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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels 显示文摘 | Longatto Filho A Martins A Costa SM Schmitt PC | 2005 | Pathol Res Pract2005，201，2： | 1 |
| 3 | Dopaminc transporter binding in Gilles de la Tourette Syndrome 显示文摘 | Serrar Mestres J Ring HA Costa PC | 2004 | Acta Paychiatr Scand2004，109，2： | 1 |
| 4 | Primary endemic Cryptococeosis gattii by molecular type VGII in the state of Pard, Brazil 显示文摘 | Santos WR Meyer W Wanke B Costa SP Trilles L Nascimento JL Medeiros R Morales BP Bezerra Cde C Macedo PC Ferreira SO Barbosa GG Perez MA Nishikawa MM Lazera Mdos S | 2008 | Meln Inst Oswaldo Cruz2008，103，8： | 1 |
| 5 | Candida bloodstream infection:data from a teachinghospital in Mato Grosso do Sul,Brazil显示文摘 | Chang MR Correia FP Costa LC Xavier PC Palhares DB Tai-ra DL | 2008 | Rev Inst Med Trop SaoPaulo2008，50，5： | 1 |
| 6 | Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods 显示文摘 | Rosa Pena Ferreira M Costa PC Femanda M | 2010 | Skin Res Technol2010，16，： | 1 |
| 7 | Potent antigen specific immunity to Toxoplasma gondii in adjuvant-free vaccination system using ROP2-Leishmania infantum Hsp83 fusion protein显示文摘 | Eeheverria PC Miguel N Costas M | 2006 | Vaccine2006，24，19： | 1 |
| 8 | Validation of the five-factor model across instruments and observers显示文摘 | McC rae RR Costa PC Jr | 1987 | Journal of Personality and Social Psychology1987，52，1： | 1 |
| 9 | Simultaneous appearance of Behcet's disease and pulmonary tuberculosis显示文摘 | Coelho PC da Silva JA Romeu JC da Costa JC de Queiroz MV | 1994 | Clin Exp Rheumatol1994，12，6： | 1 |
| 10 | An expeditious synthesis of 3-nitropropionic acid and its ethyl and methyl esters 显示文摘 | Silva PC Costa JS Pereira VLP | 2001 | Synth Commun2001，31，4： | 1 |
| 11 | Efficacy of anti-wrinkle products in skin surface appearance:a comparative study using non-invasive methods显示文摘 | Pena Ferreira MR Costa PC Bahia FM | | 0，，04： | 1 |
| 12 | Potent antigenspecific immunity to Toxoplasma gondii in adjuvant-free vaccination system using Rop2-Leishmania infantum Hsp83 fusion protein 显示文摘 | Echeverria PC de Miguel N Costas M | 2006 | Vaccine2006，24，19： | 1 |
| 13 | Cutaneous prototheco- sis--case report显示文摘 | Silva PC Costa e Silva SB Lima RB | 2013 | An Bras Dermatol2013，88，61： | 1 |
| 14 | Automated evaluation of the effect of ionic liquids on catalase activity显示文摘 | Pinto PC Costa AD Lima JL | 2011 | Chemosphere2011，82，11： | 1 |
| 15 | Galactomannan and polymerase chain reaction for the diagnosis of primary digestive aspergillosis in a patient with acute myeloid leukaemia 显示文摘 | Chambon PC Costa JM Chaumette MT | 2001 | J Infect2001，43，3： | 1 |
| 16 | Dopaminc transporter binding in Gilles de la Tourette Syndrome显示文摘 | Serrar Mestres J Ring HA Costa PC | 2004 | Acta Psychiatr Scand2004，109，2： | 1 |
| 17 | Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheoslosis 显示文摘 | Hellemans J Preobrazhenska O Willaert A Debeer P Verdonk PC Costa T | 2004 | Nat Genet2004，36，11： | 1 |
| 18 | Analysis of 12 variants in the development of gastric and colorectal cancers显示文摘AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in CASP8,CYP2 E1,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 genes) were genotyped in a single PCR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PCR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS v.20.RESULTS After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of GC. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of CRC. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. Carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing GC than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing CRC than carriers of other combinations.CONCLUSION These findings are important for the comprehension of gastric and CRC development,particularly in highly admixed populations,such as the Brazilian population. | Giovanna C Cavalcante Marcos AT Amador Andre M Ribeiro dos Santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F Costa Ney PC Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos | 2017 | World Journal of Gastroenterology2017，23，48： | 0 |
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