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| 1 | Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria显示文摘Infections caused by drug-resistant“superbugs”pose an urgent public health threat due to the lack of effective drugs;however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacterial agents that target cell metabolism or the cytoplasmic membrane, the LCs act by hydrolyzing the major components of bacterial outer membrane, lipopolysaccharides, which are crucial for the survival of Gram-negative bacteria. The LC of factor VII exhibits in vitro efficacy towards all Gram-negative bacteria tested, including extensively drug-resistant (XDR) pathogens, at nanomolar concentrations. It is also highly effective in combating XDR Pseudomonas aeruginosa and Acinetobacter baumannii infections in vivo. Through decoding a unique mechanism whereby factors VII, IX and X behave as antimicrobial proteins, this study advances our understanding of the coagulation system in host defense, and suggests that these factors may participate in the pathogenesis of coagulation disorder-related diseases such as sepsis via their dual functions in blood coagulation and resistance to infection. Furthermore, this study may offer new strategies for combating Gram-negative “superbugs”. | Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song | 2019 | Cell Research2019，29，9： | 6 |
| 2 | Dynamic Model and Motion Mechanism of Magnetotactic Bacteria with Two Lateral Flagellar Bundles显示文摘 | Cenyu Yang Chuanfang Chen Qiufeng Ma Longfei Wu Tao Song | 2012 | Journal of Bionic Engineering2012，9，2： | 4 |
| 3 | Preparation and Characterization of Ultrafine ZrO_2 Powders from Solvent Extraction of Zr(Ⅳ) with Tri-n-butyl Phosphate in Kerosene from Nitric Acid Solutions显示文摘Zr(IV) was extracted by tri-n-butyl phosphate in kerosene from concentrated nitric acid solutions and the formation of the third phase during extraction was experimentally investigated. Zirconia powders were prepared by using the loaded organic phase as the bulk solution precipitated with aqueous ammonia or NaOH solution. The powder prepared was characterized with TEM, XRD,EDAX and TG-DTA. Effects of some conditions on powder preparation were studied and it was shown that nanosized particles could be obtained from this extraction system but conditions should be carefully controlled for powder purity and particle size. | Chuanfang YANG and Jiayong CHEN (Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080, China)(To whom correspondence should be addressed) | 1996 | Journal of Materials Science & Technology1996，12，6： | 3 |
| 4 | Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice显示文摘Dear Editor,Hypercholesterolemia is the leading risk factor for cardiovascular diseases.Current evidence suggests that the heritability for blood cholesterol levels is high,with 40%-60%in different cohorts.1,2 Genome-wide association study(GWAS)is a powerful tool to ascertain the contribution of common genetic variants in population-wide disease variability.It has been performed extensively on blood lipids traits and hundreds of genome variants are associated with dyslipidemia.However,approximately 95%of these variants are located in genome noncoding regions and cluster in more than 300 loci in different populations. | Fangfang Han Xiao Liu Chuanfang Chen Yinan Liu Mingkun Du Yu Zhou Yong Liu Bao-Liang Song Housheng Hansen He Yan Wang | 2020 | Cell Research2020，30，4： | 2 |
| 5 | Pre- paration and characterization of the waterborne polyurethane modified with nanosilica显示文摘 | Chen Jingjing Zhu Chuanfang Deng Hongtao | 2009 | Polym Res2009，，16： | 1 |
| 6 | Preparation and Characterization of the Waterborne Polyurethane Modified Nanosilica显示文摘 | Chen Jingjing Zhu Chuanfang Deng Hongtao | 2009 | Polymer Research2009，16，： | 1 |
| 7 | 17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level显示文摘 | Ziyi Zhao Changjin Chen Yu Liu Chuanfang Wu | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
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