|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | N末端脑利钠肽(NT-proBNP)对硬皮病相关性肺动脉高压的作用显示文摘Aims: The aims of this study were to evaluate the diagnostic value and to explore the prognostic value of N-terminal brain natriuretic peptide(N-TproBNP) in patients with systemic sclerosis(SSc) both with and without pulmonary arterial hypertension(PAH). Methods and results: N-TproBNP, six minute walk distance(SMWD), haemodynamics(at right heart catheterization) or tricuspid gradient(by echocardiography), and survival were assessed in 109 patients with SSc. The study population included 68 individuals with PAH[mean pulmonary artery pressure(PAP) >25 mmHg and pulmonary capillary wedge pressure< 15 mmHg] and 41 individuals without PAH. In patients with PAH, the prognostic value of baseline and change in WHO functional class, N-TproBNP levels, and SMWD were compared using Kaplan-Meier survival curves and Cox proportional hazard analysis. The mean duration of follow-up was 10 months(range 1-18 months). One year survival in patients with normal PAP was 100%when compared with 83.5%in those with SSc-PAH(P< 0.05). The patients without PAH had a mean N-TproBNP level of 139 pg/mL(SD 151); those with SSc-PAH had a significantly higher mean NTproBNP level of 1474 pg/mL(SD 2642)(P=0.0002). Among patients with PAH for every order of magnitude increase in N-TproBNP level there was a four-fold increased risk of death(P=0.002 for baseline level and P=0.006 for follow-up level). Baseline N-TproBNP levels were correlated positively with mean PAP(r=0.62; P< 0.0001), pulmonary vascular resistance(PVR)(r=0.81; P< 0.0001), and inversely with SMWD(r=-0.46; P< 0.0001). Among patients with SSc-PAH, 13 patients(19%) were in WHO functional classes Ⅱ and had mean NTproBNP levels of 325 pg/mL(SD 388). Fifty-three patients(78%) were in WHO classes Ⅲ and IV and had significantly higher mean N-TproBNP levels of 1677 pg/mL(SD 2835)-(P=0.02). At an N-TproBNP level of 395 pg/mL, the sensitivity and specificity for predicting the presence of SSc-PAH were 56 and 95%respectively. Conclusion: Raised N-TproBNP levels are directly related to the severity of PAH. In screening programs, SSc patients with an N-TproBNP in excess of 395 pg/mL have a very high probability of having pulmonary hypertension. Baseline and serial changes in N-TproBNP levels are highly predictive of survival. A 10-fold increase in N-TproBNP level on therapy is associated with a greater than three-fold increase in mortality, and may indicate therapeutic failure. | Williams M.H. Handler C.E. Akram R. J.G. Coghlan 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 4 |
| 2 | The structure and function of the helical heart and its buttress wrapping. I. The normal macroscopic structure of the heart显示文摘 | Francisco Torrent-Guasp Gerald D. Buckberg Carmine Clemente James L. Cox H.Cecil Coghlan Morteza Gharib | 2001 | Seminars in Thoracic and Cardiovascular Surgery2001，，4： | 2 |
| 3 | Use of alfentanil with propofol for nasotracheal intubation without neuromuscular block 显示文摘 | Coghlan SFE McDonald PF Csepregi G | 1993 | Br J Anaesth1993，70，1： | 1 |
| 4 | The anti-inflammatory effects of dexamethasone and therapeutic ultrasound in oral surgery显示文摘 | ElHag M Coghlan K Christmas P | 1985 | Br J Oral Maxillofac Surg1985，23，1： | 1 |
| 5 | PCR-based microsatellite analysis for differentiation and genetic monitoring of nine inbred SENCAR mouse strains显示文摘 | Benavides F Glasscock E Coghlan L G | | 0，，02： | 1 |
| 6 | The effect of physician-based cognitive behavioural therapy among preg- nant women with depressive symptomatology: a pilot quasi- experimental trial 显示文摘 | MCGREGOR M COGHLAN M DENNIS CL | 2014 | Early Interv Psychiatry2014，8，4： | 1 |
| 7 | Potassium channels:molecular defects, diseases, and therapeutic opportunities 显示文摘 | Shieh CC Coghlan M Sullivan JP | 2000 | Pharmacol Rev2000，52，4： | 1 |
| 8 | Tracking affective components of satisfaction 显示文摘 | Coghlan A Pearce P(2010) | 2010 | Tourism and Hospitality Research2010，4258，： | 1 |
| 9 | Recent Developments in the Biology and Medicinal Chemistry of Potassium Channel Modulators: Update from fl Decade of Progress 显示文摘 | COGHLAN MJ CARROLL WA GOPAL AKRISHNAN M | 2001 | J Med Chem( S0022 - 2623 )2001，44，： | 1 |
| 10 | The psy- chology of ownerships: work environment structure, or- ganisational commitment and citizenship behaviours 显示文摘 | O'DRISEOLL M P PIERCE J L COGHLAN A | 2006 | Group & Organisation Management2006，31，3： | 1 |
| 11 | Connective tissue disease associated pulmonary arterial hypertension显示文摘 | Coghlan JG Handler C | 2006 | Lupus2006，15，3： | 1 |
| 12 | The Psychology of Ownership Work Environment Structure, Organizational Commitment, and Citizenship Behaviors 显示文摘 | MICHAEL P O'DRISCOLL JON L PIERCE ANN-MARIE COGHLAN | 2006 | Group Organization Management2006，31，6： | 1 |
| 13 | Distraction osteogenesis of the mandible in the previously irradiated patient显示文摘 | Holmes SB Lloyd T Coghlan KM | 2002 | J Oral Maxillofac Surg2002，60，3： | 1 |
| 14 | Towards an integrated image-based typology of volunteer tourism organizations 显示文摘 | Coghlan A | 2007 | Journal of Sustainable Tourism2007，15，3： | 1 |
| 15 | A facile method for monoacetylatlon of sy- metrical diols: application to the total synthesis of Z - 8 - dodecenyl acetate, the sex attractant of the oriental fruit moth显示文摘 | Babler J H Coghlan M J | 1979 | Tetrahedron Letters1979，20，22： | 1 |
| 16 | Fluorescence evidence of polar hy- drocarbon interaction on mineral surfaces and implications to alter- ation of reservoir wettability 显示文摘 | Liu K Eadington P Coghlan D | 2003 | Journal of Petroleum Science and Engineering2003，39，34： | 1 |
| 17 | Feasibility and preliminary accuracy of high-resolution imaging of the liver and pancreas using FNA compatible microendoscopy (with video)显示文摘 | Renu Regunathan Jenny Woo Mark C. Pierce Alexandros D. Polydorides Mohammad Raoufi Sasan Roayaie Myron Schwartz Daniel Labow Dongsuk Shin Rei Suzuki Manoop S. Bhutani Lezlee G. Coghlan Rebecca Richards-Kortum Sharmila Anandasabapathy Michelle Kang Kim | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 18 | Endothelin receptor antagonism:role in the treatment of pulmonary arterial hypertension related to scleroderma显示文摘 | Kabunga P Coghlan G | 2008 | Drugs2008，68，12： | 1 |
| 19 | Fluorescence evidence of po- lar hydrocarbon interaction on mineral surfaces and implica tions to alteration of reservoir wetability显示文摘 | Liu K Eadington P Coghlan D | 2003 | Journal of Petro- leum Engineering2003，39，： | 1 |
| 20 | Neurological damage after sagittal split osteotomy显示文摘 | Irvine GH | 1986 | Int J Oral Maxillofac Surg1986，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员