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1Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19.Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral 2021Cellular & Molecular Immunology2021,18,9:2
2Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 2013ACS Nano2013,7,5:1
3Rare-earth-doped transparent glass ceramics 显示文摘Goncalves M Clara Luis F Santos Rui M Almeida 2002Comptes Rendus Chimie2002,5,12:1
4Use of lateral circumflex femoral artery system free flaps in skull base reconstruction 显示文摘Daniel C Angel F Clara M 2011J Craniofac Surg2011,22,3:1
5Headspace solid -phase micro -extraction and gas chromatography-ion trap tandem mass spectrometry method for butyhin analysis in sediments: Optimization and validation显示文摘Pedro N Carvalho Luiz F Pinto M Clara P Basto 2007Microchemical journal2007,87,2:1
6Rapid detection and serotyping of prunus necrotic ringspot virus in perennial crops by enzymelinked immmosorbent assay显示文摘Barbars D J ClarA M F Threch J M 1978Ann Appl Biol1978,90,:1
7Cerqueira functional characterisation and antimicrobial efficiency assessment of smart nanohydrogels containing natamycin incorporated into polysaccharide-based films 显示文摘CLARA F MARTIN M MIGUEL A 2015Food and bioprocess technology2015,8,7:1
8A new bacterial disease of pears显示文摘Clara F M 1932Sciences1932,75,:1
9Estrogen replace- ment therapy regulation of energy metabolism in female mouse hy- pothalamus显示文摘ROBERTA F SARA DT CLARA M 2014Endocrinology2014,155,20:1
10Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010:a systematic analysis显示文摘Nair H Simoes E A Rudan I Gessner B D AzzizBaumgartner E Zhang J S Feikin D R Mackenzie G A Moisi J C Roca A Baggett H C Zaman S M SingletonR J Lucero M G Chandran A Gentile A Cohen C Krishnan A Bhutta Z A Arguedas A Clara A W Andrade A L Ope M Ruvinsky R O Hortal M McCracken J P Madhi S A Bruce N Qazi S A Morris S S El Arifeen S Weber M W Scott J A Brooks W A Breiman R F Campbell H 2013Lancet2013,381,9875:1
11BAALC, a novel marker of human hematopoietic progenitor cells显示文摘Claudia D Baldus Stephan M Tanner Donna F Kusewitt Sandya Liyanarachchi Changsun Choi Michael A Caligiuri Clara D Bloomfield Albert de la Chapelle 2003Experimental Hematology2003,,11:1
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