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| 1 | Inhibitory effect of IGF-Ⅱ antisense RNA on malignant phenotype of hepatocellular carcinoma显示文摘INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression vector.The constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱexpression.The biological behavior changes ofhepatoma cells were observed.All these | Dong Hua Yang Ming Qing Zhang Jiang Du Chong Xu Oiao Ming Liang Ji Fang Mao Han Rong Qin Zi Rong Fan Department of Gastroenterology,Zhujiang Hospital,the First Military Medical University,Guangzhou 510282,China Laboratory of Molecular Biology,Zhujiang Hospital,the First Military Medical University,Guangzhou,China Departrnent of Biochemistry,the Second Military Medical University,Shanghai,China | 2000 | World Journal of Gastroenterology2000，6，2： | 54 |
| 2 | Effect of specimen size on energy dissipation characteristics of red sandstone under high strain rate显示文摘In this experiment, red sandstone specimens, having slenderness ratios of 0.5, 0.7, 0.9 and 1.1 respectively, were subjected to blow tests using a Split Hopkinson Pressure Bar(SHPB) system at a pressure of 0.4 atmospheres. In this paper, we have analyzed the effect of slenderness ratio on the mechanical properties and energy dissipation characteristics of red sandstone under high strain rates. The processes of compaction, elastic deformation and stress softening deformation of specimens contract with an increase in slenderness ratio, whilst the nonlinear deformation process extends correspondingly. In addition, degrees of damage of specimens reduced gradually and the type of destruction showed a transformation trend from stretching failure towards shear failure when the slenderness ratio increased. A model of dynamic damage evolution in red sandstone was established and the parameters of the constitutive model at different ratios of length to diameter were determined. By comparison with the experimental curve, the accuracy of the model, which could reflect the stress–strain dynamic characteristics of red sandstone, was verified. From the view of energy dissipation, an increase in slenderness ratio of a specimen decreased the proportion of energy dissipation and caused a gradual fall in the capability of energy dissipation during the specimen failure process. To some extent, the study indicated the effects of slenderness ratios on the mechanical properties and energy dissipation characteristics of red sandstone under the high strain rate, which provides valuable references to related engineering designs and academic researches. | Li Ming Mao Xianbiao Lu Aihong Tao Jing Zhang Guanghui Zhang Lianying Li Chong | 2014 | International Journal of Mining Science and Technology2014，24，2： | 24 |
| 3 | Power Requirements of Vertical Flight in the Dronefly显示文摘 | Chong Shen Mao Sun | 2015 | Journal of Bionic Engineering2015，12，2： | 5 |
| 4 | A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis显示文摘Phosphorus(P)is an indispensable macronutrient required for plant growth and development.Natural phosphate(Pi)reserves are finite,and a better understanding of Pi utilization by crops is therefore vital for worldwide food security.Ammonium has long been known to enhance Pi acquisition efficiency in agriculture;however,the molecular mechanisms coordinating Pi nutrition and ammonium remains unclear.Here,we reveal that ammonium is a novel initiator that stimulates the accumulation of a key regulatory protein,STOP1,in the nuclei of Arabidopsis root cells under Pi deficiency.We show that Pi deficiency promotes ammonium uptake mediated by AMT1 transporters and causes rapid acidification of the root surface.Rhizosphere acidification-triggered STOP1 accumulation activates the excretion of organic acids,which help to solubilize Pi from insoluble iron or calcium phosphates.Ammonium uptake by AMT1 transporters is downregulated by a CIPK23 protein kinase whose expression is directly modulated by STOP1 when ammonium reaches toxic levels.Taken together,we have identified a STOP1-centered regulatory network that links external ammonium with efficient Pi acquisition from insoluble phosphate sources.These findings provide a framework for developing possible strategies to improve crop production by enhancing the utilization of non-bioavailable nutrients in soil. | Wen Hao Tian Jia Yuan Ye Meng Qi Cui Jun Bo Chang Yu Liu GuiXin Li Yun Rong Wu Ji Ming Xu Nicholas P.Harberd Chuan Zao Mao Chong Wei Jin Zhong Jie Ding Shao Jian Zheng | 2021 | Molecular Plant2021，14，9： | 5 |
| 5 | Semisolid A356 alloy feedstock poured through a serpentine channel显示文摘Fine spheroidal and equiaxed nondendritic microstructures required for semisolid casting can be formed through a serpentine pouring channel.Effects of the pouring temperature and the vertical section length of the serpentine pouring channel were studied.The results indicate that both favorable semisolid microstructures of A356 aluminum alloy can be generated by a serpentine pouring channel,and the solid shell inside the channel can be avoided when the pouring temperature is in the range from 660 to 680°C.It is also shown that the vertical section length of the serpentine pouring channel has a significant influence on the microstructure of the feedstock,namely both the microstructure of the feedstock and the microstructure uniformity in the radial direction get worse when the vertical section length is shortened;moreover,the pouring temperature for obtaining the feedstock with suitable microstructure decreases.The relevant mechanisms were discussed. | Xiao-rong Yang Wei-min Mao Chong Gao | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，5： | 4 |
| 6 | Regulating catalyst morphology to boost the stability of Ni–Mo/Al_(2)O_(3) catalyst for ebullated-bed residue hydrotreating显示文摘Hydrotreating of vacuum residue by ebullated-bed shows tremendous significance due to more stringent environmental regulations and growing demand for lighter fuels. However, enhancing the catalyst stability still remains as a challenging task. Herein, two Ni–Mo/Al_(2)O_(3) catalysts with distinct morphologies(i.e., spherical and cylindrical) were first designed, and the morphology effect on deactivation was systematically elucidated employing multi-characterizations, such as HRTEM with EDX mapping, electron microprobe analysis, FT-IR, TGA and Raman. It is found that spherical catalyst exhibits superior hydrotreating stability over 1600 h. The carbonaceous deposits on spherical catalyst with less graphite structure are lighter, and the coke weight is also smaller. In addition, the metal deposits uniformly distribute in the spherical catalyst, which is better than the concentrated distribution near the pore mouth for the cylindrical catalyst. Furthermore, the intrinsic reason for the differences was analyzed by the bed expansion experiment. Higher bed expansion rate together with the better mass transfer ability leads to the enhanced performance. This work sheds new light on the design of more efficient industrial hydrotreating catalyst based on morphology effect. | Huihong Zhu Zhiwei Mao Bin Liu Tao Yang Xiang Feng Hao Jin Chong Peng Chaohe Yang Jifeng Wang Xiangchen Fang | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 7 | Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults显示文摘Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study.Cognitive impairment was assessed by the Chinese Mini-Mental State Examination.Handgrip strength was calculated from the means of the right and left hand values.Calf circumference was measured at the site of maximum circumference of the non-dominant leg.The formula developed by Ishii was used to define sarcopenia.Multiple logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive impairment.Results The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q_(2),Q_(3),and Q_(4))were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),respectively.Compared with individuals in Q1 of handgrip strength,the adjusted ORs for Q_(2),Q_(3),and Q_(4) were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),respectively.Conclusion Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment. | WU Bing LYU Yue Bin CAO Zhao Jin WEI Yuan SHI Wan Ying GAO Xiang ZHOU Jin Hui KRAUS Virginia Byers ZHAO Feng CHEN Xin LU Feng ZHANG Ming Yuan LIU Ying Chun TAN Qi Yue SONG Shi Xun QU Ying Li ZHENG Xu Lin SHEN Chong MAO Chen SHI Xiao Ming | 2021 | Biomedical and Environmental Sciences2021，34，11： | 2 |
| 8 | EMC10 governs male fertility via maintaining sperm ion balance显示文摘Infertility is a severe public health problem worldwide that prevails up to 15% in reproductive-age couples,and male infertility accounts for half of total infertility.Studies on genetically modified animal models have identifed lots of genes involved in the pathogenesis of male infertility.The underlying causes,however,remain largely unclear.In this study,we provide evidence that EMCIO,one subunit of endoplasmic reticulum (ER)membrane protein complex (EMC),is required for male fertility.EMC10 is significantly decreased in spermatozoa from patients with asthenozoospermia and positively associated with human sperm motility. Male mice lacking Emc10 gene are completely sterile.Emc10-null spermatozoa exhibit multiple defects including abnormal morphology,decreased motility,impaired capacitation,and impotency of acrosome reaction,thereby which are incapable of fertilizing intact or ZP-free oocytes.However,intracytoplasmic sperm injection could rescue this defect caused by EMC10 deletion. Mechanistically,EMC10 deficiency leads to inactivation of Na/K-ATPase,in turn giving rise to an increased level of intraceltutar Na^+ in spermatozoa,which contributes to decreased sperm motility and abnormal morphology.Other mechanistic investigations demonstrate that the absence of EMC10 results in a reduction of HCO3^- entry and subsequent decreases of both cAMP-dependent protein kinase A substrate phosphorylation and protein tyrosine phosphorytation.These data demonstrate that EMC10 is indispensable to mate fertility via maintaining sperm ion balance of Na^+ and HCO3^-,and also suggest that EMC10 is a promising biomarker for male fertility and a potential pharmaceutical target to treat male infertility. | Yuchuan Zhou Fei Wu Man Zhang Zuquan Xiong Qianqian Yin Yanfei Ru Huijuan Shi Jinsong Li Shanhua Mao Yanliang Li Xinyi Cao Renming Hu Chong Wee Liew Qiang Ding Xuanchun Wang Yonglian Zhang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 2 |
| 9 | Tetra-armed conjugated microporous polymers for gas adsorption and photocatalytic hydrogen evolution显示文摘Two novel tetra-armed conjugated microporous polymers with different geometries have been designed and synthesized via Suzuki-Miyaura cross coupling polycondensation. Both polymers are stable in various organic solvents tested and are thermally stable. The pyrene-containing polymer of PrPy with the rigid pyrene unit shows a higher Brunauer-Emmet-Teller specific surface area of 1219 m^2 g^(-1) than the tetraphenylethylene-containing polymer of PrTPE(770 m^2 g^(-1)), which leads to a high CO_2 uptake ability of 3.89 mmol g^(-1) at 1.13 bar/273 K and a H_2 uptake ability of 1.69 wt% at 1.13 bar/77 K. The photocatalytic hydrogen production experiments revealed that PrPy also shows a better photocatalytic performance than PrTPE due to the higher conjugation degree and planar structure, the broader UV-visible(UV-Vis) absorption, the lower photoluminescence lifetime, and the higher specific surface area. | Yunfeng Xu Chong Zhang Pan Mu Na Mao Xue Wang Qian He Feng Wang Jia-Xing Jiang | 2017 | Science China Chemistry2017，60，8： | 1 |
| 10 | Experimental study of temperature distribution on anodic surface of MEA inside a PEMFC with parallel channels flow bed显示文摘 | Hang Guo Mao Hai Wang Fang Ye Chong Fang Ma | 2012 | International Journal of Hydrogen Energy2012，，17： | 1 |
| 11 | Dynamic flight stability of a model dronefly in vertical flight显示文摘The dynamic flight stability of a model dronefly in hovering and upward flight is studied.The method of computational fluid dynamics is used to compute the stability derivatives and the techniques of eigenvalue and eigenvector used to solve the equations of motion.The major finding is as following.Hovering flight of the model dronefly is unstable because of the existence of an unstable longitudinal and an unstable lateral natural mode of motion.Upward flight of the insect is also unstable,and the instability increases as the upward flight speed increases.Inertial force generated by the upward flight velocity coupled with the disturbance in pitching angular velocity is responsible for the enhancement of the instability. | Chong Shen Mao Sun | 2014 | Acta Mechanica Sinica2014，30，6： | 1 |
| 12 | Alterations of nitric oxide synthase expression with aging and hypertension in rats 显示文摘 | Tz chong chou Mao Hsiung yen Chi yuan li | 2007 | Hypertension2007，31，： | 1 |
| 13 | Numerical simulation of micro-mixing in gas–liquid and solid–liquid stirred tanks with the coupled CFD-E-model显示文摘The coupled CFD-E-model for multiphase micro-mixing was developed,and used to predict the micro-mixing effects on the parallel competing chemical reactions in semi-batch gas–liquid and solid–liquid stirred tanks.Based on the multiphase macro-flow field,the key parameters of the micro-mixing E-model were obtained with solving the Reynolds-averaged transport equations of mixture fraction and its variance at low computational costs.Compared with experimental data,the multiphase numerical method shows the satisfactory predicting ability.For the gas–liquid system,the segregated reaction zone is mainly near the feed point,and shrinks to the exit of feed-pipe when the feed position is closer to the impeller.Besides,surface feed requires more time to completely exhaust the added H+solution than that of impeller region feed at the same operating condition.For the solid–liquid system,when the solid suspension cloud is formed at high solid holdups,the flow velocity in the clear liquid layer above the cloud is notably reduced and the reactions proceed slowly in this almost stagnant zone.Therefore,the segregation index in this case is larger than that in the dilute solid–liquid system. | Xiaoxia Duan Xin Feng Chong Peng Chao Yang Zaisha Mao | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 1 |
| 14 | Protection of Citrullus colocynthis Fruit Extracts on Carbon Tetrachloride-induced and Bacillus Calmette-Guerin plus Lipopolysaccharide-induced Hepatotoxicity in Mice显示文摘Objective To investigate the hepatoprotective activities of the extracts from Citrullus colocynthis(ECC),a native plant used as traditional Uigur Medicine on acute liver injury in mice.Methods The activities of ECC of petroleum ether(ECCPE),chloroform(ECCC),ethyl acetate(ECCEA),n-butyl alcohol(ECCBA),and water(ECCW)were evaluated in vivo using two experimental models,carbon tetrachloride(CCl4)-and bacillus calmette-guerin(BCG)plus lipopolysaccharide(LPS)-induced acute hepatotoxicity in mice.The contents of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in serum were determined and the liver histological examination was carried out,respectively.Results The pretreatment with ECC for 7 d obviously reduced the impact of CCl4toxicity on the serum markers of liver damage,ECCEA and ECCC with a significant difference of AST(P<0.01,0.05,respectively)and ALT(P<0.05,0.01,respectively).The protective activity was reconfirmed against BCG+LPS-induced injury and the serum enzymatic levels were obviously elevated,for ECCEA and ECCC with a significant difference of AST(P<0.05,0.01,respectively)and ALT(P<0.01,0.05,respectively).Conclusion That ECCEA and ECCC are the potent hepatoprotective extracts that could protect liver against the acute injury,and this ability might be attributed to their hepatoprotective potentials. | YANG Wei-jun GU Zheng-yi TURSUN Dilnur CHEN Bo HASIMU Hamulati LIU Chong HE Jiang XU Lei MAO Yan | 2013 | Chinese Herbal Medicines2013，5，3： | 1 |
| 15 | Unidirectional p-GaN gate HEMT with composite source-drain field plates显示文摘Dear editor,Ga N-on-Si high electron mobility transistors(HEMTs)have attracted attention for power device applications due to their low cost and large-area availability[1].Recently,bidirectional switches are highly desirable in many industrial bidirectional power conversion applications,such as rolling mills,elevators,and wind power generation.In addition,normally-off unidirectional HEMTs can be valuable devices to implement the high-performance bidirectional switches[2,3]. | Haiyong WANG Wei MAO Shenglei ZHAO Yuanhao HE Jiabo CHEN Ming DU Xuefeng ZHENG Chong WANG Chunfu ZHANG Jincheng ZHANG Yue HAO | 2022 | Science China(Information Sciences)2022，65，2： | 1 |
| 16 | Radiation Safety Report of HIRFL in 2011显示文摘 | Su Youwu Li Zongqiang Li Wuyuan Xu Junkui Mao Wang Yan Weiwei Xu Chong | 2011 | IMP & HIRFL Annual Report2011，，1： | 1 |
| 17 | 6 - 34 Individual Dose Monitoring and National Individual Dose Comparison Results of External Exposure of IMP in 2012显示文摘 | Mao Wang Li Wuyuan Xu Chong Su Youwu | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 18 | 6 - 35 Measurement Results of Soil Radiation Level around HIRFL in 2012显示文摘 | Xu Chong Xu Junkui Su Youwu Pang Chengguo Mao Wang | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 19 | 6-43 Radiation Safety Report of HIRFL in 2016显示文摘The total operation time of HIRFL is 7 488 h in 2016,the user beam time is about 5 547.5 h(from 21 Dec.2015 to 21 Dec.2016).3 178 h for physics experiment,238.5 h for biological physics science research,2 023 h for irradiation effect research,and 108 h for machine research.There are 26 heavy ions beams were provided by HIRFL in 2016.The highest ions energy provided is 7.9 MeV/u,the maximum accumulated ion intensity is 1μA.Environment radiation level was measured with TLDs which were placed in the yard of the institute around HIRFL,15 sites of radiation level show no difference with environment background level of Gansu province[1]. | Su Youwu Xu Junkui Li Zongqiang Li Wuyuan Mao Wang Wang Lijun Xu Chong Yan Weiwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 20 | 6-44 Studying of Residual Activity Induced by 300 MeV/u Carbon Ion in Copper Target显示文摘Activation of accelerator components due to beam losses is an important issue for a high-energy heavy ion accelerator.The induced components may become a main source of exposure to maintenance workers and a serious access-restriction for“hand-on”maintenance,and also have a certain radiation influence over the environment.In this work,experimental of residual activation induced by 300 MeV/u carbon ions was studied at the deep-therapy terminal of HIRFL. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo Yan Weiwei Xu Chong Mao Wang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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