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| 1 | 应用Rho激酶抑制剂对大鼠阴茎勃起的作用显示文摘目的 :探讨将RhoA/Rho激酶抑制剂Y 2 76 32涂抹于阴茎白膜表面以及阴茎龟头皮肤表面有无促进阴茎勃起的作用及其对体循环的影响。 方法 :2 0只成年雄性SD大鼠 ,体重为 2 5 0~ 30 0g ,随机分为实验组和对照组。全身麻醉后颈动脉和海绵体插管连续监测平均动脉压 (MAP)和阴茎海绵体内压 (CCP)的变化。寻找盆腔星状神经节(MPG)并以系列电刺激诱发勃起。向海绵体白膜表面及阴茎龟头皮肤表面涂抹Y 2 76 32 ,观察用药前后阴茎勃起的改变及MAP的改变。 结果 :将Rho激酶抑制剂Y 2 76 32涂抹于大鼠阴茎白膜表面和阴茎龟头皮肤表面均可促进在无阴茎支配神经电刺激下发生勃起 (ICP/MAP明显升高 ) ,在系列电刺激MPG时用药后发生的勃起反应较用药前亦明显增强。表面用药后还发现大鼠体循环血压有不同程度的降低。 结论 :阴茎皮肤表面应用Rho激酶抑制剂是一种安全有效的ED治疗方法 。 | 戴玉田 孙则禹 Chitaley K Webb RC Mills TM Lewis RW | 2004 | 中华男科学杂志2004，10，8： | 5 |
| 2 | The SDA alternatives program phase Ⅲ:comparison of in vitro data with animal eye irritation data on solvents,surfactants,oxidizing agents,and prototype cleaning products显示文摘 | Bagley DM Balls M Lewis RW | 1994 | J Toxicol-Cut & Ocular Toxicol1994，13，2： | 1 |
| 3 | Genetic structure of camouflage grouper, Epinephelus polyphekadion(Pisces:Serranidae), in the western central Pacific显示文摘 | Rhodes K L Lewis R I Chapman RW Sadovy Y | 2003 | Marine Biology2003，142，4： | 1 |
| 4 | Vasoconstriction,RhoA/Rho-kinase and the erectile response显示文摘 | Mills TM Lewis RW Wingard CJ | 2003 | Int J Impot Res2003，15，5： | 1 |
| 5 | B-type natriuretic peptides:looking to the future显示文摘 | Troughton RW lewis LK Yandle TG | 2011 | Ann Med2011，43，3： | 1 |
| 6 | Vasoconstrictors in erectile physiology显示文摘 | Mills TM Chitaley K Lewis RW | 2001 | Int J Impot Res2001，13，5： | 1 |
| 7 | Epidemiology of erectile sfunction显示文摘 | Lewis RW | 2001 | Urol Clin North Am2001，28，2： | 1 |
| 8 | Associated and non-associated visco-plasticity and plasticity in soil mechanics 显示文摘 | Zienkiewicz OC Humpheson C Lewis RW | 1975 | Ceotechnique1975，25，4： | 1 |
| 9 | Variational formulation based Contaet algorithm for rigid boundaries in twodimensional SPH applications显示文摘 | Kulasegaram S Bonet J Lewis RW | 2004 | Computational Mechanics2004，33，： | 1 |
| 10 | Hemodynamic, hormone,and urinary effects of adrenomedullin infusion in essential hypertension 显示文摘 | Troughton RW Lewis LK Yandle TG | 2000 | Hypertension2000，36，4： | 1 |
| 11 | Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection显示文摘 | Mills TM Chitaley K Lewis RW | 2002 | Eur J Pharmacol2002，439，13： | 1 |
| 12 | Long-term prospective study of lumbosacral discectomy 显示文摘 | Lewis PJ Weir BKA Broad RW | 1987 | J Neurosurg1987，67，1： | 1 |
| 13 | Basic scienceand treatment options for articular cartilage injuries 显示文摘 | Lewis PB McCarty LP 3rd Kang RW | 2006 | JOrthop Sports Phys Ther2006，36，10： | 1 |
| 14 | Induction of apoptosis by mifepristone and tamoxifen in human LNCaP prostate cancer cells in culture 显示文摘 | El Etreby MF Liang Y Lewis RW | 2000 | Prostate2000，43，1： | 1 |
| 15 | Placental transfusion: umbilical cord clamping and preterm infants 显示文摘 | Ibrahim HM Krouskop RW Lewis DF | 2000 | J Perinatol2000，20，： | 1 |
| 16 | Late preferm birth显示文摘 | Loftin RW Habli M Snyder CC Cormier CM Lewis DF De-franco EA | 2010 | Rev Obstet Gynecol2010，3，1： | 1 |
| 17 | Androgenic maintenance of the rat erectile response via a non-nitric-oxide-dependent pathway显示文摘 | Reilly CM Lewis RW Stopper VS | 1997 | J Androl1997，18，6： | 1 |
| 18 | Comparison of non-intensive care unit(ICU) versus ICU rates of catheter- associated urinarytract infection in community hospitals显示文摘 | Lewis SS Knelson LP Moehring RW | 2013 | Infect Control Hosp Epidemiol2013，34，7： | 1 |
| 19 | Associated and Non-associated Visco-plasticity and Plasticity in Soil Mechanics显示文摘 | Zienkiewice O C Humpheson Cand Lewis RW | 1975 | Geotechnique1975，25，4： | 1 |
| 20 | Inhibition of tonic contraction--a novel way to approach erectile dysfunction显示文摘 | Mills TM Lewis RW Wingard CJ | 2002 | J Androl2002，23，5： | 1 |
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