|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria显示文摘Infections caused by drug-resistant“superbugs”pose an urgent public health threat due to the lack of effective drugs;however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacterial agents that target cell metabolism or the cytoplasmic membrane, the LCs act by hydrolyzing the major components of bacterial outer membrane, lipopolysaccharides, which are crucial for the survival of Gram-negative bacteria. The LC of factor VII exhibits in vitro efficacy towards all Gram-negative bacteria tested, including extensively drug-resistant (XDR) pathogens, at nanomolar concentrations. It is also highly effective in combating XDR Pseudomonas aeruginosa and Acinetobacter baumannii infections in vivo. Through decoding a unique mechanism whereby factors VII, IX and X behave as antimicrobial proteins, this study advances our understanding of the coagulation system in host defense, and suggests that these factors may participate in the pathogenesis of coagulation disorder-related diseases such as sepsis via their dual functions in blood coagulation and resistance to infection. Furthermore, this study may offer new strategies for combating Gram-negative “superbugs”. | Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song | 2019 | Cell Research2019，29，9： | 6 |
| 2 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 3 | Open-pore LiFePO_4/C microspheres with high volumetric energy density for lithium ion batteries显示文摘LiFePO_4/C microspheres with different surface morphologies and porosities were prepared from different carbon sources.The effects of the surface morphology and pore structure of the microspheres on their electrochemical properties and electrode density were investigated.The electrochemical performance and electrode density depended on the morphology and pore structure of the LiFePO_4/C microspheres.Open-pore LiFePO_4/C microspheres with rough surfaces exhibited good adhesion with current collectors and a high electrode density(2.6g/cm^3).They also exhibited high performance in a half cell and full battery with a high volumetric energy density. | Lei Wen Xiaodong Hu Hongze Luo Feng Li Huiming Cheng | 2015 | Particuology2015，13，5： | 3 |
| 4 | Exceptionally Preserved Punctatus triangulicostalis and Its Post-embryonic Development显示文摘Objective The putative coronatean Punctatus flourished at the beginning of the Cambrian explosion,and is significant in the exploration of the origin and evolution of early life.Liu Yunhuan established a new species:Punctatus triangulicostalis Liu,2006.Two questions remain:how was the special body plan of P.triangulicostalis formed?How does P.triangulicostalis transform from embryo | WANG Qi LIU Yunhuan QIN Jiachen ZHANG Hu ZHANG Ya'nan SHAO Tiequan ZHANG Ting WEI Ronghao ZHANG Hongze WANG Feng | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员