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| 1 | High valence metals engineering strategies of Fe/Co/Ni-based catalysts for boosted OER electrocatalysis显示文摘Electrocatalysis for the oxygen evolution reactions(OER)has attracted much attention due to its important role in water splitting and rechargeable metal-air batteries.Therefore,designing highly efficient and low-cost catalysts for OER process is essential as the conventional catalysts still rely on precious metals.Transition metal-based compounds have been widely investigated as active OER catalysts,and renewed interest in the high valence metals engineered compounds has been achieved for superior catalytic activity and stability.However,an in-depth understanding of the construction strategies and induced effects for the high valence metals engineered catalysts is still lacking and desired.In this review,we have summarized the construction strategies of high valence metals as dopants or formed heterostructures with the iron/cobalt/nickel(Fe/Co/Ni)-based catalysts.Then the induced effects on Fe/Co/Ni-based catalysts by incorporating high valence metals,e.g.,accelerating the surface reconstruction,forming amorphous structure,generating vacancies/defects,and acting as stabilizers,are highlighted.The impacts of high valence metals on OER performance are elucidated based on different elements,including molybdenum(Mo),tungsten(W),cerium(Ce),vanadium(V),chromium(Cr),manganese(Mn),niobium(Nb),zirconium(Zr).The correlations of construction strategies,induced effects,catalytic activity and OER reaction pathways are elaborated.Finally,the remaining challenges for further enhancements of OER performance induced by high valence metals are presented. | Lu Li Xianjun Cao Juanjuan Huo Junpeng Qu Weihua Chen Chuntai Liu Yufei Zhao Hao Liu Guoxiu Wang | 2023 | Journal of Energy Chemistry2023，，1： | 3 |
| 2 | Haze trends over the capital cities of 31 provinces in China, 1981–2005显示文摘 | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou John J. Qu Xianjun Hao | 2009 | Theoretical and Applied Climatology (-)2009，，3： | 1 |
| 3 | Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay显示文摘 | Yulan Sun Mifang Liang Jing Qu Cong Jin QuanFu Zhang Jiandong Li Xiaolin Jiang Qin Wang Jing Lu Wen Gu Shuo Zhang Chuan Li XianJun Wang Faxian Zhan Wenqing Yao Zhenqiang Bi Shiwen Wang Dexin Li | 2011 | Journal of Clinical Virology2011，，1： | 1 |
| 4 | Electrochemical Carbon Dioxide Reduction to Ethylene:From Mechanistic Understanding to Catalyst Surface Engineering显示文摘Electrochemical carbon dioxide reduction reaction(CO_(2)RR)provides a promising way to convert CO_(2)to chemicals.The multicarbon(C_(2+))products,especially ethylene,are of great interest due to their versatile industrial applications.However,selectively reducing CO_(2)to ethylene is still challenging as the additional energy required for the C–C coupling step results in large overpotential and many competing products.Nonetheless,mechanistic understanding of the key steps and preferred reaction pathways/conditions,as well as rational design of novel catalysts for ethylene production have been regarded as promising approaches to achieving the highly efficient and selective CO_(2)RR.In this review,we first illustrate the key steps for CO_(2)RR to ethylene(e.g.,CO_(2)adsorption/activation,formation of~*CO intermediate,C–C coupling step),offering mechanistic understanding of CO_(2)RR conversion to ethylene.Then the alternative reaction pathways and conditions for the formation of ethylene and competitive products(C_1 and other C_(2+)products)are investigated,guiding the further design and development of preferred conditions for ethylene generation.Engineering strategies of Cu-based catalysts for CO_(2)RR-ethylene are further summarized,and the correlations of reaction mechanism/pathways,engineering strategies and selectivity are elaborated.Finally,major challenges and perspectives in the research area of CO_(2)RR are proposed for future development and practical applications. | Junpeng Qu Xianjun Cao Li Gao Jiayi Li Lu Li Yuhan Xie Yufei Zhao Jinqiang Zhang Minghong Wu Hao Liu | 2023 | Nano-Micro Letters2023，15，10： | 1 |
| 5 | Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma显示文摘 | Jianjun Gao Yoshinori Inagaki Peipei Song Xianjun Qu Norihiro Kokudo Wei Tang | 2011 | Pharmacological Research2011，，1： | 1 |
| 6 | Evaluating remotely sensed live fuel moisture estimations for fire behavior predictions in Georgia, USA 显示文摘 | Dasgupta S Qu J J Hao Xianjun | 2007 | Remote Sensing of Environment2007，108，： | 1 |
| 7 | SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than Gemcitabine 显示文摘 | Cuirong Zhao Bin Yue Huiping Liu Cuicui Sun Wenbao Li Xianjun Qu | 2012 | Toxicology and Applied Pharmacology2012，262，： | 1 |
| 8 | Investigating phenological changes using MODIS vegetation indices in deciduous broadleaf forest over continental U.S. during 2000–2008显示文摘 | Min Li John J. Qu Xianjun Hao | 2010 | Ecological Informatics2010，，5： | 1 |
| 9 | Post-hurricane forest damage assessment using satellite remote sensing显示文摘 | Wanting Wang John J. Qu Xianjun Hao Yongqiang Liu John A. Stanturf | 2009 | Agricultural and Forest Meteorology2009，，1： | 1 |
| 10 | AnImproved Algorithm for Small and Cool Fire Detec- tion Using MODIS Data: A Preliminary Study in the Southeastern United States显示文摘 | Wang Wanting Qu J J Hao Xianjun | 2007 | Remote Sensing of Environment2007，108，： | 1 |
| 11 | Haze trends over the capital cities of 31 provinces in China, 1981–2005显示文摘 | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou John J. Qu Xianjun Hao | 2009 | Theoretical and Applied Climatology (-)2009，，3： | 1 |
| 12 | Haze trends over the capital cities of 31 provinces in China, 1981–2005显示文摘 | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou John J. Qu Xianjun Hao | 2009 | Theoretical and Applied Climatology2009，，3： | 1 |
| 13 | An improved algorithm for small and cool fire detection using MODIS data: A preliminary study in the southeastern United States显示文摘 | Wanting Wang John J. Qu Xianjun Hao Yongqiang Liu William T. Sommers | 2006 | Remote Sensing of Environment2006，，2： | 1 |
| 14 | Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca_(ER)^(2+)perturbation in hepatocellular carcinoma显示文摘The well-known insulin-like growth factor 1(IGF1)/IGF-1 receptor(IGF-1R)signaling pathway is overexpressed in many tumors,and is thus an attractive target for cancer treatment.However,results have often been disappointing due to crosstalk with other signals.Here,we report that IGF-1R signaling stimulates the growth of hepatocellular carcinoma(HCC)cells through the translocation of IGF-1R into the ER to enhance sarco-endoplasmic reticulum calcium ATPase 2(SERCA2)activity.In response to ligand binding,IGF-1Rβis translocated into the ER byβ-arrestin2(β-arr2).Mass spectrometry analysis identified SERCA2 as a target of ER IGF-1Rβ.SERCA2 activity is heavily dependent on the increase in ER IGF-1Rβlevels.ER IGF-1Rβphosphorylates SERCA2 on Tyr^(990)to enhance its activity.Mutation of SERCA2-Tyr^(990)disrupted the interaction of ER IGF-1Rβwith SERCA2,and therefore ER IGF-1Rβfailed to promote SERCA2 activity.The enhancement of SERCA2 activity triggered Ca_(ER)^(2+)perturbation,leading to an increase in autophagy.Thapsigargin blocked the interaction between SERCA2and ER IGF-1Rβand therefore SERCA2 activity,resulting in inhibition of HCC growth.In conclusion,the translocation of IGF-1R into the ER triggers Ca_(ER)^(2+)perturbation by enhancing SERCA2 activity through phosphorylating Tyr^(990)in HCC. | Yanan Li Keqin Li Ting Pan Qiaobo Xie Yuyao Cheng Xinfeng Wu Rui Xu Xiaohui Liu Li Liu Jiangming Gao Wenmin Yuan Xianjun Qu Shuxiang Cui | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 15 | Activation of insulin-like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-Ⅰ显示文摘Insulin-like growth factor-1 receptor(IGF-1R) has been made an attractive anticancer target due to its overexpression in cancers.However,targeting it has often produced the disappointing results as the role played by cross talk with numerous downstream signalings.Here,we report a disobliging IGF-1R signaling which promotes growth of cancer through triggering the E3 ubiquitin ligase MEX3A-mediated degradation of RIG-I.The active β-arrestin-2 scaffolds this disobliging signaling to talk with MEX3A.In response to ligands,IGF-1Rβ activated the basal βarr2 into its active state by phosphorylating the interdomain domain on Tyr64 and Tyr250,opening the middle loop(Leu130-Cys141) to the RING domain of MEX3A through the conformational changes of βarr2.The models of βarr2/IGF-1Rβ and βarr2/MEX3A could interpret the mechanism of the activated-IGF-1R in triggering degradation of RIG-I.The assay of the mutants βarr2Y64Aand βarr2Y250Afurther confirmed the role of these two Tyr residues of the interlobe in mediating the talk between IGF-1Rβ and the RING domain of MEX3A.The truncated-βarr2 and the peptide ATQAIRIF,which mimicked the RING domain of MEX3A could prevent the formation of βarr2/IGF-1Rβ and βarr2/MEX3A complexes,thus blocking the IGF-1R-triggered RIG-I degradation.Degradation of RIG-I resulted in the suppression of the IFN-I-associated immune cells in the TME due to the blockade of the RIG-I-MAVS-IFN-I pathway.Poly(I:C) could reverse anti-PD-L1 insensitivity by recovery of RIG-I.In summary,we revealed a disobliging IGF-1R signaling by which IGF-1Rβ promoted cancer growth through triggering the MEX3A-mediated degradation of RIG-I. | Qiaobo Xie Yanyan Chu Wenmin Yuan Yanan Li Keqin Li Xinfeng Wu Xiaohui Liu Rui Xu Shuxiang Cui Xianjun Qu | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 16 | Assessing the Impact of Year 2012 Drought on Corn Yield in the US Corn Belt Using Precipitation Data显示文摘 | Joe Wan Michael Qu Xianjun Hao Ray Motha John J. Qu | 2015 | Journal of Earth Science and Engineering2015，5，6： | 0 |
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