a high spatial resolution of 1 mm over a gauge length of 40 mm and a strain resolution of 0.491 Hz/μεwere achieved. | Chengang Lyu Ziqi Liu Ziqiang Huo Chunfeng Ge Xin Cheng Haw-Yaw Tam | 2020 | Photonics Research2020，8，7： | 2 |
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