|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hybrid artificial bee colony algorithm with variable neighborhood search and memory mechanism显示文摘Artificial bee colony(ABC) is one of the most popular swarm intelligence optimization algorithms which have been widely used in numerical optimization and engineering applications. However, there are still deficiencies in ABC regarding its local search ability and global search efficiency. Aiming at these deficiencies,an ABC variant named hybrid ABC(HABC) algorithm is proposed.Firstly, the variable neighborhood search factor is added to the solution search equation, which can enhance the local search ability and increase the population diversity. Secondly, inspired by the neuroscience investigation of real honeybees, the memory mechanism is put forward, which assumes the artificial bees can remember their past successful experiences and further guide the subsequent foraging behavior. The proposed memory mechanism is used to improve the global search efficiency. Finally, the results of comparison on a set of ten benchmark functions demonstrate the superiority of HABC. | FAN Chengli FU Qiang LONG Guangzheng XING Qinghua | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 49 |
| 2 | Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy显示文摘The prevalence of skin cancer is rising along with the rapid population aging in recent years.Traditional therapies,such as surgical treatment,radiotherapy,chemotherapy,photodynamic therapy,and immunotherapy,may accompany serious side effects,limiting their clinical benefits.According to the biological characteristics of skin cancer,we have already established two kinds of synergetic systems of photothermal therapy(microneedle)and chemotherapy,containing gold nanorods(GNR).Although the microneedle system exhibited great potential for skin cancer treatment,the system could be still improved further.So,we designed a near-infrared lightresponsive 5-fluorouracil(5-Fu)and indocyanine green(ICG)loaded monomethoxy-poly(ethylene glycol)-polycaprolactone(MPEG-PCL)nanoparticle(5-Fu-ICG-MPEG-PCL),and then 5-Fu-ICG-MPEG-PCL was integrated with a hyaluronic acid dissolvable microneedle system(HA MN)to get 5-Fu-ICG-MPEG-PCL loaded HA MN for treating skin cancers,including human epidermoid cancer and melanoma.In this system,hyaluronic acid,the microneedle carrier,possesses good skin penetration ability and is approved by FDA as a pharmaceutical adjuvant;5-Fu is recommended by FDA for skin cancer treatment;ICG,a photothermal agent,possesses a strong photothermal ability and is approved by FDA for its use in the human body.We hypothesized that 5-Fu-ICG-MPEG-PCL could be delivered by the dissolvable microneedle through the skin,and the release behavior of the drug in the nanoparticle could be controlled by near-infrared light for achieving a single-dose cure of skin cancer,improving the cure rate of skin cancer and providing a new idea and possibility for the clinical treatment of skin cancer. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2020 | Bioactive Materials2020，5，3： | 17 |
| 3 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 4 | Ripple-effect analysis for operational architecture of air defense systems with supernetwork modeling显示文摘In order to solve the problem that the ripple-effect analysis for the operational architecture of air defense systems(OAADS)is hardly described in quantity with previous modeling approaches,a supernetwork modeling approach for the OAADS is put forward by extending granular computing. Based on that operational units and links are equal to different information granularities, the supernetwork framework of the OAADS is constructed as a 'fournetwork within two-layer' structure by forming dynamic operating coalitions, and measuring indexes of the ripple-effect analysis for the OAADS are given combining with Laplace spectral radius. In this framework, via analyzing multidimensional attributes which inherit relations between operational units in different granular scales, an extended granular computing is put forward integrating with a topological structure. Then the operation process within the supernetwork framework, including transformation relations between two layers in the vertical view and mapping relations among functional networks in the horizontal view, is studied in quantity. As the application case shows, comparing with previous modeling approaches, the supernetwork model can validate and analyze the operation mechanism in the air defense architecture, and the ripple-effect analysis can be used to confirm the key operational unit with micro and macro viewpoints. | Zhigang Zou Fuxian Liu Shiman Sun Lu Xia Chengli Fan | 2014 | Journal of Systems Engineering and Electronics2014，25，2： | 5 |
| 5 | Optimal index shooting policy for layered missile defense system显示文摘In order to cope with the increasing threat of the ballistic missile(BM)in a shorter reaction time,the shooting policy of the layered defense system needs to be optimized.The main decisionmaking problem of shooting optimization is how to choose the next BM which needs to be shot according to the previous engagements and results,thus maximizing the expected return of BMs killed or minimizing the cost of BMs penetration.Motivated by this,this study aims to determine an optimal shooting policy for a two-layer missile defense(TLMD)system.This paper considers a scenario in which the TLMD system wishes to shoot at a collection of BMs one at a time,and to maximize the return obtained from BMs killed before the system demise.To provide a policy analysis tool,this paper develops a general model for shooting decision-making,the shooting engagements can be described as a discounted reward Markov decision process.The index shooting policy is a strategy that can effectively balance the shooting returns and the risk that the defense mission fails,and the goal is to maximize the return obtained from BMs killed before the system demise.The numerical results show that the index policy is better than a range of competitors,especially the mean returns and the mean killing BM number. | LI Longyue FAN Chengli XING Qinghua XU Hailong ZHAO Huizhen | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 1 |
| 6 | Double adaptive selection strategy for MOEA/D显示文摘Since most parameter control methods are based on prior knowledge, it is difficult for them to solve various problems.In this paper, an adaptive selection method used for operators and parameters is proposed and named double adaptive selection(DAS) strategy. Firstly, some experiments about the operator search ability are given and the performance of operators with different donate vectors is analyzed. Then, DAS is presented by inducing the upper confidence bound strategy, which chooses suitable combination of operators and donates sets to optimize solutions without prior knowledge. Finally, the DAS is used under the framework of the multi-objective evolutionary algorithm based on decomposition, and the multi-objective evolutionary algorithm based on DAS(MOEA/D-DAS) is compared to state-of-the-art MOEAs. Simulation results validate that the MOEA/D-DAS could select the suitable combination of operators and donate sets to optimize problems and the proposed algorithm has better convergence and distribution. | GAO Jiale XING Qinghua FAN Chengli LIANG Zhibing | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 1 |
| 7 | Role-based approaches for operational tasks modeling and flexible decomposition显示文摘In order to realize the fact that operational tasks can be decomposed flexibly with new tasks random adding, role-based approaches for operational tasks model and the flexibility decomposition are proposed. Firstly, aiming at the shortcomings of previous task decomposition methods, operational role concepts are introduced to design a computing framework of task flexibility decomposition. Within the framework, task structure matrixes are constructed for tasks decomposition with the mapping relations of information interaction and action process among tasks. On basis of this, via giving operational decomposition granularity, a flexibility approach of operational task decomposition is put forward with three parts about task decomposition granularity adjustment, tasks module partition with different operational role patterns and task decomposition scheme evaluation. Finally, as an application case shown, it is validated that the proposed approaches for tasks modeling and decomposition are available. By comparing with previous decomposition approaches, the proposed approach, within three types of operational roles, has strong environmental adaptability and scheme diversity, which can restrain calculation complexity increment for realizing task flexible decomposition effectively. | ZhigangZou Wangfang Che Shusheng Wang Yun Bai Chengli Fan | 2016 | Journal of Systems Engineering and Electronics2016，27，6： | 1 |
| 8 | Erratum to “Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy” [Bioact. Mater. 5 (2020) 542–552]显示文摘This is an erratum to our published paper,the scale bar in Fig.6A was wrong[1].In the paper mentioned above,the scale bar in Fig.6A was wrong[1].We missed a decimal point of the scale bar.The correct scale bar of 5-Fu-ICG-MPEG-PCL@HA MN should be 1.00 mm instead of 100 mm.We have corrected the scale bar in Fig.6 as follows. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2021 | Bioactive Materials2021，6，1： | 0 |
| 9 | Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2-Knockout Rat Model of Rett Syndrome显示文摘Rett syndrome is a progressive neurodevelopmental disorder that lacks effective treatments.Although deep-brain stimulation can alleviate some symptoms in Rett model mice,this interventional manipula-tion requires deliberate surgical operations.Here,we report that electro-acupuncture stimulation(EAS)can ameliorate symptoms of an Mecp2-knockout rat model of Rett syndrome from the remote acupoints Baihui(GV 20),Yongquan(KI 1),and Shenmen(HT 7).We find that EAS not only prolongs the survival time of Rett rats,but also improves their behavior ability,including locomotion,motor coordination,and social interaction.Neural activation was observed in the substantia nigra of the midbrain,corpus striatum,and cerebral cortex of wild-type and Rett model rats,as reflected by the increased expression of the c-Fos protein.Hence,EAS provides a potential promising therapeutic tool for treating neurodevel-opmental diseases. | Yanhong Sun Zhifang Chen Yi Xu Yuefang Zhang Zhilei Ge Chenglie Lin Yi Zhou Fangfei Zhao Meiling Yan Xinyi Liu Ying Zhu Jimin Gao Hongyi Li Lihua Wang Jun Hu Zilong Qiu Chunhai Fan | 2022 | Engineering2022，8，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员