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| 1 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 2 | Interface self‐reinforcing ability and antibacterial effect of natural chitosan modified polyvinyl chloride‐based wood flour composites显示文摘 | Kaimeng Xu Kaifu Li Tuhua Zhong Chengping Xie | 2014 | J. Appl. Polym. Sci2014，，3： | 2 |
| 3 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 4 | Human malignant glioma cells expressing functional formylpeptide receptor recruit endo- thelial progenitor cells for neovascularization 显示文摘 | Chengping Xu Huarong Zhang Feilan Chen | 2010 | Intemational Immu- nopharmacology2010，10，12： | 1 |
| 5 | Adding Fuel to the Fire by Increased GABAergic Inhibition:A Seizure-Amplifying Nigra-Parafascicular Pathway显示文摘Epilepsy is a common neurological disorder characterized by recurrent seizures.Most anti epileptic drugs (AEDs)work by regulating the balance of the excitatory glutamatergic and inhibitory GABAergic transmission.However,the current AEDs cannot successfully control seizures in most (>70%) patients with temporal lobe epilepsy (TLE)[1],in whom seizures typically begin in the hippocampus.This may be caused by changes in the synaptic efficacy and remodeling of neural circuits,such as alterations in the distribution/expression of GABA_A receptor subunits and mossy-fiber sprouting.Since Dr.Karen Gale and colleagues originally described the seizure-modulating effects of nigral GABAergic transmission in the early 1980s [2]。 | Yeping Ruan Rongrong Chen Jie Yu Chengping Wen Zhenghao Xu | 2021 | Neuroscience Bulletin2021，37，1： | 1 |
| 6 | Effects of input method and display mode of situation map on early warning aircraft reconnaissance task performance with different information complexities显示文摘Early Warning Aircraft(EWA)are the main force for air detection and its Human-Machine Interface(HMI)should be designed to support task efficiency and safety.With the appli-cation of advanced input method and interface design in EWA,little is known about their actual usability in terms of human factors and ergonomics.The aim of this study was to investigate the effects of the input method and display mode of the situation map on EWA reconnaissance task performance with different information complexities.Eighteen participants attended a three-factor within-subject design experiment with input method(touch screen and mouse),display mode of the situation map(color and grayscale),and information complexity(high and low)as the inde-pendent variables.Participant behavior performance,subjective workload,heart rate/heart rate variability,and eye movements were recorded as the dependent variables.The results suggest that a touch screen requires greater task completion time and has greater physical demands than mouse operation;however,it also facilitates information processing by reducing the average fixation time.Color mode significantly decreases saccade counts compared to grayscale mode and is considered more appropriate for target search tasks as it induces less visual search load.High information complexity produces significant negative effects on behavior performance and subjective workload.It also has significant interaction effects with input method on fixation and saccade counts.The findings have implications in the optimization design of Human–Machine Interface for EWA task systems. | Chaoran LIANG Shuang LIU Xiaoru WANYAN Chengping LIU Xu XIAO Yuchen MIN | 2023 | Chinese Journal of Aeronautics2023，36，1： | 1 |
| 7 | Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial显示文摘Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19. | Jianfeng Bao Zhijun Xie Shourong Liu Lin Huang Jing Sun Yujun Tang Haiping Chen Jianjiang Qi Jianchun Guo Liangbin Miao Zhaoyi Li Hui Yang Yi Zhang Zhiyu Li Yuan Xu Shengyou Lin Yunhao Xun Li Zhang Jie Bao Zhaobin Cai Jinsong Huang Chengping Wen | 2021 | Clinical Complementary Medicine and Pharmacology2021，1，1： | 0 |
| 8 | Brain Pathology in COVID-19:Clinical Manifestations and Potential Mechanisms显示文摘Neurological manifestations of coronavirus disease 2019(COVID-19)are less noticeable than the respiratory symptoms,but they may be associated with disability and mortality in COVID-19.Even though Omicron caused less severe disease than Delta,the incidence of neurological manifestations is similar.More than 30%of patients experienced“brain fog”,delirium,stroke,and cognitive impairment,and over half of these patients presented abnormal neuroimaging outcomes.In this review,we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with those in patients with influenza infection.We also illustrate the structure and cellular invasion mechanisms of SARS-CoV-2 and describe the pathway for central SARS-CoV-2 invasion.In addition,we discuss direct damage and other pathological conditions caused by SARS-CoV-2,such as an aberrant interferon response,cytokine storm,lymphopenia,and hypercoagulation,to provide treatment ideas.This review may offer new insights into preventing or treating brain damage in COVID-19. | Zhixing Xu Hui Wang Siya Jiang Jiao Teng Dongxu Zhou Zhong Chen Chengping Wen Zhenghao Xu | 2024 | Neuroscience Bulletin2024，40，3： | 0 |
| 9 | Nickel-Catalyzed Cross-Electrophile Coupling of Triazine Esters with Aryl Bromides显示文摘Cross-electrophile coupling of triazine esters with aryl bromides could be facilely accomplished by employing nickel as catalyst,magnesium as metal mediator,and lithium chloride as additive.The reactions proceeded efficiently in THF at room temperature through C—O bond activation to afford an array of structurally different diaryl ketones in moderate to good yields with wide functional group tolerance.Control experiments showed that nickel,magnesium,lithium chloride,and THF are all indispensable for the good performance of the coupling reaction.Preliminary mechanistic exploration indicated that in situ formed arylmagnesium reagent by the insertion of magnesium into aryl bromide might serve as the key intermediate of the cross-coupling.The method which avoids the utilization of moisture-labile and relatively difficult-to-obtain organometallics is step-economical,cost-efficient,and operationally simple,potentially serving as an attractive alternative to documented methods. | Xiang Liu Cai-Yu He Hao-Nan Yin Chengping Miao Xue-Qiang Chu Weidong Rao Hao Xu Xiaocong Zhou Zhi-Liang Shen | 2023 | Chinese Journal of Chemistry2023，41，24： | 0 |
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