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| 1 | 应用Rho激酶抑制剂对大鼠阴茎勃起的作用显示文摘目的 :探讨将RhoA/Rho激酶抑制剂Y 2 76 32涂抹于阴茎白膜表面以及阴茎龟头皮肤表面有无促进阴茎勃起的作用及其对体循环的影响。 方法 :2 0只成年雄性SD大鼠 ,体重为 2 5 0~ 30 0g ,随机分为实验组和对照组。全身麻醉后颈动脉和海绵体插管连续监测平均动脉压 (MAP)和阴茎海绵体内压 (CCP)的变化。寻找盆腔星状神经节(MPG)并以系列电刺激诱发勃起。向海绵体白膜表面及阴茎龟头皮肤表面涂抹Y 2 76 32 ,观察用药前后阴茎勃起的改变及MAP的改变。 结果 :将Rho激酶抑制剂Y 2 76 32涂抹于大鼠阴茎白膜表面和阴茎龟头皮肤表面均可促进在无阴茎支配神经电刺激下发生勃起 (ICP/MAP明显升高 ) ,在系列电刺激MPG时用药后发生的勃起反应较用药前亦明显增强。表面用药后还发现大鼠体循环血压有不同程度的降低。 结论 :阴茎皮肤表面应用Rho激酶抑制剂是一种安全有效的ED治疗方法 。 | 戴玉田 孙则禹 Chitaley K Webb RC Mills TM Lewis RW | 2004 | 中华男科学杂志2004，10，8： | 5 |
| 2 | Vasoconstrictors in erectile physiology显示文摘 | Mills TM Chitaley K Lewis RW | 2001 | Int J Impot Res2001，13，5： | 1 |
| 3 | The ups and downs of Rho-kinase and penile erection:upstream regulators and downstream substrates of rho-kinase and their potential role in the eretile response显示文摘 | Chitaley K Webb RC Mills TM | 2003 | Int J Impot Res2003，15，2： | 1 |
| 4 | RhoA/Rho-kinase,vascular changes,and hypertension显示文摘 | Chitaley K Weber D Webb RC | 2001 | Curr Hypertens Rep2001，3，2： | 1 |
| 5 | Anatomy,physiology,and pathophysiology of erectile dysfunction显示文摘 | Gratzke C Angulo J Chitaley K | 2010 | Journal of Sexual Medicine2010，7，1： | 1 |
| 6 | Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection显示文摘 | Mills TM Chitaley K Lewis RW | 2002 | Eur J Pharmacol2002，439，13： | 1 |
| 7 | RhoA/Rho-kinase:a novel player in the regulation of penile erection显示文摘 | Chitaley K Webb RC Mills TM | 2001 | Int J Impot Res2001，13，2： | 1 |
| 8 | Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation显示文摘 | Mills TM Chitaley K Wingard CJ | 2001 | J Appl Physiol2001，91，3： | 1 |
| 9 | Topical application of a Rho-kinase inhibitor in rats causes penile erection显示文摘 | Dai Y Chitaley K Webb RC | 2004 | Int J Impot Res2004，16，3： | 1 |
| 10 | The ups and downs of Rho-kinase and penile erection; upstream regulators and downstream substrates of Rho-kinase and their potential role in the erectile response显示文摘 | Chitaley K Webb RC Mills TM | 2003 | Int J Impot Res2003，15，： | 1 |
| 11 | Antagonism of Rho- kinase stimulates rat penile erection via a nitric oxide-independent pathway显示文摘 | Chitaley K Wingard CJ Clinton Webb R | 2001 | Nat Med2001，7，1： | 1 |
| 12 | Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection 显示文摘 | Mills TM Chitaley K Lewis RW | 2002 | Eur J Pharmacol2002，439，13： | 1 |
| 13 | Anatomy, physiology,and pathophysiology of erectile dysfunction 显示文摘 | Gratzke C Angulo J Chitaley K | 2010 | J Sex Med2010，7，12： | 1 |
| 14 | Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway显示文摘 | Chitaley K Wingard C J Clinton Webb R | 2001 | Nat Med2001，7，1： | 1 |
| 15 | Nitric oxide inhibits RhoA/Rho-kinase signaling to cause erection显示文摘 | Mills TM Chitaley K Lewis RW | 2002 | EurJ Pharmacol2002，439，13： | 1 |
| 16 | Antagonism of Rho kinase stimulates rat penile erection via a nitric oxide-independent pathway显示文摘 | Chitaley K Wingard CJ Clinton WebbR | 2001 | Nat Med2001，7，： | 1 |
| 17 | Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation 显示文摘 | Mills TM Chitaley K Wingard C J | 2001 | J Appl Physiol2001，91，3： | 1 |
| 18 | Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats显示文摘 | Chitaley K Bivalacqua TJ Champion HC | 2002 | Biochem Biophys Res Commun2002，298，： | 1 |
| 19 | T- and L-type voltage- gated calciumchannels: their role in diabetic bladder dysfunction 显示文摘 | Jiang X Luttrell I Chitaley K | 2014 | Neurourol Urodyn2014，33，1： | 1 |
| 20 | Nitric oxide inhibits RhoA/Rho kinase signaling to cause erectile erection显示文摘 | Mills TM Chitaley K Lewis RW | 2002 | Eur J Pharmacol2002，439，： | 1 |
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