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| 1 | miR-137 inhibits melanoma cell proliferation through downregulation of GLO1显示文摘Late-stage melanoma is refractory to current therapies. MicroRNAs (miRNAs) can modulate many physiological and pathological processes of melanoma. Studies have demonstrated that miR-137 acts as a tumor suppressor by inhibiting the proliferation of melanoma cells through targeting multiple mRNAs. The glyoxalase system member glyoxalase 1 (GLO1) is the principal scavenging enzyme of methylglyoxal (MG), a toxic byproduct of glycolysis. Using 35S in vivo/vitro labelling analysis for dynamic proteomics (SiLAD), we found that miR-137 downregulated the expression of GLO1 in melanoma cells.Bioinformatics analysis predicted that GLO1 is a direct target of miR-137. This was validated by dual luciferase reporter assay.Quantitative RT-PCR (qRT-PCR) and western blot analysis indicated that miR-137 could decrease endogenous GLO1 expression.Furthermore, siRNA targeting of GLO1 mimicked inhibition of melanoma cell proliferation caused by miR-137 overexpression.Re-expression of GLO1 was able to restore miR-137-mediated suppression of melanoma cell proliferation. Therefore, these results suggest that miR-137 inhibits the proliferation of melanoma cells by targeting GLO1. | Na Lv Shuai Hao Chonglin Luo Alia Abukiwan Ying Hao Fei Gai Weiwei Huang Lingyun Huang Xueyuan Xiao Stefan B.Eichmüller Dacheng He | 2018 | Science China(Life Sciences)2018，61，5： | 7 |
| 2 | Adsorption and Desorption of Gold on the Magnetic Activated Carbon显示文摘Adsorption and desorption of gold on the magnetic activated carbon (MAC) were investigated The adsorption rate of gold is higher than that of conventional coconut carbon in cyanide leach solution The loading gold can be easily desorbed as coconut carbon. Crushed fine magnetic carbon can be selected by a magnetic separator, It is suggested that the MAC can be used in carbon-in-pulp (CIP)process for increasing the recovery rate of | Chonglin WANG Qingcai LIU Xiaozhen CHENG and Zuhong SHEN (Institute of Metal Research, Academia Sinica, Shenyang, 110015, China)(To whom correspondence should be addressed) | 1994 | Journal of Materials Science & Technology1994，10，2： | 3 |
| 3 | Residual current compensation for single-phase grounding fault in coal mine power network显示文摘The way of neutral point to earth via full compensation arc suppression coil can solve the problem of residual current compensation in coal mine power network effectively. Based on the analysis on the grounding current detection results of Xieqiao coal mine, the conclusion that harmonic component of grounding current is dominated by higher harmonics with complex harmonic sources in coal mine power network system was obtained. The influences of harmonic source type and fault point position on harmonic voltage and harmonic current were analyzed theoretically. The influences of earthed fault feeder detection result and the estimation errors of parameters to earth on residual current compensation were analyzed. A new thought of residual current prediction and the selections of model method and control method were proposed on this basis. The simulation results prove that harmonic amplitudes of zero sequence voltage and zero sequence current are determined by harmonic source type as well as fault point position in coal mine power network, and also prove that zero sequence voltage detection can avoid the unstable problem of coal mine power network system caused by undercompensation of capacitive current. Finally, the experimental device of full compensation arc suppression coil is introduced. | Jia Chenxi Wang Chonglin Du Guifu | 2014 | International Journal of Mining Science and Technology2014，24，2： | 3 |
| 4 | High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS显示文摘Discovery of drugs rapidly and effectively is an important aspect for Alzheimer's disease(AD).In this study,a novel high-throughput screening(HTS)method aims at screening the small-molecules with amyloid-β(Aβ)binding affinity from natural medicines,based on the combinational use of biolayer interferometry(BLI)and ultra-high-performance liquid chromatography coupled with diode-array detector and quadrupole/time-of-flight tandem mass spectrometry(UHPLC−DAD-Q/TOF-MS/MS)has been firstly developed.Briefly,the components in natural medicines disassociated from biotinylated Aβwere collected to analyze their potential Aβbinding affinity by UHPLC−DAD-Q/TOF-MS/MS.Here,baicalein was confirmed to exhibit the highest binding affinity with Aβin Scutellaria baicalensis.Moreover,polyporenic acid C(PPAC),dehydrotumulosic acid(DTA),and tumulosic acid(TA)in Kai-Xin-San(KXS)were also identified as potent Aβinhibitors.Further bioactivity validations indicated that these compounds could inhibit Aβfibrillation,improve the viability in Aβ-induced PC-12 cells,and decrease the Aβcontent and improve the behavioral ability in Caenorhabditis elegans.The molecular docking results confirmed that PPAC,DTA,and TA possessed good binding properties with Aβ.Collectively,the present study has provided a novel and effective HTS method for the identification of natural inhibitors on Aβfibrillation,which may accelerate the process on anti-AD drugs discovery and development. | Minsong Guo Fengdan Zhu Wenqiao Qiu Gan Qiao Betty Yuen-Kwan Law Lu Yu Jianming Wu Yong Tang Chonglin Yu Dalian Qin Xiaogang Zhou Anguo Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 5 | C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death显示文摘Lysosomes are degradation and signaling centers within the cell,and their dysfunction impairs a wide variety of cellular processes.To understand the cellular effect of lysosome damage,we screened natural smallmolecule compounds that induce iysosomal abnormality using Caenorhabditis elegans (C.elegans)as a model system.A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D)were identified that caused lysosome enlargement in C.elegans macrophage-like cells.Intriguingly,these compounds triggered cell death in the germ line independently of the canonical apoptosis pathway.In mammalian cells, ervachinines A-D induced lysosomal enlargement and damage,leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death.Further analysis revealed that this ervachinine-induced lysosome damage and lysosomal cell death depended on STAT3 signaling,but not RIP1 or RIP3 signaling.These findings suggest that lysosomedamaging compounds are promising reagents for dissecting signaling mechanisms underlying lysosome homeostasis and lysosome-related human disorders. | Yang Li Yu Zhang Qiwen Gan Meng Xu Xiao Ding Guihua Tang Jingjing Liang Kai Liu Xuezhao Liu Xin Wang Lingli Guo Zhiyang Gao Xiaojiang Hao Chonglin Yang | 2018 | Protein & Cell2018，9，12： | 2 |
| 6 | Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans显示文摘Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental disorder.It is largely unknown if defective arginine catabolism has any effects on mitochondria.Here we report that normal arginine catabolism is essential for mitochondrial homeostasis in Caenorhabditis elegans.Mutations of the arginase gene argn-1 lead to abnormal mitochondrial enlargement and reduced adenosine triphosphate(ATP)production in C elegans hypodermal cells.ARGN-1 localizes to mitochondria and its loss causes arginine accumulation,which disrupts mitochondrial dynamics.Heterologous expression of human ARGl or ARG2 rescued the mitochondrial defects of argn-1 mutants.Importantly,genetic inactivation of the mitochondrial basic amino acid transporter SLC-25A29 or the mitochondrial glutamate transporter SLC-25A18.1 fully suppressed the mitochondrial defects caused by argn-1 mutations.These findings suggest that mitochondrial damage probably contributes to the pathogenesis of hyperargininemia and provide clues for developing therapeutic treatments for hyperargininemia. | Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan Zhao Qiwen Gan Liyuan Zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang | 2020 | Journal of Genetics and Genomics2020，47，3： | 2 |
| 7 | Ali- phatic C--H and oxygenated surface functional groups of diesel in-cylinder soot: Characterizations and impact on soot oxidation behavior 显示文摘 | Wang Lin Song Chonglin Song Jin' ou | 2012 | Proceedings of the Combus- tionlnstitute2012，34，2： | 1 |
| 8 | Cobalt(Ⅱ)coordination polymers as anodes for lithium-ion batteries with enhanced capacity and cycling stability显示文摘Coordination polymer Co-btca(H4 btca = 1,2,4,5-benzenetetracarboxylic acid) was synthesized using a simply hydrothermal method.In particular,the as-prepared Co-btca was applied as an anode material for lithium-ion battery for the first time.Single crystal X-ray diffraction results indicated that the asprepared Co-btca displayed unique layer structure,which was beneficial to transport Li ions and electrons.Also,owing to the porous structure and appropriate specific surface area,Co-btca electrode delivered a reversible capacity of 801.3 m A h/g after 50 cycles at a current density of 200 m A/g.The reversible capacity of 773.9 m A h/g was maintained after 200 cycles at a current density of 500 m A/g,exhibiting enhanced cycle stability.It also showed improved rate performance,making it a promising anode material and a new choice for lithium-ion batteries. | Yumei Luo Lixian Sun Fen Xu Siyue Wei Qingyong Wang Hongliang Peng Chonglin Chen | 2018 | Journal of Materials Science & Technology2018，34，8： | 1 |
| 9 | The arc-suppression coil with three phases and five columns and its compensation principle显示文摘 | Wang Chonglin Liu Jianhua | 1999 | Journal of North China Electric Power University1999，26，2： | 1 |
| 10 | Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells显示文摘 | Gang Chen Wenjun Yang Weidong Jin Yi Wang Chonglin Tao Zhengping Yu | 2012 | Molecular Biology Reports2012，，10： | 1 |
| 11 | Comparative effects of MTBE and ethanol additions into gasoline on exhaust emissions显示文摘 | Song Chonglin Zhang Wenmei Pei Yiqiang | 2006 | Atmospheric Environment2006，40，11： | 1 |
| 12 | Selective catalytic reduction of nitric oxide with ammonia over zirconium-doped copper/ZSM-5 catalysts显示文摘 | Feng Bin Chonglin Song Gang Lv Jinou Song Shaohua Wu Xiaodong Li | 2014 | Applied Catalysis B: Environmental2014，，： | 1 |
| 13 | Biomimetic deposition of calcium phosphate minerals on the surface of partially demineralized dentine modified with phosphorylated chitosan 显示文摘 | Xu Z GeeNeoh K ChongLin C | 2011 | J Biomed MaterRes: Part B2011，98，1： | 1 |
| 14 | Simultaneous removals of NO, HC and PM from diesel exhaust emissions by dielectric barrier discharges 显示文摘 | Song Chonglin Bin Feng Tao Zemin | 2009 | Journal of Hazardous Materials2009，166，1： | 1 |
| 15 | Diesel soot oxidation during the late combustion phase显示文摘 | Jinou Song Chonglin Song Ye Tao Gang Lv Surong Dong | 2010 | Combustion and Flame2010，，3： | 1 |
| 16 | Aliphatic C–H and oxygenated surface functional groups of diesel in-cylinder soot: Characterizations and impact on soot oxidation behavior显示文摘 | Lin Wang Chonglin Song Jinou Song Gang Lv Huating Pang Wei Zhang | 2013 | Proceedings of the Combustion Institute2013，，2： | 1 |
| 17 | Research on mean square exponential stability of networked control systems with multi-step delay显示文摘 | Ma Chonglin Fang Huajing | 2006 | Applied Mathematical Modelling2006，30，9： | 1 |
| 18 | Study on grafting maleic anhydride onto polypropylene in microcolloid systems by coirradiation显示文摘 | Tan Xiumin Xu Yongshen Qian Jun Wang Chonglin | 2007 | Polymer Engineering and Science2007，47，10： | 1 |
| 19 | An everlasting role of animal models in understanding human disease显示文摘Model organisms have been widely used to dissect important biological phenomena, as well as to explore potential causes and treatments for human disorders. Much of our knowledge on molecular mechanisms underlying the heredity, development as well as physiology is largely derived from the researches of model organisms. We have | Dr. Xiao Yang Genetic Laboratory of Development and Diseases, State Key Laboratory of Proteomics, Institute of Biotechnology, Beijing 100071, China Dr. Chonglin Yang Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Journal of Genetics and Genomics2010，37，9： | 1 |
| 20 | Simulta- neous Removals of NOx, HC and PM From Diesel Exhaust Emissions by Dielectric Barrier Discharges 显示文摘 | SONG Chonglin BIN Feng TAO Zemin | 2008 | Journal of Hazardous Materials2008，166，1： | 1 |
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