|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver显示文摘Dear Editor,RNA knockdown in vivo carries significant potential for dis-ease modeling and therapies.Despite the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes,strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of genome DNA is not appropriate,and RNA virus infection diseases when pathogenic DNA is not available(such as SARS-Cov-2 and MERS infections). | Bingbing He Wenbo Peng Jia Huang Hang Zhang Yingsi Zhou Xiali Yang Jing Liu Zhijle Li Chunlong Xu Mingxing Xue Hui Yang Pengyu Huang | 2020 | Protein & Cell2020，11，7： | 7 |
| 2 | Long-term effects of early antibiotic intervention on blood parameters,apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels显示文摘Backgroud: This study aimed to determine the effects of early antibiotic intervention(EAI) on subsequent blood parameters, apparent nutrient digestibility, and fecal fermentation profile in pigs with different dietary crude protein(CP) levels. Eighteen litters of piglets(total 212) were randomly allocated to 2 groups and were fed a creep feed diet with or without in-feed antibiotics(olaquindox, oxytetracycline calcium and kitasamycin) from postnatal d 7 to d 42. On d 42, the piglets within the control or antibiotic group were mixed, respectively, and then further randomly assigned to a normal-(20%, 18%, and 14% CP from d 42 to d 77, d 77 to d 120, and d 120 to d 185,respectively) or a low-CP diet(16%, 14%, and 10% CP from d 42 to d 77, d 77 to d 120, and d 120 to d 185,respectively), generating 4 groups. On d 77(short-term) and d 185(long-term), serum and fecal samples were obtained for blood parameters, microbial composition and microbial metabolism analysis.Results: EAI increased(P < 0.05) albumin and glucose concentrations in low-CP diet on d 77, and increased(P < 0.05) urea concentration in normal-CP diet. On d 185, EAI increased(P < 0.05) globulin concentration in normal-CP diets, but decreased glucose concentration. For nutrient digestibility, EAI increased(P < 0.05)digestibility of CP on d 77. For fecal microbiota, the EAI as well as low-CP diet decreased(P < 0.05) E. coli count on d 77. For fecal metabolites, on d 77, EAI decreased(P < 0.05) total amines concentration but increased skatole concentration in low-CP diet. On d 185, the EAI increased(P < 0.05) putrescine and total amines concentrations in low-CP diets but reduced(P < 0.05) in the normal-CP diets. The low-CP diet decreased the concentrations of these compounds.Conclusions: Collectively, these results indicate that EAI has short-term effects on the blood parameters and fecal microbial fermentation profile. The effects of EAI varied between CP levels, which was characterized by the significant alteration of glucose and putrescine concentration. | Miao Yu Chuanjian Zhang Yuxiang Yang Chunlong Mu Yong Su Kaifan Yu Weiyun Zhu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 6 |
| 3 | Geochemical Characteristics and Tectonic Significance of Triassic Granite from Taer Region, the Northern Margin of West Kunlun显示文摘Late Hercynian-early Indosinian (Triassic) granite is widely distributed around the Taer region of the northern margin of West Kunlun. The rock mass is mainly composed of calc-alkaline porphyroid biotite adamellite and characterized by SiO2-rich, high-Ca, moderate-alkaline, and strongly peraluminous attributes, and relatively low ΣREE with LREE enrichment and a moderate Eu anomaly. As shown in the trace element spider web diagram, distinct peaks appear for Th, La, Nd, and Zr and clearly low values appear for Ba, Nb, Sr, P, and Ti. Further, compared with the primitive mantle, Rb/Sr and Rb/Ba are considerably higher and Nd/Th and Nb/Ta are relative low, all falling into the scope of the crust-origin rocks, indicating the characteristics of the crust-origin S-type granite. The rock mass's zircon U-Pb isotopic age is determined to be 235.7 ± 3.9 Ma. On the basis of the age data, spatio-temporal location, lithology, and geochemistry of the rock mass, we conclude that the formation of the rock mass is closely related to the strong compressional orogenic movement (240 Ma) of the Tianshuihai terrane and the South Kunlun terrane. The rock mass is the product of the collision orogenic movement. However, distinct differences are observed between the studied rock mass and the synorogenic Bulunkou rock mass, which may be caused by the different collision strength and different positions with respect to the collision zone. | HUANG Jianguo YANG Ruidong YANG Jian CUI Chunlong | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 6 |
| 4 | Differentiation of embryonic versus adult rat neural stem cells into dopaminergic neurons in vitro显示文摘BACKGROUND:It has been reported that the conversion of neural stem cells into dopaminergic neurons in vitro can be increased through specific cytokine combinations. Such neural stem cell-derived dopaminergic neurons could be used for the treatment of Parkinson’s disease. However, little is known about the differences in dopaminergic differentiation between neural stem cells derived from adult and embryonic rats. OBJECTIVE: To study the ability of rat adult and embryonic-derived neural stem cells to differentiate into dopaminergic neurons in vitro. DESIGN: Randomized grouping design. SETTING: Department of Neurosurgery in the First Affiliated Hospital of Sun Yat-sen University. MATERIALS: This experiment was performed at the Surgical Laboratory in the First Affiliated Hospital of Sun Yat-sen University (Guangzhou, Guangdong, China) from June to December 2007. Eight, adult, male, Sprague Dawley rats and eight, pregnant, Sprague Dawley rats (embryonic day 14 or 15) were provided by the Experimental Animal Center of Sun Yat-sen University. METHODS: Neural stem cells derived from adult and embryonic rats were respectively cultivated in serum-free culture medium containing epidermal growth factor and basic fibroblast growth factor. After passaging, neural stem cells were differentiated in medium containing interleukin-1α, interleukin-11, human leukemia inhibition factor, and glial cell line-derived neurotrophic factor. Six days later, cells were analyzed by immunocytochemistry and flow cytometry. MAIN OUTCOME MEASURES: Alterations in cellular morphology after differentiation of neural stem cells derived from adult and embryonic rats; and percentage of tyrosine hydroxylase-positive neurons in the differentiated cells. RESULTS: Neural stem cells derived from adult and embryonic rats were cultivated in differentiation medium. Six days later, differentiated cells were immunoreactive for tyrosine hydroxylase. The percentage of tyrosine hydroxylase positive neurons was (5.6 ± 2.8)% and (17.8 ± 4.2)% for adult and embryonic cells, respectively, with a significant difference between the groups (P < 0.01). CONCLUSION: Neural stem cells from embryonic rats have a higher capacity to differentiate into dopaminergic neurons than neural stem cells derived from adult rats. | Chunlong Ke Baili Chen Shaolei Guo Chao Yang | 2008 | Neural Regeneration Research2008，3，8： | 6 |
| 5 | Panax notoginseng saponins influence on transplantation of neural stem cell-derived dopaminergic neurons in a rat model of Parkinson’s disease显示文摘BACKGROUND: Dopaminergic neurons differentiated from neural stem cells have been successfully used in the treatment of rat models of Parkinson’s disease; however, the survival rate of transplanted cells has been low. Most cells die by apoptosis as a result of overloaded intracellular calcium and the formation of oxygen free radicals. OBJECTIVE: To observe whether survival of transplanted cells, transplantation efficacy, and dopaminergic differentiation from neural stem cells is altered by Panax notoginseng saponins (PNS) in a rat model of Parkinson’s disease. DESIGN, TIME AND SETTING: Cellular and molecular biology experiments with randomized group design. The experiment was performed at the Animal Experimental Center, First Hospital of Sun Yat-sen Uni- versity from April to October 2007. MATERIALS: Thirty-two adult, healthy, male Sprague Dawley rats, and four healthy Sprague Dawley rat embryos at gestational days 14-15 were selected. The right ventral mesencephalon was injected with 6-hydroxydopamine to establish a model of Parkinson’s disease. 6-hydroxydopamine and apomorphine were purchased from Sigma, USA. METHODS: Neural stem cells derived from the mesencephalon of embryonic rats were cultivated and passaged in serum-free culture medium. Lesioned animals were randomly divided into four groups (n = 8): dopaminergic neuron, dopaminergic neuron + PNS, PNS, and control. The dopaminergic neuron group was injected with 3 μL cell suspension containing dopaminergic neurons differentiated from neural stem cells. The dopaminergic neurons + PNS group received 3 μL dopaminergic cell suspension combined with PNS (250 mg/L). The PNS group received 3 μL PNS (250 mg/L), and the control group received 3 μL DMEM/F12 culture medium. MAIN OUTCOME MEASURES: The rats were transcardially perfused with 4% paraformaldehyde at 60 days post-grafting for immunohistochemistry. The rats were intraperitoneally injected with apomorphine (0.5 mg/kg) to induce rotational behavior. RESULTS: Cell counts of tyrosine hydroxylase-positive neurons in the dopaminergic neuron + PNS group were (732±82.6) cells/400-fold field. This was significantly greater than the dopaminergic neuron group [(326 ± 34.8) cells/400-fold field, P < 0.01]. Compared to the control group, the rotational asymmetry of rats that received dopaminergic neuron transplants was significantly decreased, beginning at 20 days after opera- tion (P < 0.01). Rotational asymmetry was further reduced between 10-60 days post-surgery in the dopaminergic neuron + PNS group, compared to the dopaminergic neuron group (P < 0.01). CONCLUSION: Panax notoginseng saponins can increase survival and effectiveness of dopaminergic neurons differentiated from neural stem cells for transplantation in a rat model of Parkinson’s disease. | Chunlong Ke Baili Chen Chao Yang Heng Zhang Zhengsong Huang | 2008 | Neural Regeneration Research2008，3，7： | 5 |
| 6 | Ultrafast Synthesis of Metal-Layered Hydroxides in a Dozen Seconds for High-Performance Aqueous Zn(Micro-)Battery显示文摘Efficient synthesis of transition metal hydroxides on conductive substrate is essential for enhancing their merits in industrialization of energy storage field.However,most of the synthetic routes at present mainly rely on traditional bottom-up method,which involves tedious steps,time-consuming treatments,or additional alkaline media,and is unfavorable for high-efficiency production.Herein,we present a facile,ultrafast and general avenue to synthesize transition metal hydroxides on carbon substrate within 13 s by Joule-heating method.With high reaction kinetics caused by the instantaneous high temperature,seven kinds of transition metal-layered hydroxides(TM-LDHs)are formed on carbon cloth.Therein,the fastest synthesis rate reaches~0.46 cm^(2)s^(-1).Density functional theory calculations further demonstrate the nucleation energy barriers and potential mechanism for the formation of metal-based hydroxides on carbon substrates.This efficient approach avoids the use of extra agents,multiple steps,and long production time and endows the LDHs@carbon cloth with outstanding flexibility and machinability,showing practical advantages in both common and micro-zinc ion-based energy storage devices.To prove its utility,as a cathode in rechargeable aqueous alkaline Zn(micro-)battery,the NiCo LDH@carbon cloth exhibits a high energy density,superior to most transition metal LDH materials reported so far. | Xiangyang Li Fangshuai Chen Bo Zhao Shaohua Zhang Xiaoyu Zheng Ying Wang Xuting Jin Chunlong Dai Jiaqi Wang Jing Xie Zhipan Zhang Yang Zhao | 2023 | Nano-Micro Letters2023，15，3： | 2 |
| 7 | CHH methylation of genes associated with fatty acid and jasmonate biosynthesis contributes to cold tolerance in autotetraploids of Poncirus trifoliata显示文摘Polyploids have elevated stress tolerance,but the underlying mechanisms remain largely elusive.In this study,we showed that naturally occurring tetraploid plants of trifoliate orange(Poncirus trifoliata(L.) Raf.) exhibited enhanced cold tolerance relative to their diploid progenitors.Transcriptome analysis revealed that whole-genome duplication was associated with higher expression levels of a range of well-characterized cold stress-responsive genes.Global DNA methylation profiling demonstrated that the tetraploids underwent more extensive DNA demethylation in comparison with the diploids under cold stress.CHH methylation in the promoters was associated with up-regulation of related genes,whereas CG,CHG,and CHH methylation in the 3’-regions was relevant to gene down-regulation.Of note,genes involved in unsaturated fatty acids(UFAs) and jasmonate(JA)biosynthesis in the tetraploids displayed different CHH methylation in the gene flanking regions and were prominently up-regulated,consistent with greater accumulation of UFAs and JA when exposed to the cold stress.Collectively,our findings explored the difference in cold stress response between diploids and tetraploids at both transcriptional and epigenetic levels,and gained new insight into the molecular mechanisms underlying enhanced cold tolerance of the tetraploid.These results contribute to uncovering a novel regulatory role of DNA methylation in better cold tolerance of polyploids. | Yue Wang Lanlan Zuo Tonglu Wei Yu Zhang Yang Zhang Ruhong Ming Dahro Bachar Wei Xiao Khan Madiha Chuanwu Chen Qijun Fan Chunlong Li Ji-Hong Liu | 2022 | Journal of Integrative Plant Biology2022，64，12： | 2 |
| 8 | Synthesis,Bioactivity Evaluation,3D-QSAR,and Molecular Docking of Novel Pyrazole-4-carbohydrazides as Potential Fungicides Targeting Succinate Dehydrogenase显示文摘To screen novel antifungal agents targeting the succinate dehydrogenase(SDH),a series of pyrazole-4-carbohydrazides were rationally designed,synthesized,and characterized under the guidance of the structures of succinate dehydrogenase inhibitors(SDHIs).Bioassay results in vitro indicated that most of the target compounds exhibited excellent activity against Rhizoctonia solani(R.solani),Fusarium graminearum(F.graminearum),Botrytis cinerea(B.cinerea)and Colletotrichum capsica(C.cinerea).Compounds 7d,7l,7t and 7x were identified as the most promoting candidates,and their anti-F.graminearum EC50 values were as low as 0.56,0.47,0.46 and 0.49μg/mL,respectively,presenting the similar antifungal activity as that of the commonly used fungicide carbendazim(0.43μg/mL).The 3D-QSAR models were built for a systematic structure-activity relationship profile to explore more potent pyrazole-4-carbohydrazides as novel fungicides.Molecular docking of 7d,7l and 7r with SDH was performed to reveal the binding modes in active pocket and analyze the interactions between the molecules and the SDH protein. | Jian Jiao Min Chen Shengxin Sun Weijie Si Xiaobin Wang Weijie Ding Xincan Fu An Wang Chunlong Yang | 2021 | Chinese Journal of Chemistry2021，39，2： | 1 |
| 9 | Genetic variation and phylogenetic analysis of porcine circovirus type 2 infections in central China显示文摘 | Chunlong Mu Qingyuan Yang Yina Zhang Yonghui Zhou Jixi Zhang Darren P. Martin Pingan Xia Baoan Cui | 2012 | Virus Genes2012，，3： | 1 |
| 10 | Theresearch progress of pesticide containnig tolyloxy benzyl 显示文摘 | WANG Minghua YANG Chunlong JIANG Mugeng | 2002 | Word Pesticides2002，24，2： | 1 |
| 11 | Gulong shale oil enrichment mechanism and orderly distribution of conventional–unconventional oils in the Cretaceous Qingshankou Formation,Songliao Basin,NE China显示文摘Through the study of organic matter enrichment,hydrocarbon generation and accumulation process of black shale of the Cretaceous Qingshankou Formation in the Songliao Basin,the enrichment mechanism of Gulong shale oil and the distribution of conventional–unconventional oil are revealed.The Songliao Basin is a huge interior lake basin formed in the Early Cretaceous under the control of the subduction and retreat of the western Pacific plate and the massive horizontal displacement of the Tanlu Fault Zone in Northeast China.During the deposition of the Qingshankou Formation,strong terrestrial hydrological cycle led to the lake level rise of the ancient Songliao Basin and the input of a large amount of nutrients,resulting in planktonic bacteria and algae flourish.Intermittent seawater intrusion events promoted the formation of salinization stratification and anoxic environment in the lake,which were beneficial to the enrichment of organic matters.Biomarkers analysis confirms that the biogenic organic matter of planktonic bacteria and algae modified by microorganisms plays an important role in the formation of high-quality source rocks with high oil generation capability.There are four favorable conditions for the enrichment of light shale oil in the Qingshankou Formation of the Gulong Sag,Songliao Basin:the moderate organic matter abundance and high oil potential provide sufficient material basis for oil enrichment;high degree of thermal evolution makes shale oil have high GOR and good mobility;low hydrocarbon expulsion efficiency leads to a high content of retained hydrocarbons in the source rock;and the confinement effect of intra-layer cement in the high maturity stage induces the efficient accumulation of light shale oil.The restoration of hydrocarbon accumulation process suggests that liquid hydrocarbons generated in the early(low–medium maturity)stage of the Qingshankou Formation source rocks accumulated in placanticline and slope after long-distance secondary migration,forming high-quality conventional and tight oil reservoirs.Light oil generated in the late(medium–high maturity)stage accumulated in situ,forming about 15 billion tons of Gulong shale oil resources,which finally enabled the orderly distribution of conventional–unconventional oils that are contiguous horizontally and superposed vertically within the basin,showing a complete pattern of“whole petroleum system”with conventional oil,tight oil and shale oil in sequence. | ZHANG Shuichang ZHANG Bin WANG Xiaomei FENG Zihui HE Kun WANG Huajian FU Xiuli LIU Yuke YANG Chunlong | 2023 | Petroleum Exploration and Development2023，50，5： | 0 |
| 12 | Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor显示文摘Approximately 140 million people worldwide are homozygous carriers of APOE4(ε4),a strong genetic risk factor for late onset familial and sporadic Alzheimer’s disease(AD),91%of whom will develop AD at earlier age than heterozygous carriers and noncarriers.Susceptibility to AD could be reduced by targeted editing of APOE4,but a technical basis for controlling the off-target effects of base editors is necessary to develop low-risk personalized gene therapies.Here,we first screened eight cytosine base editor variants at four injection stages(from 1-to 8-cell stage),and found that FNLS-YE1 variant in 8-cell embryos achieved the comparable base conversion rate(up to 100%)with the lowest bystander effects.In particular,80%of AD-susceptibleε4 allele copies were converted to the AD-neutralε3 allele in humanε4-carrying embryos.Stringent control measures combined with targeted deep sequencing,whole genome sequencing,and RNA sequencing showed no DNA or RNA off-target events in FNLS-YE1-treated human embryos or their derived stem cells.Furthermore,base editing with FNLS-YE1 showed no effects on embryo development to the blastocyst stage.Finally,we also demonstrated FNLS-YE1 could introduce known protective variants in human embryos to potentially reduce human susceptivity to systemic lupus erythematosus and familial hypercholesterolemia.Our study therefore suggests that base editing with FNLS-YE1 can efficiently and safely introduce known preventive variants in 8-cell human embryos,a potential approach for reducing human susceptibility to AD or other genetic diseases. | Yinghui Wei Meiling Zhang Jing Hu Yingsi Zhou Mingxing Xue Jianhang Yin Yuanhua Liu Hu Feng Ling Zhou Zhifang Li Dongshuang Wang Zhiguo Zhang Yin Zhou Hongbin Liu Ning Yao Erwei Zuo Jiazhi Hu Yanzhi Du Wen Li Chunlong Xu Hui Yang | 2023 | Protein & Cell2023，14，6： | 0 |
| 13 | Novel 1,3,5-thiadiazine-2-thione derivatives containing a hydrazide moiety:Design, synthesis and bioactive evaluation against phytopathogenic fungi in vitro and in vivo显示文摘A series of novel 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety were designed, synthesized and evaluated for their antifungal activities against Rhizoctonia solani (Rs), Fusarium graminearum (Fg), Botrytis cinerea (Bc) and Colletotrichum capsici (Cc). The in vitro antifungal bioassays indicated that most of title compounds displayed good selectivity and specificity aganist Rs relative to Fg, Bc and Cc. Strikingly, the title compound N'-(4-chlorophenyl)-2-(5-phenyl-6-thioxo-1,3,5-thiadiazinan-3-yl)acethydrazide (5b) obviously inhibited the Rs growth in vitro with the EC50 value of 0.24μg/mL, which is approximately 2-folds more effective than the commercialized fungicide carbendazim (0.55 μg/mL). The in vivo anti-Rs effects of title compound 5b were further evaluated on rice leaves with control efficacies of 98.58% at 200 μg/mL and 61.27% at 100 μg/mL. The above researches provide a significant reference for the further structural optimization of 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety as potential fungicides. | Xiaobin Wang Xincan Fu Min Chen An Wang Jinghua Yan Yudong Mei Mengqi Wang Chunlong Yang | 2019 | Chinese Chemical Letters2019，30，7： | 0 |
| 14 | Recent progress and challenges in interdigital microbatteries:Fabrication, functionalization and integration显示文摘Currently,the increasing demands for portable,implantable,and wearable electronics have triggered the interest in miniaturized energy storage devices.Different from conventional energy storage devices,interdigital microbatteries(IMBs) are free of separators and prepared on a single substrate,potentially achieving a short ionic diffusion path and better performance.Meanwhile,they can be easily fabricated and integrated into on-chip miniaturized electronics,holding the promise to provide long-lasting power for advanced microelectronic devices.To date,while many seminal works have been reviewed the topic of microbatteries,there is no work that systematically summarizes the development of IMBs of high energy density and stable voltage platforms from fabrication,functionalization to integration.The current review focuses on the most recent progress in IMBs,discussing advanced micromachining techniques with compatible features to construct high-performance IMBs with smart functions and intelligent integrated systems.The future opportunities and challenges of IMBs are also highlighted,calling for more efforts in this dynamic and fast-growing research field. | Li Song Xuting Jin Chunlong Dai Yuyang Han Jiatao Zhang Yang Zhao Zhipan Zhang Liangti Qu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 15 | Synthesis, Biological Activity and 3D-QSAR Study of Novel Pyrrolidine-2,4-dione Derivatives Containing N-Substituted Phenylhydrazine Moiety显示文摘 | ZHANG Lizhi REN Zhengjiao LU Aimin ZHAO Zheng XU Wenqin BAO Qianqian DING Weijie YANG Chunlong | 2015 | Chemical Research in Chinese Universities2015，31，2： | 0 |
| 16 | 射频超导腔体在线清洗显示文摘In 2018,detailed studies on RF induced plasma for the in-situ cleaning of the HWR cavity were conducted to improve the performance of the cavity.For the purpose of cleaning the HWR cavities in cryomodule,an apparatus for the discharge experiments was designed at room temperature,which duplicates the assembly of cavities inside cryomodule,where the FPC was used for power coupling. | Wu Andong Huang Shichun Yang Lei Hua Chuanfei Li Chunlong Tan Teng Xiong Pingran Guo Hao Yue Weiming Pan Feng Chen Long Zhang Shenghu He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 17 | Development of RF Cavities at the Department of RF Cavity in 2019显示文摘The cavity design including RF design and multi-physics analysis of the RFQ for the CAFe(Chinese Accelerator Facility for super-heavy Elements)project have been completed by the end of 2019. | Zhang Zhouli Yue Weiming Li Chenxing Li Chunlong Huang Yulu Wang Ruoxu Xu Xianbo Zhang Shengxue Zhang Shenghu He Tao Yang Lei Xing Chaochao Lin Zeqiang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 18 | Status of Plasma in-situ Cleaning from Vertical Test Towards Online显示文摘The reactive oxygen plasma cleaning was proved an efficient method to decrease the field emission effect of the HWR superconducting cavities on the vertical test platform. | Wu Andong Huang Shichun Jiang Tiancai Li Chunlong Tan Teng Yang Ziqing RF Surface Technology Group | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 19 | Formation conditions of Sinian–Cambrian large lithologic gas reservoirs in the north slope area of central Sichuan Basin,SW China显示文摘Based on analyses of characteristics,hydrocarbon charging history and geological conditions for the formation of Sinian-Cambrian reservoirs in the north slope area of central Sichuan paleo-uplift,the natural gas origin,accumulation evolution,accumulation pattern and formation conditions of large lithologic gas reservoirs have been investigated.Through comprehensive analyses of natural gas composition,carbon and hydrogen isotopic compositions,fluid inclusions,reservoir bitumen,and geological conditions such as lithofacies paleogeography and beach body characterization,it is concluded that:(1)The natural gas in the Sinian-Cambrian of the north slope area is mainly oil cracking gas,and different contribution ratios of multiple sets of source rocks lead to different geochemical characteristics of natural gas in different reservoirs.(2)Although the both Sinian and Cambrian gas reservoirs in this area are lithologic gas reservoirs under monocline background,the former has normal-pressure and the latter has high-pressure.There are three types of source-reservoir-caprock combinations:single source with lower generation and upper reservoir,double sources with lower generation and upper reservoir or with side source and lateral reservoir,double sources with lower generation and upper reservoir or with upper generation and lower reservoir.The Permian-Triassic is the main generation period of oil,Early-Middle Jurassic is the main generation period of oil cracking gas and wet gas,and Late Jurassic-Cretaceous is the main generation period of dry gas.(3)The Sinian-Cambrian system of the north slope area has two favorable conditions for formation of large lithologic gas reservoirs,one is that the large scale beach facies reservoirs are located in the range of ancient oil reservoirs or near the source rocks,which is conducive to the'in-situ'large-scale accumulation of cracked gas in the paleo-oil reservoirs,the other is that the large scale mound-beach complex reservoirs and sealing layers of inter beach tight zones match effectively to form large lithologic traps under the slope background.The research results confirm that the north slope area has large multi-layer lithologic gas reservoirs with more than one trillion cubic meters of natural gas resources and great exploration potential. | WEI Guoqi XIE Zengye YANG Yu LI Jian YANG Wei ZHAO Luzi YANG Chunlong ZHANG Lu XIE Wuren JIANG Hua LI Zhisheng LI Jin GUO Jianying | 2022 | Petroleum Exploration and Development2022，49，5： | 0 |
| 20 | 6-15 Plasma Discharge for In-situ Cleaning of SRF Cavities显示文摘Field emission occurred in superconducting radio-frequency(SRF)cavities is the major obstacle of the accelerators operating at high gradient,which partly caused by the inner surface contamination,such as the hydrocarbons and the absorbed residual gas.The plasma processing can be an effective method to solve the field emission issues.The properties of low temperature glow discharge,which was argon plasma with the chemically reactive oxygen,were investigated for the SRF cavities used for CADS project. | Wu Andong Yang Lei Li Yongming Yue Weiming Li Chunlong Xiong Pingran Guo Hao Song Yukun Chu Qingwei Jiang Tiancai Zhang Shengxue You Zhiming Zhang Shenghu He Yuan Zhao Hongwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员