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| 1 | Leaching ion adsorption rare earth by aluminum sulfate for increasing efficiency and lowering the environmental impact显示文摘The leaching efficiency(LE) of ion adsorption rare earth(IARE) by the sulfate and chloride of ammonium,magnesium and aluminum were comparatively determined using column leaching method. It is found that at equal equivalent concentration of cation, the LE of IARE by aluminum sulfate is the highest, and the zeta potential of clay mineral particles in the tailing is near to zero, which means a lower risk of landslide and pollutant emission. Furthermore, the optimum concentration of aluminum sulfate is determined to be0.02 mol/L, which is much lower than that of ammonium sulfate and magnesium sulfate. To reduce the production cost and environmental impact, we proposed a multi-stage leaching process, which was firstly leaching with ammonium sulfate and then with aluminum sulfate, following by water washing and lime neutralizing. With the ratio of ammonium sulfate to aluminum sulfate varying from 1:0 to 0.5:0.5, the residual ammonium in tailing decreases from 11.2% to 0.6%, however, the LE of RE shows an optimum value at 0.8:0.2. By neutralizing the pH of tailing with lime water to over 6, the ion concentration in water rinsing solution can meet the requirement for water discharge. At the same time, the zeta potential of clay particles is found to be around-5 mV, means a relatively lower risk of landslide. These facts indicate that the LE of IARE can be increased and the danger caused by tailings landslides and pollutant emissions can be reduced by replacing ammonium sulfate with aluminum sulfate as leaching reagent. | Lifen Yang Cuicui Li Dashan Wang Fengyang Li Yanzhu Liu Xuezhen Zhou Mingbiao Liu Xiufeng Wang Yongxiu Li | 2019 | Journal of Rare Earths2019，37，4： | 19 |
| 2 | Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration显示文摘Macrophages play an important role in material-related immune responses and bone formation,but the functionality of macrophage-derived extracellular vesicles(EVs)in material-mediated bone regeneration is still unclear.Here,we evaluated intracellular communication through small extracellular vesicles(sEVs)and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen(IMC).After implantation in the bone defect area,IMC generated more neobone and recruited more mesenchymal stem cells(MSCs)than did extrafibrillarly mineralized collagen(EMC).More CD63+CD90+and CD63+CD163+cells were detected in the defect area in the IMC group than in the EMC group.To determine the functional roles of sEVs,extracellular vesicles from macrophages cultured on different mineralized collagen were isolated,and they showed no morphological differences.However,macrophage-derived sEVs in the IMC group showed an enhanced Young’s modulus and exerted beneficial effects on the osteogenic differentiation of bone marrow MSCs by increasing the expression of the osteoblastic differentiation markers BMP2,BGLAP,COL1,and OSX and calcium nodule formation.Mechanistically,sEVs from IMC-treated macrophages facilitated MSC osteogenesis through the BMP2/Smad5 pathway,and blocking sEV secretion with GW4869 significantly impaired MSC proliferative,immunomodulative and osteogenic potential.Taken together,these findings show that macrophage-derived sEVs may serve as an emerging functional tool in biomaterial-mediated endogenous bone regeneration. | Anqi Liu Shanshan Jin Cuicui Fu Shengji Cui Ting Zhang Lisha Zhu Yu Wang Steve G.F.Shen Nan Jiang Yan Liu | 2020 | International Journal of Oral Science2020，12，4： | 5 |
| 3 | Separation of chalcopyrite and pyrite from a copper tailing by ammonium humate显示文摘Copper tailings constitute a large proportion of mine wastes. Some of the copper tailings can be recycled to recover valuable minerals. In this paper, a copper tailing was studied through the chemical analysis method, Xray diffraction and scanning electron microscope-energy dispersive spectrum. It turned out that chalcopyrite(Cu) and pyrite(S) were the main recoverable minerals in the tailing. In order to separate chalcopyrite from pyrite in low pulp pH, ammonium humate(AH) was singled out as the effective regulator. The depression mechanism of AH on the flotation of pyrite was proved by FTIR spectrum and XPS spectrum, demonstrating that there was a chemical adsorption between AH and pyrite. By Response Surface Methodology(RSM), the interaction between AH, pulp pH and iso-butyl ethionine(Z200) was discussed. It was illustrated that the optimal dosage of AH was 1678 g·t^(-1) involving both the recovery of Cu and S. The point prediction by RSM and the closed-circuit flotation displayed that the qualified Cu concentrate and S concentrate could be obtained from the copper tailing.The study indicated that AH was a promising pyrite depressor in the low pulp pH from copper tailings. | Cuicui Lü Yongliang Wang Peng Qian Ya Liu Guoyan Fu Jian Ding Shufeng Ye Yuanfa Chen | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 5 |
| 4 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 5 | Structural insights into SUN-KASH complexes across the nuclear envelope显示文摘nucleoskeleton 和细胞骨架(LINC ) 的连接器建筑群由阳光和 KASH 包含域的蛋白质组成并且衔接原子信封的内部、外部的膜。LINC 建筑群在原子放,房间极化和细胞的僵硬起关键作用。以前,我们报导了人的 SUN2 的 homotrimeric 结构。我们现在决定了人的 SUN2-KASH 建筑群的水晶结构。在复杂结构, SUN 领域 homotrimer 绑在三独立 “ hook”相似 KASH 肽。在建筑群的 SUN 领域的全面符合构造非常处于它的 apo 状态类似于 SUN 领域。一个主要 conformational 变化包含 KASH 固定的阳光领域的 AA'-loop,它重排形成微型 β与 KASH 肽交往的表。KASH 领域的磅主题在 SUN 领域的 homotrimeric 接口上紧适合进一个恐水病的衣袋,我们它称为双性人衣袋。而且, SUN 领域 homotrimer 三明治的二邻近的 protomers 由结合的恐水病的相互作用和氢的 KASH 领域。这些有约束力的地点的变化在 vitro 破坏或减少在 SUN 和 KASH 域之间的协会。另外, transfection 野类型,然而并非变异, SUN2 在 Ovcar-3 房间支持房间移植。这些结果提供 LINC 建筑群的一个结构的模型,它为另外的学习是必要的物理、功能在细胞质和核质之间联合。 | Wenjia Wang Zhubing Shi Shi Jiao Cuicui Chen Huizhen Wang Guoguang Liu Qiang Wang Yun Zhao Mark I Greene Zhaocai Zhou | 2012 | Cell Research2012，22，10： | 3 |
| 6 | N-doped porous graphene for carbon dioxide separation:a molecular dynamics study显示文摘Using molecular dynamics simulations,it is shown that N-doped porous graphene membrane can efficiently separate CO2from the CO2/CH4mixture.The effects of pore rim modifications,N-doping sites,initial gas pressure,and feed gas compositions on CO2separation performance of N-doped porous graphene membrane are also examined.It is found that gas permeability increases with increasing initial gas pressure or the feed gas percentages.Pore rim modifications with nitrogen atoms(pyridinic N)can significantly improve the selectivity of CO2over CH4owing to the enhanced electrostatic interactions compared to the unmodified one,and the all-N-modified pore-16 shows the highest CO2selectivity over CH4(*29).Doping N atoms on the graphene sheets(quaternary N)has little effect on the CO2selectivity.Our study demonstrates that the N-doped porous graphene is an excellent candidate for CO2separation,which may be beneficial for the realization of a low carbon society. | Qingzhong Xue Meixia Shan Yehan Tao Zilong Liu Cuicui Ling Yonggang Du | 2014 | Chinese Science Bulletin2014，59，29： | 3 |
| 7 | Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TG Fpi pathways via off-VEGF signaling显示文摘Objective:Bevacizumab is a recombinant humanized monoclonal antibody that blocks vascular endothelial growth factor(VEGF)with clear clinical benefits.However,overall survival of some cancer types remains low owing to resistance to bevacizumab therapy.While resistance is commonly ascribed to tumor cell invasion induced by hypoxia-inducible factor(HIF),less attention has been paid to the potential involvement of endothelial cells(ECs)in vasculature activated by anti-angiogenic drugs.Methods:Human umbilical vein ECs(HUVECs),bEnd.3 cells,and mouse retinal microvascular ECs(MRMECs)were treated with bevacizumab under conditions of hypoxia and effects on biological behaviors,such as migration and tube formation,examined.Regulatory effects on TGFpi and CD 105(endoglin)were established via determination o f protein and mRNA levels.We further investigated whether the effects of bevacizumab could be reversed using the receptor tyrosine kinase inhibitor anlotinib.Results:Bevacizumab upregulated TGFpi as well as CD 105,a component o f the TGFP receptor complex and an angiogenesis promoter.Elevated CD 105 induced activation of Sm adl/5,the inflammatory pathway and endothelial-mesenchymal transition.The migration ability of HUVECs was enhanced by bevacizumab under hypoxia.Upregulation o f CD 105 was abrogated by anlotinib,which targets multiple receptor tyrosine kinases including VEGFR2/3,FGFR1-4,PD G FRα/β,C-Kit,and RET.Conclusions:Bevacizumab promotes migration and tube formation of HUVECs via activation of the TGFβi pathway and upregulation of CD105 expression.Anlotinib reverses the effects of bevacizumab by inhibiting the above signals. | Xiaoling Zhang Yan Zhang Yanan Jia Tingting Qin Cuicui Zhang Yueya Li Chengmou Huang Zhujun Liu Jing Wang Kai Li | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 8 | Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p 15^INK4B, p 16^INK4A, and p57^KIP2 transcription显示文摘 | Qingping Zheng Hongjia Fan Zhenzhen Meng Lin Yuan Cuicui Liu You Peng Weiwei Zhao Lulu Wang Jing Li Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 9 | Moderate papain addition improves the physicochemical,microbiological,flavor and sensorial properties of Chouguiyu,traditional Chinese fermented fish显示文摘The objective of this study was to investigate the effect of papain on the physicochemical and microbiological properties,volatile compound profiles,and sensorial attributes of Chouguiyu.Papain was applied at a dose of 10,50,200,400 U/g fish.Results showed that papain addition improved the release of free amino acids,essential amino acids,eicosapentaenoi acid(EPA,C20:5n3),and docosapentenoic acid(DPA,C22:5n6),respectively.Lower biogenic amines content,higher the volatile compound concentrations and relative abundance of Lactobacillales were also observed.Further results showed that the papain dose group decreased the fermentation time from 10 to 7 days while good organoleptic quality was remained,especially in the 200 U/g dose group.The redundancy analysis(RDA)showed a high correlation between Lactobacillus and the key volatile compounds in the 200 U/g and 400 U/g groups,which indicated that Lactobacillus could contribute to the fatty flavor.In summary,proper papain addition(i.e.200 U/g or 400 U/g)could reduce biogenic amines contents and maintain acceptable sensorial properties of Chouguiyu in a shorter fermentation time. | Wenhuan Xu Cuicui Jiang Aoxue Liu Ruiqi Bao Wenqing Wang Zuoli Zhang Chaofan Ji Huipeng Liang Sufang Zhang Xinping Lin | 2022 | Food Bioscience2022，46，2： | 2 |
| 10 | Loss-induced nonreciprocity显示文摘Nonreciprocity is important in both optical information processing and topological photonics studies.Conventional principles for realizing non reciprocity rely on magnetic fields,spatiotemporal modulation,or nonlinearity.Here we propose a generic principle for generating nonreciprocity by taking advantage of energy loss,which is usually regarded as harmful.The loss in a resonance mode induces a phase lag,which is independent of the energy transmission direction.When multichannel lossy resonance modes are combined,the resulting interference gives rise to nonreciprocity,with different coupling strengths for the forward and backward directions,and unidirectional energy transmission.This study opens a new avenue for the design of nonreciprocal devices without stringent requirements. | Xinyao Huang Cuicui Lu Chao Liang Honggeng Tao Yong-Chun Liu | 2021 | Light(Science & Applications)2021，10，2： | 2 |
| 11 | Rapid thin-layer WS_(2) detection based on monochromatic illumination photographs显示文摘The thickness of two-dimensional(2D)nanomaterials shows a significant effect on their optical and electrical properties.Therefore,a rapid and automatic detection technology of 2D nanomaterials with desired layer-number is required to extend their practical application in optoelectronic devices.In this paper,an image recognition technology was proposed for rapid and reliable identification of thin-layer WS_(2) samples,which combining a layer-thickness identification criterion and a novel image segmentation algorithm.The criterion stemmed from optical contrast study of monochromatic illumination photographs,and the algorithm was based on Canny operator and edge connection iteration.This optical identification method can seek out thin-layer WS_(2) samples on complex surfaces,which provides a promising approach for automatic search of thin-layer nanomaterials. | Xiangmin Hu Cuicui Qiu Dameng Liu | 2021 | Nano Research2021，14，3： | 2 |
| 12 | Preparation of Surface-enhanced Raman Scattering(SERS)-active Optical Fiber Sensor by Laser-induced Ag Deposition and Its Application in Bioidentification of Biotin/Avidin显示文摘 | LIU Chunyu WANG Shaoyan FU Cuicui LI Haibo XU Shuping XU Weiqing | 2015 | Chemical Research in Chinese Universities2015，31，1： | 2 |
| 13 | Specific RNA Recognition by Designer Pentatricopeptide Repeat Protein显示文摘由设计者 Pentatricopeptide 重复蛋白质 dPPR 的特定的 RNA 识别。 | Cuicui Shen Xiang Wang Yexing Liu Quanxiu Li Zhao Yang Nieng Yan Tingting Zou Ping Yin | 2015 | Molecular Plant2015，8，4： | 2 |
| 14 | Recognition System for Leaf Diseases of Ophiopogon japonicus Based on PCA-SVM显示文摘Taking leaf black spot,anthracnose and leaf blight of Ophiopogon japonicus as the research objects,lesions were separated by K-Means clustering segmentation technology.PCA(principal component analysis)was carried out on the 46-dimensional eigenvectors composed of color,shape and texture features,and then the multi-level classifier designed by SVM(support vector machine)was used to identify lesions.The recognition rate of the developed leaf disease recognition system of O.japonicus achieved 93.3%.The results indicates that the system is of great significance to the prevention and control of O.japonicus diseases and the modernization of O.japonicus industry. | Yang Tao Liu Cuicui | 2020 | Plant Diseases and Pests2020，11，2： | 2 |
| 15 | Genetically engineered bacterial-like particles induced specific cellular and humoral immunity as effective tick-borne encephalitis virus vaccine显示文摘Tick-borne encephalitis(TBE)is a natural focal disease with fatal encephalitis induced by tick-borne encephalitis virus(TBEV),seriously threatening human and public health.Protection of TBE depends on vaccination with inactivated vaccine,which requires high cost and multiple immunizations.Here,we construct genetically engineered bacterial-like particles(BLPs)as an effective TBEV vaccine with simplified immunizations and improved immune efficacy.The TBEV BLPs involve the combination of the gram-positive enhancer matrix from Lactococcus lactis,and TBEV envelope(E)protein expressed by genetically engineered recombinant baculovirus.The prepared TBEV BLPs can effectively stimulate the activation of dendritic cells to present the TBEV E proteins to T and B cells,leading to strong and durable cellular and humoral immune responses in mice.Surprisingly,the serum levels of specific IgG antibodies in mice remain about 10^(6)at 6 months after the secondary immunization.Overall,the TBEV BLPs can be used as a potent vaccine candidate,laying the foundation for developing novel TBEV genetically engineered vaccines. | Mengyao Zhang Hongli Jin Yuanyuan Li Cuicui Jiao Pei Huang Yujie Bai Zhiyuan Gong Haili Zhang Shunjie Liu Hualei Wang | 2023 | Aggregate2023，4，3： | 1 |
| 16 | SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than Gemcitabine 显示文摘 | Cuirong Zhao Bin Yue Huiping Liu Cuicui Sun Wenbao Li Xianjun Qu | 2012 | Toxicology and Applied Pharmacology2012，262，： | 1 |
| 17 | Sequential solvent extraction for forms of antimony in five selected coals 显示文摘 | Qi Cuicui Liu Guijian Yu Kang | 2008 | The Journal Of Geology2008，116，2： | 1 |
| 18 | Numerical Simulation of Flow and Heat Transfer from Slot Jets Impinging on a Cylindrical Convex Surface显示文摘Flow and heat transfer characteristics of slot jets impingement to a cylindrical convex surface are numerically investigated.Suitable turbulence models have been determined through comparison with the experimental data.Flow structures are described and impingement heat transfer characteristics are discussed.The effects of Re,H/B and D/B on single-slot jets impingement heat transfer are analyzed and heat transfer characteristics of multiple-slot jets are investigated.The results show that:Gas flows along the convex surface and boundary layer separation occurs in both single and multiple-slot jets impingement.A maximum stagnation Nu appears at H/B=8 and the local Nu decreases with increasing H/B in the region far away from the stagnation.The Nu in the stagnation region decreases with increasing D/B but the Nu is nearly the same in the region far away from the stagnation.Pressure gradient is an important factor on heat transfer enhancement.Correlations of the Num for single-slot,double-slot and quadric-slot jets impinging on a convex surface are obtained.It indicates the effects of Re and D/B on Num could become more important in less slot jets impingement. | Zeyi JIANG Cuicui LIU Xinxin ZHANG Qiang MA Yusheng SUN | 2011 | Journal of Thermal Science2011，20，5： | 1 |
| 19 | Risk Management Model of a Micro-Grid Wind Farm显示文摘 | Jicheng Liu Suhua Wang Dexiang Wu CuiCui Luo Yajuan Yang | 2013 | Human and Ecological Risk Assessment: An International Journal2013，，5： | 1 |
| 20 | Evolution of drug regulations and regulatory innovation for anticancer drugs in China显示文摘Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovation in drug research and development(R&D).In this study,we outlined the revolution of drug regulation in China since the establishment of the State Drug Administration in 1998.More particularly,we performed a comprehensive analysis of newly approved anticancer drugs in China from the year 2005 to May 2021,as a powerful illustration of how the revolution has changed the drug R&D landscape.Innovative drug development in China has boomed,benefiting in particular from pro-innovation policies as well as expedited program designations by the authority.We found a significant increase in the number of both imported and domestic new anticancer drugs from 2005 to 2021,with the emergence of drugs with novel mechanisms of action,including immune checkpoint inhibitors and cell therapy products.Drug lag has also been dramatically shortened by more than 70%for imported drugs in years 2016-2020 compared to years 2006-2010.Furthermore,we provide an insight into the potential approaches to further optimize the science-based and clinical value-based regulatory and R&D drug ecosystem in China.This review provides evidence of significant impacts of regulations and policies on drug R&D and suggests that the constantly adapting regulatory ecosystem will speed up drug development in China and worldwide. | Yang Liu Ning Zhang Cuicui Xie Yale Jiang Yunhe Qin Liyun Zhou Yi Fan Lianjie Ren Chen Yin Huan Yang Wei Xie Qing Zhai Guanqiao Li Hongzhuan Chen Xiaoyuan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 1 |
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