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| 1 | Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes显示文摘Quercetin(QE; 3,5,7,3′,4′-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE after ischemic insults. Therefore, in this study, we investigated the effects of QE on ischemic injury and the expression of antioxidant enzymes in the hippocampal CA1 region of gerbils subjected to 5 minutes of transient cerebral ischemia. QE was pre-treated once daily for 15 days before ischemia. Pretreatment with QE protected hippocampal CA1 pyramidal neurons from ischemic injury, which was confirmed by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence staining. In addition, pretreatment with QE significantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury. These findings demonstrate that pretreated QE displayed strong neuroprotective effects against transient cerebral ischemia by increasing the expression of antioxidant enzymes. | Bai Hui Chen Joon Ha Park Ji Hyeon Ahn Jeong Hwi Cho In Hye Kim Jae Chul Lee Moo-Ho Won Choong-Hyun Lee In Koo Hwang Jong-Dai Kim Il Jun Kang Jun Hwi Cho Bich Na Shin Yang Hee Kim Yun Lyul Lee Seung Min Park | 2017 | Neural Regeneration Research2017，12，2： | 9 |
| 2 | Microbiology and risk factors for gram-positive Cocci bacteremia in biliary infections显示文摘Background:The rapid antibiotics treatment targeted to a specific pathogen can improve clinical outcomes of septicemia.We aimed to evaluate the clinical characteristics and outcomes of biliary septicemia caused by cholangitis or cholecystitis according to causative organisms.Methods:We performed a retrospective cohort study in 151 patients diagnosed with cholangitis or cholecystitis with bacterial septicemia from January 2013 to December 2015.All patients showed clinical evidence of biliary tract infection and had blood isolates that demonstrated septicemia.Results:Gram-negative,gram-positive,and both types of bacteria caused 84.1%(127/151),13.2%(20/151),and 2.6%(4/151)episodes of septicemia,respectively.The most common infecting organisms were Escherichia coli among gram-negative bacteria and Enterococcus species(Enterococcus casseliflavus and Enterococcus faecalis)among gram-positive bacteria.There were no differences in mortality,re-admission rate,and need for emergency decompression procedures between the gram-positive and gram-negative septicemia groups.In univariate analysis,previous gastrectomy history was associated with gram-positive bacteremia.Multivariate analysis also showed that previous gastrectomy history was strongly associated with gram-positive septicemia(Odds ratio=5.47,95%CI:1.19–25.23;P=0.029).Conclusions:Previous gastrectomy history was related to biliary septicemia induced by gram-positive organisms.This information would aid the choice of empirical antibiotics. | Ik Hyun Jo Yeon-Ji Kim Woo Chul Chung Jaeyoung Kim Seonhoo Kim Eun Sun Lim Honggeun Ahn Seong Yul Ryu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 4 |
| 3 | Oenanthe javanica extract increases immunoreactivities of antioxidant enzymes in the rat kidney显示文摘 | Hyun-Jin Tae Joon Ha Park Jeong-Hwi Cho In Hye Kim Ji Hyeon Ahn Jae Chul Lee Jong-Dai Kim Jinseu Park Soo Young Choi Moo-Ho Won | 2014 | Chinese Medical Journal2014，，21： | 3 |
| 4 | High-frequency magnetic stimulation attenuates beta-amyloid protein 1-42 neurotoxicity in organotypic hippocampal slices显示文摘Repetitive transcranial magnetic stimulation (rTMS) has been utilized as a therapeutic tool for neurodegenerative disorders including Alzheimer’s disease.However,the precise mechanisms of its clinical effects remain unknown.β-amyloid (Aβ) exhibits direct neurotoxic effects and is closely related to neuronal degeneration in Alzheimer’s disease.Therefore,it has been hypothesized that the neuroprotective effects of rTMS are related to the mechanisms of protection against Aβ neurotoxicity.Organotypic hippocampal slices were prepared from 8-day old,Sprague Dawley rats.The tissue slices were exposed to 100 μmol/L Aβ1-42 since day 12 in vitro with and without high-frequency (20 Hz) magnetic stimulation.Magnetic stimulation efficacy was evaluated by measuring neuronal nuclei (NeuN) protein expression and by observing cultures following propidium iodide fluorescence staining and bromodeoxyuridine (BrdU) immunohistochemistry.Lactate dehydrogenase activity was detected in the culture media to evaluate hippocampal neuronal damage.Our results demonstrated that high-frequency magnetic stimulation significantly reversed the reduction of NeuN protein expression because of Aβ1-42 exposure (P < 0.05) and significantly reduced the number of damaged cells in the hippocampal slices (P < 0.05).However,lactate dehydrogenase levels and anti-BrdU staining results did not reveal any statistical differences.These findings indicate that high-frequency magnetic stimulation might have protective effect on hippocampal neurons from Aβ1-42 neurotoxicity. | Don-Kyu Kim Young Chul Yoon Soo Ahn Chae Kyung Mook Seo Tai Ryoon Han Si-Hyun Kang | 2010 | Neural Regeneration Research2010，5，18： | 2 |
| 5 | 健康男性的胰岛素抵抗指数、肥胖、血清PSA水平间的关系显示文摘本研究旨在确定血清PSA水平低于4ngmL^-1的健康男性的胰岛素抵抗指数、肥胖和血清前列腺特异性抗原(PSA)水平之间的关系。调查对象为韩国水力原子力株式会社的11827名健康男性职员,在2003年1月到2008年12月间接受了体检,体检项目包括空腹血糖水平、空腹胰岛素水平和血清PSA水平。用稳态模式评估法(HOMA;[空腹血糖水平×空腹胰岛素水平]/22.5)和定量胰岛素敏感性检验指数(QUICKI;1/[10g(空腹胰岛素水平)+log(空腹血糖水平)])测定胰岛素抵抗指数。协方差分析(ANOVA)和Duncan’s多重比较试验显示,随着用HOMA和OuICKI测定的胰岛素抵抗指数四分位的上升,年龄标化体重指数(BMI)也显著增加(P〈0.001)。多变量线性回归分析表明,相对于血清PSA水平,年龄、BMI、以及用HOMA或QUICKI测得的胰岛素抵抗指数都是显著的独立变量(P〈0.001)。本研究说明胰岛素抵抗指数和BMI都是血清PSA水平的独立变量,在健康男性体内,两者都与血清PSA水平呈负相关,两者之间呈正相关。 | June Hyun Han Yong Taec Lee Kyung Won Kwak Seung Hyun Ahn In Ho Chang Soon Chul Myung Seung Young Oh Yong-Seong Lee Wonyong Kim Young-Woo Jin Tae-In Choi Sook Hee Sung | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 6 | Mg含量对Al-Cu-Mg合金烧结行为和力学性能的影响(英文)显示文摘采用粉末冶金方法制备Al-3Cu-Mg合金,将各合金元素的空气雾化粉末与不同含量的Mg混合,通过控制压制压力分别得到弹性变形、局部塑性变形和塑性变形的粉末样品。确定不同成分合金的烧结温度,使烧结过程中Cu的液相烧结起主导作用。采用光学显微镜和扫描电子显微镜对合金的烧结行为和断口特征进行了分析。烧结后合金的横向断裂强度随Mg含量的增加而减小,Al-3Cu-0.5Mg合金具有适中的横向断裂强度和较高的比强度。 | Min Chul OH Byungmin AHN | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 7 | Serial blood concentration of polyethoxylated tallow amine and clinical presentations in acute herbicide poisoning显示文摘Most commercially available herbicides contain surfactants as co-formulants to increase adhesion and absorption by plant leaves.Ethoxylated amines,one of the most used surfactants,are non-ionic and derived from animal fats.They represent a class of surfactants with similar structural features,including polyethoxylated tallow amine(POEA).POEA is widely used in glyphosate,glufosinate-containing herbicides.In 2015,the European Food Safety Society(EFSA)concluded that POEA was more toxic than glyphosate when tested in glyphosate-based formulations.[1]They also attributed the poisoning following ingestion by humans to the presence of POEA. | Jungsoo Park Sun Cheun Kim Youngjoon Jeon Yong Chul Cho Changshin Kang Yeonho You Hong Joon Ahn Seung Ryu Jihan Lee Wonjoon Jeong | 2022 | World Journal of Emergency Medicine2022，13，4： | 2 |
| 8 | Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment:An experimental mouse model显示文摘BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,named as the secretome,have been evaluated for overcoming the limitations of cell-based therapy while maintaining its advantages.AIM To improve cell-free therapy by adding disease-specificity through stimulation of MSCs using disease-causing materials.METHODS We collected the secretory materials(named as inducers)released from AML12 hepatocytes that had been pretreated with thioacetamide(TAA)and generated the TAA-induced secretome(TAA-isecretome)after stimulating adipose-derived stem cells with the inducers.The TAA-isecretome was intravenously administered to mice with TAA-induced hepatic failure and those with partial hepatectomy.RESULTS TAA-isecretome infusion showed higher therapeutic potential in terms of(1)restoring disorganized hepatic tissue to normal tissue;(2)inhibiting proinflammatory cytokines(interleukin-6 and tumor necrosis factor-α);and(3)reducing abnormally elevated liver enzymes(aspartate aminotransferase and alanine aminotransferase)compared to the naïve secretome infusion in mice with TAA-induced hepatic failure.However,the TAA-isecretome showed inferior therapeutic potential for restoring hepatic function in partially hepatectomized mice.Proteomic analysis of TAA-isecretome identified that antioxidant processes were the most predominant enriched biological networks of the proteins exclusively identified in the TAA-isecretome.In addition,peroxiredoxin-1,a potent antioxidant protein,was found to be one of representative components of TAA-isecretome and played a central role in the protection of TAA-induced hepatic injury.CONCLUSION Appropriate stimulation of adipose-derived stem cells with TAA led to the production of a secretome enriched with proteins,especially peroxiredoxin-1,with higher antioxidant activity.Our results suggest that appropriate stimulation of MSCs with pathogenic agents can lead to the production of a secretome specialized for protecting against the pathogen.This approach is expected to open a new way of developing various specific therapeutics based on the high plasticity and responsiveness of MSCs. | Ok-Hee Kim Ha-Eun Hong Haeyeon Seo Bong Jun Kwak Ho Joong Choi Kee-Hwan Kim Joseph Ahn Sang Chul Lee Say-June Kim | 2020 | World Journal of Stem Cells2020，12，1： | 2 |
| 9 | Chorea-ballism associated with nonketotic hyperglycaemia or diabetic ketoacidosis: Characteristics of 25 patients in Korea显示文摘 | Seung-Hwan Lee Jeong-Ah Shin Ji-Hyun Kim Jang-Won Son Kang-Woo Lee Seung-Hyun Ko Seung-Ho Yang Byung Chul Son Yu-Bae Ahn | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 10 | Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells显示文摘BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,called secretome,rather than cells,has been evaluated for overcoming the limitations of cell-based therapy,while maintaining its advantages.However,the use of na?ve secretome may not fully satisfy the specificity of each disease.Therefore,it appears to be more advantageous to use the functionally reinforced secretome through a series of processes involving physico-chemical adjustments or genetic manipulation rather than to the use na?ve secretome.AIM To determine the therapeutic potential of the secretome released from miR-122-transfected adipose-derived stromal cells(ASCs).METHODS We collected secretory materials released from ASCs that had been transfected with antifibrotic miR-122(MCM)and compared their antifibrotic effects with those of the na?ve secretome(CM).MCM and CM were intravenously administered to the mouse model of thioacetamide-induced liver fibrosis,and their therapeutic potentials were compared.RESULTS MCM infusion provided higher therapeutic potential in terms of:(A)Reducing collagen content in the liver;(B)Inhibiting proinflammatory cytokines;and(C)Reducing abnormally elevated liver enzymes than the infusion of the na?ve secretome.The proteomic analysis of MCM also indicated that the contents of antifibrotic proteins were significantly elevated compared to those in the na?ve secretome.CONCLUSION We could,thus,conclude that the secretome released from miR-122-transfected ASCs has higher antifibrotic and anti-inflammatory properties than the na?ve secretome.Because miR-122 transfection into ASCs provides a specific way of potentiating the antifibrotic properties of ASC secretome,it could be considered as an enhanced method for reinforcing secretome effectiveness. | Kee-Hwan Kim Jae Im Lee Ok-Hee Kim Ha-Eun Hong Bong Jun Kwak Ho Joong Choi Joseph Ahn Tae Yun Lee Sang Chul Lee Say-June Kim | 2019 | World Journal of Stem Cells2019，11，11： | 2 |
| 11 | Endothelial dysfunction and inflammatory reactions of elderly and middle-aged men with obstructive sleep apnea syndrome显示文摘 | Seockhoon Chung In-Young Yoon Yoon-Kyung Shin Chul Hee Lee Jeong-Whun Kim Hee Jeong Ahn | 2009 | Sleep and Breathing2009，，1： | 1 |
| 12 | Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population显示文摘 | Yong-Ho Lee Eun Seok Kang So Hun Kim Seung Jin Han Chul Hoon Kim Hyeong Jin Kim Chul Woo Ahn Bong Soo Cha Moonsuk Nam Chung Mo Nam Hyun Chul Lee | 2008 | Journal of Human Genetics (-)2008，，11： | 1 |
| 13 | Tandem Synthesis of Photoactive Benzodifuran Moieties in the Formation of Microporous Organic Networks显示文摘 | Narae Kang Ji Hoon Park Kyoung Chul Ko Jiseul Chun Eunchul Kim Hee‐Won Shin Sang Moon Lee Hae Jin Kim Tae Kyu Ahn Jin Yong Lee Seung Uk Son | 2013 | Angew. Chem. Int. Ed2013，，24： | 1 |
| 14 | Design of Low-Pass Filters Using Defected Ground Structure显示文摘 | LIM Jong Sik KIM Chul Soo DAL Ahn | 2005 | IEEE Transactions on Microwave Theory and Techniques2005，53，8： | 1 |
| 15 | Bilateral Discoid Lateral Meniscus in Knees: Evaluation of the Contralateral Knee in Patients With Symptomatic Discoid Lateral Meniscus显示文摘 | Jin Hwan Ahn Sang Hak Lee Jae Chul Yoo Han-Jun Lee Jae Sung Lee | 2010 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2010，，10： | 1 |
| 16 | Measurement of the graft angles for the anterior cruciate ligament reconstruction with transtibial technique using postoperative magnetic resonance imaging in comparative study显示文摘 | Jin Hwan Ahn Sang Hak Lee Jae Chul Yoo Hae Chan Ha | 2007 | Knee Surgery Sports Traumatology Arthroscopy2007，，11： | 1 |
| 17 | A novel 1-D periodic defected ground structure for planar cir- cuits 显示文摘 | Kim Chul Soo Park Jun Seok Ahn Dal | 2000 | IEEE Microwace and Guided Wave Letters2000，10，4： | 1 |
| 18 | A New Suggestion for the Radiation Target Volume After a Subtotal Gastrectomy in Patients With Stomach Cancer显示文摘 | Heerim Nam Do Hoon Lim Sung Kim Won Ki Kang Tae Sung Sohn Jae Hyung Noh Yong Il Kim Chan Hyung Park Chul Keun Park Yong Chan Ahn Seung Jae Huh | 2008 | International Journal of Radiation Oncology Biology Physics2008，，2： | 1 |
| 19 | Increased plasma homocysteine is an independent predictor of new atherothrombotic brain infarction in older persons显示文摘 | Wilbert S Aronow Chul Ahn Hal Gutstein | 2000 | The American Journal of Cardiology2000，，5： | 1 |
| 20 | Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large‐volume center显示文摘 | Sung‐Gyu Lee Shin Hwang Deok‐Bog Moon Chul‐Soo Ahn Ki‐Hun Kim Kyu‐Bo Sung Gi‐Young Ko Kwang‐Min Park Tae‐Yong Ha Gi‐Won Song | 2008 | Liver Transpl2008，，7： | 1 |
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