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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | EULAR recommendations for the management of large vessel vasculitis显示文摘 | Mukhtyar C Guillevin L Cid MC | 2009 | Ann Rheum Dis2009，68，3： | 1 |
| 3 | Laparoscopic surgery in the elderly patient显示文摘 | Bàllesta López C Cid JA Poves I | 2003 | Surg Endosc2003，17，2： | 1 |
| 4 | Third-order nonlinear optical properties of bismuth-borate glasses measured by conventional and thermally managed eclipse Z scan 显示文摘 | Gomes A S L Falc o Filho E L de Araujo Cid B etal | 2007 | J Appl Phys2007，101，03： | 1 |
| 5 | Proteomic characteriza- tion of protein phosphatase 1 complexes in ischemia reperfiision and ischemic tolerance 显示文摘 | Cid C Garcia-Bonilla L Camafeita E el al | 2007 | Proteomics2007，7，： | 1 |
| 6 | Biogenic amines in traditional fermented sausages produced in selected European countries 显示文摘 | Latorre- Moratalla M L Veciana- Nogus T Borer- Cid S | 2007 | Food Chemistry2007，107，2： | 1 |
| 7 | Deletion of the late comified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis显示文摘 | de Cid R Riveira-Munoz E Zeeuwen P L | 2009 | Nature Genetics2009，41，2： | 1 |
| 8 | Proteomiccharacterization of protein phosphatase 1 complexes inischemia-reperfusion and ischemic tolerance显示文摘 | Cid C Garcia-Bonilla L Camafeita E | 2007 | Protepmics2007，7，： | 1 |
| 9 | Concentrations of polybrominated di- phenyl ethers ,hexachlorobenzenne and polycyclic aromatic hydrocarbons in various foodstuffs before and after cooking显示文摘 | Gemma Perell6 Roser Marti - Cid Victoria Castell Juan M Llobet Jose L Domingo | 2009 | Food and Chemical Toxicology2009，，47： | 1 |
| 10 | Cross-cultural invariance of the basic psychological needs in exercise scale and need satisfaction latent mean differences among Greek, Spanish, Portuguese and Turkish samples显示文摘 | Vlachopoulos S P Asci F H Cid L | 2013 | Psychology of Sport and Exercise2013，14，： | 1 |
| 11 | Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance显示文摘 | Cid C Garcia-Bonilla L Camafeita E | 2007 | Protepmics2007，7，17： | 1 |
| 12 | Use of adefovir in the treatment of the chronic hepatitis B virus infection with resistance to lamivudine显示文摘 | Barcena Marugan R Cid Gomez L Lopez Serrano P | 2003 | Transplant Proc2003，35，5： | 1 |
| 13 | Positivity and lower and upper solutions for fourth order boundary value problems 显示文摘 | Cabada A Cid J Sanchez L | 2007 | Nonlinear Anal2007，67，： | 1 |
| 14 | Potassium iodide catalysed monoalkyla- tion of anilines under microwave irradia- tion显示文摘 | Romera J L Cid J M Trabanco A A | 2004 | Trtrahedron Letters2004，45，： | 1 |
| 15 | EULAR recommendations for the management of large vessel vasculitis显示文摘 | Mukhtyar C Guillevin L Cid MC | 2009 | Ann Rheum Dis2009，68，： | 1 |
| 16 | Influence of partial replacement of NaC1 with KC1 on lipid Fraction of dry fermented sausages inoculated with mixture of Lactobacillus plantarum and Staphylococcus carnosus显示文摘 | QUINTANILLA L IBANEZ C CID C | | 0，，3： | 1 |
| 17 | A general method for the preparation of N - sulfonylaldimines and ketimines 显示文摘 | RUANO J L G ALEMAN J CID M B | 2005 | Organic Letters2005，7，2： | 1 |
| 18 | Infrared- to-visible CW frequency upconversion in Er^3+-doped fluo- roindate glasses显示文摘 | Cid B de Araujo Menezes L S Maciel S G | 1996 | Appl Phys Lett1996，68，5： | 1 |
| 19 | Evolotion and developmental regulation of the major histocompatability complex 显示文摘 | SALTER - CID L FLAJNIK M F | 1995 | Crit Rev Immunol1995，15，1： | 1 |
| 20 | Expression of MHC class Ia and class Ib during ontogeny: High expression in epithlia and coequlation of class Ia and Imp7 genes显示文摘 | SALTER - CID L NONAKA M FLAJNIK M F | 1998 | J Immunol1998，160，： | 1 |
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