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| 1 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 2 | INTEGRATED APPROACH TO ASSEMBLY SEQUENCE PLANNING OF C0MPLEX PRODUCTS显示文摘Assembly sequence planning will be more difficult due to the in-creasing complexity of products.An integrated approach to assembly sequence planning of complex products applying de-composition-planning-combination strategy is presented.First,an assembly is decomposed into a hierarchical structure using an assembly structure representation based on connectors.Then,an assembly planning system is used to generate the sequences that are locally optimal for each leaf partition in the structure hierarchy.By combining the local sequences systematically in a bottom-up manner and choosing suitable ones from the merged sequences,the assembly sequence of each parent structure including the whole assembly is generated.An integrated system has been completed.A complex product is given to illustrate the feasibility and the practicality of the approach. | Wang Junfeng Liu Jihong Zhong Yifang CAD Center,Huazhong University of Science and Technology,Wuhan 430074, China | 2004 | Chinese Journal of Mechanical Engineering2004，17，2： | 8 |
| 3 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 4 | Reputation-based secure spectrum situation fusion in distributed cognitive radio networks显示文摘In distributed cognitive radio(CR) network, the cooperative spectrum situation sensing based on consensus scheme may be disrupted by spectrum sensing data falsification(SSDF) attacks. In this paper, a secure spectrum situation fusion scheme based on reputation is proposed to counter attacks. The neighboring nodes of secondary users(SUs) get the corresponding dynamic trust value according to their behavior, which restrict the impact of the malicious behavior on the premise to ensure information interaction of normal nodes. Theoretical analysis and simulation results show that the consensus fusion scheme based on reputation has better performance than the existing algorithm which eliminates the neighboring node with the biggest deviation value from mean value. It demonstrates that the proposed scheme not only achieves better convergence properties but also has higher detection probability than the existing scheme in the process of spectrum situation fusion. | Li Fangwei Liu Fan Zhu Jiang Nie Yifang | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，3： | 6 |
| 5 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 6 | Collaborative validation of GlobeLand30:Methodology and practices显示文摘30-m Global Land Cover(GLC)data products permit the detection of land cover changes at the scale of most human land activities,and are therefore used as fundamental information for sustainable development,environmental change studies,and many other societal benefit areas.In the past few years,increasing efforts have been devoted to the accuracy assessment of GlobeLand30 and other finer-resolution GLC data products.However,most of them were conducted either within a limited percentage of map sheets selected from a global scale or in some individual countries(areas),and there are still many areas where the uncertainty of 30-m resolution GLC data products remains to be validated and documented.In order to promote a comprehensive and collaborative validation of 30-m GLC data products,the GEO Global Land Cover Community Activity had organized a project from 2015 to 2017,to examine and explore its major problems,including the lack of international agreed validation guidelines and on-line tools for facilitating collaborative validation activities.With the joint effort of experts and users from 30 GEO member countries or participating organizations,a technical specification for 30-m GLC validation was developed based on the findings and experiences.An on-line validation tool,GLCVal,was developed by integrating land cover validation procedures with the service computing technologies.About 20 countries(regions)have completed the accuracy assessment of GlobeLand30 for their territories with the guidance of the technical specification and the support of GLCVal. | Jun Chen Lijun Chen Fei Chen Yifang Ban Songnian Li Gang Han Xiaohua Tong Chuang Liu Vanya Stamenova Stefan Stamenov | 2021 | Geo-Spatial Information Science2021，24，1： | 5 |
| 7 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 8 | Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century显示文摘Air pollution is a severe threat to public health globally,afecting everyone in developed and developing countries alike.Among diferent air pollutants,particulate mater(PM),particularly combustion-produced ine PM(PM2.5) has been shown to play a major role in inducing various adverse health efects.Strong associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality,cardiopulmonary diseases,asthma and allergic sensitization,and lung cancer.he mechanisms of PM-induced toxicological efects are related to their size,chemical composition,lung clearance and retention,cellular oxidative stress responses and pro-inlammatory efects locally and systemically.Particles in the ultraine range(<100 nm),although they have the highest number counts,surface area and organic chemical content,are oten overlooked due to insuicient monitoring and risk assessment.Yet,ample studies have demonstrated that ambient ultraine particles have higher toxic potential compared with PM2.5.In addition,the rapid development of nanotechnology,bringing ever-increasing production of nanomaterials,has raised concerns about the potential human exposure and health impacts.All these add to the complexity of PM-induced health efects that largely remains to be determined,and mechanistic understanding on the toxicological efects of ambient ultraine particles and nanomaterials will be the focus of studies in the near future. | Tian Xia Yifang Zhu Lina Mu Zuo-Feng Zhang Sijin Liu | 2016 | National Science Review2016，3，4： | 3 |
| 9 | Epidemiological Study of Outpatients in Rabies Post-Exposure Prophylaxis Clinics—Tianjin Municipality,China,2020显示文摘Summary What is already known on this topic?Rabies remains a serious public health problem in China.The only way to prevent the fatal disease was through timely and adequate post-exposure prophylaxis(PEP).What is added by this report?Among all the 126,133 cases visited Tianjin PEP clinics during 2020,more than 90%of the patients were injured by domestic dogs or cats,and about 70%of the animals received vaccination.Most outpatients have knowledge of rabies and show high compatibility with PEP. | Yifang Liu Lin Li Jie Lyu Cheng Su | 2021 | China CDC weekly2021，3，39： | 3 |
| 10 | Evaluating the Role of International Trade in the Growth of China's CO_2 Emissions显示文摘International trade matters in assessing the extent of China’s responsibility for CO2 emissions.A determining factor is whether emissions are measured in production or in consumption terms.Based on a series of input-output tables,an empirical analysis is conducted to measure the impact of international trade on China’s emissions growth during the period 1997 to 2007.The authors also measure the impact on emissions of bilateral trade between China and US,European Union and Japan.As the largest of the developing countries,China has a trade surplus that can substantially influence its measured responsibility for emissions.The authors consider some policy implications for international negotiations to reduce global greenhouse gas emissions. | JIANG Xuemei LIU Yifang ZHANG Jin ZU Lei WANG Shouyang GREEN Christopher | 2015 | Journal of Systems Science & Complexity2015，28，4： | 3 |
| 11 | Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy显示文摘 | Yifang Han Hui Cai Liye Ma Yibo Ding Xiaojie Tan Wenjun Chang Wei Guan Yan Liu Qiuxia Shen Yongwei Yu Hongwei Zhang Guangwen Cao | 2013 | Cancer2013，，19： | 2 |
| 12 | Phase Boundary Mapping in ZrNiSn Half-Heusler for Enhanced Thermoelectric Performance显示文摘The solubility range of interstitial Ni in the ZrNi1+xSn half-Heusler phase is a controversial issue,but it has an impact on the thermoelectric properties.In this study,two isothermal section phase diagrams of the Zr-Ni-Sn ternary system at 973K and 1173 K were experimentally constructed based on the binary phase diagrams of Zr-Ni,Zr-Sn,and Ni-Sn.The thermodynamic equilibrium phases were obtained after a long time of heating treatment on the raw alloys prepared by levitation melting.Solubilities of x<0:07 at 973 K and x<0:13 at 1173 K were clearly indicated.An intermediate-Heusler phase with a partly filled Ni void was observed,which is believed to be beneficial to the lowered lattice thermal conductivity.The highest ZT value~0:71 at 973 K was obtained for ZrNi_(1.11)Sn_(1.04).The phase boundary mapping provides an important instruction for the further optimization of ZrNiSn-based materials and other systems. | Xiaofang Li Pengbo Yang Yumei Wang Zongwei Zhang Dandan Qin Wenhua Xue Chen Chen Yifang Huang Xiaodong Xie Xinyu Wang Mujin Yang Cuiping Wang Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2020 | Research2020，，1： | 2 |
| 13 | The Effect of Corporate Governance on Debt Financing Cost of Listed Companies显示文摘In recent years,bank credit business is booming with the increasing borrowing intention of China’s listed companies,and debt financing has become the major approach among listed companies’financing strategies.As a series of institutional arrangements about rights,responsibilities and benefits between different shareholders,corporate governance mechanism has a significant influence on the cost of debt financing.This paper employs variable coefficient panel data model to investigate the relationship of the listed company’s debt financing costs and corporate governance mechanism in terms of structural characteristics and time series characteristics.The results show that optimizing the structure of both Board of Directors and Board of Supervisors,establishing a reasonable management incentive system and reducing the concentration of ownership properly can directly contribute to a lower company’s debt financing costs.Meanwhile,property rights have an interactive influence on corporate governance from four aspects,which indirectly effect in company’s debt financing costs. | LI Lin DONG Fangyu LIU Yifang HUANG Haijun WANG Shouyang | 2016 | Journal of Systems Science & Complexity2016，29，3： | 2 |
| 14 | Novel lowdensity lipoprotein (LDL) oxidation model: Antioxidant capacity for the inhibition of LDL oxidation 显示文摘 | CHU Yifang LIU Ruihai | 2004 | J Agricultural and Food Chemistry2004，52，： | 1 |
| 15 | Comparison of the crystalline properties and structural changes of starches from high-amylose transgenic rice and its wild type during heating显示文摘 | Cunxu Wei Fengling Qin Weidong Zhou Bin Xu Chong Chen Yifang Chen Youping Wang Minghong Gu Qiaoquan Liu | 2011 | Food Chemistry2011，，3： | 1 |
| 16 | Research and Implementation of Task Management Model in Product Development Process Management显示文摘The implementation of product development process management (PDPM) is an effective means of developing products with higher quality in shorter lead time. It is argued in this paper that product, data, person and activity are basic factors in PDPM With detailed analysis of these basic factors and their relations in product developmed process, all product development activities are considered as tasks and the management of product development process is regarded as the management of task execution A task decomposition based product development model is proposed with methods of constructing task relation matrix from layer model and constraint model resulted from task decomposition. An algorithm for constructing directed task graph is given and is used in the management of tasks. Finally, the usage and limitation of the proposed PDPM model is given with further work proposed. | Liu Qinghua Wan Li Zhong Yifang (CAN Center, Huazhong University of Science and Technology, Hubei, China Qhliu hust 263.net) | 2000 | Computer Aided Drafting,Design and Manufacturing2000，10，1： | 1 |
| 17 | Symbolic computation and families of Jacobi elliptic function solutions of the (2 + 1)-dimensional Nizhnik-Novikov-Veselov equation显示文摘 | Wang Dengshan Liu Yifang Zhang Hongqing | | 0，，02： | 1 |
| 18 | Antioxidant and antiproliferativeactivities of common fruits显示文摘 | SUN Jie CHU Yifang LIU Ruihai | 2002 | Journal of Agricultural and Food Chemistry2002，50，25： | 1 |
| 19 | Thermal properties measurements of renatured gelatin using conventional and temperature modulated differential scanning calorimetry显示文摘 | Dai Chian Chen Yifang LIU Mingwei | 2006 | JAppl Polymer Science2006，99，4： | 1 |
| 20 | A Novel Ant Colony Algorithm for Assembly Sequence Planning 显示文摘 | Wang Junfeng Liu Jihong Zhong Yifang | 2004 | Advanced Manufacturing Technology2004，25，1112： | 1 |
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