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| 1 | Current developments in pharmacological therapeutics for chronic constipation显示文摘Chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride,the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. | Chunhuan Jiang Qinglong Xu Xiaoan Wen Hongbin Sun | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 23 |
| 2 | Tuneable red,green,and blue single-mode lasing in heterogeneously coupled organic spherical microcavities显示文摘Tuneable microlasers that span the full visible spectrum,particularly red,green,and blue(RGB)colors,are of crucial importance for various optical devices.However,RGB microlasers usually operate in multimode because the mode selection strategy cannot be applied to the entire visible spectrum simultaneously,which has severely restricted their applications in on-chip optical processing and communication.Here,an approach for the generation of tuneable multicolor single-mode lasers in heterogeneously coupled microresonators composed of distinct spherical microcavities is proposed.With each microcavity serving as both a whispering-gallery-mode(WGM)resonator and a modulator for the other microcavities,a single-mode laser has been achieved.The colors of the single-mode lasers can be freely designed by changing the optical gain in coupled cavities owing to the flexibility of the organic materials.Benefiting from the excellent compatibility,distinct color-emissive microspheres can be integrated to form a heterogeneously coupled system,where tuneable RGB single-mode lasing is realized owing to the capability for optical coupling between multiple resonators.Our findings provide a comprehensive understanding of the lasing modulation that might lead to innovation in structure designs for photonic integration. | Yuxiang Du Chang-Ling Zou Chunhuan Zhang Kang Wang Chan Qiao Jiannian Yao Yong Sheng Zhao | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 3 | Antioxidant activity of microwave-assisted extract of Buddleia officinalis and its major active component显示文摘 | Yingming Pan Chunhuan He Hengshan Wang Xiaowen Ji Kai Wang Peizhen Liu | 2010 | Food Chemistry2010，，2： | 2 |
| 4 | Influence of undercoating on rolling contact fatigue performance of Fe-based coating显示文摘 | Zhongyu Piao Binshi Xu Haidou Wang Chunhuan Pu | 2009 | Tribology International2009，，1： | 1 |
| 5 | Antio- xidant activity of microwave-assisted extract of Buddleia offi- cinalis and its major active component显示文摘 | Pan Yingming He Chunhuan Wang Hengshan | 2010 | Food Chemistry2010，121，： | 1 |
| 6 | An Optically Reconfigurable Förster Resonance Energy Transfer Process for Broadband Switchable Organic Single-Mode Microlasers显示文摘Miniaturized lasers with multicolor output and high spectral purity are indispensable for various ultracompact photonic devices.Here,we propose an optically reconfigurable Förster resonance energy transfer(FRET)process to realize broadband switchable single-mode lasing based on in situ activation of acceptors.The stoichiometric ratio of the donor and acceptor in the ready-made microstructures could be modulated readily by precisely activating the acceptors through a photoisomerization process,leading to a reconstructed FRET process to achieve dynamically switchable lasing.Furthermore,dual-color switchable single-mode lasing was realized by selectively constructing the FRET process in an identical coupled microdisks system.These results advance a comprehensive understanding of excited-state dynamics in organic composite material systems,thereby providing new ideas for the rational design of miniaturized photonic materials and devices with desired performances. | Chan Qiao Chunhuan Zhang Zhonghao Zhou Jiannian Yao Yong Sheng Zhao | 2022 | CCS Chemistry2022，4，1： | 1 |
| 7 | Antioxidant activity of microwave - assisted extract of Buddleia of cinalis and its major active component 显示文摘 | Yingming Pan Chunhuan He Hengshan Wang | 2010 | Food Chemistry2010，121，： | 1 |
| 8 | Antio-xidant activity of microwave-assisted extract of Buddleia ofcinalis and its major active component显示文摘 | Yingming Pan Chunhuan He Hengshan Wang | 2010 | Food Chemistry2010，121，： | 1 |
| 9 | Adsorption Performance and Mechanism for Removal of Cd(11) from Aqueous Solutions by D001 Cation-Exchange Resin显示文摘 | Zheng Yuqiang Xiong Chunhuan Yao Caiping | 2014 | Water Sci Technol2014，69，4： | 1 |
| 10 | Antioxidant activity of alcoholic extract of Agrimonia pilosa Ledeb 显示文摘 | Chunhuan He Xiaowen Ji Yingming Pan | 2009 | Med Chem Res2009，19，5： | 1 |
| 11 | SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy显示文摘Currently,artificial enzymes-based photodynamic therapy(PDT)is attractive due to its efficient capacity to change the immunosuppressive tumor microenvironment(TME).It is of great significance to study the therapeutic mechanism of novel artificial enzymes in TME through a monitoring strategy and improve the therapeutic effect.In this study,Au@carbon dots(Au@CDs)nanohybrids with a core-shell structure are synthesized,which not only exhibit tunable enzyme-mimicking activity under near-infrared(NIR)light,but also excellent surface-enhanced Raman scattering(SERS)properties.Therefore,Au@CDs show a good capability for monitoring NIR-photoinduced peroxidase-like catalytic processes via a SERS strategy in tumor.Moreover,the Au@CDs deplete glutathione with the cascade catalyzed reactions,thus elevating intratumor oxidative stress amplifying the reactive oxygen species damage based on the NIR-photoinduced enhanced peroxidase and glutathione oxidase-like activities,showing excellent and fast PDT therapeutic effect promoted by photothermal property in 3 min,finally leading to apoptosis in cancer cells.Through SERS monitoring,it is further found that after removing the NIR light source for 33 min,the reactive oxygen species(ROS)activity of the TME is counteracted and eliminated due to the presence of glutathione.This work presents a guidance to rationally design of artificial enzyme for ROS-involved therapeutic strategies and a new spectroscopic tool to evaluate the tumor catalytic therapy. | Linjia Li Jin Yang Jiahui Wei Chunhuan Jiang Zhuo Liu Bai Yang Bing Zhao Wei Song | 2022 | Light(Science & Applications)2022，11，10： | 0 |
| 12 | Elevated temperature strain softening characteristics of 12Cr1MoV steel friction welding pipe joints显示文摘Elevatedtemperaturestrainsofteningcharacteristicsof12Cr1MoVsteelfrictionweldingpipejointsYANGDexin;ZHAOXiujuan;LIUZhiquan;CHE... | YANG Dexin ZHAO Xiujuan LIU Zhiquan CHEN Chunhuan and LUO Yu (Welding Department of Dalian Railway Institute. Dalian. 116028.) | 1996 | China Welding1996，5，1： | 0 |
| 13 | Organic composite materials:Understanding and manipulating excited states toward higher light-emitting performance显示文摘Organic composite materials have been attracting extensive research interest for light-emitting applications.A wide variety of luminescent organic composite materials have been synthesized,which are of great significance for both the investigation of basic photophysics and the realization of high-performance photonic devices.Function-oriented syntheses of luminescent organic composite materials rely on the understanding and manipulating of molecular excited states.In this review,we focus on the discussion about the structure design and dynamics modulation of the electronic excited states in the organic composite materials.The excited-state structures and dynamics involve singlet/triplet levels,vibronic transition,charge transfer,and energy transfer,and so on,while the light-emitting behaviors include fluorescence,phosphorescence,persistent luminescence,electroluminescence,and lasing.We aim to give insight into the relationship between light-emitting properties and excited states of organic composite materials,which is beneficial for reaching higher tiers of design and applications of luminescent organic composite materials. | Haiyun Dong Chunhuan Zhang Jiannian Yao Yong Sheng Zhao | 2021 | Aggregate2021，2，4： | 0 |
| 14 | Error estimation of practical convolution discrete Gaussian sampling with rejection sampling显示文摘Dear editor,Discrete Gaussian sampling is a fundamental tool in lattice cryptography which has been used in digital signatures,identify-based encryption,attribute-based encryption,zeroknowledge proof,and fully homomorphic cryptosystem.As a subroutine of lattice-based scheme,a high precision sampling usually leads to a high security level and also brings large time and space complexity. | Zhongxiang ZHENG Xiaoyun WANG Guangwu XU Chunhuan ZHAO | 2021 | Science China(Information Sciences)2021，64，3： | 0 |
| 15 | Improving electrochemical activity of PtRu/SnO_2/C catalyst by reduction treatment and alkaline etching显示文摘PtRu/SnO_2/C catalyst was prepared in a polyol process, followed by reduction treatment and alkaline etching. X-ray diffraction, transmission electron microscope with energy dispersive spectrometer and Xray photoelectron spectroscopy were used to characterize the morphology, structure and composition of the catalysts. CO and methanol electro-oxidation activities of the catalysts were evaluated by CO stripping voltammetry, cyclic voltammetry and chronoamperometry measurements. Reduction treatment of the prepared PtRuSnO_2/C catalyst in a polyol process induced the enrichment of Sn on the surface, inhibiting methanol dissolution and CO adsorption on Pt. Alkaline etching removed Sn or SnO_x and thus exposed PtRu on the surface, resulting in enhanced activities for CO and methanol electro-oxidation due to the synergy effects of PtRu on the surface and Sn species beneath. | Qi Wang Hualong Tao Zhiqiang Li Chunhuan Chen Shanshan Liu Lei Han Xing Lu | 2016 | Journal of Energy Chemistry2016，25，5： | 0 |
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