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| 1 | Exocrine pancreatic insufficiency in adults:A shared position statement of the Italian association for the study of the pancreas显示文摘This is a medical position statement developed by the Exocrine Pancreatic Insufficiency collaborative group which is a part of the Italian Association for the Study of the Pancreas(AISP).We covered the main diseases associated with exocrine pancreatic insufficiency(EPI)which are of common interest to internists/gastroenterologists,oncologists and surgeons,fully aware that EPI may also occur together with many other diseases,but less frequently.A preliminary manuscript based on an extended literature search(Medline/PubMed,Cochrane Library and Google Scholar)of published reports was prepared,and key recommendations were proposed.The evidence was discussed at a dedicated meeting in Bologna during the National Meeting of the Association in October 2012.Each of the proposed recommendations and algorithms was discussed and an initial consensus was reached.The final draft of the manuscript was then sent to the AISP Council for approval and/or modification.All concerned parties approved the final version of the manuscript in June 2013. | Raffaele Pezzilli Angelo Andriulli Claudio Bassi Gianpaolo Balzano Maurizio Cantore Gianfranco Delle Fave Massimo Falconi Luca Frulloni the Exocrine Pancreatic Insufficiency collaborative(EPIc) Group | 2013 | World Journal of Gastroenterology2013，19，44： | 16 |
| 2 | Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study显示文摘AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at 'regular', double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of patients who consumed the LGG formulation, and bowel cleansing did not affect LGG adhesion. UC patients who consumed the double LGG dose had increased mucosal concentrations of the bacteria and reduced TNFα and IL-17 expression compared with patients who consumed the regular dose (48% and 40% reduction, respectively, P < 0.05).CONCLUSION In an ex vivo organ culture model, LGG showed consistent adhesion and anti-inflammatory effects. Colonization by LGG after consumption for a week was demonstrated in vivo in the human colon. Increasing the administered dose increased the adhesion and effectiveness of the bacteria. For the first time, we demonstrated that LGG effectively adheres to the colonic mucosa and exerts antiinflammatory effects, both ex vivo and in vivo. | Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio Di Giulio Gianfranco Delle Fave | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 3 | Static and rotational intensity modulated techniques for head-neck cancer radiotherapy: A planning comparison显示文摘 | Sara Broggi Lucia Perna Francesco Bonsignore Giuseppe Rinaldin Claudio Fiorino Anna Chiara Cristina Frigerio Ivana Butti Giulia Sangalli Italo Dell’Oca Nadia Di Muzio Giovanni Mauro Cattaneo Fausto Declich | 2014 | Physica Medica2014，，： | 1 |
| 4 | Intensity-Modulated Proton Therapy Versus Helical Tomotherapy in Nasopharynx Cancer: Planning Comparison and NTCP Evaluation显示文摘 | Lamberto Widesott Alessio Pierelli Claudio Fiorino Italo Dell’Oca Sara Broggi Giovanni Mauro Cattaneo Nadia Di Muzio Ferruccio Fazio Riccardo Calandrino Marco Schwarz | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，： | 1 |
| 5 | Collaborative strategies in design-intensive industries: knowledge diversity and innovation 显示文摘 | Claudio Dell'Era Roberto Verganti | 2010 | Long Range Planning2010，1，43： | 1 |
| 6 | Nonfunctioning pancreatic endocrine tumors: a multicenter clinical study显示文摘 | Lucio Gullo Marina Migliori Massimo Falconi Paolo Pederzoli Rossella Bettini Riccardo Casadei Gianfranco Delle Fave Vito D Corleto Claudio Ceccarelli Donatella Santini Paola Tomassetti | 2003 | The American Journal of Gastroenterology2003，，11： | 1 |
| 7 | An integrated chemical,thermal,and microbiological approach to compost stability evaluation显示文摘 | Claudio Mondini Maria Teresa Dell Abate Liviana Leita | 2003 | Journal of Environmental Quality2003，32，6： | 1 |
| 8 | An integrated chemical, thermal, and microbiological approach to compost stability evaluation显示文摘 | Claudio Mondini Maria Teresa Dell Abate Liviana Leita | 2003 | Journal of Environmental Quality2003，32，6： | 1 |
| 9 | An integrated chemical, thermal, and microbiological approach to compost stability evaluation显示文摘 | Claudio Mondini Maria Teresa Dell Abate Liviana Leita Anna Benedetti | 2003 | Journal of Environmental Quality2003，32，6： | 1 |
| 10 | Identification of PCR-based markers (RAPD, AFLP) linked to a novel powdery mildew resistance gene (ol-2) in tomato显示文摘 | Claudio De Giovanni Pasqua Dell Orco | 2004 | Plant Science2004，，166： | 1 |
| 11 | Reaction-induced strain loealization:Torsion experiments on dolomite显示文摘 | Claudio Delle Piane Luigi Burlini Bernard Grobety | 2007 | Earth and Planetary Science Letters2007，256，12： | 1 |
| 12 | Reaction-indueed strain localization:Torsion experiments on dolomite 显示文摘 | Claudio Delle Piane Luigi Burlini Bernard Grobety | 2007 | Earth and Planetary Science Letters2007，256，12： | 1 |
| 13 | HCV carriers with normal alanine aminotransferase levels: Healthy persons or severely ill patients?显示文摘 | Claudio Puoti Lia Bellis Riccardo Guarisco Orlando Dell’ Unto Lucia Spilabotti Olga Mitidieri Costanza | 2009 | European Journal of Internal Medicine2009，，： | 1 |
| 14 | Prognosis of Breast Cancer Patients after Mastectomy and Dissection of Internal Mammary Nodes显示文摘 | UMBERTO VERONESI NATALE CASCINELLI MARCO GRECO ROSARIA BUFALINO ALBERTO MORABITO DOMENICO GALLUZZO RUDI CONTI RICCARDO DE LELLIS VINCENZO DELLE DONNE PATRIZIA PIOTTI VIRGILIO SACCHINI CLAUDIO CLEMENTE BRUNO SALVADORI | 1985 | Annals of Surgery1985，，6： | 1 |
| 15 | Identifi- cation of PCR-based markers (RAPD, AFLP) linked to a novel powderymildew resistance gene(ol-2)in tomato显示文摘 | Claudio De G Pasqua Dell' Orco Angela B | 2004 | Plant Science2004，166，1： | 1 |
| 16 | An in-depth multi-technique characterization of rare earth carbonates-RE_(2)(CO_(3))_(3)·2H_(2)O-owning tengerite-type structure显示文摘The present study has been conducted to contribute,once and for all,filling the lack of structural information for the whole class of rare earth(RE)carbonates owning the tengerite-(Y)structure.A complete structural characterization,carried out by Rietveld refinement of X-ray powder diffraction(XRD)data,was comparatively performed for the first time on several hydrated RE carbonates,having the general chemical formula RE_(2)(CO_(3))_(3)·χH_(2)O,RE=Y,Gd,Tb,Dy,Ho and Er.All samples share the same space group and lattice parameters similar to tengerite-(Y);the structures are also closely related,consisting in all cases of a three-dimensional framework of nine-fold coordinated RE atom polyhedral,linked together by carbonate ions.In addition to relatively minor changes in fractional coordinates of atom sites and corresponding interatomic distances,the only perceivable difference lies in the lattice parameters affected by the ionic radius of RE^(3+).However,in the case of Er,which has the lowest cationic radius among the analyzed RE,the stabilization of tengerite structure is at its limit condition,because the carbonate groups are heavily distorted.Furthermore,FT-IR and Raman spectra confirm the main structural features obtained by Rietveld refinements.The observed morphology of the various samples is almost the same,being characterized by the presence of bidimensional rod-like particles grouped in agglomerates,typical of tengerite crystals,thus indicating that the crystallization mechanism occurring during the hydrothermal synthesis is the same,irrespective of the involved RE cation. | Luca Spiridigliozzi Mauro Bortolotti Grazia Accardo Alessandro Vergara Domenico Frattini Claudio Ferone Raffaele Cioffi Gianfranco Dell'Agli | 2022 | Journal of Rare Earths2022，40，8： | 0 |
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