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| 1 | Classification of anemia for gastroenterologists显示文摘Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classifi cation (microcytic, macrocytic and normocytic) and pathogenic classi-fication (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other comple-mentary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time. | Jose Antonio Moreno Chulilla Maria Soledad Romero Colás Martín Gutiérrez Martín | 2009 | World Journal of Gastroenterology2009，15，37： | 6 |
| 2 | Damage in hot rolling work rolls显示文摘 | Rafael Colás Jorge Ram??rez Ignacio Sandoval Julio C Morales Luis A Leduc | 1999 | Wear1999，，1： | 1 |
| 3 | Condensation in a square minichannel: application of the VOF method 显示文摘 | Bortolin S Da Riva E Del Col D | 2014 | Heat Transfer Engineering2014，35，2： | 1 |
| 4 | Ophiolite hosted chromitite formed by supra-subduction zone peridotite–plume interaction显示文摘Chromitite bodies hosted in peridotites typical of suboceanic mantle(s.l.ophiolitic)are found in the northern and central part of the Loma Caribe peridotite,in the Cordillera Central of the Dominican Republic.These chromitites are massive pods of small size(less than a few meters across)and veins that intrude both dunite and harzburgite.Compositionally,they are high-Cr chromitites[Cr#=Cr/(Cr+Al)atomic ratio=0.71-0.83]singularly enriched in TiO2(up to 1.25 wt.%),Fe2 O3(2.77-9.16 wt.%)as well as some trace elements(Ga,V,Co,Mn,and Zn)and PGE(up to 4548 ppb in whole-rock).This geochemical signature is unknown for chromitites hosted in oceanic upper mantle but akin to those chromites crystallized from mantle plume derived melts.Noteworthy,the melt estimated to be in equilibrium with such chromite from the Loma Caribe chromitites is similar to basalts derived from different source regions of a heterogeneous Caribbean mantle plume.This mantle plume is responsible for the formation of the Caribbean Large Igneous Province(CLIP).Dolerite dykes with back-arc basin basalt(BABB)and enriched mid-ocean ridge basalt(E-MORB)affinities commonly intrude the Loma Caribe peridotite,and are interpreted as evidence of the impact that the Caribbean plume had in the off-axis magmatism of the back-arc basin,developed after the Caribbean island-arc extension in the Late Cretaceous.We propose a model in which chromitites were formed in the shallow portion of the back-arc mantle as a result of the metasomatic reaction between the supra-subduction zone(SSZ)peridotites and upwelling plume-related melts. | Júlia Farré-de-Pablo Joaquín A.Proenza JoséMaría González-Jiménez Thomas Aiglsperger Antonio Garcia-Casco Javier Escuder-Viruete Vanessa Colás Francisco Longo | 2020 | Geoscience Frontiers2020，11，6： | 1 |
| 5 | Knockdown of nurr1 in the rat hippocampus:implications to spatial discrimination learning and memory显示文摘 | Colón-Cesario W I Martínez-Montemayor M M Morales S | 2006 | Learn Mem2006，13，6： | 1 |
| 6 | Condensation of pure and near-azeotropic refrigerants in microfin tubes: A new computational procedure 显示文摘 | Cavallini A Del Col D Manein S | 2009 | International Journal of Refrigeration2009，32，1： | 1 |
| 7 | Smoothened (SMO) receptor mutations dictate resistance to vismedegib in basal cell carcinoma显示文摘 | Pricl S Cortelazzi B Dal Col V | 2015 | Mol Oncol2015，9，2： | 1 |
| 8 | Metaanalysis:excess mortality after hip fracture among older women and men显示文摘 | Haentjens P Magaziner J Colón-Emeric C S | 2010 | Annals of Internal Medicine2010，152，6： | 1 |
| 9 | Performance of compostable baby used diapers in the composting process with the organic fraction of municipal solid waste显示文摘 | Joan Colón Maria Mestre-Montserrat Ignasi Puig-Ventosa Antoni Sánchez | 2013 | Waste Management2013，，5： | 1 |
| 10 | Retinoic acid stabilizes p27Kipl in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cksl proteins 显示文摘 | Zancai P Dal Col J Piccinin S | 2005 | Oncogene2005，24，15： | 1 |
| 11 | Mechanical properties of smal fragment screws显示文摘 | Col inge CA Stern S Cordes S | | 0，，373： | 1 |
| 12 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 13 | Pla sm a fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality:an individual participant Meta-analysis显示文摘 | Col lab or at ion FS Da ne sh J L ew i ng t on S | 2005 | JAMA2005，294，14： | 1 |
| 14 | Social Capital in the Creation of Human Capital显示文摘 | COL | 1988 | AmericanJournal of Sociological Review1988，94，95： | 1 |
| 15 | A long-term experience with the Cabrol root replacement technique for the management of ascending aortic aneurysms and dissections显示文摘 | GELSOMINO S FRASSANI R DA COL P | 2003 | Ann Thorac Surg2003，75，1： | 1 |
| 16 | 查看详情显示文摘 | Serrano T G6mez I Colás R Cavazos J | | 0，，： | 1 |
| 17 | Hydrothermal synthesis of BiVO4:Structural and morphological influence on the photocatalytic activity显示文摘 | Obregón S Caballero A Colón G | 2012 | Appl Catal B:Environmental2012，，： | 1 |
| 18 | Study of deformation and aging behaviour of iron–silicon alloys显示文摘 | Tanya Ros-Yanez Daniel Ruiz José Barros Yvan Houbaert Rafael Colás | 2006 | Materials Science & Engineering A2006，，1： | 1 |
| 19 | Enhanced water use efficiency in a mixed Eucalyptus globulus and Acacia mearnsii plantation显示文摘 | Forrester D I Theiveyanathanc S Col lopya J J | 2010 | Forest Ecology and Management2010，259，： | 1 |
| 20 | Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD 显示文摘 | LAWRENCE N S AN S K MATAIX- COLS D | 2007 | Biol Psychiatry2007，61，9： | 1 |
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