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1广东大宝山地区重金属污染水田土壤的Cu Pb Zn Cd全量与DTPA浸提态含量的相互关系研究显示文摘通过现场采样及室内测试,分析了广东大宝山地区酸性金属矿长期污染水稻田的土壤特性,研究了重金属Cu、Pb、Zn、Cd的全量与DTPA浸提态含量的相互关系。结果表明,除Pb外,Cu、Zn和Cd的全量不同程度超标,而4种重金属的DTPA浸提态含量均较高,Pb和Cu的DTPA浸提率高于Zn和Cd。金属全量及其DTPA浸提量之间极显著相关。土壤酸性和有机质对金属Pb、Zn、Cd的DTPA浸出率表现出显著的促进作用,而与Cu的浸出率相关不显著。DTPA态金属可以作为测定该类水稻土壤金属有效态含量的简便指标。金属的全量、种类,土壤pH、有机质等属性,以及农业耕作等因素影响金属的DTPA态含量及有效性。李永涛 刘科学 张池 Thierry Becquer Cécile Quantin MarcB enedtti Patrick Lavelle 戴军 2004农业环境科学学报2004,23,6:60
2酸性矿山废水污染的水稻田土壤中重金属的微生物学效应显示文摘采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 Cu、Pb、Zn、Cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学效应的因素。结果表明 :土壤高含硫 ,强酸性 ,有机碳、全氮较低 ,4种金属的全量普遍超标。DTPA可提取态金属含量较高 ,不仅与其全量呈显著正相关 ,而且与土壤酸度和粘粒含量正相关 ,和 Mn含量负相关。过量的金属显著降低了土壤微生物生物量 C、N、微生物商、生物量 N/全 N比 ,并抑制了微生物呼吸强度和对有机碳的矿化率 ,导致了土壤 C/N比的升高。同时 ,金属对微生物群落及生理代谢指标 ,如微生物生物量 C/N比和代谢商的影响不显著。 DTPA可提取态金属 ,特别是 DTPA- Cu是导致微生物生物量和活性指标变化的主要因素。以有机碳 (或全氮 )为基数的复合微生物指标降低了土壤性质差异造成的干扰 ,较单一指标更能准确指示微生物对金属胁迫的反应。土壤硫没有对金属有效性和微生物指标产生明显影响 。李永涛 Thierry Becquer Cécile Quantin Marc Benedetti Patric kLavelle 戴军 2004生态学报2004,24,11:31
3粤北大宝山高含硫多金属矿污染的水稻土壤污染元素的多元分析显示文摘调查了粤北大宝山高含硫多金属矿长期污染的水稻田的污染状况,用主成分分析法分析了环境变量间的关系及污染物在样点的空间分布.结果表明:长期的污灌导致了被调查水田土壤中铁矿、硫铜矿和铅锌矿酸性矿泥的沉积,引起土壤酸化和硫、铜、铅和镉的积累.上述污染元素与pH及矿质元素铁、钙之间高度相关,而与锰和铬的相关性差.李永涛 张池 刘科学 Thierry BECQUE Cécile QUANTIN Marc BENEDETTI Patrick LAVELLE 戴军 2005华南农业大学学报2005,26,2:26
4不同形态有机碳的有效性在两种重金属污染水平下水稻土壤中的差异显示文摘调查分析了两块不同重金属污染水平下的水稻田土壤有机碳活性组分的含量,以评价重金属胁迫条件下有机碳摹质的微生物有效性。结果显示,重污染水稻土的总有机碳(TOC)、0.5mol·-L^-1 K3SO4溶解态有机碳(K2SO4-C)、微生物生物量碳(MBC)、1~7d(CO2-C1-7d)和8.28d矿化的有机碳(CO2-C8-28d)的含量均显著低于轻污染土壤(P〈0.001)。碳有效性指标中,微生物商(MBC/TOC比)和8-28d的有机碳矿化率(CO2-C8-28d·TOC^-1 d^-1))在轻污染土壤中较高,而K2SO4-C/TOC和代谢商(qCO2)在重污染土壤较高(P〈0.001)。1—7d的有机碳矿化率(CO2-C1-7d·TOC^-1d^-1)在两种土壤中差异不显著。两种土壤培养初期的有机碳矿化率远高于培养后期(P〈0.001)。逐步回归分析显示,CO2-C1-7d与活性组分K2SO4-C和MBC显著相关(r^2=0.83,P〈0.001),而CO2-C8-28d只与TOC显著相关(r^2=0.70,P〈0.001)。研究表明,尽管如SO4溶解态有机碳在供试的重金属污染的水稻土中是较易被分解的活性碳基质,但重金属污染抑制了微生物数量及其呼吸活性,降低了活性有机碳库的矿化率,这是导致土壤中K2SO4溶解态碳积累的原因。溶解性有机碳叉能提高重金属的有效性,进一步抑制微生物对有机碳的矿化。因此,评价重金属污染的水稻土有机碳的有效性,应当综合考虑小同有机碳库的活性、微生物的矿化能力和碳基质在不同阶段的供应潜力。李永涛 戴军 Thierryecquer Cécile Quantin Marc Benedetti Patrick Lavelle 2006生态学报2006,26,1:14
5Polymeric foams for flexible and highly sensitive low-pressure capacitive sensors显示文摘Flexible low-pressure sensors(<10 kPa)are required in areas as diverse as blood-pressure monitoring,human–computer interactions,robotics,and object detection.For applications,it is essential that these sensors combine flexibility,high sensitivity,robustness,and low production costs.Previous works involve surface micro-patterning,electronic amplification(OFET),and hydrogels.However,these solutions are limited as they involve complex processes,large bias voltages,large energy consumption,or are sensitive to evaporation.Here,we report a major advance to solve the challenge of scalable,efficient and robust e-skin.We present an unconventional capacitive sensor based on composite foam materials filled with conductive carbon black particles.Owing to the elastic buckling of the foam pores,the sensitivity exceeds 35 kPa^(−1) for pressure<0.2 kPa.These performances are one order of magnitude higher than the ones previously reported.These materials are low-cost,easy to prepare,and display high capacitance values,which are easy to measure using low-cost electronics.These materials pave the road for the implementation of e-skin in commercialized applications.Mickaël Pruvost Wilbert J.Smit Cécile Monteux Philippe Poulin Annie Colin 2019npj Flexible Electronics2019,3,1:5
6Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes.Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau 2014World Journal of Gastroenterology2014,20,1:4
7Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS.Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin 2011World Journal of Gastroenterology2011,17,8:4
8Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care显示文摘AIM:To describe and analyse factors associated with Clostridium difficile infection(CDI)severity in hospitalised medical intensive care unit patients.METHODS:We performed a retrospective cohort study of 40 patients with CDI in a medical intensive care unit(MICU)at a French university hospital.We include patients hospitalised between January 1,2007and December 31,2011.Data on demographics characteristics,past medical history,CDI description was collected.Exposure to risk factors associated with CDI within 8 wk before CDI was recorded,including previous hospitalisation,nursing home residency,antibiotics,antisecretory drugs,and surgical procedures.RESULTS:All included cases had their first episode of CDI.The mean incidence rate was 12.94 cases/1000admitted patients,and 14.93,8.52,13.24,19.70,and8.31 respectively per 1000 admitted patients annually from 2007 to 2011.Median age was 62.9[interquartile range(IQR)55.4-72.40]years,and 13(32.5%)were women.Median length of MICU stay was 14.0d(IQR 5.0-22.8).In addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 patient.The duration of diarrhoea was 13.0(8.0-19.5)d.In addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 patient.Prior to CDI,38patients(95.0%)were exposed to antibiotics,and 12(30%)received at least 4 antibiotics.Fluoroquinolones,3rdgeneration cephalosporins,coamoxiclav and tazocillin were prescribed most frequently(65%,55%,40%and 37.5%,respectively).The majority of cases were hospital-acquired(n=36,90%),with 5 cases(13.9%)being MICU-acquired.Fifteen patients had severe CDI.The crude mortality rate within 30 d after diagnosis was 40%(n=16),with 9 deaths(9 over 16;56.3%)related to CDI.Of our 40 patients,15(37.5%)had severe CDI.Multivariate logistic regression showed that male gender[odds ratio(OR):8.45;95%CI:1.06-67.16,P=0.044],rising serum C-reactive protein levels(OR=1.11;95%CI:1.02-1.21,P=0.021),and previous exposure to fluoroquinolones(OR=9.29;95%CI:1.16-74.284,P=0.036)were independently associated with severe CDI.CONCLUSION:We report predictors of severe CDI not dependent on time of assessment.Such factors could help in the development of a quantitative score in ICU’s patients.Nagham Khanafer Abdoulaye Touré Cécile Chambrier Martin Cour Marie-Elisabeth Reverdy Laurent Argaud Philippe Vanhems 2013World Journal of Gastroenterology2013,19,44:2
9Laparoscopic subtotal colectomy for acute or severe colitis complicating inflammatory bowel disease: A case-matched study in 88 patients显示文摘Cécile Marceau Arnaud Alves Mehdi Ouaissi Yoram Bouhnik Patrice Valleur Yves Panis 2007Surgery2007,,5:2
10Retinoic acid receptors and cancer: from molecular mechanisms to therapy显示文摘Alessandra di Masi Loris Leboffe Elisabetta De Marinis Francesca Pagano Laura Cicconi Cécile Rochette-Egly Francesco Lo Coco Paolo Ascenzi Clara Nervi 2014Molecular Aspects of Medicine2014,,:2
11Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT 2A serotonin receptors显示文摘Cécile Vindis Romina D’Angelo Elodie Mucher Anne Nègre-Salvayre Angelo Parini Jeanne Mialet-Perez 2009Biochemical and Biophysical Research Communications2009,,1:2
12Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study显示文摘AIM: To evaluate the efficacy of adalimumab induction therapy in patients with ulcerative colitis who previously responded to infliximab and then lost response or became intolerant. METHODS: Ten patients with ulcerative colitis were enrolled in a 4-wk open-label trial. The patients received a loading dose of 160 mg adalimumab at wk 0 followed by 80 mg at wk 2. The primary efficacy measure was clinical improvement at wk 4, as defined by a decrease in clinical activity index (CAI) of more than 4. RESULTS: Four of 10 patients (40%) benefited from subsequent adalimumab therapy; one patient achieved remission (CAI < 4) and 3 had clinical improvement at wk 4. 6 patients had no response (60%); 2 of 6 (33.3%) subsequently underwent colectomy. This was accompanied by a decrease in median CRP concentration from 16.8 mg/mL at baseline to 3.85 mg/mL at wk 4, excluding two patients who underwent colectomy after two infusions of adalimumab. Among the 6 patients with severe colitis (CAI > 12) at baseline, none achieved remission and only one patient had clinical improvement at wk 4. CONCLUSION: The small advantage of adalimumab in patients with mild to moderate ulcerative colitis and lost response or intolerance to infliximab needs to be confirmed in randomised, double-blind, placebo- controlled trials.Laurent Peyrin-Biroulet Cécile Laclotte Xavier Roblin Marc-André Bigard 2007World Journal of Gastroenterology2007,13,16:2
13Functional Analysis of Yeast bcs1 Mutants Highlights the Role of Bcs1p-Specific Amino Acids in the AAA Domain显示文摘Cécile Nouet Gilles Truan Lise Mathieu Geneviève Dujardin 2009Journal of Molecular Biology2009,,2:2
14Naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names显示文摘Article 59.1,of the International Code of Nomenclature for Algae,Fungi,and Plants(ICN;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 July 2011.Since that date,each fungal species can have one nomenclaturally correct name in a particular classification.All other previously used names for this species will be considered as synonyms.The older generic epithet takes priority over the younger name.Any widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the Nomenclature Committee for Fungi(NCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic genera.In the case of pleomorphic genera,we follow the rulings of the current ICN and propose single generic names for future usage.The taxonomic placements of 1261 genera are listed as an outline.Protected names and suppressed names for 34 pleomorphic genera are listed separately.Notes and justifications are provided for possible proposed names after the list of genera.Notes are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data.Nalin N.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina J.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth Jones Johannes Z.Groenewald Ruvishika Jayawardena James D.Lawrey Jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.Nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka N.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.Jayarama Bhat Cécile Gueidan Putarak Chomnunti G.Sybren De Hoog Kerry Knudsen Wen-Jing Li Eric H.C.McKenzie Andrew N.Miller Alan J.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers Joanne E.Taylor Qing Tian Yong Wang Joyce H.C.Woudenberg Lei Cai Walter M.Jaklitsch Kevin D.Hyde 2014Fungal Diversity2014,,6:2
15Effects of microcystin-LR on development of medaka fish embryos ( Oryzias latipes )显示文摘Claire Jacquet Violette Thermes Amaury de Luze Simone Puiseux-Dao Cécile Bernard Jean-Stéphane Joly Franck Bourrat Marc Edery 2003Toxicon2003,,2:1
16A new complex homozygous large rearrangement of the PINK1 gene in a Sudanese family with early onset Parkinson’s disease显示文摘Cécile Cazeneuve Channkanira San Salah A. Ibrahim Maowia M. Mukhtar Musa M. Kheir Eric LeGuern Alexis Brice Mustafa A. Salih 2009neurogenetics2009,,3:1
17High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard 2011International Journal of Radiation Oncology Biology Physics2011,,3:1
18Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics显示文摘Cécile Sauvanet Stéphane Duvezin-Caubet Jean-Paul di Rago Manuel Rojo 2010Seminars in Cell and Developmental Biology2010,,6:1
19Stimulating creative play in children with autism through sandplay显示文摘Lucy Lu Fiona Petersen Louise Lacroix Cécile Rousseau 2009The Arts in Psychotherapy2009,,1:1
20Breast Milk as a Possible Route of Vertical Transmission of Dengue Virus?显示文摘Anne Barthel Ann-Claire Gourinat Cécile Cazorla Corinne Joubert Myrielle Dupont-Rouzeyrol Elodie Descloux 2013Clinical Infectious Diseases2013,,3:1
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