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| 1 | The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis显示文摘The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neovascularization-associated diseases in adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controlling tool that could have important applications in treatment of retinal diseases. | Minhua Zheng Zifeng Zhang Xingcheng Zhao Yuqiang Ding Hua Han | 2010 | Journal of Genetics and Genomics2010，37，9： | 13 |
| 2 | Long-term inorganic plus organic fertilization increases yield and yield stability of winter wheat显示文摘An understanding of wheat yield and yield stability response to fertilization is important for sustainable wheat production. A 36-year long-term fertilization experiment was employed to evaluate the yield and yield stability of winter wheat. Five fertilization regimes were compared,including(1) CK, no fertilizer;(2) NPK, inorganic fertilizer only;(3) O, organic fertilizer only;(4)NPKO, 50% of NPK plus 50% of O, and(5) HNPKO, 80% of NPK plus 80% of O. The greatest yield increase was recorded in HNPKO, followed by NPKO, with O producing the lowest mean yield increase. Over the 36 years, the rate of wheat yield increase in fertilized plots ranged from95.31 kg ha-1 year-1 in the HNPKO to 138.65 kg ha-1 year-1 in the O. Yield stability analysis using the additive main effects and multiplicative interactions(AMMI) method assigned 62.3%, 26.3%,and 11.4% of sums of squares to fertilization effect, environmental effect, and fertilization ×environment interaction effect, respectively. The combination of inorganic and organic fertilization(NPKO and HNPKO) appeared to produce more stable yields than O or NPK, with lower coefficients of variation and AMMI stability value. However, wheat grown with O seemed to be the most susceptible to climate change and the least productive among the fertilized plots.Significant correlations of grain yield with soil properties and with mean air temperature were observed. These findings suggest that inorganic + organic fertilizer can increase wheat yield and its stability by improvement in soil fertility and reduction in variability to climate change. | Huan Chen Aixing Deng Weijian Zhang Wei Li Yuqiang Qiao Taiming Yang Chengyan Zheng Chengfu Cao Fu Chen | 2018 | The Crop Journal2018，6，6： | 5 |
| 3 | The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma显示文摘Background: Primary chronic angle-closure glaucoma(PCACG) is one of the main types of glaucoma in China. Trabeculectomy is the most commonly used glaucoma filtration surgery for glaucoma in the world. Conventional trabeculectomy is prone to anesthesia-related complications intraoperative and operationrelated complications postoperative in PCACG treatment. Modified minimally invasive trabeculectomy maybe can reduce the incidence of complications.Methods: We conducted a prospective case series study and performed modified fornix-based trabeculectomy in 27 patients(30 eyes) under topical anesthesia; we then observed intraoperative anesthesia and cooperation ef ect, intraoperative and postoperative complications, preoperative and postoperative visual acuity, intraocular pressure(IOP), visual field, and the use of ocular hypotensive drugs. The patients were followed up for at least 12 months.Results: All operations were completed successfully with no intraoperative complications. All 27 patients(30 eyes) were followed up for at least 12 months. No significant decrease in visual acuity was observed at days 1 or 7 and at months 1, 3, 6, and 12 after operation; however, a signii cant decrease in IOP was observed at days 1 and 7 and at months 1, 3, 6, and 12 after operation. Moreover, no significant progression in visual field mean defect was observed at month 12 after operation, and the number of ocular hypotensive drugs required was significantly reduced at months 6 and 12 after operation. By month 12 after operation, the overall success rate was 93.33%(28/30).Conclusions: Modii ed minimally invasive trabeculectomy is safe and ef ective for the treatment of PCACG. | Zhenggen Wu Chukai Huang Ce Zheng Yuqiang Huang Wanqi Zhang Di Ma | 2015 | Eye Science2015，30，4： | 3 |
| 4 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 5 | Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer显示文摘Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease.Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer.HOTAIR is an effective epigenetic agent known as long noncoding RNA(lncRNA).HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors,leading to genomic stability,proliferation,survival,invasion,migration,metastasis,and drug resistance.In the present article,we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer,whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes,leading to the development of potential therapeutic strategies. | Wencheng Kong Guang Yin Sixin Zheng Xinchun Liu Akao Zhu Panpan Yu Jian Zhang Yuqiang Shan Rongchao Ying Huicheng Jin | 2022 | Genes & Diseases2022，9，5： | 3 |
| 6 | Stiffness calculation and predetermined preload optimal design of cable control system 显示文摘 | Yang Chunning Mu Yuqiang You Zheng | 2011 | Advanced Materials Re- search2011，，： | 1 |
| 7 | Adaptive output feedback stabilization for nonholonomic systems with strong nonlinear drifts显示文摘 | Xiuyun Zheng Yuqiang Wu | 2008 | Nonlinear Analysis2008，，2： | 1 |
| 8 | Preparation of a novel chloromethylated polystyrene- 2-Amino-I, 3, 4-thiadiazole chelating resin and its ad- sorption properties and mechanism for separation and recovery of Pt (IV) from aqueous solutions 显示文摘 | Xiong Chunhua Zheng Yuqiang Feng Yujie | 2014 | J Mater ChemA2014，2，15： | 1 |
| 9 | Adaptive output feedback stabilization for nonholonomic systems with strong nonlinear drifts显示文摘 | Zheng Xiuyun Wu Yuqiang | 2009 | Nonlinear Analysis2009，70，2： | 1 |
| 10 | Adaptive output feedback stabilization for nonholonomic systems with strong nonlinear drifts 显示文摘 | Zheng Xiuyun Wu Yuqiang | 2009 | Nonlinear Analysis2009，70，2： | 1 |
| 11 | Adsorption Performance and Mechanism for Removal of Cd(11) from Aqueous Solutions by D001 Cation-Exchange Resin显示文摘 | Zheng Yuqiang Xiong Chunhuan Yao Caiping | 2014 | Water Sci Technol2014，69，4： | 1 |
| 12 | A Report on Two Cases of Mediterranean Spotted Fever显示文摘2 Cases of Mediterranean spotted fever in France were reported in this paper. Both had traveled in the endemic areas before onset. Their clinical manifestations included fever, headache, myalgia, eruption and black eschar. Serologic tests such as Weil-Felix reaction, Indirect immunoflurescence and complement fixation confirmed the diagnosis. The patients recovered without complications and were discharged from hospital after effective treatment. Simultaneously, the epidemiology, clinical diagnosis, treatment and prevention of the disease were reviewed and the possibility of the disease being introduced into this territory was discussed. The author held that attention should be paid to the prophylaxis and treatment of the disease in the international travel health care. | Zheng Yuqiang Guangdong Health Quarantine Bureau, P. R. China | 1995 | 旅行医学科学1995，1，4： | 0 |
| 13 | Expert Consensus on Diagnosis and Treatment of End-Stage Liver Disease Complicated with Infections显示文摘End-stage liver disease(ESLD)is a life-threatening clinical syndrome that markedly increases mortality in patients with infections.In patients with ESLD,infections can induce or aggravate the occurrence of liver decompensation.Consequently,infections are among the most common complications of disease progression.There is a lack of working procedure for early diagnosis and appropriate management for patients with ESLD complicated by infections as well as local and international guidelines or consensus.This consensus assembled up-to-date knowledge and experience across Chinese colleagues,providing data on principles as well as working procedures for the diagnosis and treatment of patients with ESLD complicated by infections. | Qin Ning Tao Chen Guiqiang Wang Dong Xu Yanyan Yu Qing Mao Taisheng Li Lanjuan Li Jun Li Xiaoju Lu Jiabin Li Zhiwei Li Wenhong Zhang Yonghong Xiao Qinghua Meng Yuqiang Mi Jia Shang Yunsong Yu Yingren Zhao Caiyan Zhao Hong Zhao Jianrong Huang Jie Peng Hong Tang Xiaoping Tang Jinhua Hu Bijie Hu Wei Guo Bo Zheng Baiyi Chen Yuexin Zhang Jia Wei Jifang Sheng Zhi Chen Minggui Wang Qing Xie Yuming Wang Fu-Sheng Wang Jinlin Hou Zhongping Duan Lai Wei Jidong Jia Chinese Society of Infectious Disease of Chinese Medical Association | 2022 | Infectious Diseases & Immunity2022，2，3： | 0 |
| 14 | Analysis of the Applicability of a Risk Quantitative Evaluation Method to High Temperature-Pressure Drilling Engineering显示文摘The optimization of methods for the quantitative evaluation of risks in drilling engineering is an effective means to ensure safety in situations where high temperature and high pressure blocks are considered.In such a context,this study analyzes the complexity of the drilled wells in such blocks.It is shown that phenomena such as well kick,loss,circulation,and sticking,are related to the imbalance of wellbore pressure.A method for risk quantitative evaluation is proposed accordingly.The method is used to evaluate the risk for 9 drilled wells.By comparing the predictions of the method with actual historical data related to these wells,it is found that the coincidence rate is about 95%. | Renjun Xie Xingquan Zhang Baolun He Ningyu Zheng Yuqiang Xu | 2023 | Fluid Dynamics & Materials Processing2023，19，6： | 0 |
| 15 | Elite sd1 alleles in japonica rice and their breeding applications in northeast China显示文摘The Green Revolution gene sd1 has been used extensively in modern rice breeding,especially in indica cultivars.However,elite sd1 alleles and related germplasm resources used for japonica rice breeding have not been identified,and extensive efforts are needed for japonica rice breeding to obtain new dwarfing sources.Data from MBKbase-Rice revealed seven sd1 haplotypes in indica and four in japonica rice.Two new sd1 alleles were identified in indica rice.In 295 japonica accessions from northeast Asia,except for the weak functional allele SD1-EQ,sd1-r was the major allele,reducing plant height in comparison with SD1-EQ.Japonica germplasm resources carrying reported sd1 alleles were identified by genotype searching and further verified by literature search,genealogical analysis,and d Caps markers.Pedigrees and geographic distribution showed that sd1-r is an excellent allele widely used in northern China and Tohoku in Japan,and sd1-j is commonly used in east China and Kyushu in Japan.Dongnong-and Xiushui-series cultivars carrying sd1-r and sd1-j,respectively,are essential branches of the backbone parents of Chinese japonica rice,Akihikari and Ce21,with the largest number of descendants and derived generations.In semi-dwarf japonica rice breeding,sd1-d was introgressed into Daohuaxiang 2(DHX2).Dwarf and semi-dwarf lines carrying sd1-d were selected and designated as 1279 and 1280,respectively,after withstanding typhoon-induced strong winds and heavy rains in 2020,and are anticipated to become useful intermediate materials for future genetic research and breeding.This work will facilitate the introduction,parental selection,and marker-assisted breeding,and provide a material basis for the next step in identifying favorable genes that selected together with the sd1 alleles in japonica backbone parents. | Hanjing Sha Hualong Liu Guangxin Zhao Zhongmin Han Huilin Chang Jingguo Wang Hongliang Zheng Jifeng Zhang Yang Yu Yuqiang Liu Detang Zou Shoujun Nie Jun Fang | 2022 | The Crop Journal2022，10，1： | 0 |
| 16 | Flavanone and flavonoid hydroxylase genes regulate fiber color formation in naturally colored cotton显示文摘Using naturally colored cotton(NCC)can eliminate dyeing,printing and industrial processing,and reduce sewage discharge and energy consumption.Proanthocyanidins(PAs),the primary coloration components in brown fibers,are polyphenols formed by oligomers or polymers of flavan-3-ol units derived from anthocyanidins.Three essential structural genes for flavanone and flavonoid hydroxylation encoding flavanone-3-hydroxylase(F3H),flavonoid 3’-hydroxylase(F3’H)and flavonoid 3’5’-hydroxylase(F3’5’H)are initially committed in the flavonoid biosynthesis pathway to produce common precursors.The three genes were all expressed predominantly in developing fibers of NCCs,and their expression patterns varied temporally and spatially among NCC varieties.In GhF3Hi,GhF3’Hi and GhF3’5’Hi silenced lines of NCC varieties XC20 and ZX1,the expression level of the three genes decreased in developing cotton fiber,negatively correlated with anthocyanidin content and fiber color depth.Fiber color depth and type in RNAi lines changed with endogenous gene silencing efficiency and expression pattern,the three hydroxylase genes functioned in fiber color formation.GhF3H showed functional differentiation among NCC varieties and GhF3’H acted in the accumulation of anthocyanin in fiber.Compared with GhF3’H,GhF3’5’H was expressed more highly in brown fiber with a longer duration of expression and caused lighter color of fibers in GhF3’5’H silenced lines.These three genes regulating fiber color depth and type could be used to improve these traits by genetic manipulation. | Hongli Zheng Bailin Duan Bo Yuan Zhengbin Chen Dongliang Yu Liping Ke Wenlong Zhou Haifeng Liu Yuqiang Sun | 2023 | The Crop Journal2023，11，3： | 0 |
| 17 | ON THE HYERS-ULAM STABILITY OF A THIRD-ORDER NONLINEAR DIFFERENTIAL EQUATION显示文摘In this paper, the Hyers-Ulam stability of a third-order nonlinear differential equation is investigated. By the integrating method and a Gronwall type inequality, the stability results are obtained in different situations on a bounded domain. Then, the study is extended to nth-order nonlinear differential equations. | Weimin Wang Yuqiang Feng Anli Zheng | 2015 | Annals of Applied Mathematics2015，31，4： | 0 |
| 18 | Adaptive stabilization of uncertain nonholonomic systems by output feedback显示文摘The adaptive output feedback control strategy is presented for a class of nonholonomic systems in chained form with nonlinearity uncertainties. A new observer and a filter are introduced for the states and parameter estimation. The proposed control strategies guarantee the convergence of the closed-loop system. The simulation example demonstrates the efficiency of the proposed method. | Xiuyun ZHENG Yuqiang WU | 2009 | 控制理论与应用(英文版)2009，7，4： | 0 |
| 19 | The quantitative proteome atlas of a model cyanobacterium显示文摘Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations of the majority of proteins in any cyanobacteria remain undetermined, representing a major challenge in using cyanobacteria for both basic and industrial researches. Here, using label-free quantitative proteomics, we map 2027 proteins of Synechocystis sp. PCC6803, a model cyanobacterium, to different subcellular compartments and generate a proteome atlas with such information. The atlas leads to numerous unexpected but important findings, including the predominant localization of the histidine kinases Hik33 and Hik27 on the thylakoid but not the plasma membrane. Such information completely changes the concept regarding how the two kinases are activated. Together, the atlas provides subcellular localization information for nearly 60% proteome of a model cyanobacterium, and will serve as an important resource for the cyanobacterial research community. | Jinlong Wang Xiahe Huang Haitao Ge Yan Wang Weiyang Chen Limin Zheng Chengcheng Huang Haomeng Yang Lingyu Li Na Sui Yu Wang Yuanya Zhang Dandan Lu Longfa Fang Wu Xu Yuqiang Jiang Fang Huang Yingchun Wang | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 20 | Robust stabilization of uncertain nonholonomic systems with strong nonlinear drifts显示文摘This paper investigates the robust stabilization of the nonholonomic control systems with strongly non-linear uncertainties. In order to make the state scaling effective and to prevent the finite time escape phenomenon from happening, the switching control strategy based on the state measurement of the first subsystem is employed to achieve the asymptotic stabilization. The recursive integrator backstepping technique is applied to the design of the robust controller. The simulation example demonstrates the efficiency and robust features of the proposed method. | Yuqiang WU Xiuyun ZHENG | 2008 | 控制理论与应用(英文版)2008，6，4： | 0 |
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